CN102988229B - Treatment process of radix scrophulariae and preparation process of radix scrophulariae based cosmetic - Google Patents
Treatment process of radix scrophulariae and preparation process of radix scrophulariae based cosmetic Download PDFInfo
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Abstract
The invention relates to a treatment process of radix scrophulariae and a preparation process of a radix scrophulariae based cosmetic. The preparation process of the radix scrophulariae based cosmetic is as follows: adding 1 to 20wt% of radix scrophulariae extract during the process of preparing the cosmetic, wherein the radix scrophulariae extract is the ginsenoside material which is prepared by the treatment process of the radix scrophulariae, including the steps of adopting korean ginseng as the raw material, stewing and drying in sun at nine times, and then extracting. The radix scrophulariae based cosmetic, prepared by the process provided by the invention, has no components harmful to the skin, and can expel toxins, eliminate abscess, smoothen blackspot, prevent pigmented naevus and fade spots, so as to improve the skin texture, homogenize the color of skin, remove the flaws, and whiten the skin; and the radix scrophulariae based cosmetic also can centrally provide sufficient moisture and nutrition to the skin, and specifically has remarkable effects of resisting oxidation, removing wrinkles and preventing ageing.
Description
Technical field
The invention belongs to cosmetic technical field, relate to the application of Radix Ginseng extract component in cosmetics, relate to a kind for the treatment of process of black ginseng and the preparation technology of black ginseng cosmetics particularly.
Background technology
Radix Ginseng is the herbaceos perennial of Araliaceae Panax, is described as " king of BAICAO " from ancient times.Just can " tonifying five ZANG-organs, peace spirit, determine soul, spasmolytic is throbbed with fear, except pathogen, the happy Fructus Alpiniae Oxyphyllae of improving eyesight " by record in Shennong's Herbal, " take for a long time make light of one's life by commiting suicide prolong life ".Li Shizhen (1518-1593 A.D.) is also very praised highly Radix Ginseng in Compendium of Material Medica, thinks that it " can control all deficient syndromes of male woman ".Radix Ginseng is all listed in " top grade " in Chinese herbal medicine for thousands of years.Radix Ginseng, so famous and precious, be just that its medical value is high, truly have effect of building body, life prolonging.Modern medicine study and assay show, main active in Radix Ginseng is the chemical substance that a class is referred to as " ginsenoside (ginsenoside; GS) ", the latter has adjustment human central nervous system, affects multiple metabolic pathway, improves body immunity, heart tonifying, resisting fatigue, anti-ageing obvious effect of having waited for a long time, and the various diseases for nervous system, cardiovascular system, hormonal system and reproductive system all has good therapeutical effect.
Radix Ginseng can be divided into polytype again according to the difference of processing stage: water join: from ground after extraction without the Radix Ginseng of any processing; Trepang: water joins dried product; Radix Ginseng: the product of dry gained again after the peeling of water ginseng; Radix Ginseng Rubra: steam to well done with high-temperature steam after first water ginseng being cleaned under the state not peeling epidermis off, dry the bronzing product of gained again, the contamination of its ginsenoside in the process cooked all increases, and has occurred the ginsenoside Rg3 with anticancer effect; Black ginseng: water ginseng or Radix Ginseng Rubra through more than 7 times cook with dry after the black product of (so-called nine steam nine shines) gained, the ginsenoside Rg3 that wherein ginsenoside particularly has an anticancer effect beats again as increase than Radix Ginseng Rubra, and therefore medical value is higher.
CN101442913A discloses the manufacture method of a kind of black ginseng, black ginseng concentrated solution and the black ginseng right fruit.Wherein, black ginseng manufacture method using water ginseng as raw material, comprise washing, cook, maturation, the operation such as the immobilization of raw material form and drying.Black ginseng concentrated solution manufacture method comprises washing, cooks, maturation, the immobilization of raw material form, extraction, filtration, concentrated, purify and the operation such as concentrated.Black ginseng right fruit manufacture method comprise raw material is washed successively, the dry and epidermis membrane removal of surface moisture, to be placed on porous disc, nine times comprise be followed successively by flood Mel, cook and the operation of maturation, first time dry, repair raw material, for the second time drying and packaging process.
CN102238878A discloses and a kind ofly to carry out fermenting the fermented red ginseng of ripening and fermented black ginseng and its manufacture method to Radix Ginseng Rubra and water ginseng.Described fermentation process carries out with the stable and condition of gentleness, comprising: (a) adds and ferment to the natural fruits comprising Fructus Armeniacae Mume and the native enzyme liquid that obtains, simultaneously in the step of 40-80 DEG C of bottom fermentation ripening 50-360h in Radix Ginseng; And (b) Radix Ginseng to the fermentation maturation stage through (a) implements hot blast damp process and gravity-flow ventilation simultaneously, and cook the step of ripening 160-720h at 35-60 DEG C.In the fermented ginseng that this invention manufactures, active constituent content absorbed by the body increases, and owing to not carrying out high-temperature process, effective ingredient does not lose substantially maybe degeneration can not occur.
The present invention finds in early-stage Study, and the ginsenoside in black ginseng particularly ginsenoside Rg3 has significant skin-care effect, has broad application prospects at cosmetic field.
Summary of the invention
One of the object of the invention is, provides a kind for the treatment of process of black ginseng to process the tanned ginseng of nine steamings nine, therefrom extracts black ginseng essential ingredient; Two of the object of the invention is, further the black ginseng essential ingredient extracted is applied to cosmetics, thus provides a kind of preparation technology of black ginseng cosmetics.
For one of achieving the above object, the present invention adopts following technical scheme:
A treatment process for black ginseng, comprises the steps:
The processing of (1) nine steaming nine tanned ginsengs:
1. gather koryo insam, clean up.
Ginseng for medicinal use famous in the world is mainly distributed in the Siberian east of the north, the Korea peninsula, Northeast China and Russia.Described koryo insam is the Radix Ginseng specially referring to that the Korea peninsula produces, wherein contain 34 kinds of ginsenosides of now clear and definite structure, compare and under, only contain 8 kind ginsenosides containing 14 kinds of ginsenosides in Japan containing in 15 kinds of ginsenosides, U.S.'s Radix Ginseng (Radix Panacis Quinquefolii) in China's Radix Ginseng (Radix Notoginseng), koryo insam is enjoyed great prestige in the world with its abundant ginsenoside's contamination.
Be raw material with koryo insam in the present invention, for abundant material base has been established in the processing of black ginseng and the extraction of ginsenoside.
Preferably, koryo insam described in the present invention is the koryo insam that trophophase reaches 4-6, trophophase at this moment between koryo insam in section ripe, the content of ginsenoside simultaneously contained is high.
Most preferably, koryo insam described in the present invention is the koryo insam that trophophase reaches 6 years, and in koryo insam now, the content of ginsenoside is the highest.
Described cleaning, should note not injuring the original shape of koryo insam or lose its composition.
2. first time steams solarization: at the temperature of 50 DEG C-70 DEG C, the koryo insam after step 1. being cleaned cooks 1.5-3.5h, then dry 70-140h at the temperature of 20 DEG C-40 DEG C.
Described 50 DEG C-70 DEG C can be such as 50 DEG C-64.2 DEG C, 53.8 DEG C-59.7 DEG C, 61 DEG C-70 DEG C, 50 DEG C, 51.3 DEG C, 52 DEG C, 54.5 DEG C, 55 DEG C, 57.4 DEG C, 58 DEG C, 60 DEG C, 60.3 DEG C, 62 DEG C, 63.2 DEG C, 65 DEG C, 67.5 DEG C, 68 DEG C, 69.1 DEG C, 70 DEG C; Be preferably 55-65 DEG C; Most preferably be 60 DEG C.
Described 1.5-3.5h can be such as 1.5-2.1h, 1.85-3.07h, 2.9-3.5h, 1.5h, 1.69h, 1.75h, 2h, 2.2h, 2.46h, 2.5h, 2.8h, 3h, 3.13h, 3.25h, 3.4h, 3.5h; Be preferably 2-3h; Most preferably be 2.5h.
Described 20 DEG C-40 DEG C can be such as 20 DEG C-34.2 DEG C, 23.8 DEG C-39.7 DEG C, 31 DEG C-40 DEG C, 20 DEG C, 20.3 DEG C, 22 DEG C, 23.2 DEG C, 25 DEG C, 27.5 DEG C, 28 DEG C, 29.1 DEG C, 30 DEG C, 30.8 DEG C, 32 DEG C, 34.5 DEG C, 35 DEG C, 37.4 DEG C, 38 DEG C, 40 DEG C; Be preferably 25-35 DEG C; Most preferably be 30 DEG C.
Described 70-140h can be such as 70-101h, 85-127h, 99-140h, 70h, 75h, 80.5h, 83h, 89.2h, 90h, 95h, 100h, 113h, 120h, 122h, 134h, 137.5h, 140h; Be preferably 90-120h; Most preferably be 108h.
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine.
After second time steaming solarization terminates, visible Radix Ginseng starts to present redness.
After the 7th steaming solarization terminates, visible Radix Ginseng starts to present black.
After the 8th steaming solarization terminates, visible Radix Ginseng substantially all becomes black.
After the 9th steaming solarization terminates, nine steam nine tanned ginsengs machines.
Steam the process of shining above-mentioned 9 times, steam the appearance color change of Radix Ginseng after shining each time as shown in Figure 1.
Carry out nine steaming nine solarizations under cryogenic, can prevent the generation of carcinogen benzopyrene, the black ginseng stability obtained is better, and the shelf-life is longer.
After steaming nine solarizations through nine, in koryo insam, original toxic component is removed, nine steam in nine tanned ginsengs the ginsenoside Rh2, ginsenoside Rg1, the ginsenoside Rg3 that yet forms both and do not have in former koryo insam and have anti-inflammation, prevent the Radix Ginseng Rubra of the content of the menthol composition, particularly ginsenoside Rg3 of aging action and absorbance ratio to be all significantly increased.
The content of ginsenoside in black ginseng and Radix Ginseng Rubra is compared, result as shown in Figure 2, in visible black ginseng, the content of ginsenoside Rg1, ginsenoside Rg3, ginsenoside Rb1, ginsenoside Rb2, Ginsenoside Rc, ginsenoside Rd is all significantly improved than in Radix Ginseng Rubra, the content particularly wherein with the ginsenoside Rg3 of anticancer effect far away higher than Radix Ginseng Rubra, will also create the ginsenoside Rh1 and ginsenoside Rh2's composition that do not have in Radix Ginseng Rubra simultaneously.
Now by ginsenoside's composition of mainly containing in black ginseng and effect brief introduction as follows:
Ginsenoside Ro: can antiinflammatory, removing toxic substances, suppression acid be coagulating platelets and activated macrophage, there is the effects such as anti-hepatitis, antithrombotic, removing toxic substances antiinflammatory.
Ginsenoside Rb1: the function of choline system, the synthesis increasing acetylcholine and release can be strengthened, there is the effects such as Improving memory power, antipyretic-antalgic, liver function protecting.
Ginsenoside Rb2: the synthesis of DNA, RNA can be promoted, reduce intracellular calcium content, remove interior free yl, antioxidation, there is arteriosclerosis, improve the effects such as myocardial ischemia reperfusion injury.
Ginsenoside Rb3: can myocardial function be strengthened, protection human autoimmune system.
Ginsenoside Rc: there is analgesia, promote protein and the effect such as lipid synthesis, anticancer.
Ginsenoside Rd: the effect promoting adrenal cortex hormone secretion;
Ginsenoside Re: Hepatocyte protection, promotes medullary cell anabolic effect;
Ginsenoside Rf: brain cell analgesic activity, anti-lipid peroxidation;
Ginsenoside Rg: the synthesis that can promote DNA, RNA, has the effects such as stimulating central nervous system, resisting fatigue, Improving memory and learning capacity.
Ginsenoside Rg1: can stimulating central nervous system, suppress platelet aggregation, there is rapid recovery fatigue, improve the effect such as learning and memory function, slow down aging.
Ginsenoside Rg2: platelet aggregation can be suppressed, improve myocardial ischemia and anoxia fast, there is Improving memory power, prevent and treat the effect such as coronary heart disease, shock.
Ginsenoside Rg3: the G2 phase that can act on the germiparity cycle, the synthesis of protein and ATP mitosis prophase of anticancer, the proliferate speed of cancerous cell is slowed down, and there is anticancer infiltration, antitumor cell transfer, effect such as promotion apoptosis of tumor cells, inhibition tumor cell growth etc.
Ginsenoside Rh: have suppress nervus centralis, hypnosis, ease pain, calm the nerves, antipyretic, promote the effects such as serum proteins synthesis.
Ginsenoside Rh1: hepatocyte growth can be promoted, promote DNA synthesis, suppress platelet aggregation, have protect the liver, the effect such as antitumor.
Ginsenoside Rh2: there is anticancer propagation and transfer, Tumor suppression propagation, enhancing human body immunity power, recover the effects such as body constitution rapidly.
Wherein, ginsenoside Rg3 because of with apoptosis of tumor cells and Nasopharyngeal neoplasms closely related, obtain to pay close attention to one of maximum ginsenoside, its chemical structural formula as shown in Figure 3, and the present invention finds in early-stage Study, ginsenoside Rg3 can significantly improve skin immunization power, recover skin elasticity, has significantly crease-resistant and anti-aging effects, considers the main active Ginsenosides material extracted in black ginseng to be applied among cosmetics thus.
(2) acquisition of black conopsea extraction:
1. step (1) nine steaming nine tanned ginsengs 3. being joined its quality 10-30 concentration is doubly in the 1,3 butylene glycol of 20wt%-40wt%, fully crosses after reaction 0.5-3h and filters impurity.
Described 10-30 doubly, can be such as 10-17.5 doubly, 13.6-24.9 doubly, 21-30 doubly, 10 times, 11.5 times, 12 times, 14.7 times, 15 times, 16.8 times, 17 times, 18 times, 19.2 times, 20 times, 22.5 times, 23 times, 25 times, 26.3 times, 27 times, 28.1 times, 29.5 times, 30 times; Be preferably 15-25 doubly; Most preferably be 20 times.
Described concentration is 20wt%-40wt%, can be such as 20wt%-32.5wt%, 27-37wt%, 24.7-38.8wt%, 20wt%, 22wt%, 23.4wt%, 25wt%, 26.1wt%, 28wt%, 29.6wt%, 30wt%, 31wt%, 33.2wt%, 35wt%, 36.5wt%, 39.3wt%, 40wt%; Be preferably 25wt%-35wt%; Most preferably be 30wt%.
Described 0.5-3h can be such as 0.5-1.1h, 0.85-2.07h, 1.9-3h, 0.5h, 0.73h, 0.95h, 1h, 1.25h, 1.4h, 1.5h, 1.69h, 1.75h, 2h, 2.2h, 2.46h, 2.5h, 2.8h, 3h; Be preferably 1-2h; Most preferably be 1.5h.
2. step operation 1. 2-5 time is repeated.
Described 2-5 time can be such as 2 times, 3 times, 4 times, 5 times, is preferably 3-4 time, most preferably is 3 times.
3. vacuum concentration step product 2. at the temperature of 40 DEG C-60 DEG C, adding its quality 20-40 concentration is doubly that the ethanol of 70wt% dilutes.
Described 40 DEG C-60 DEG C can be such as 40 DEG C-54.2 DEG C, 43.8 DEG C-59.7 DEG C, 51 DEG C-60 DEG C, 40 DEG C, 41.3 DEG C, 42 DEG C, 44.5 DEG C, 45 DEG C, 47.4 DEG C, 48 DEG C, 50 DEG C, 50.3 DEG C, 52 DEG C, 53.2 DEG C, 55 DEG C, 57.5 DEG C, 58 DEG C, 59.1 DEG C, 60 DEG C; Be preferably 45-55 DEG C; Most preferably be 50 DEG C.
Described 20-40 doubly, can be such as 20-27.5 doubly, 23.6-34.9 doubly, 31-40 doubly, 20 times, 22.5 times, 23 times, 25 times, 26.3 times, 27 times, 28.1 times, 29.5 times, 30 times, 31.5 times, 32 times, 34.7 times, 35 times, 36.8 times, 37 times, 38 times, 39.2 times, 40 times; Be preferably 25-35 doubly; Most preferably be 30 times.
4. in step product 3., add the antiseptic of its quality 0.2wt%-2wt%.
Described 0.2wt%-2wt% can be such as 0.2wt%-0.84wt%, 0.6wt%-1.47wt%, 1.1wt%-2wt%, 0.2wt%, 0.35wt%, 0.4wt%, 0.49wt%, 0.5wt%, 0.65wt%, 0.7wt%, 0.8wt%, 0.91wt%, 1wt%, 1.06wt%, 1.2wt%, 1.35wt%, 1.4wt%, 1.54wt%, 1.6wt%, 1.7wt%, 1.8wt%, 1.86wt%, 1.9wt%, 2wt%; Be preferably 0.5wt%-1.5wt%; Most preferably be 1wt%.
Preferably, described antiseptic is selected oneself the combination of any one or at least two kinds in glycol, Flos Magnoliae glycol, tropolone, and described combination can be such as from hexanediol/Flos Magnoliae glycol, Flos Magnoliae glycol/tropolone, hexanediol/tropolone, hexanediol/Flos Magnoliae glycol/tropolone.
In sum, concrete technical scheme of the present invention is as follows:
A treatment process for black ginseng, comprises the steps:
The processing of (1) nine steaming nine tanned ginsengs:
1. gather koryo insam, clean up;
2. first time steams solarization: at the temperature of 50 DEG C-70 DEG C, the koryo insam after step 1. being cleaned cooks 1.5-3.5h, then dry 70-140h at the temperature of 20 DEG C-40 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
(2) acquisition of black conopsea extraction:
1. step (1) nine steaming nine tanned ginsengs 3. being joined its quality 10-30 concentration is doubly in the 1,3 butylene glycol of 20wt%-40wt%, fully crosses after reaction 0.5-3h and filters impurity;
2. step operation 1. 2-5 time is repeated;
3. vacuum concentration step product 2. at the temperature of 40 DEG C-60 DEG C, adding its quality 20-40 concentration is doubly that the ethanol of 70wt% dilutes;
4. in step product 3., add the antiseptic of its quality 0.2wt%-2wt%, described antiseptic is selected oneself the combination of any one or at least two kinds in glycol, Flos Magnoliae glycol, tropolone.
Technical scheme after the present invention optimizes is as follows:
A treatment process for black ginseng, comprises the steps:
The processing of (1) nine steaming nine tanned ginsengs:
1. gather the koryo insam that trophophase reaches 4-6, clean up;
2. first time steams solarization: at the temperature of 55 DEG C-65 DEG C, the koryo insam after step 1. being cleaned cooks 2-3h, then dry 90-120h at the temperature of 25 DEG C-35 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
(2) acquisition of black conopsea extraction:
1. step (1) nine steaming nine tanned ginsengs 3. being joined its quality 15-25 concentration is doubly in the 1,3 butylene glycol of 25wt%-35wt%, fully crosses after reaction 1-2h and filters impurity;
2. step operation 1. 3-4 time is repeated;
3. vacuum concentration step product 2. at the temperature of 45 DEG C-55 DEG C, adding its quality 25-35 concentration is doubly that the ethanol of 70wt% dilutes;
4. in step product 3., add the antiseptic of its quality 0.5wt%-1.5wt%, described antiseptic is selected oneself the combination of any one or at least two kinds in glycol, Flos Magnoliae glycol, tropolone.
The technical scheme of optimum of the present invention is as follows:
A treatment process for black ginseng, comprises the steps:
The processing of (1) nine steaming nine tanned ginsengs:
1. gather the koryo insam that trophophase reaches 6 years, clean up;
2. first time steams solarization: at the temperature of 60 DEG C, the koryo insam after step 1. being cleaned cooks 2.5h, then dry 108h at the temperature of 30 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
(2) acquisition of black conopsea extraction:
1. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 20 times is in the 1,3 butylene glycol of 30wt%, fully crosses after reaction 1.5h and filters impurity;
2. step operation 1. 3 times are repeated;
3. vacuum concentration step product 2. at the temperature of 50 DEG C, the concentration adding its quality 30 times is that the ethanol of 70wt% dilutes;
4. in step product 3., add the antiseptic of its quality 1wt%, described antiseptic is selected oneself the combination of any one or at least two kinds in glycol, Flos Magnoliae glycol, tropolone.
For achieve the above object two, the present invention adopts following technical scheme:
A preparation technology for black ginseng cosmetics, adds the black conopsea extraction that content is 1wt%-20wt% in preparation process.
Described 1wt%-20wt% can be such as 1wt%-8wt%, 4.5wt%-12.6wt%, 11.5wt%-20wt%, 1wt%, 2wt%, 2.5wt%, 3wt%, 3.1wt%, 3.6wt%, 4wt%, 5wt%, 5.4wt%, 6wt%, 6.7wt%, 7.5wt%, 9wt%, 9.2wt%, 10wt%, 11.3wt%, 12wt%, 14wt%, 15wt%, 16.9wt%, 18wt%, 19wt%, 20wt%; Be preferably 3wt%-15wt%; Most preferably be 5wt%-10wt%.
In sum, the technical scheme after the present invention's optimization is as follows:
A preparation technology for black ginseng cosmetics, adds the black conopsea extraction that content is 3wt%-15wt% in preparation process;
The technical scheme of optimum of the present invention is as follows:
A preparation technology for black ginseng cosmetics, adds the black conopsea extraction that content is 5wt%-10wt% in preparation process.
The all expression technological parameters, constituent content, reaction condition etc. that use in the specification and in the claims are all appreciated that the modification adding term " about " in all cases.Therefore, unless indicated to the contrary, the difference of the character that given in the specification and in the claims numerical value can obtain desired by the present invention and changing.At bottom line, and be not used in the scope application of equivalent principle being defined as claim, each numerical value should at least make an explanation by using common rounding method according to the value of reported significant digits.And all scopes announced at this are all appreciated that the starting point and end point values that comprise scope, comprise and are included in wherein among a small circle with all arbitrarily.Such as, certain scope " 1-10 " should be considered to comprise (included) between minima 1 and maximum 10 any and among a small circle all; Namely all initial with the minima being more than or equal to 1, and with the maximum being less than or equal to 10 terminate among a small circle all, such as 2-7,3.9-5.4, or 8.5-9.8.
Compared with prior art, the preparation technology of black ginseng cosmetics of the present invention adds in the preparation process of cosmetics has remarkable antioxidation, antiinflammatory, the black conopsea extraction composition of crease-resistant effect, make the black ginseng cosmetics prepared not only not containing the composition be harmful to for skin, toxin can be discharged on the contrary, eliminate abscess, smooth speckle trace, prevention melanotic nevus, desalination mottle, thus improve skin quality, even skin tone, eliminate flaw, skin whitening, can concentrate for skin simultaneously and sufficient moisture and nutrition are provided, moisturizing, lock water, moisturizing, maintain the water oil poised state of skin the best, particularly also there is significant antioxidation, eliminating wrinkle, anti-aging effect, preceding factors comprehensive function, thus recover elasticity and the gloss of skin, healthy anger and vigor are inculcated to skin, skin is got back to and keeps young state.
Technical scheme of the present invention is further illustrated by detailed description of the invention below in conjunction with accompanying drawing; but following example is only simple and easy example of the present invention; do not represent or limit the scope of the present invention, interest field of the present invention is as the criterion with claims.
Accompanying drawing explanation
Fig. 1 is that koryo insam steams in solarization process the appearance color variation diagram after steaming solarization each time for 9 times.
Fig. 2 is the comparison diagram of ginsenoside's component content in black participation Radix Ginseng Rubra.
Fig. 3 is the chemical structural formula of ginsenoside Rg3.
Fig. 4 is the inhibition comparison diagram of black conopsea extraction for collagen hydrolysate enzyme (MMP-1) activity of variable concentrations in test example 1.
Fig. 5 is the moisture-retaining capacity extended the in time change comparison diagram of black conopsea extraction in test example 2,1,3 butylene glycol, water.
Fig. 6 is the change comparison diagram that in test example 3, experimenter uses periocualr skin situation before and after black ginseng cosmetics.
Detailed description of the invention
For better the present invention being described, be convenient to understand technical scheme of the present invention, typical but non-limiting embodiment of the present invention is as follows:
Embodiment 1:
Black conopsea extraction is prepared according to following technique:
1. gather the koryo insam that trophophase reaches 6 years, clean up;
2. first time steams solarization: at the temperature of 60 DEG C, the koryo insam after step 1. being cleaned cooks 2.5h, then dry 108h at the temperature of 30 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
4. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 20 times is in the 1,3 butylene glycol of 30wt%, fully crosses after reaction 1.5h and filters impurity;
5. step operation 1. 3 times are repeated;
6. vacuum concentration step product 2. at the temperature of 50 DEG C, the concentration adding its quality 30 times is that the ethanol of 70wt% dilutes;
7. the antiseptic of its quality 1wt% is added in the product 6. obtained to step, the compositions that described antiseptic is hexanediol, Flos Magnoliae glycol, tropolone are formed according to the mass ratio of 1:1:1.
Embodiment 2:
Black conopsea extraction is prepared according to following technique:
1. gather the koryo insam that trophophase reaches 4 years, clean up;
2. first time steams solarization: at the temperature of 50 DEG C, the koryo insam after step 1. being cleaned cooks 3.5h, then dry 140h at the temperature of 20 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
4. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 30 times is in the 1,3 butylene glycol of 35wt%, fully crosses after reaction 0.5h and filters impurity;
5. step operation 1. 2 times are repeated;
6. vacuum concentration step product 2. at the temperature of 60 DEG C, the concentration adding its quality 40 times is that the ethanol of 70wt% dilutes;
7. in step product 6., add the antiseptic hexanediol of its quality 0.5wt%.
Embodiment 3:
Black conopsea extraction is prepared according to following technique:
1. gather the koryo insam that trophophase reaches 5 years, clean up;
2. first time steams solarization: at the temperature of 70 DEG C, the koryo insam after step 1. being cleaned cooks 1.5h, then dry 70h at the temperature of 40 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
4. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 10 times is in the 1,3 butylene glycol of 20wt%, fully crosses after reaction 3h and filters impurity;
5. step operation 1. 5 times are repeated;
6. vacuum concentration step product 2. at the temperature of 40 DEG C, the concentration adding its quality 20 times is that the ethanol of 70wt% dilutes;
7. in step product 6., add the antiseptic Flos Magnoliae glycol of its quality 2wt%.
Embodiment 4:
Black conopsea extraction is prepared according to following technique:
1. gather koryo insam, clean up;
2. first time steams solarization: at the temperature of 65 DEG C, the koryo insam after step 1. being cleaned cooks 2h, then dry 90h at the temperature of 35 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
4. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 25 times is in the 1,3 butylene glycol of 40wt%, fully crosses after reaction 1h and filters impurity;
5. step operation 1. 4 times are repeated;
6. vacuum concentration step product 2. at the temperature of 45 DEG C, the concentration adding its quality 25 times is that the ethanol of 70wt% dilutes;
7. in step product 6., add the antiseptic tropolone of its quality 0.2wt%.
Embodiment 5:
Black conopsea extraction is prepared according to following technique:
1. gather the koryo insam that trophophase reaches 6 years, clean up;
2. first time steams solarization: at the temperature of 55 DEG C, the koryo insam after step 1. being cleaned cooks 3h, then dry 120h at the temperature of 25 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
4. concentration step (1) nine steaming nine tanned ginsengs 3. being joined its quality 25 times is in the 1,3 butylene glycol of 25wt%, fully crosses after reaction 2h and filters impurity;
5. step operation 1. 3 times are repeated
6. vacuum concentration step product 2. at the temperature of 55 DEG C, the concentration adding its quality 35 times is that the ethanol of 70wt% dilutes;
7. the antiseptic of its quality 1.5wt% is added in the product 6. obtained to step, the compositions that described antiseptic is hexanediol, Flos Magnoliae glycol, tropolone are formed according to the mass ratio of 1:1:1.
Embodiment 6:
A kind of black ginseng cosmetics, are made up of the raw material components of following mass percent (wt%):
The black conopsea extraction of 10wt% embodiment 1, 8wt% glyceryl alcohol 26, 5wt% butanediol, 5wt% glycerol, 4wt% Bo Niao Suan Na, 2wt% nicotine amine, 1wt% sea water, 1wt% isostearyl glyceryl pentaerythrityl ether, 0.525wt% ethohexadiol, 0.22wt% 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers, 0.2wt%PEG-60 castor oil hydrogenated, 0.175wt% glycerol caprylate, 0.15wt%PEG-40 castor oil hydrogenated, 0.15wt%PPG-26-butylol polyether-26, 0.14wt% carbomer, 0.14wt% triethanolamine, 0.1wt% Herba Portulacae extract, 0.055wt% prickly-pear cactus extract, 0.05wt% perfume, 0.05wt% UVNUL MS-40, 0.05wt% xanthan gum, 0.045wt% Fructus Hordei Germinatus extract, 0.04wt% adenosine, 0.02wt% caramel, 0.01wt% ethylenediamine tetraacetic ethyl disodium, 0.01wt% hydroxypropyl cyclodextrin, 0.01wt% Chinese juniper xylem extract, all the other are water.
Test example 1:
The black conopsea extraction of testing example 1 is for the active inhibition of collagen hydrolysate enzyme (MMP-1):
Test method:
The black conopsea extraction of embodiment 1 is diluted to respectively 0.001g/ml, 0.0025g/ml, 0.005g/ml, 0.01g/ml, 0.025g/ml five Concentraton gradient, respectively getting the concentration that 5ml joins 100ml is respectively in the aqueous solution of collagen hydrolysate enzyme (MMP-1) of 10wt%, observes the impact of black conopsea extraction for collagen hydrolysate enzymatic activity of variable concentrations.
Result of the test:
As shown in Figure 4, wherein abscissa represents the concentration (g/ml) of black conopsea extraction, and the activity that vertical coordinate represents collagen hydrolysate enzyme suppresses degree.As can be seen from the figure, black conopsea extraction is proportionate for the inhibition of collagen hydrolysate enzymatic activity and the concentration of himself, concentration more Gao Ze is stronger for the inhibition of collagen hydrolysate enzymatic activity, when the concentration of black conopsea extraction is 0.025g/ml, there is the activity inhibited of the collagen hydrolysate enzyme of 50%.Visible black conopsea extraction effectively can suppress the activity of collagen hydrolysate enzyme, thus protection collagen protein, maintain skin elasticity.
Test example 2:
The moistening effect of the black conopsea extraction of testing example 1:
Test method:
The black conopsea extraction of Example 1,1,3 butylene glycol, water equivalent, observe the moisture-retaining capacity of three respectively.
Result of the test:
As shown in Figure 5, wherein abscissa represents the time, and vertical coordinate represents moisture-retaining capacity (in initial moisture-retaining capacity for 100%).As can be seen from the figure, the moisture-retaining capacity of prolongation three is in time all in decline, but the moisture-retaining capacity of water declines the fastest, and the moisture-retaining capacity of black conopsea extraction declines the slowest; After 24h, the moisture-retaining capacity of water drops to 0, and the moisture-retaining capacity that the moisture-retaining capacity of black conopsea extraction drops to black conopsea extraction after initial 20%, 24h is the highest in three.Visible black conopsea extraction has good moisturizing, lock water effect, can increase skin vitality, slow down aging.
Test example 3:
The anti-wrinkle effect of the black ginseng cosmetics of testing example 6:
Test method:
The black ginseng cosmetics of Example 6 are applied to experimenter's periocualr skin, each 0.2ml, every day 2 times, within 7 days, observe the situation of change of experimenter's periocualr skin afterwards.
Result of the test:
As shown in Figure 6, wherein [picture 1] uses the contrast photo of front and back periocualr skin situation, [picture 2] to be [picture 1] by duplicating gained picture after version image analysing computer for experimenter.As can be seen from the figure, after employing black ginseng cosmetics, the situation of experimenter's periocualr skin obtains obvious improvement, mottle desalination, skin quality water profit, the colour of skin is even, wrinkle is thin out and reduce, the elasticity of skin and gloss strengthens.Visible black ginseng cosmetics have significant light speckle, moisturizing, crease-resistant, white-skinned face function, make skin return young state.
It should be noted that and understand, when not departing from the spirit and scope of the present invention required by accompanying claim, various amendment and improvement can be made to the present invention of foregoing detailed description.Therefore, the scope of claimed technical scheme is not by the restriction of given any specific exemplary teachings.
Applicant states, the present invention illustrates proportioning raw materials of the present invention and preparation process by above-described embodiment, but the present invention is not limited to said ratio and preparation process, does not namely mean that the present invention must rely on above-mentioned preparation process and could implement.Person of ordinary skill in the field should understand, any improvement in the present invention, to equivalence replacement and the interpolation of auxiliary element, the concrete way choice etc. of raw material selected by the present invention, all drops within protection scope of the present invention and open scope.
Claims (24)
1. a treatment process for black ginseng, is characterized in that, comprises following processing step:
The processing of (1) nine steaming nine tanned ginsengs:
1. gather koryo insam, clean up;
2. first time steams solarization: at the temperature of 55 DEG C-70 DEG C, the koryo insam after step 1. being cleaned cooks 1.5-3.5h, then dry 70-140h at the temperature of 20 DEG C-40 DEG C;
3. repeat step operation 2. 8 times, complete second time and steam the process of shining-nine steamings and shining, obtain the tanned ginseng of nine steamings nine;
(2) acquisition of black conopsea extraction:
1. step (1) nine steaming nine tanned ginsengs 3. being joined its quality 10-30 concentration is doubly in the 1,3 butylene glycol of 20wt%-40wt%, fully crosses after reaction 0.5-3h and filters impurity;
2. step operation 1. 2-5 time is repeated;
3. vacuum concentration step product 2. at the temperature of 40 DEG C-60 DEG C, adding its quality 20-40 concentration is doubly that the ethanol of 70wt% dilutes;
4. in step product 3., add the antiseptic of its quality 0.2wt%-2wt%.
2. treatment process according to claim 1, is characterized in that, described step (1) 1. described in koryo insam be the koryo insam that trophophase reaches 4-6.
3. treatment process according to claim 2, is characterized in that, described step (1) 1. described in koryo insam be the koryo insam that trophophase reaches 6 years.
4., according to the treatment process one of claim 1-3 Suo Shu, it is characterized in that, described step (1) 2. in, described in the temperature that cooks be 55 DEG C-65 DEG C.
5. treatment process according to claim 4, is characterized in that, described step (1) 2. in, described in the temperature that cooks be 60 DEG C.
6. treatment process according to claim 1, is characterized in that, described step (1) 2. in, described in time of cooking be 2-3h.
7. treatment process according to claim 6, is characterized in that, described step (1) 2. in, described in time of cooking be 2.5h.
8. treatment process according to claim 1, is characterized in that, described step (1) 2. in, the temperature of described drying is 25 DEG C-35 DEG C.
9. treatment process according to claim 8, is characterized in that, described step (1) 2. in, the temperature of described drying is 30 DEG C.
10. treatment process according to claim 1, is characterized in that, described step (1) 2. in, the time of described drying is 90-120h.
11. treatment process according to claim 10, is characterized in that, described step (1) 2. in, the time of described drying is 108h.
12. treatment process according to claim 1, is characterized in that, described step (2) 1. in, the quality of 1,3 butylene glycol be the 15-25 of the tanned ginseng quality of nine steamings nine doubly.
13. treatment process according to claim 12, is characterized in that, described step (2) 1. in, the quality of 1,3 butylene glycol is 20 times of the tanned ginseng quality of nine steamings nine.
14. treatment process according to claim 1, is characterized in that, described step (2) 1. in, the concentration of described 1,3 butylene glycol is 25wt%-35wt%.
15. treatment process according to claim 14, is characterized in that, described step (2) 1. in, the concentration of described 1,3 butylene glycol is 30wt%.
16. treatment process according to claim 1, is characterized in that, described step (2) 2. in, the number of times of described repetitive operation is 3-4 time.
17. treatment process according to claim 16, is characterized in that, described step (2) 2. in, the number of times of described repetitive operation is 3 times.
18. treatment process according to claim 1, is characterized in that, described step (2) 3. in, described temperature is 45-55 DEG C.
19. treatment process according to claim 18, is characterized in that, described step (2) 3. in, described temperature is 50 DEG C.
20. treatment process according to claim 1, is characterized in that, described step (2) 3. in, the addition of the ethanol of described 70wt% be 25-35 doubly.
21. treatment process according to claim 20, is characterized in that, described step (2) 3. in, the addition of the ethanol of described 70wt% is 30 times.
22. treatment process according to claim 1, is characterized in that, described step (2) 4. in, the addition of described antiseptic is the 0.5wt%-1.5wt% of step product quality 3..
23. treatment process according to claim 22, is characterized in that, described step (2) 4. in, the addition of described antiseptic is the 1wt% of step product quality 3..
24. treatment process according to claim 1, is characterized in that, described step (2) 4. in, described antiseptic is selected oneself the combination of any one or at least two kinds in glycol, Flos Magnoliae glycol, tropolone.
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| KR102021463B1 (en) * | 2013-04-24 | 2019-09-16 | (주)아모레퍼시픽 | External composition for skin containing Ginsenoside Rg3 |
| KR102024572B1 (en) * | 2013-04-24 | 2019-09-24 | (주)아모레퍼시픽 | External composition for skin containing Ginsenoside Rf |
| CN103719848A (en) * | 2013-12-18 | 2014-04-16 | 张宇 | Processing method of black ginseng |
| CN104523465B (en) * | 2014-11-21 | 2017-09-15 | 澳宝化妆品（惠州）有限公司 | A kind of sizing remediation composition with foam performance containing black conopsea extraction |
| CN104382920A (en) * | 2014-11-27 | 2015-03-04 | 北京师范大学 | New application of ginsenoside Rf |
| KR101776288B1 (en) * | 2015-06-15 | 2017-09-11 | 주식회사 다누림 | Black ginseng liquor using decocting black ginseng and the manufacturing method thereof |
| CN107581452A (en) * | 2016-07-06 | 2018-01-16 | 辽宁中书堂黑参有限公司 | It is a kind of directly to join case with the steaming that red ginseng is the black ginseng of Raw material processing |
| CN108142924A (en) * | 2016-12-06 | 2018-06-12 | 张成中 | The preparation and its application of purplish red ginseng |
| CN108743490A (en) * | 2018-08-29 | 2018-11-06 | 延边大学 | A kind of black conopsea extraction and preparation method thereof, the lotion of resisting age of skin and preparation method thereof containing black conopsea extraction |
| CN111617119A (en) * | 2020-05-22 | 2020-09-04 | 北京心无挂碍文化传播有限公司 | Ginseng processing technology |
| CN111603434B (en) * | 2020-06-03 | 2023-06-06 | 广州智尚生物科技有限公司 | Composition for improving skin wrinkles and cosmetic thereof |
| CN112353829A (en) * | 2020-11-18 | 2021-02-12 | 尊草(威海)生物科技有限公司 | Processing method of black ginseng |
| CN113116778B (en) * | 2021-04-16 | 2022-03-08 | 广州中草世家化妆品有限公司 | Ginseng extracting solution and preparation method and application thereof |
| CN113599314B (en) * | 2021-06-08 | 2022-12-13 | 水羊化妆品制造有限公司 | Black ginseng extract, preparation method thereof and application thereof in cosmetics |
| CN114181275A (en) * | 2021-12-29 | 2022-03-15 | 水羊化妆品制造有限公司 | Ginsenoside Rg3, and preparation method and application thereof |
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