CN103041327A - Traditional Chinese medicine for treating sick sinus syndrome single nucleotide and preparation method thereof - Google Patents
Traditional Chinese medicine for treating sick sinus syndrome single nucleotide and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of medicines and in particular relates to a traditional Chinese medicine for treating sick sinus syndrome single nucleotide and a preparation method thereof. The traditional Chinese medicine has the effects of invigorating qi and nourishing yin, activating yang and restoring the pulse, is applicable to a patient with deficiency of both qi and yin, irregular pulse and vigorous heart beat, as well as the sick sinus syndrome single nucleotide with the traditional Chinese medicine symptoms of irregular pulse, vigorous heart beat, arrhythmia and atrioventricular premature beat. The traditional Chinese medicine comprises the following materials in parts by weight: 5-7 parts of honey-fried licorice root, 4-5 parts of gingers, 3-4 parts of ginsengs, 20-22 parts of dried rhizomes of rehmannia, 4-5 parts of cassia twigs, 3-4 parts of donkey-hide gelatins, 10-12 parts of radix ophiopogonis, 5-7 parts of fructus cannabis and 10-12 parts of jujubes, which are prepared into granules by the preparation method.
Description
One, technical field:
The present invention relates to medical technical field, be specifically related to a kind of Chinese medicine and preparation method for the treatment of sick sinus syndrome.
Two, technical background:
Sick sinus syndrome is the pathological changes by sinuatrial node (SAN) and sinuatrial node surrounding tissue, causes SAN pace-making or antrum conductive impairment, thereby produces dizzy, nervous, heart rate rhythm of the heart speed alternately, even one group of syndrome of fainting.
The primary disease performance is varied, normal intermittently generation.The lighter can be asymptomatic, so that be difficult to find; Severe one reduces because of cerebral blood flow, can cause dizzy, personality change, hypomnesis, even faint and Adams-Stokes Syndrome and sudden death occur.
Cause the reason of sick sinus syndrome: generally be secondary to coronary heart disease, hypertension and myocarditis, cardiomyopathy, the most common with coronary heart disease.Pathological changes was often more extensive when sinuatrial node was suffered a loss, sinuatrial node, and the atrium, chamber junction point and other conducting systems all can be impaired.
The sick sinus syndrome diagnosis basis: Electrocardiogram Feature is sinus bradycardia, sinus arrest, sinoatrial block, can accompany paroxysmal auricular fibrillation or flutter, or tachycardia on the chamber.When outbreak stops, before recovering sinus rate, easily see the long intermission.
Modern medicine is etiological treatment and to ARR symptomatic treatment to the treatment of sick sinus syndrome, advocates simultaneously to settle artificial pacemaker.
The disease of sick sinus syndrome is mostly slow, is 5～10 years or longer from symptom occurring to serious symptom.The minority acute attack sees acute myocardial infarction and acute myocarditis.
Three, summary of the invention
The present invention is in order to solve the deficiency of above-mentioned technical background, a kind of Chinese medicine and the preparation method that can effectively treat or improve the treatment sick sinus syndrome of symptom to be provided.
For achieving the above object, the technical solution used in the present invention is: a kind of Chinese medicine for the treatment of sick sinus syndrome is characterized in that: described raw material of Chinese medicine is comprised of following weight portion raw material: Radix Glycyrrhizae Preparata 5-7 weight portions, Rhizoma Zingiberis Recens 4-5 weight portions, Radix Ginseng 3-4 weight portions, the Radix Rehmanniae 20-22 weight portions, Ramulus Cinnamomi 4-5 weight portions, Colla Corii Asini 3-4 weight portions, Radix Ophiopogonis 10-12 weight portion, Fructus Cannabis 5-7 weight portions, Fructus Jujubae 10-12 weight portions.
Described raw material of Chinese medicine also comprises following adjuvant: soluble starch 3-4 weight portions, yellow wine 40-45 weight portions.
A kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome is: above-mentioned Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae are added water boiling and extraction 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time above-mentioned yellow wine and 5 times of water gagings decocted 1.5 hours, twice decoction liquor merges, and the extractum that is evaporated to relative density and is 1.13-1.18 is for subsequent use; It is fine powder more than 200 orders that above-mentioned Radix Ginseng, Ramulus Cinnamomi, Colla Corii Asini three flavor Chinese medicines are pulverized, and adds soluble starch, and mix homogeneously is bed material, granulates by fluidized drying pelletizer.
Described fluidized drying pelletizer compressed air pressure is controlled at 0.4-0.6 Mpa, and temperature is controlled at 50-80 ℃, and the blower fan FREQUENCY CONTROL is at 30-50Hz, and atomizing pressure is controlled at 0.2-0.25Mpa.
The method that described fluidized drying pelletizer is granulated is: at first extractum is pushed in the clamp of spray gun middle level by peristaltic pump; with the spray gun internal layer, outer field compressed air crosses at nozzle Chu Chu, makes fluid extract form fan-shaped atomizing bundle with pressure; spray to the medicated powder stream of ascension, granulation.
Compared with prior art, the advantage and the effect that have of the present invention is as follows:
1. monarch, minister in of the present invention group are helped, are made, and medicine is clear and definite, and dosage is accurate.
2. the present invention utilizes pharmacology to coordinate and special procures the flavour of a drug compatible combination, receives modern biology to the newest research results of medicine, pays attention to biological activity and efficiently utilizes, and the specific part of optimized choice medicine is in the hope of optimum medicine efficacy, outstanding key property, determining rationally, quantitatively.
3. the present invention according to congenital blunt hexagram, changes the day after tomorrow into from hexagram according to Chinese medical theory innovative design novel composing prescription, select God's gas, become the theoretical foundation of thing the day after tomorrow, take the monarch drug Radix Glycyrrhizae Preparata as principal agent, the gas of spleen reinforcing, with Rhizoma Zingiberis Recens, Fructus Jujubae the spleen and stomach regulating, with heavy dose of Radix Rehmanniae nourishing spleen yin, mend stomach-Yin Radix Ophiopogonis, gather the gas of blunt hexagram, the sun of Ramulus Cinnamomi reinforcing the heart, the Radix Ginseng reinforcing the heart is cloudy, promotes blunt cyclostrophic to turn to from gas.It is descending from fire that Fructus Cannabis draws the heart; Colla Corii Asini is fiery in water with great concentration, with being overexcited of restriction heart; So that reach coordinating water and fire steady statue, thereby reach gentle therapeutic effect.
4. the present invention has again benefiting qi and nourishing yin, and the effect of the multiple arteries and veins that activates yang is applicable to deficiency of both QI and YIN, irregularly intermittent and regularly intermittent pulse, and cardiopalmus is moved the patient, and tcm symptom is irregularly intermittent and regularly intermittent pulse, and cardiopalmus is moving.Be used for arrhythmia, the premature beat of heart chamber, the treatment of sick sinus syndrome.
Four, description of drawings:
Fig. 1 is production technological process of the present invention.
Five, the specific embodiment:
1, the drug effect of each component of the present invention:
Radix Glycyrrhizae Preparata: modern study, Radix Glycyrrhizae Preparata contain the number of chemical compositions such as Radix Glycyrrhizae Radix Betae, enoxolone, Angelica Polysaccharide, have antiinflammatory and anti-allergy action, the scalable body's immunity; Antitumor and analgesic effect, so the main effect of Radix Glycyrrhizae Preparata is and middle emergency lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription; Be usually used in weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse can be separated the Radix Aconiti Lateralis Preparata poison.
Rhizoma Zingiberis Recens: the Rhizoma Zingiberis Recens acrid in the mouth is warm in nature, is longer than dispersing wind-cold, preventing phlegm from forming and stopping coughing, again can warming middle-JIAO to arrest vomiting, detoxifcation, and effect: dispel the wind, induce sweat, stomach function regulating, antalgic.Effect: obviously analgesic, antibiotic, antiinflammation is arranged; Calmness, emesis, antiallergic, antiplatelet aggregative activity are arranged; The trichomonas vaginitis effect is killed in the water logging agent in vitro; Sucus Zingberis has inhibitory action to multiple pathomycete; The water logging agent has powerful bactericidal action to multiple pathogen; Etc..
Radix Ginseng: mainly contain the ginsenoside, studies show that the Experimental Arrhythmia that Herba Herminii or Radix Ginseng Saponin can cause antiadrenergic drug; The ginsenoside contains the measurer dual regulation to cAMP in the myocardial cell and cGMP, so keep the factor that the balance of cAMP and cGMP also is antagonism cardiac arrhythmia under stress state; Stem and leaf of Radix Ginseng total saponins has protective effect to the experimental sinus node function damage of rabbit.
The Radix Rehmanniae: the chemical constituent of Radix Rehmanniae is take glycoside as main, wherein again take iridoid glycosides as main, and sweet-bitter flavor, cold in nature and enter blood system, clearing away heat and cooling blood; Cure mainly fever due to yin deficiency, quench one's thirst, spit blood, epistaxis, metrorrhagia, menoxenia, frequent fetal movement, the moon is hindered constipation.
Ramulus Cinnamomi: expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Short yang transforming qi; Exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; The amenorrhea dysmenorrhea; The mass in the abdomen caking; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.
Colla Corii Asini: enrich blood; Hemostasis; YIN nourishing; Moisturize; Main syndrome of deficiency of blood; The asthenia spitting of blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Gestation hemorrhage; Metrorrhagia; The vexed insomnia of the deficiency of YIN; Deficiency of the lung bath is coughed; The tic of fainting of the convulsion of stirring-up of pathogenic wind in the interior resulting from deficiency.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire; Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria; YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: few thirsty, the dry cough spitting of blood in Tianjin that is used for lung-stomach yin deficiency; The cards such as the palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat.
Fructus Cannabis: the main fatty wet goods composition of Fructus Cannabis; The tonification asthenia is for the cloudy dryness of the intestine patient of losing that quenches one's thirst, and the many and same usefulness of supplementing QI for promoting the production of body fluid medicine is moisturized with the YIN nourishing tonify deficiency; Fructus Cannabis has the effect of repairing cardiac muscle, heart damage is had repair and health-care effect.
Fructus Jujubae: contain abundant vitamin C, Citrin in the Fructus Jujubae, to perfecting blood capillary, keeping vessel wall elasticity, atherosclerosis is very useful; Contain cAMP in the Fructus Jujubae, its pharmacological action shows as and improves microcirculation in human body, and coronary artery dilator increases the amount of blood supply of brain and heart, and decreasing heart rate reduces myocardial oxygen consumption and improves the metabolism of ischemic myocardium, so can prevent and treat cardiovascular and cerebrovascular disease.
Said components Raw medicine standard all adopts " the Chinese medicine standard that Chinese pharmacopoeia is recorded, yellow wine employing food standard.
2, the embodiment of the invention:
Embodiment one:
A kind of Chinese medicine for the treatment of sick sinus syndrome is comprised of following weight portion raw material: Radix Glycyrrhizae Preparata 5 weight portions, Rhizoma Zingiberis Recens 4 weight portions, Radix Ginseng 3 weight portions, the Radix Rehmanniae 20 weight portions, Ramulus Cinnamomi 4 weight portions, Colla Corii Asini 3 weight portions, Radix Ophiopogonis 10 weight portion, Fructus Cannabis 5 weight portions, Fructus Jujubae 10 weight portions.
Described raw material of Chinese medicine also comprises following adjuvant: soluble starch 3 weight portions, yellow wine 40 weight portions.
Described a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome is: above-mentioned Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae are added water boiling and extraction 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time above-mentioned yellow wine and 5 times of water gagings decocted 1.5 hours, twice decoction liquor merges, and the extractum that is evaporated to relative density and is 1.13-1.18 is for subsequent use; It is fine powder more than 200 orders that above-mentioned Radix Ginseng, Ramulus Cinnamomi, Colla Corii Asini three flavor Chinese medicines are pulverized, and adds soluble starch, and mix homogeneously is bed material, granulates by fluidized drying pelletizer.
The method that described fluidized drying pelletizer is granulated is: at first extractum is pushed in the clamp of spray gun middle level by peristaltic pump; with the spray gun internal layer, outer field compressed air crosses at nozzle Chu Chu, makes fluid extract form fan-shaped atomizing bundle with pressure; spray to the medicated powder stream of ascension, granulation.
Described fluidized drying pelletizer compressed air pressure is controlled at 0.4 Mpa, and temperature is controlled at 50 ℃, and the blower fan FREQUENCY CONTROL is at 30Hz, and atomizing pressure is controlled at 0.2Mpa.
Embodiment two:
A kind of Chinese medicine for the treatment of sick sinus syndrome is comprised of following weight portion raw material: Radix Glycyrrhizae Preparata 7 weight portions, Rhizoma Zingiberis Recens 5 weight portions, Radix Ginseng 4 weight portions, the Radix Rehmanniae 22 weight portions, Ramulus Cinnamomi 5 weight portions, Colla Corii Asini 4 weight portions, Radix Ophiopogonis 12 weight portion, Fructus Cannabis 7 weight portions, Fructus Jujubae 12 weight portions.
Described raw material of Chinese medicine also comprises following adjuvant: soluble starch 4 weight portions, yellow wine 45 weight portions.
Described a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome is: above-mentioned Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae are added water boiling and extraction 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time above-mentioned yellow wine and 5 times of water gagings decocted 1.5 hours, twice decoction liquor merges, and the extractum that is evaporated to relative density and is 1.13-1.18 is for subsequent use; It is fine powder more than 200 orders that above-mentioned Radix Ginseng, Ramulus Cinnamomi, Colla Corii Asini three flavor Chinese medicines are pulverized, and adds soluble starch, and mix homogeneously is bed material, granulates by fluidized drying pelletizer.
The method that described fluidized drying pelletizer is granulated is: at first extractum is pushed in the clamp of spray gun middle level by peristaltic pump; with the spray gun internal layer, outer field compressed air crosses at nozzle Chu Chu, makes fluid extract form fan-shaped atomizing bundle with pressure; spray to the medicated powder stream of ascension, granulation.
Described fluidized drying pelletizer compressed air pressure is controlled at 0.6 Mpa, and temperature is controlled at 80 ℃, and the blower fan FREQUENCY CONTROL is at 50Hz, and atomizing pressure is controlled at 0.25Mpa.
Embodiment three:
A kind of Chinese medicine for the treatment of sick sinus syndrome is comprised of following weight portion raw material: Radix Glycyrrhizae Preparata 6 weight portions, Rhizoma Zingiberis Recens 4.5 weight portions, Radix Ginseng 3.5 weight portions, the Radix Rehmanniae 21 weight portions, Ramulus Cinnamomi 4.5 weight portions, Colla Corii Asini 3.4 weight portions, Radix Ophiopogonis 11 weight portion, Fructus Cannabis 6 weight portions, Fructus Jujubae 11 weight portions.
Described raw material of Chinese medicine also comprises following adjuvant: soluble starch 3.6 weight portions, yellow wine 43 weight portions.
Described a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome is: above-mentioned Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae are added water boiling and extraction 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time above-mentioned yellow wine and 5 times of water gagings decocted 1.5 hours, twice decoction liquor merges, and the extractum that is evaporated to relative density and is 1.13-1.18 is for subsequent use; It is fine powder more than 200 orders that above-mentioned Radix Ginseng, Ramulus Cinnamomi, Colla Corii Asini three flavor Chinese medicines are pulverized, and adds soluble starch, and mix homogeneously is bed material, granulates by fluidized drying pelletizer.
The method that described fluidized drying pelletizer is granulated is: at first extractum is pushed in the clamp of spray gun middle level by peristaltic pump; with the spray gun internal layer, outer field compressed air crosses at nozzle Chu Chu, makes fluid extract form fan-shaped atomizing bundle with pressure; spray to the medicated powder stream of ascension, granulation.
Described fluidized drying pelletizer compressed air pressure is controlled at 0.5 Mpa, and temperature is controlled at 65 ℃, and the blower fan FREQUENCY CONTROL is at 40Hz, and atomizing pressure is controlled at 0.22Mpa.
3, the animal experiment method of the present invention's employing proves its effect property:
1) affects the isolated myocardium physiological property
Rat is with the right atrium of sinuatrial node, be suspended in the bath that fills the 20ml tyrode's solution, add the multiple arteries and veins particle solution of 8.09g/L, can obviously suppress the self-disciplining of isolated right atrium after 10 minutes, frequency by administration before 176.4 ± 13.8 beats/mins, slow to 156.8 ± 12.5 beats/mins after the administration.
2) affect the action potential of isolated myocardium
Guinea pig papillary muscles, put in the improvement Tai Shi solution, the circulation perfusion, add multiple arteries and veins particle solution 8.09g/L, energy is action potential duration, APD (APD) and the effective refractory period (EPR) of prolonged guinea pig papillary muscle action potentials of cells obviously, and can reduce its maximum depolarization speed (Vmax), these effects are dose dependent, but resting potential (RP) is had no significant effect.
3) reperfusion injury that resists myocardial ischemia
Multiple arteries and veins granule liquid 6.09/L is poured in isolated rat heart anterior descending coronary (LAD) ligation again, can significantly reduce rat ischemia phase ventricular tachycardia (VT), when pouring into quiver (VF) and the total incidence rate of arrhythmia in the chamber again; Multiple arteries and veins particle solution 3/kg gavages rat, day 1 time, continuous 4 days, can significantly reduce ventricular premature contraction (VP) and the total incidence rate of arrhythmia that again perfusion is brought out; Gavage rat with the multiple arteries and veins granule of dosage, can significantly dwindle the rear myocardial infarct size of again perfusion.
4) anti-" deficiency of YIN " rat experiment model
Continuous five day, copy " deficiency of YIN " syndrome model to the left-handed thyroid of subcutaneous injection 0.5mg/kg of rat every day.
(1) anti-" deficiency of YIN " rat ventricular; 3.0g/kg multiple arteries and veins particle solution is irrigated " deficiency of YIN " rat, day 3 times, obviously decreased heart rate is eliminated arrhythmia, reduces ventricular premature contraction (VP) incidence rate.
(2) multiple arteries and veins particle solution 3.0g/kg irrigates rat, day 3 times, can significantly improve the arrhythmia that quiet notes epinephrine causes, being mainly manifested in the various arrhythmia time of origins such as ventricular premature contraction (VP), ventricular tachycardia (VT) and conduction block (AVB) postpones, incidence rate descends, and significantly increases and bring out the used Epinephrine dose of arrhythmia.
4, the clinical trial of the present invention's employing proves its effectiveness:
1) efficacy assessment standard is: produce effects: transference cure: the flat heart rate increase by 5 times of crouching/and more than the min, and or SNRT(sinus node recovery time), rectification sinus node recovery time (CSNRT) recovers normally or is approaching normal.
2) improve: sx↓, flat sleeping heart rate increases 2-4 time/min, reaches or sinus node recovery time, rectification sinus node recovery time significantly shorten.
3) invalid: symptom is not improved, flat sleeping 2 times/min of heart rate, and or sinus node recovery time, rectification sinus node recovery time without change.
5, case of the present invention is selected:
The diagnostic criteria sick sinus syndrome of the relevant coronary heart disease of diagnosis basis World Health Organization (WHO) is with reference to the diagnostic criteria of formulating in the Beijing area sick sinus syndrome forum in 1977, to have got rid of Folium Digitalis Purpureae, propranolol, reserpine, guanethidine for following various situations, the medicines such as quinidine, isoptin, segondin, the impact of the factors such as blood potassium is too high, and vagus nerve function is hyperfunction is diagnosed; 1. sinoatrial block; 2. part sinus arrest time 〉=2s, or completeness sinus arrest companion escape rhythm; 3. long significantly sinus bradycardia＜50 times/min, simultaneously with (1) and/or (2), if the simple significantly hole heart is slow, through atropine test, heart rate behind double 2-step exercise test and the isoproterenol＜90 time/min, diagnosis also can be set up; 4. have above-mentioned 1. 2. 3. primary condition and the quick rhythm of the heart of paroxysmal dystopy that occurs together; 5. 1. 2. 3. on the ARR basis, be associated with simultaneously atrioventricular junction pacing function barrier (the junctional escape beat periods rules or 〉=2s) and/or atrioventricular block; 3. 2. 1. 6. basic expressions arranged, also exist simultaneously in the room in various degree, chamber, intraventricular conduction defect.
Group technology:
Be diagnosed as sick sinus syndrome, its subjective symptoms form of expression can be intermittent; The lighter is weak, dizzy, dim eyesight, insomnia, intermittent memory loss, bradykinesia or emotional; Have during disease progression that language is ambiguous, paresis, misjudge, of short duration loss of consciousness, have a dizzy spell and be similar to and faint.The common typical case of severe one and serious symptom is fainted and amaurosis, obvious brain symptom occurs in medical main cause often; Without significantly tachycardia, rhythm abnormality, be divided into ill antrum syndrome group, clinical common performance had palpitation, pareordia are uncomfortable, uncomfortable in chest etc. significantly is divided into the arrhythmia group.
Therapeutic Method:
Take the embodiment of the invention three medicines, every day three times, each serving with 15 the gram, taking continuously 21 days is a course for the treatment of.
Result of implementation:
⑴ arrhythmia group: amount to 92 examples
This product is used for atrial ventricle's premature beat 19 examples, supraventricular tachycardia 14 examples of atrial fibrillation paroxysmal, and chamber passes to retardance (I degree---III degree) and indoor infull property retardance, bradycardia 36 examples, rheumatic heart disease, cardiomyopathy and unknown cause arrhythmia 23 examples.Cure as a result (subjective symptoms disappears, and check letter electrograph recovers normal person) 72 examples, take a turn for the better 7 examples, invalid 3 examples 1-2 weeks, total effective rate 94%.
(2) ill antrum syndrome group amounts to 78 examples:
Use the embodiment of the invention three medicines, each serving using 15g, every day three times; 3 weeks of the course for the treatment of, treatment bradycardia and sick sinus syndrome 78 examples, produce effects 46 examples as a result, effective 26 examples, invalid 6 examples, total effective rate 91%.
6, model case of the present invention and therapeutic outcome thereof:
Case 1: Chen, the male, 51 years old, be interrupted cardiopalmus, dizzy 1 year, from touching about 30 beats/mins of pulse, without chest pain, pulse is 50-60 times/minutes at ordinary times during outbreak.Faint once in July, 2008, and the companion twitches and urinary incontinence, clear-headed after about 2 minutes, and go to a doctor.Previously body is strong, haves a medical check-up, and blood pressure 120/90mmhg ordinary circumstance is good, and two lungs sounds are clear, and heart circle is little, and heart rate about 50 times/minutes is heard rich about 5 times/minutes early, and is remaining without unusual.Ultrasoundcardiogram is normal, and myocardium enzyme is normal.25 hr Ambulatory EKG Monitoring are shown the case bradycardia, 30 beats/mins of sinoatrial blocks of the slowest heart rate, and the rich junctional area ease of mixing of Dou Xingting is rich, the room that takes place frequently, premature beat, long RR pause 2.2 seconds changes and the QT interval prolongation without ST-T.Atropine test is negative, is 2100ms through Pipe About Transesophageal Atrial Pacing ell hole knot recovery time, is diagnosed as the disease hole, and the patient refuses to settle heart heartstart, then seeks treatment by Chinese herbs, takes the embodiment of the invention three medicines, each serving with 15g every day three times.After taking 21 days, transference cure.
Case 2: the Wang, the male 55 years old, in the previous tretament process, is diagnosed as arrhythmia, coronary heart disease.Often with Radix Salviae Miltiorrhizae Injection SHENMAI ZHUSHEYE, the Drug therapys such as storax pill for treating coronary heart disease.Existing symptom: shortness of breath and palpitation, the ambition dull pain of feeling oppressed, dizzy, weak, aversion to cold and cold limbs, complexion is turned white.Corpulent tongue is large, and matter is light, white and thin fur, and there is indentation on the limit, deep-thready pulse and tie generation, 54 times/min of heart rate, arrhythmia, electrocardiogram shows: arrhythmia, excessively slow, atrioventricular block, the ST-T section changes.Be diagnosed as the disease hole.Tcm diagnosis gastropathy: cardiopalmus, QI and blood deficiency gives multiple arteries and veins granule and takes, and is aided with simultaneously 5% glucose injection 250ml, and SHENFU ZHUSHEYE 40ml dead point once a day, assists to stop dead point after 7 days, continues the oral embodiment of the invention three medicines.Subjective symptomss are improved after 3 weeks, only tired have when angry nervous, cardiopalmus, symptom uncomfortable in chest enjoins it to continue to take multiple arteries and veins granule, transference cure after 3 months, 3 times electrocardiogram shows, and is no abnormal, the disease recovery from illness.
Case 3: Liu, woman, 52 years old.Because cardiopalmus was shown effect more than 3 months repeatedly, insecure in the heart since telling nearly two months in first visit in 2009, and increase the weight of gradually, meet labor person very, can not be autonomous when serious, accompany uncomfortable in chest, vomiting and nausea, insomnia and dreamful sleep, look thing yarn Mongolian.Buy propranolol dinitrate tablets by oneself and slightly alleviated in oral 15 days, withdraw then and send out.Have a medical check-up: 36.5 ℃ of T, 160 times/min of P, BP 130/80 mm Hg, breast pulmonary checks no abnormality seen, 140 times/min of heart rate, rule are not heard and noise together.Lab testing: three large routines, blood glucose, blood fat, hepatic and renal function are all normal.Syndrome in TCM is seen: spiritlessness and weakness, and shortness of breath and palpitation, dizzy spontaneous perspiration, nausea nausea, pale tongue with white fur, stringy,thready and rapid pulse is unable.Dialectical is deficiency of heart-QI, hypofunction of clear YANG, controls in Yiqi and vein recovery, resolving phlegm lowering turbidity, takes the embodiment of the invention three medicines three months, transference cure, and further consultation such as ordinary person, it is normal that electrocardiogram recovers.Follow up a case by regular visits to 3 months without uncomfortable.
Case 4:: Zhao, woman, 51 years old.First visit: tell nervous, cardiopalmus, breathe hard and do not heal in 2 years, the Multiple Hospitalization treatment all is diagnosed as " arrhythmia-Frequent atrial premature beats secondary ", this is sick send out be in hospital after, once used anti-arrhythmic, tranquilizer, cardiac nutrition cell medicine, effect.Disease is seen: cardiopalmus is losed heart, when uncomfortable in chest and chest pain, and moving then cardiopalmus aggravation, vexed spontaneous perspiration, insomnia and dreamful sleep, spiritlessness and weakness, headache poor appetite, light purplish tongue, deep-thready pulse and tying generation.Dialectical genus deficiency of both QI and YIN, the qi depression to blood stasis internal resistance is Primary Asthenia-Secondary Sthenia Syndrome.Treatment is with benefiting qi and nourishing yin, the multiple arteries and veins that activates yang, blood circulation promoting and blood stasis dispelling.Three examine: after taking the embodiment of the invention three medicines, certainly appeal to disease calming down, the check electrocardio diagram rhythm of the heart is neat, and following up a case by regular visits to did not have recurrence in 1 year.
Claims (5)
1. Chinese medicine for the treatment of sick sinus syndrome, it is characterized in that: described raw material of Chinese medicine is comprised of following weight portion raw material: Radix Glycyrrhizae Preparata 5-7 weight portions, Rhizoma Zingiberis Recens 4-5 weight portions, Radix Ginseng 3-4 weight portions, the Radix Rehmanniae 20-22 weight portions, Ramulus Cinnamomi 4-5 weight portions, Colla Corii Asini 3-4 weight portions, Radix Ophiopogonis 10-12 weight portion, Fructus Cannabis 5-7 weight portions, Fructus Jujubae 10-12 weight portions.
2. a kind of Chinese medicine for the treatment of sick sinus syndrome according to claim 1, it is characterized in that: described raw material of Chinese medicine also comprises following adjuvant: soluble starch 3-4 weight portions, yellow wine 40-45 weight portions.
3. a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome according to claim 1, it is characterized in that: described preparation method is: above-mentioned Radix Glycyrrhizae Preparata, Rhizoma Zingiberis Recens, the Radix Rehmanniae, Radix Ophiopogonis, Fructus Cannabis, Fructus Jujubae are added water boiling and extraction 2 times, adding for the first time 10 times of water gagings decocted 2 hours, add for the second time above-mentioned yellow wine and 5 times of water gagings decocted 1.5 hours, twice decoction liquor merges, and the extractum that is evaporated to relative density and is 1.13-1.18 is for subsequent use; It is fine powder more than 200 orders that above-mentioned Radix Ginseng, Ramulus Cinnamomi, Colla Corii Asini three flavor Chinese medicines are pulverized, and adds soluble starch, and mix homogeneously is bed material, granulates by fluidized drying pelletizer.
4. a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome according to claim 3; it is characterized in that: the method that described fluidized drying pelletizer is granulated is: at first extractum is pushed in the clamp of spray gun middle level by peristaltic pump; with the spray gun internal layer; outer field compressed air crosses at nozzle Chu Chu; make fluid extract form fan-shaped atomizing bundle with pressure; spray to the medicated powder stream of ascension, granulation.
5. a kind of preparation method for the treatment of the Chinese medicine of sick sinus syndrome according to claim 3; it is characterized in that: described fluidized drying pelletizer compressed air pressure is controlled at 0.4-0.6 MPa; temperature is controlled at 50-80 ℃; the blower fan FREQUENCY CONTROL is at 30-50Hz, and atomizing pressure is controlled at 0.2-0.25MPa.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796880A (en) * | 2016-03-30 | 2016-07-27 | 王银法 | Medicine for treating sick sinus syndrome |
| CN105833219A (en) * | 2015-11-12 | 2016-08-10 | 北京祥和康健科技发展有限公司 | Traditional Chinese medicine composition for treating premature beat |
| CN112641915A (en) * | 2020-12-30 | 2021-04-13 | 辽宁上药好护士药业（集团）有限公司 | Traditional Chinese medicine ointment formula for treating palpitation and preparation method thereof |
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2012
- 2012-12-11 CN CN2012105303726A patent/CN103041327A/en active Pending
Non-Patent Citations (2)
| Title |
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| 刘旭海 等: "流化床制粒设备的制药探讨", 《江西中医药》 * |
| 周平安: "对炙甘草汤方证及煎服法的思考", 《北京中医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105833219A (en) * | 2015-11-12 | 2016-08-10 | 北京祥和康健科技发展有限公司 | Traditional Chinese medicine composition for treating premature beat |
| CN105796880A (en) * | 2016-03-30 | 2016-07-27 | 王银法 | Medicine for treating sick sinus syndrome |
| CN112641915A (en) * | 2020-12-30 | 2021-04-13 | 辽宁上药好护士药业（集团）有限公司 | Traditional Chinese medicine ointment formula for treating palpitation and preparation method thereof |
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Application publication date: 20130417 |