CN103044399B - 一种雷贝拉唑及其钠盐的制备方法 - Google Patents
一种雷贝拉唑及其钠盐的制备方法 Download PDFInfo
- Publication number
- CN103044399B CN103044399B CN201110308163.2A CN201110308163A CN103044399B CN 103044399 B CN103044399 B CN 103044399B CN 201110308163 A CN201110308163 A CN 201110308163A CN 103044399 B CN103044399 B CN 103044399B
- Authority
- CN
- China
- Prior art keywords
- rabeprazole
- preparation
- methyl
- organic solvent
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Abstract
Description
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110308163.2A CN103044399B (zh) | 2011-10-12 | 2011-10-12 | 一种雷贝拉唑及其钠盐的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110308163.2A CN103044399B (zh) | 2011-10-12 | 2011-10-12 | 一种雷贝拉唑及其钠盐的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103044399A CN103044399A (zh) | 2013-04-17 |
CN103044399B true CN103044399B (zh) | 2014-08-06 |
Family
ID=48057283
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110308163.2A Active CN103044399B (zh) | 2011-10-12 | 2011-10-12 | 一种雷贝拉唑及其钠盐的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103044399B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106349220A (zh) * | 2016-08-25 | 2017-01-25 | 岳阳正昊化学科技有限公司 | 一种右旋雷贝拉唑钠的纯化方法 |
CN114933588A (zh) * | 2022-06-16 | 2022-08-23 | 岳阳职业技术学院 | 雷贝拉唑钠粗品的精制方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1381443A (zh) * | 2001-04-20 | 2002-11-27 | 中国医学科学院药物研究所 | 催化氧化硫醚类化合物制备含亚砜基类药物的方法 |
CN1229341C (zh) * | 2000-03-13 | 2005-11-30 | 埃斯特维化学股份有限公司 | 氧化硫醚基成为亚砜基的方法 |
WO2006049486A1 (en) * | 2004-11-08 | 2006-05-11 | Dishman Pharmaceuticals And Chemicals Ltd. | A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES |
WO2007026188A1 (en) * | 2005-09-01 | 2007-03-08 | Wockhardt Limited | Process for the manufacture of antiulceratives |
WO2009027533A1 (en) * | 2007-08-31 | 2009-03-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing 2-sulfinyl-1h-benzimidazoles |
CN101514197A (zh) * | 2008-02-22 | 2009-08-26 | 中国科学院成都有机化学有限公司 | 苯并咪唑类质子泵抑制剂的制备新方法 |
CN102070498A (zh) * | 2011-01-12 | 2011-05-25 | 华东师范大学 | 一种亚砜的制备方法 |
-
2011
- 2011-10-12 CN CN201110308163.2A patent/CN103044399B/zh active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1229341C (zh) * | 2000-03-13 | 2005-11-30 | 埃斯特维化学股份有限公司 | 氧化硫醚基成为亚砜基的方法 |
CN1381443A (zh) * | 2001-04-20 | 2002-11-27 | 中国医学科学院药物研究所 | 催化氧化硫醚类化合物制备含亚砜基类药物的方法 |
WO2006049486A1 (en) * | 2004-11-08 | 2006-05-11 | Dishman Pharmaceuticals And Chemicals Ltd. | A PREPARATION METHOD FOR SUBSTITUTED 2-(2-PYRIDYLMETHOYLSULPHINYL)-l-H-BENZIMID AZOLES |
WO2007026188A1 (en) * | 2005-09-01 | 2007-03-08 | Wockhardt Limited | Process for the manufacture of antiulceratives |
WO2009027533A1 (en) * | 2007-08-31 | 2009-03-05 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for preparing 2-sulfinyl-1h-benzimidazoles |
CN101514197A (zh) * | 2008-02-22 | 2009-08-26 | 中国科学院成都有机化学有限公司 | 苯并咪唑类质子泵抑制剂的制备新方法 |
CN102070498A (zh) * | 2011-01-12 | 2011-05-25 | 华东师范大学 | 一种亚砜的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN103044399A (zh) | 2013-04-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103980263B (zh) | 卡格列净的合成工艺 | |
CN104418841B (zh) | 一种光学纯雷贝拉唑及其钠盐的制备方法 | |
EP2181107A1 (en) | Process for preparing 2-sulfinyl-1h-benzimidazoles | |
CN113402511B (zh) | 一种苯唑草酮的制备方法 | |
CN102993181B (zh) | 埃索美拉唑的制备方法及埃索美拉唑盐的制备方法 | |
CN103044399B (zh) | 一种雷贝拉唑及其钠盐的制备方法 | |
CN102395591B (zh) | 一种合成普拉格雷的方法 | |
CN102558004B (zh) | 一种s-(4-甲苯基)苯磺酸酯的化学合成方法 | |
EP1966188A1 (de) | Enantioselektive herstellung von benzimidazolderivaten und ihren salzen | |
CN103755626A (zh) | 一种贝托斯汀关键中间体的合成方法 | |
CN101805327B (zh) | 一种雷贝拉唑钠化合物及其制法 | |
CN102977073B (zh) | 由2-噻吩乙醇合成2-噻吩乙酸的方法 | |
BR102018002942A2 (pt) | Método para preparar azoxistrobina | |
CN104230743B (zh) | 一种4-苄基-1-苯乙基哌嗪-2,6-二酮的制备方法 | |
CN103319417B (zh) | 三氯苯达唑亚砜的制备方法 | |
PT2176235E (pt) | Um método de fabrico de ácido 4'-[[4-metil-6-(1-metil-1hbenzimidazol- 2-il)-2-propil-1h-benzimidazol-1- il]metil]bifenil-2-carboxílico (telmisartan) | |
CN106554354A (zh) | 利格列汀或其类似物的中间体与利格列汀或其类似物的制备方法 | |
CN105745191A (zh) | 一种西洛多辛及其中间体的制备方法 | |
CN103044401A (zh) | 苯并咪唑类化合物的制备方法 | |
CN103601671B (zh) | 碘代三氟甲基吡啶的制备方法 | |
CN108409615B (zh) | 一种合成对映纯叔丁基亚磺酰胺的方法 | |
CN102079720B (zh) | 一种制备1-苄基-4-哌啶甲醛的方法 | |
CN103613518B (zh) | 一种α-苯乙磺酸的制备方法 | |
CN106316957B (zh) | 一种依达拉奉杂质的中间体及其制备方法和用途 | |
CN1318400C (zh) | 制备1-(巯基甲基)-环丙烷乙酸的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: 100871 Beijing, Haidian District into the house road, founder of the building on the 5 floor, No. 298 Applicant after: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Applicant after: PKU HEALTHCARE Corp.,Ltd. Applicant after: PKU HEALTHCARE INDUSTRY Group Address before: 100871 Beijing, Haidian District into the house road, founder of the building on the 5 floor, No. 298 Applicant before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Applicant before: SOUTHWEST SYNTHETIC PHARMACEUTICAL Corp.,Ltd. Applicant before: Pku Healthcare Industry Group Co.,Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221014 Address after: 3007, Hengqin international financial center building, No. 58, Huajin street, Hengqin new area, Zhuhai, Guangdong 519031 Patentee after: New founder holdings development Co.,Ltd. Patentee after: PKU HEALTHCARE Corp.,Ltd. Patentee after: Peking University Medical Management Co.,Ltd. Address before: 100871, Beijing, Haidian District Cheng Fu Road 298, founder building, 5 floor Patentee before: PEKING UNIVERSITY FOUNDER GROUP Co.,Ltd. Patentee before: PKU HEALTHCARE Corp.,Ltd. Patentee before: PKU HEALTHCARE INDUSTRY Group |