CN103055219B - A kind of respiratory diseases in pigs health care Chinese medicine powder and preparation technology thereof - Google Patents

A kind of respiratory diseases in pigs health care Chinese medicine powder and preparation technology thereof Download PDF

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CN103055219B
CN103055219B CN201210542262.1A CN201210542262A CN103055219B CN 103055219 B CN103055219 B CN 103055219B CN 201210542262 A CN201210542262 A CN 201210542262A CN 103055219 B CN103055219 B CN 103055219B
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radix
health care
stemona
chinese medicine
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CN103055219A (en
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梁世仁
温庆琪
周盛昌
施建成
黄静
肖丽萍
姜文
叶俊标
吴有林
艾春香
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Jiangxi Yixinbao Biotechnology Co ltd
Fujian Aonong Biological Technology Group Co Ltd
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Jiangxi Aoxin Biotechnology Co Ltd
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Abstract

The invention provides a kind of respiratory diseases in pigs health care Chinese medicine powder, it is characterized in that being combined by weight proportion by following main ingredient, 20-35 parts of Bulbus Fritillariae Cirrhosaes, 20-35 parts of the tubers of stemona, 15-25 parts, Radix Glycyrrhizae, 20-35 parts of radix platycodis, 10-20 parts of SEMEN RAPHANIs. The present invention also provides the preparation technology of this Chinese prescription, it is characterized in that preparation method's step is as follows: it is above as standby material that (1) is crushed to 180 orders with micronizer respectively using Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi. (2) SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use. (3) take above-mentioned for subsequent use former medicine by above-mentioned part by weight respectively and be placed in V-Mixer and mix 25-30 minutes, blanking is packaged into bag.

Description

A kind of respiratory diseases in pigs health care Chinese medicine powder and preparation technology thereof
Technical field
The invention belongs to herbal medicine field of pharmaceutical technology, for a kind of traditional Chinese powder medicine and preparation technology of respiratory diseases in pigs health care.
Background technology
PRDC is a kind of disease of complexity, worldwide endangers pig industry. PRDC sees the pig farm of different management and facility; comprise large scale of pig farm field; it is the breathing problem of a kind of normal occurring in pig industry in recent years; it is the mixed infection by some pathogen, and the comprehensive disease causing in the acting in conjunction of the many factors such as environmental condition, feeding and management. The sick syndrome of porcine respiratory has become the most important thing of the current swine disease of China, almost there is generation on all pig farms, and be difficult to remove, it is except causing direct death, more seriously slowly (5%--25%), efficiency of feed utilization reduce (5%--25%), marketing time is postponed (15--20 days) to make pig weightening finish, and carry for a long time multiple related diseases substance. The incidence of disease on some pig farm can reach 40%--80%, immediate mortality more than 10%, weightening finish decline or growth retardation reach 70%, some pig farms are even forced to the pig in this stage all to eliminate, and have a strong impact on the economic benefit on pig farm.
At present, the popular feature that has occurred that some are new of breathing problem syndrome, the one, the pathogen of mixed infection changes more to some extent, shows as by one or more bacteriums, virus the mixed infection causing. There are in the porcine respiratory of breathing problem syndrome clinical symptoms three kinds of cause of diseases that are the most often separated to: mycoplasma pneumoniae (MH), porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus (SIV). The 2nd, the change of disease time, after wean, the pig in each stage all can fall ill, and 2 weeks from weaning start, until breathing problem syndrome can occur fattening period, each stage of sow also can hair tonic respiratory syndrome. The 3rd, the mixed infections such as the normal and bacterium of this virus, mycoplasma, PCV-II, CSFV, Pseudorabies virus, swine influenza virus, PRCV, make the incidence of disease such as swinery bacteriosis, swine fever, pseudoabies increase, other diseases as eperythrozoon, streptococcosis, wean after multisystem exhaustion syndrome also increase. Therefore, porcine respiratory disease has become the obstacle of large-scale pig farm maximum. The health hygienic work of carrying out pig farm breathing problem is very important.
The medicine that is used for the treatment of at present such disease is a lot, but mainly taking chemical classes medicine as main, due to long-term clinical Irrational Use of Drugs, causes drug resistance to strengthen year by year, and its curative effect also reduces gradually. Therefore, adopt herbal medicine preparation to treat porcine respiratory disease syndrome and become goal in research in recent years.
Summary of the invention
The object that technical problem to be solved by this invention invents is: the traditional Chinese powder medicine for respiratory diseases in pigs health care of a kind of good effect, good stability is provided, and the health care that both can be used for respiratory diseases in pigs also can be used for the treatment of clinical breathing problem.
The technical scheme that realizes the object of the invention and adopt is:
A kind of respiratory diseases in pigs health care Chinese medicine powder, is characterized in that being combined by weight proportion by following main ingredient: Bulbus Fritillariae Cirrhosae 20---35 parts, the tuber of stemona 20---35 parts, Radix Glycyrrhizae 15---20 parts of 25 parts, radix platycodis 20---35 parts, SEMEN RAPHANI 10---.
The preparation technology of above-mentioned said Chinese prescription, is characterized in that preparation method's step is as follows:
(1) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material;
(2) SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use;
(3) taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---30 minutes, to obtain final product.
The using method of above-mentioned said a kind of respiratory diseases in pigs health care Chinese medicine powder is: spice is fed, and every 1000 kilogram of feed are admixed 3 kilograms of this product, evenly mixes pig free choice feeding.
The usefulness of technique scheme is:
1, a kind of respiratory diseases in pigs health care Chinese medicine powder of the present invention and preparation technology, the advantage possessing through test confirmation and positive effect show as, clinical testing is used this powder can prevent the generation of pig farm breathing problem, and to having infected the live pig of breathing problem, its cure rate can reach more than 80%, and the generation that has no drug resistance. Clinical testing evaluation thinks, Bulbus Fritillariae Cirrhosae has moistening lung only to cough and reduce phlegm, the effect of heat-clearing dissipating bind; Antibacterial and the anti-viral effect of tuber of stemona tool antibechic; Radix Glycyrrhizae has the effects such as clearing heat and detoxicating cough-relieving; Radix platycodi has antibechic, antipyretic and antiinflammatory action; SEMEN RAPHANI has the effect of anti-inflammatory, analgesia and removing toxic substances. This traditional Chinese medicine of the five flavours itself has and complements each other, and is the effective combination that prevents and treats breathing problem, and the powder patent medicine being prepared into through technique of the present invention has good clinical effectiveness.
2, this research prescription employing Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, radix platycodi, SEMEN RAPHANI are main ingredient, and wherein Bulbus Fritillariae Cirrhosae has moistening lung only to cough and reduce phlegm, the effect of heat-clearing dissipating bind; Antibacterial and the anti-viral effect of tuber of stemona tool antibechic; Radix Glycyrrhizae has the effects such as clearing heat and detoxicating cough-relieving; Radix platycodi has antibechic, antipyretic and antiinflammatory action; SEMEN RAPHANI has the effect of anti-inflammatory, analgesia and removing toxic substances. Be aided with the health care that suitable powder pharmaceutical technology can be used for porcine respiratory, its clinical effectiveness is good.
Detailed description of the invention
Make specific description below in conjunction with the embodiment providing.
Embodiment 1:
(1) 20 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of the tubers of stemona, 15 parts, Radix Glycyrrhizae, 25 parts of radix platycodis, 10 parts of SEMEN RAPHANIs.
(2) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material; SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use; Taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---and 30 minutes, blanking was packaged into bag.
Embodiment 2:
(1) 25 parts of Bulbus Fritillariae Cirrhosaes, 25 parts of the tubers of stemona, 18 parts, Radix Glycyrrhizae, 25 parts of radix platycodis, 12 parts of SEMEN RAPHANIs.
(2) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material; SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use; Taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---and 30 minutes, blanking was packaged into bag.
Embodiment 3:
(1) 23 parts of Bulbus Fritillariae Cirrhosaes, 28 parts of the tubers of stemona, 18 parts, Radix Glycyrrhizae, 30 parts of radix platycodis, 15 parts of SEMEN RAPHANIs.
(2) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material; SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use; Taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---and 30 minutes, blanking was packaged into bag.
Embodiment 4:
(1) 25 parts of Bulbus Fritillariae Cirrhosaes, 30 parts of the tubers of stemona, 20 parts, Radix Glycyrrhizae, 30 parts of radix platycodis, 15 parts of SEMEN RAPHANIs.
(2) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material; SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use; Taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---and 30 minutes, blanking was packaged into bag.
Embodiment 5:
(1) 25 parts of Bulbus Fritillariae Cirrhosaes, 20 parts of the tubers of stemona, 18 parts, Radix Glycyrrhizae, 30 parts of radix platycodis, 15 parts of SEMEN RAPHANIs.
(2) Bulbus Fritillariae Cirrhosae, the tuber of stemona, Radix Glycyrrhizae, four kinds of main ingredients of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material; SEMEN RAPHANI is crushed to 40 orders with pulverizer above for subsequent use; Taking above-mentioned for subsequent use former medicine by above-mentioned part by weight is respectively placed in V-Mixer and mixes 25---and 30 minutes, blanking was packaged into bag.
With the traditional Chinese powder medicine of the said a kind of respiratory diseases in pigs health care of the present invention, pig is prevented and is treated the test report example of porcine respiratory disease.
(1) a kind of test of traditional Chinese powder medicine treatment porcine respiratory disease of respiratory diseases in pigs health care.
1, materials and methods
In June, 2012, there are 650 piglets on pig farm, Guangxi Bobai County, most of piglet occurs that spirit is depressed, feed intake declines or do not eat, have a running nose, cough, have difficulty in breathing, be abdominal respiration, under ear and abdomen, skin is blue, eye discharge increases, and occurs conjunctivitis symptom etc., doubtful porcine respiratory syndrome. Select the piglet on this pig farm, male and female pig all has, 60 ~ 70 ages in days, and body weight is 23.6 ~ 25.8kg, wherein 140, be divided into 7 groups, every group of 20 piglet is for examination. Test grouping and administration: 1 ~ 5 group of test group, adopt respectively embodiment 1 ~ 5 to be prepared medicine, and respectively according to the using method medication of the embodiment of the present invention 1 ~ 5. Infecting control group is to be infected but the piglet of not administration; Normal healthy controls group is the healthy piglet without catching; All the other each group is used in conjunction 7. Observation period is 15 days after administration, and weighing and body condition observation before and after every pig is tested. Index of assessment of curative effect:
(1) death rate=dead piglet/test piglet number × 100%;
(2) cure rate=piglet is cured number/test piglet number × 100%;
(3) efficient=treat effective piglet number/test piglet number × 100%;
(4) rate of body weight gain. The body weight of every pig when starting and when off-test, the weightening finish of calculating every pig, then calculates average weight gain and the standard deviation of every group of test pig according to this. Rate of body weight gain/normal healthy controls group rate of body weight gain × 100% of the relative weight gain rate=each medication group or infected group, wherein normal healthy controls group is set as 100%;
(5) data analysis and process: use SPSS15.0 software data processing, the wherein death rate, cure rate, efficient all with Ka Shi inspection, weightening finish employing t inspection, statistical results are in table 1.
2, result
Table 1 medicine of the present invention is to porcine respiratory syndrome curative effect statistics.
Test result analysis: test group 1-5 with infect control group in the death rate, cure rate, efficiently there is significant difference (P < 0.01), test group 1-5 all has significant curative effect to porcine respiratory syndrome; Test group 1-5 has significant difference (P < 0.01) with the relative weight gain rate that infects control group, but all lower than normal healthy controls group, wherein the curative effect of test group 5 is best, judges that this group medicine is best of breed.
(2) a kind of test of traditional Chinese powder medicine prevention porcine respiratory disease of respiratory diseases in pigs health care.
1, materials and methods
1.1, test drug: above-mentioned example 5 drug regimen powders are provided by the inventor. Ai Lixin is provided by Hunan vast animal and veterinary research and development Co., Ltd, and Main Ingredients and Appearance is 5% tartaric acid acetylisovaleryl tylosin, and product authentication code is 180352242, and product batch number is 2012082401.
1.2, experimental animal: random choose kind is identical, body weight is close, raising is consistent with management condition, 90 of the piglets of approximately 80 ages in days, is divided at random 3 groups, 30 every group.
1.3, the feeding and management condition of test pig: testing each group of pig and all raise in same seat pigsty, feeds in point 6 hurdles, and every 15 pigs are closed a hurdle, free choice feeding. The basal diet of 3 groups of pigs is identical, searches for food, drinking-water, sanitary condition is consistent, adopts conventional child care phase feed diet formula to feed.
1.4, test method:
1.4.1, by 90 random packet subfields of test pig, under the same terms, feed one week, weigh on an empty stomach morning, and keep a record.
First group: in basal diet, add above-mentioned test group 5 medicine 3 kg/ton feeds, raise continuously 15, hereinafter referred to as Chinese drug-treated group.
Second group: in basal diet, add and like the new 1 kg/ton feed of profit, raise continuously 15, hereinafter referred to as Ai Lixin group.
The 3rd group: in basal diet, not adding any medicine, is control group.
After above medicine mixes with basal diet, take cafeteria feeding mode, every mornings 9 point, 4 observations in afternoon, record that piglet breathes, status of cough and death toll, until 140 ages in days.
1.4.2, the criterion of test pig breathing problem:
Slight: piglet has sneezes or coughs with interior for obvious and continuous 5 times;
Moderate: piglet has obvious and continuous 5 above coughs;
Serious: piglet has obviously and coughs and pant continuously, is abdominal respiration, and it is serious to become thin.
2, result
The situation of duration of test viewing test pig, the result of the test of record is as table 2
Table 2 test group, a situation arises for control group porcine respiratory disease.
Respiratory symptom Chinese drug-treated group Ai Lixin group Control group
Nothing 27 26 16
Slightly 1 1 6
Moderate 1 1 4
Seriously 1 0 4
Breathing problem incidence of disease % 10% 6.6% 46.7%
By observing, overall mental status, the diet situation of Chinese drug-treated group and Ai Lixin group test pig are better than control group, and the incidence of disease of breathing problem is also starkly lower than control group.

Claims (2)

1. a respiratory diseases in pigs health care Chinese medicine powder, is characterized in that: it is combined by weight proportion by following Chinese medicine: 20-35 parts of Bulbus Fritillariae Cirrhosaes, 20-35 parts of the tubers of stemona, 15-25 parts, Radix Glycyrrhizae, 20-35 parts of radix platycodis, 10-20 parts of Radish seeds.
2. a preparation technology for respiratory diseases in pigs health care Chinese medicine powder, is characterized in that: it comprises the following steps:
(1) 20-35 parts of Bulbus Fritillariae Cirrhosaes, 20-35 parts of the tubers of stemona, 15-25 parts, Radix Glycyrrhizae, 20-35 parts of four kinds of Chinese medicines of radix platycodi are crushed to 180 orders with micronizer respectively above as standby material;
(2) 10-20 parts of Radish seeds are crushed to 40 orders with pulverizer above for subsequent use;
(3) take above-mentioned for subsequent use former medicine by above-mentioned part by weight respectively and be placed in mixer and mix 25-30 minutes, blanking is packaged into bag.
CN201210542262.1A 2012-12-14 2012-12-14 A kind of respiratory diseases in pigs health care Chinese medicine powder and preparation technology thereof Active CN103055219B (en)

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CN108208399A (en) * 2017-12-31 2018-06-29 定远县恒基牧业有限公司 A kind of organic feed for improving the sow speed of growth and preparation method thereof
CN108125039A (en) * 2017-12-31 2018-06-08 定远县恒基牧业有限公司 A kind of piglet organic feed for improving the speed of growth and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1068740A (en) * 1991-07-13 1993-02-10 贾虎子 The compound method of pneumonia Xiaolingsan
CN101406686A (en) * 2008-11-14 2009-04-15 宋冰 Medicament for mainly curing bronchial asthma and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1068740A (en) * 1991-07-13 1993-02-10 贾虎子 The compound method of pneumonia Xiaolingsan
CN101406686A (en) * 2008-11-14 2009-04-15 宋冰 Medicament for mainly curing bronchial asthma and preparation method thereof

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