CN102988639A - Medicament for treating cervical spondylosis and preparation method of medicament - Google Patents

Abstract

The invention discloses a medicament for treating cervical spondylosis and a preparation method of the medicament. The medicament is mainly prepared from root of red-rooted salvia, caulis spatholobi, pseudo-ginseng, safflower, ligusticum wallichii, radix paeoniae alba, astragalus membranaceus, bighead atractylodes rhizome, cassia twig, ramulus mori, Chinese angelica and the like according to a certain weight proportion. The medicament has functions of relaxing the muscles, stimulating the blood circulation, dredging meridians and collaterals, and strengthening tendon and muscle, and is high in effect taking speed, short in treatment course, and high in curative rate when used for treating the cervical spondylosis without causing reoccurrence.

Description

A kind of medicine for the treatment of cervical spondylosis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of cervical spondylosis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Cervical spondylosis refers to that the plump hypertrophy of degeneration of cervical intervertebral disc, cervical vertebra and neck injury etc. cause hyperosteogeny of cervical vertebra, or prolapse of intervertebral disc, ligament thicken, and stimulates or compressing cervical spinal, cervical region are neural, blood vessel and produce the clinical syndrome of series of symptoms.Main manifestations is neck and shoulder pain, dizziness headache, upper limb numbness, amyotrophy, the two lower limb spasm of severe patient, difficulty in walking, even quadriplegia, and paralysis appears in the defecation obstacle.Multiple at middle-aged and elderly people, male's sickness rate is higher than the women.Cervical spondylosis is brought great puzzlement to patient's Working Life, and at present western medicine cervical spondylosis poor effect, and long-term taking Western medicine has certain side effect, and therefore, there is great demand in people to the Chinese medicine of effective treatment cervical spondylosis.

Summary of the invention

The inventor has finally found the medicine of effective treatment cervical spondylosis, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.

Purpose of the present invention just provides a kind of composition of medicine that can treat cervical spondylosis.

Another object of the present invention has just provided the preparation method of this composition of medicine.

Medicine of the present invention selects Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Notoginseng, Flos Carthami, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Ramulus Mori, Radix Angelicae Sinensis, Poria, Radix Clematidis, Radix Puerariae, Radix Polygoni Multiflori, Rhizoma Drynariae, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Typhonii, Herba Cistanches and Cortex Acanthopancis to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby can fast treating cervical vertebra palindromia.Wherein select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor enters the heart, Liver Channel, and blood circulation and promoting silt is arranged, calming heart and tranquilizing mind, evacuation of pus, the function of pain relieving is controlled angina cordis, menoxenia, and dysmenorrhea, to close, metrorrhagia leukorrhagia mass in the abdomen gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Selecting Caulis Spatholobi is because its property bitter but sweet flavor, and temperature enters the heart, spleen two warps, have invigorate blood circulation, the function of Shujin, control soreness of waist and knee joint, paralysis and numbness, menoxenia.Selecting Radix Notoginseng is that temperature enters liver, stomach, large intestine channel, and hemostasis is arranged because of its property sweet and slightly bitter taste, dissipating blood stasis, and detumescence, the function of analgesic therapy is controlled haematemesis, hemoptysis, epistaxis is had blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain.Select Flos Carthami to be because its nature and flavor are hot, temperature enters the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Rhizoma Chuanxiong to be because its nature and flavor are hot, temperature enters liver, gallbladder meridian, and activating QI to alleviate the depression is arranged, dispeiling pathogenic wind and removing dampness, and the function of promoting blood circulation and stopping pain is controlled air-cooled headache and is revolved dizzyly, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Selecting the Radix Paeoniae Alba is that cold enters liver, spleen channel, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select the Radix Astragali to be because its nature and flavor are sweet, tepor enters lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature enters spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension is had loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Selecting Ramulus Cinnamomi is that temperature enters bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Ramulus Mori to be because its nature and flavor are bitter, flat, enter Liver Channel, wind-damp dispelling is arranged, sharp joint, the function of row aqueous vapor is controlled anemofrigid-damp arthralgia, spasm of the limbs, beriberi edema, human body pruritus due to wind pathogen.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Radix Clematidis to be because its nature and flavor suffering is salty, temperature, poisonous, enter urinary bladder channel, wind-damp dispelling is arranged, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump is controlled gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Radix Puerariae to be because the sweet suffering of its nature and flavor is flat, enter spleen, stomach warp, the yang invigorating expelling pathogenic factors from muscles is arranged, rash antidiarrheal, the function that relieving restlessness is quenched the thirst, it is cold to cure the wound, warm, headache, stiffness of the nape, dysphoria with smothery sensation disappears and drinks, and has loose bowels, and dysentery, abnormal pigmentary deposit on the skin are examined not saturating, hypertension, angina pectoris, deafness.Select Radix Polygoni Multiflori to be because its property bitter but sweet flavor is puckery, tepor enters liver, kidney channel, and tonifying liver is arranged, and kidney tonifying nourishes blood, the function of dispeling the wind, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and the waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Rhizoma Drynariae to be because its nature and flavor are bitter, temperature enters liver, kidney channel, and the kidney invigorating is arranged, and invigorates blood circulation, and the function of hemostasis is controlled suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, clavus.Select Fructus Corni to be because its nature and flavor are sour, tepor has invigorating the liver and kidney, and the function of arresting seminal emission gas is controlled sexual impotence, seminal emission, and the deficiency of the liver cold and heat, the heart shakes scattered pulse.Select Radix Rehmanniae Preparata to be because its nature and flavor are sweet, tepor enters liver, kidney channel, and YIN nourishing is arranged, and the function of enriching blood is controlled deficiency of YIN insufficiency of blood, the waist knee flaccidity, and the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision.Select Rhizoma Typhonii to be because its nature and flavor are hot, temperature is returned stomach, Liver Channel, the expectorant that dispels the wind, and the antispasmodic function is controlled apoplexy, facial hemiparalysis, facial paralysis, migraine, tetanus, tuberculous lymphadenitis, carbuncle.Select Herba Cistanches to be because the sweet acid of its nature and flavor is salty, temperature enters kidney, large intestine channel, and the kidney invigorating is arranged, and benefit is smart, moisturizes, and the function of bowel relieving is controlled impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.Select Cortex Acanthopancis to be because its property and flavor of peppery and warm is returned liver, kidney channel, wind-damp dispelling is arranged, strengthening bone and muscle, the function of blood circulation and promoting silt is controlled anemofrigid-damp arthralgia, and the sliding contraction of muscle is anxious, edema beriberi, skin ulcer cellulitis toxic swelling, traumatic injury impairment caused by overstrain.

The specific embodiment

The drug dose of component of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Radix Salviae Miltiorrhizae 10-20 gram Caulis Spatholobi 15-25 gram Radix Notoginseng 8-20 gram

Flos Carthami 10-20 gram Rhizoma Chuanxiong 15-20 gram Radix Paeoniae Alba 10-20 gram

Radix Astragali 25-35 gram Rhizoma Atractylodis Macrocephalae 10-20 gram Ramulus Cinnamomi 10-20 gram

Ramulus Mori 3-20 gram Radix Angelicae Sinensis 15-25 gram Poria 10-20 gram

Radix Clematidis 15-20 gram Radix Puerariae 10-20 gram Radix Polygoni Multiflori 8-20 gram

Rhizoma Drynariae 10-20 Keshan Fructus Corni 13-20 gram Radix Rehmanniae Preparata 15-25 gram

Rhizoma Typhonii 10-20 gram Herba Cistanches 8-15 gram Cortex Acanthopancis 8-14 gram

Wherein, be preferably

Radix Salviae Miltiorrhizae 15 gram Caulis Spatholobis 20 gram Radix Notoginseng 10 grams

The Flos Carthami 15 gram Rhizoma Chuanxiongs 18 gram Radix Paeoniae Albas 12 grams

The Radix Astragali 30 gram Rhizoma Atractylodis Macrocephalaes 15 gram Ramulus Cinnamomi 15 grams

Ramulus Mori 15 gram Radix Angelicae Sinensis 20 gram Poria 15 grams

Radix Clematidis 18 gram Radix Puerariaes 12 gram Radix Polygoni Multiflori 10 grams

Rhizoma Drynariae 12 Keshan Fructus Corni 16 gram Radix Rehmanniae Preparata 18 grams

Rhizoma Typhonii 12 gram Herba Cistanches 10 gram Cortex Acanthopanciss 10 grams

The preparation method of medicine of the present invention is as follows

One, gets the raw materials ready

1, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

2, Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

3, Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

4, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

5, Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

6, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

7, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

8, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

9, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;

10, Ramulus Mori: choose decontamination, clean, be soaked in water, after running through, cutting is dried;

11, Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

12, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

13, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;

14, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;

15, Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice dry;

16, Rhizoma Drynariae: remove sediment contamination, clean, slightly soak, run through, section is dried;

17, Fructus Corni: clean, except removal core and impurity, dry;

18, Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;

19, Rhizoma Typhonii: remove impurity;

20, Herba Cistanches: choose clean impurity, clear water soaks, and changes water every day 1-2 times (as being salty Herba Cistanches, bubble is salinity to the greatest extent), runs through, and section (vertically) is dried;

21, Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying.

Two, preparation

Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Notoginseng, Flos Carthami, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Ramulus Mori, Radix Angelicae Sinensis, Poria, Radix Clematidis, Radix Puerariae, Radix Polygoni Multiflori, Rhizoma Drynariae, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Typhonii, Herba Cistanches and the Cortex Acanthopancis medicine of described weight are added 2000 ml waters, intense fire decocts boiling 30 minutes, used again slow fire boiling 20 minutes, filter namely to get and take medicinal liquid, medicinal liquid is equally divided into 3 doses.

Medicine of the present invention has Shujin, invigorates blood circulation, and stimulates the menstrual flow, and the function of strengthening bone and muscle is used for the treatment of the cervical spondylosis instant effect, and short treating period does not recur, and cure rate is high.

Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, once a day, serve on 7 days, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data:

Accept out-patient's 175 examples for medical treatment.

2, diagnostic criteria:

The cervical spondylosis cardinal symptom is:

(1) neck is takeed on to ache and can be radiated to headrest section and upper limb;

(2) one sides shoulders back sense of heaviness, upper myasthenia of limbs is pointed numbly, and limb skin is felt to go down, and it is unable to hold thing, and the automatic thing of holding lands sometimes.

(3) often ache with the head neck shoulder arm, neck has a stiff neck, limitation of activity.

(4) have with dizziness, house rotation, severe one is unable to leave the bed with nausea and vomiting, minority can have dizzy, dampings off.

3, Therapeutic Method

Select above-mentioned medicament, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 7 days is a course for the treatment of, takes continuously 5 courses for the treatment of.

4, efficacy assessment standard

Produce effects: clinical symptom disappearance after the treatment, cervical vertebra recover normal, observe half a year without the recidivist;

Take a turn for the better: clinical symptoms is obviously improved, and cervical vertebra condition of illness progressively recovers;

Invalid: clinical partial symptoms disappears or without change, does not reach improvement standard person.

5, therapeutic outcome

In above-mentioned treatment, with Drug therapy Patients with Cervical Spondylopathy 175 examples of the present invention, produce effects 168 examples as a result, obvious effective rate is 96%, 4 examples that take a turn for the better, improvement rate is 2.29%, invalid 3 examples, total effective rate is 98.29%.

Claims (3)

1. medicine for the treatment of cervical spondylosis, it is characterized in that: it is to be made by the crude drug in the following weight scope:

Radix Salviae Miltiorrhizae 10-20 gram Caulis Spatholobi 15-25 gram Radix Notoginseng 8-20 gram

Flos Carthami 10-20 gram Rhizoma Chuanxiong 15-20 gram Radix Paeoniae Alba 10-20 gram

Radix Astragali 25-35 gram Rhizoma Atractylodis Macrocephalae 10-20 gram Ramulus Cinnamomi 10-20 gram

Ramulus Mori 3-20 gram Radix Angelicae Sinensis 15-25 gram Poria 10-20 gram

Radix Clematidis 15-20 gram Radix Puerariae 10-20 gram Radix Polygoni Multiflori 8-20 gram

Rhizoma Drynariae 10-20 Keshan Fructus Corni 13-20 gram Radix Rehmanniae Preparata 15-25 gram

Rhizoma Typhonii 10-20 gram Herba Cistanches 8-15 gram Cortex Acanthopancis 8-14 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Radix Salviae Miltiorrhizae 15 gram Caulis Spatholobis 20 gram Radix Notoginseng 10 grams

The Flos Carthami 15 gram Rhizoma Chuanxiongs 18 gram Radix Paeoniae Albas 12 grams

The Radix Astragali 30 gram Rhizoma Atractylodis Macrocephalaes 15 gram Ramulus Cinnamomi 15 grams

Ramulus Mori 15 gram Radix Angelicae Sinensis 20 gram Poria 15 grams

Radix Clematidis 18 gram Radix Puerariaes 12 gram Radix Polygoni Multiflori 10 grams

Rhizoma Drynariae 12 Keshan Fructus Corni 16 gram Radix Rehmanniae Preparata 18 grams

Rhizoma Typhonii 12 gram Herba Cistanches 10 gram Cortex Acanthopanciss 10 grams.

3. the preparation method of described medicine according to claim 1 and 2, it is characterized in that: it comprises the following steps:

(1) gets the raw materials ready

(1) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;

(2) Caulis Spatholobi: water runs through, section, or steam and take advantage of fervent sheet after soft, dry;

(3) Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;

(4) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(5) Rhizoma Chuanxiong: choose decontamination, separate large and small, be soaked in water, solarization is dried in the air, and cuts into slices drying behind the moistening;

(6) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(7) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(8) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out behind the bubble, run through, section is dried;

(9) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;

(10) Ramulus Mori: choose decontamination, clean, be soaked in water, after running through, cutting is dried;

(11) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;

(12) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(13) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;

(14) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, in time section is dried;

(15) Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice dry;

(16) Rhizoma Drynariae: remove sediment contamination, clean, slightly soak, run through, section is dried;

(17) Fructus Corni: clean, except removal core and impurity, dry;

(18) Radix Rehmanniae Preparata: get crude drug, steam to surperficial corvinus, take out, when solarization is done to eighty per cant, section, drying;

(19) Rhizoma Typhonii: remove impurity;

(20) Herba Cistanches: choose clean impurity, clear water soaks, and changes water every day 1-2 times (as being salty Herba Cistanches, bubble is salinity to the greatest extent), runs through, and section (vertically) is dried;

(21) Cortex Acanthopancis: choose clean impurity, wash, slightly after the profit, cut into slices drying;

(2) preparation

Radix Salviae Miltiorrhizae, Caulis Spatholobi, Radix Notoginseng, Flos Carthami, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Ramulus Cinnamomi, Ramulus Mori, Radix Angelicae Sinensis, Poria, Radix Clematidis, Radix Puerariae, Radix Polygoni Multiflori, Rhizoma Drynariae, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Typhonii, Herba Cistanches and the Cortex Acanthopancis medicine of described weight are added 2000 ml waters, intense fire decocts boiling 30 minutes, used again slow fire boiling 20 minutes, filter namely to get and take medicinal liquid, medicinal liquid is equally divided into 3 doses.