CN103083411A - Traditional Chinese animal medicine preparation for treating poultry colibacillosis - Google Patents
Traditional Chinese animal medicine preparation for treating poultry colibacillosis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese animal medicine preparation for treating poultry colibacillosis. The traditional Chinese animal medicine preparation is prepared from the following traditional Chinese medicinal materials in parts by weight of 18-26 parts of pomegranate rind, 16-20 parts of rhizoma atractylodis, 16-20 parts of dandelion, 12-18 parts of angelica sinensis, 12-18 parts of Chinese knotweed herb, 12-18 parts of fructus forsythia, 8-11 parts of gypsum powder, 8-12 parts of fructus arctii and 2-6 parts of licorice. By applying the traditional Chinese animal medicine preparation disclosed by the invention, the poultry colibacillosis can be effectively controlled; and the morbidity and the death rate of the poultry colibacillosis are reduced.
Description
Technical field
The invention belongs to the veterinary drug technical field, in particular to a kind of herbal medicine preparation that is used for the treatment of poultry colibacillosis, particularly a kind of veterinary drug preparation that is used for the treatment of chicken colibacillosis.
Background technology
Colibacillosis is a kind of common multiple general disease that is caused by the pathological form escherichia coli.This disease can be given birth in various age chicken mass-sendings, and as infective pathogen, its caused disease belongs to the opportunistic illnesses category.Be not good in feeding and management, improper ventilation, sanitary condition relatively poor poultry farm, when the resistance of poultry reduces, will encroach on body and cause colibacillosis.In feeding and management and sanitary condition good poultry-farm, environmental pollution is lighter, and poultry immunity power and resistance are stronger, and the Colibacillosis rate is lower, and the loss that causes is less; Colibacillary antigen construct is complicated, and pathogenic serotype is a lot of, and this has run into a larger difficult problem with regard to the vaccine production that makes colibacillosis.The vaccine of producing now is because its protective rate is limited, and duration of immunity is short, and troublesome poeration has run into larger resistance in popularization, so in immune programme for children is not listed colibacillary epidemic prevention so far yet by many plants.In preventing and treating the medicine of colibacillosis, antibiotic and sulfonamides are effectively, but because the abuse to medicine is in recent years had a greatly reduced quality their curative effect, people have to seek new means of prevention to control the infringement of this disease.At present, mostly adopt chemicals and antibiotic control escherichia coli both at home and abroad, due to chemicals and antibiotic a large amount of use, make colibacillary drug tolerance of strain more and more stronger, Antibiotic Resistance is also more and more wider.Some coli strains even also show very strong drug resistance to the new antibiotic that not yet is used for veterinary clinic.And chemicals and antibiotic all have certain toxicity, side effect, can also pass to the mankind by meat, egg, come very large problem for the food sanitary pad.
Chinese herbal medicine belongs to natural drug, and the application and research in China has accumulated rich experience.Utilize Chinese herbal medicine to prevent and treat attention and favor that colibacillosis more and more is subjected to people, more and more be widely accepted, that mechanism of action, model of action and the advantage unique with it is inseparable, put it briefly, the herbal control disease has Accommodation, strengthening vital QI to eliminate pathogenic factors, have no drug resistance and the incomparable characteristics and advantages of other medicines such as nuisanceless.Show: (1) Chinese herbal medicine has Accommodation to body, and so-called Accommodation is exactly that rise and fall of yin and yang with medicine reconditioner body makes body reach the relative equilibrium of YIN and YANG, keeps or recovers normal physiological function, plays the effect of preventing and curing diseases.The Accommodation of Chinese herbal medicine has also shows as dual regulation to body.To the body functional status too vigorous make it suppress to get off, can it be psyched up to what functional status too failed again, thereby return to normal functional status, this is that Western medicine is incomparable.(2) Chinese herbal medicine also has the effect of strengthening vital QI to eliminate pathogenic factors, reinforcing body resistance to body, and the preventive and therapeutic effect of Chinese herbal medicine is not outer in reinforcing body resistance and the large rule of dispeling disease and evil two.Righting and eliminating evil is that the deficiency and excess situation according to disease reaction decides.The generation of disease, developing and lapse to process, is the process of good and evil both sides struggle, and pathogen preponderating over vital QI disease advances, and vital QI preponderating over pathogen is retired due to illness.(3) another distinguishing feature of herbal control colibacillosis and advantage are to have no drug resistance.As everyone knows, prolonged application antibiotic and chemical drugs, easily develop immunity to drugs clinically, and great majority are owing to having produced a large amount of adaptives enzyme and persister.And this class disadvantage just seldom appears in Chinese herbal medicine.Reason is that Chinese herbal medicine mostly is compound action, and general the application mostly is compound recipe, with disease plus-minus medicine, disturbs bacterial metabolism with Multiple components in compound recipe from the links of ribonucleic acid, DNA (deoxyribonucleic acid), energy metabolism.Can suppress breathing and the nucleic acid metabolism of staphylococcus aureus as Rhizoma Coptidis; Cortex Phellodendri can suppress the synthetic of its ribonucleic acid; Radix Et Rhizoma Rhei can suppress its dehydrogenase; Radix Glycyrrhizae can stop its DNA (deoxyribonucleic acid) metabolism, and this prescriptions of Chinese medicine just is difficult for pathogen is developed immunity to drugs like this.(4) outstanding feature and the advantage of herbal control colibacillosis are nuisanceless, raising and China joined WTO along with people's living standard, though the livestock products of China have larger price advantage in the international market, but due to ecological environment and the defective product quality problem that causes of working condition, be the main cause that China's livestock products outlet is obstructed.How to improve the quality of livestock products, reduce medicine residual, the green livestock products of production high-quality, nutrition, safety non-pollution have become the theme of 21 century sustainable development of animal husbandry.(5) Chinese herbal medicine when the control livestock and poultry, the toxic and side effects of harm person poultry safety and physiological function seldom occurs.Along with the development of modern medicine, some iatrogenic disorders have correspondingly appearred, namely cause the toxicity, side effects such as body canceration, deformity, physiological function damage, even appearance paralysis, death due to application antibiotic, chemical drugs, hormone medicine.And Chinese herbal medicine is long at the applicating history of China, and curative effect is certain, and it has play a part huge to multiplying and being prosperous of China poultry with human health.Long-term clinical practice proves, above-mentioned toxic and side effects seldom appears in Chinese herbal medicine.
Therefore, the nuisanceless advantage of Chinese medicine is that antibiotic, chemicals, hormone medicine etc. are incomparable.So utilize the herbal control livestock and poultry, have the Accommodation of strengthening vital QI to eliminate pathogenic factors, effective, and do not have the residue problem of antibiotic medicine, highly beneficial to the animal husbandry products export of China.In addition, Chinese herbal medicine also has low price, wide material sources, and the advantage such as easy to use is one of developing direction of veterinary drug from now on.
Summary of the invention
The object of the invention is to by a large amount of animal experiment studies, a kind of herbal medicine preparation that is used for the treatment of poultry colibacillosis is provided.
The object of the present invention is achieved like this:
A kind of herbal medicine preparation that is used for the treatment of poultry colibacillosis is prepared from by the Chinese crude drug of following weight portion: Pericarpium Granati 18-26 part, Rhizoma Atractylodis 16-20 part, Herba Taraxaci 16-20 part, Radix Angelicae Sinensis 12-18 part, Herb Polygoni Chinensis 12-18 part, Fructus Forsythiae 12-18 part, Gypsum Fibrosum powder 8-11 part, Fructus Arctii 8-12 part, Radix Glycyrrhizae 2-6 part.
Preferably, the described herbal medicine preparation that is used for the treatment of poultry colibacillosis is prepared from by the Chinese crude drug of following weight portion: 22 parts of Pericarpium Granatis, 18 parts of Rhizoma Atractylodis, 18 parts of Herba Taraxacis, 15 parts of Radix Angelicae Sinensis, 15 parts of Herb Polygoni Chinensiss, 15 parts of Fructus Forsythiaes, 10 parts of Gypsum Fibrosum powders, 10 parts of Fructus Arctiis, 4 parts, Radix Glycyrrhizae.
Further preferably, the described herbal medicine preparation that is used for the treatment of poultry colibacillosis is granule.
Further preferably, described poultry comprises chicken, duck, goose, Carnis Coturnicis japonicae.
According to the Chinese medicine Historical Data Data About, above-mentioned Chinese crude drug has following pharmacologically active and function cures mainly:
Pericarpium Granati: astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery is had blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.Select the peel of Punicaceae plant Punica granatum L. PunicaGranatumL..
Rhizoma Atractylodis: drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Select the rhizome of feverfew Atractylodes lancea (Thunb.) DC., Atractylis chinensis or atractylodes japonica.
Herba Taraxaci: have heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the effect of inducing diuresis for treating stranguria syndrome.Be used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Be selected from the herb of dry Herba Taraxaci.
Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Select the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.
Herb Polygoni Chinensis: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Be used for diarrhea due to damp-heat, dysentery, jaundice, laryngopharynx swelling and pain, herpes simplex rash.Select the dry herb of polygonaceae plant Herb Polygoni Chinensis Polygonum chinense L..
Fructus Forsythiae: control calentura from the beginning of, anemopyretic cold, heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis, pyretic stranguria.Be selected from Oleaceae (Oleaceae) Forsythia (Forsythia) plant Fructus Forsythiae (Forsythia suspensa(Thunb.) Vahl) dry fruit.
Gypsum Fibrosum powder: expelling pathogenic factors from muscles for clearing heat, relieving restlessness quench the thirst, heat-clearing and toxic substances removing, pathogenic fire purging.Control the calentura high fever and do not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, the lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat is sent out the speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.The external treatment ulcer sores is burst and is not closed up, the burning hot wound of soup.
Fructus Arctii: have the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule not thoroughly, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select the Fisch. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis, Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..
Above-mentioned each Chinese crude drug is prepared into the preparation method of herbal medicine preparation of the present invention, comprises the steps:
The first step, preparation clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug that cleans up by recipe quantity, pulverize, standby;
2) decoct: decoct with water, first fries in shallow oil every tank, and to add water be 8 times of medical material total amount, kept 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tank; Second fries in shallow oil the water heating extraction that adds 6 times of medical material amounts, protects to boil 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: in settling tank, the extracting solution precipitation is 24～36 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: being concentrated into relative density in triple effect evaporator when supernatant is 1.05～1.10(40 ℃ of mensuration) time, rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in the cream bucket, standby;
5) drying: vacuum: 0.01MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
Second step, according to the clear paste powder: dextrin: 55% ethanol is that the weight ratio of 1:1～3:0.1～0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, clear paste powder and dextrin are dropped in trough type mixing machine, stirred 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts granulations, 65～75 ℃ of dryings 2 hours, taking-up cools and namely gets described granule.
Colibacillosis be the most common in poultry husbandry, also be to endanger one of the most serious epidemic disease.Because colibacillary drug resistance is strong, breed hen for meat particularly, in order to prevent and cure diseases, short its growth, the frequent regular or irregular antibiotic that adds in feedstuff, when causing morbidity, the invalid or curative effect of medication descends.The inventor prevents and treats poultry colibacillosis with Chinese herbal and crude drugs preparations, from our experimental result, uses herbal medicine preparation of the present invention and can effectively control chicken colibacillosis, reduces the M ﹠ M of chicken colibacillosis.Compared with prior art, no matter be prevention, or treatment, significant difference, but also do not produce drug resistance, and apply through test of many times and small size, obtained good effect, the chicken house economic benefit is obviously improved.
The specific embodiment
Further illustrate the present invention below by embodiment.Embodiments of the invention are only used for illustrating the present invention, rather than limitation of the present invention, and the simple modifications to preparation method of the present invention under design prerequisite of the present invention all belongs to the scope of protection of present invention.
The preparation of embodiment 1-3 veterinary drug granule
The prescription of table 1 embodiment 1-3 veterinary drug granule
| Chinese crude drug | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Pericarpium Granati | 220g | 260g | 180g |
| Rhizoma Atractylodis | 180g | 160g | 200g |
| Herba Taraxaci | 180g | 160g | 180g |
| Radix Angelicae Sinensis | 150g | 120g | 180g |
| The Herb Polygoni Chinensis | 150g | 180g | 120g |
| Fructus Forsythiae | 150g | 180g | 120g |
| Gypsum Fibrosum powder | 100g | 80g | 100g |
| Fructus Arctii | 100g | 80g | 120g |
| Radix Glycyrrhizae | 40g | 60g | 20g |
Preparation technology:
The first step, preparation clear paste powder:
1) get the raw materials ready: take the above-mentioned Chinese crude drug that cleans up by recipe quantity, pulverize, standby;
2) decoct: decoct with water, first fries in shallow oil every tank, and to add water be 8 times of medical material total amount, kept 3 hours after ebuillition of heated, and extracting solution filters through 200 order filters and enters settling tank; Second fries in shallow oil the water heating extraction that adds 6 times of medical material amounts, protects to boil 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: in settling tank, the extracting solution precipitation is 24 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: being concentrated into relative density in triple effect evaporator when supernatant is 1.05(40 ℃ of mensuration) time, rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters, concentrating and be mixed to relative density is 1.30～1.32(90 ℃ of mensuration) time go out cream, to storing in the cream bucket, standby;
5) drying: vacuum: 0.01MPa wherein, temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder;
Second step, according to the clear paste powder: dextrin: 55% ethanol is that the weight ratio of 1:2:0.1～0.3 takes clear paste powder, dextrin and 55% ethanol, and wherein 55% ethanol refers to that volumetric concentration is 55% ethanol water;
The 3rd step, clear paste powder and dextrin are dropped in trough type mixing machine, stirred 20 minutes, slowly add while stirring 55% ethanol, to making soft material, with 12 order stainless steel sifts granulations, 70 ℃ of dryings 2 hours, taking-up cools and namely gets described granule.
The curative effect science research of embodiment 4 veterinary drug granules of the present invention to manual-induced chicken colibacillosis
With chicken colibacillosis 0
2With escherichia coli 0
78Mixed liquor.Before use, to preserve strain and first inoculate ordinary flat, after 37 ℃ of cultivation 24h, selecting colonies typical is inoculated in meat soup, take out after 37 ℃ of cultivation 18h again, cultured solution of broth inoculation chicken is cultivated from dead chicken liver separating Escherichia coli after rejuvenation, preparation escherichia coli liquid is cultivated counting method with flat board and is measured its growth turbidity unit for containing 1.5 * 10
5Individual bacterium/mL.
120 of the Sanhuang broilers of 1 age in days health, without any vaccine immunity, male and female has concurrently, is divided into Normal group, model control group, positive controls and Chinese drug-treated group, 30 every group.Each organizes conventional feeding and management, free choice feeding and drinking-water.Except Normal group, every thoracic muscle Escherichia Coli Injection liquid 0.8mL.
12h after the inoculation cause of disease treats by the mode of table 2, is used in conjunction 3d.Continuous Observation 15d after drug withdrawal, every day, clinical symptoms and the death toll of chicken respectively organized in record, dead chicken in time cutd open inspection, and get pathological material of disease and carry out Isolation and culture of agent and evaluation.
Table 2 is respectively organized test chicken grouping and administration
Mortality rate: escherichia coli disease symptoms died appears in duration of test, and cuing open inspection air bag, liver and heart discovery has the typical cytopathic feature, and pathological material of disease can be isolated colibacillary, is judged as to infect death, and each is organized according to dead chicken number calculating
Mortality rate.
Effective percentage: all at duration of test clinical symptom remission after medication, spirit appetite recovers normal, body weight increases before than medication, cut open inspection after execution without pathological changes person, comprise the chicken of curing fully and there is no death but have the chicken of clinical symptoms performance to be judged to effectively, accounting for the percentage rate calculating effective percentage of test chicken number with the chicken number of every group of survival.The effective percentage of model control group accounts for the percentage ratio of experimental chicken number for it takes a turn for the better naturally.
Cure rate: at duration of test, the mental status, appetite recover normal after administration, and the clinical symptoms such as the excrement that no longer occurs having loose bowels all belong to healing, calculate respectively and respectively organize cure rate.The cure rate of model control group is the spontaneous recovery rate.Effective percentage accounts for the percentage ratio of experimental chicken number for it takes a turn for the better naturally.
The clinical trial result of each group of table 3 to artificial challenge's chicken colibacillosis
Colibacillosis be the most common in poultry husbandry, also be to endanger one of the most serious epidemic disease.Because colibacillary drug resistance is strong, breed hen for meat particularly, in order to prevent and cure diseases, short its growth, the frequent regular or irregular antibiotic that adds in feedstuff, when causing morbidity, the invalid or curative effect of medication descends.Improve colibacillary prevention effect, improve the resistance against diseases of chicken body self.The inventor prevents and treats poultry colibacillosis with Chinese herbal and crude drugs preparations, from our experimental result, no matter be prevention, or treatment, significant difference, but also do not produce drug resistance, apply through test of many times and small size, obtained good effect, the chicken house economic benefit is obviously improved.
Claims (4)
1. herbal medicine preparation that is used for the treatment of poultry colibacillosis, it is characterized in that: the Chinese crude drug by following weight portion is prepared from: Pericarpium Granati 18-26 part, Rhizoma Atractylodis 16-20 part, Herba Taraxaci 16-20 part, Radix Angelicae Sinensis 12-18 part, Herb Polygoni Chinensis 12-18 part, Fructus Forsythiae 12-18 part, Gypsum Fibrosum powder 8-11 part, Fructus Arctii 8-12 part, Radix Glycyrrhizae 2-6 part.
2. the herbal medicine preparation that is used for the treatment of poultry colibacillosis according to claim 1, it is characterized in that: the Chinese crude drug by following weight portion is prepared from: 22 parts of Pericarpium Granatis, 18 parts of Rhizoma Atractylodis, 18 parts of Herba Taraxacis, 15 parts of Radix Angelicae Sinensis, 15 parts of Herb Polygoni Chinensiss, 15 parts of Fructus Forsythiaes, 10 parts of Gypsum Fibrosum powders, 10 parts of Fructus Arctiis, 4 parts, Radix Glycyrrhizae.
3. the herbal medicine preparation that is used for the treatment of poultry colibacillosis according to claim 1 and 2 is characterized in that: it is granule.
4. the herbal medicine preparation that is used for the treatment of poultry colibacillosis according to claim 1 and 2, it is characterized in that: described poultry comprises chicken, duck, goose, Carnis Coturnicis japonicae.
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