CN102973973B - Air-freshening bacteriostatic agent and preparation method thereof - Google Patents
Air-freshening bacteriostatic agent and preparation method thereof Download PDFInfo
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- CN102973973B CN102973973B CN201210583245.2A CN201210583245A CN102973973B CN 102973973 B CN102973973 B CN 102973973B CN 201210583245 A CN201210583245 A CN 201210583245A CN 102973973 B CN102973973 B CN 102973973B
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Abstract
The invention discloses a traditional Chinese medicine air sterilization freshening agent and a preparation method thereof. The method provides a formula comprising components in parts by weight as follows: 100-120 parts of indigowoad roots, 40-55 parts of sophorae, 70-80 parts of dandelion, 30-40 parts of flos caryophyllata, 30-35 parts of golden cypress, 5-15 parts of gentian, 5-20 parts of common cnidium fruit, 0-10 parts of glabrous greenbrier rhizome, 30-50 parts of common andrographis herb and 45-60 parts of wild chrysanthemum flower are immersed in an ethanol solution and extracted, a filtrate is collected for filling, and the air-freshening bacteriostatic agent is obtained. The air-freshening bacteriostatic agent can be used for preventing colds and treating respiratory diseases and the like, and can not only inhibit and kill harmful bacteria and viruses in the air, but also expel parasites, relieve itching and prevent virus colds.
Description
Technical field
The present invention relates to a kind of air fresh bacteriostat for fresh air, particularly relate to a kind of take the Chinese crude drug air fresh bacteriostat formulated as raw material extracts and the preparation method of this antibacterial.
Background technology
The insect aerosol of the air freshener of selling on market and the use that repels mosquitoes and flies, because containing a large amount of chemical compositions, all has certain toxicity to human body more.Widely used indoor insecticidal aerosol in the world for example, adopts a kind of insecticidal constituent of universally acknowledged safe pyrethroid exactly.Yet home and abroad environment toxicologist tests confirmation, pyrethroid insecticides also has obvious toxicity to people and animals' nervous system, and Long Term Contact can cause nervous system toxicity, causes the nervous symptoms such as the abnormal and dizziness headache of neural paralysis, sensory nerve.
High development along with social material civilization, air pollution is room air pollution particularly, in its degree, greatly increase, cause the ill frequency of some people respiratory tract disease to increase and occur dizzy, the tired symptom such as feel sick, bring puzzlement and worried to many people's work and life, the mankind healthy has been subject to increasing threat.How to eliminate and to prevent room air pollution to become the focus that people are concerned about, also the released one after another product of pure and fresh and disinfecting air of many producers, but these freshener exist larger problems and shortcomings in the market, the one, the overwhelming majority is chemicals, only adds some essence and is injected in and in air, just has aromatic odor and do not possess sterilizing effect; The 2nd, adopt chemical products as raw material, when doing pure and fresh sterilization like this, increased again new pollution; The 3rd, traditional medicine sterile products, although there is stronger sterilization, often the smell is awful (as lysol), common people are difficult to accept, or sterilize with fluoric acid, but all can not improve indoor air ambient completely.
Therefore, both at home and abroad well-known expert once advised, the duty ventilation of windowing, carrys out environment purification by fresh and salubrious natural air, is the first selection of fresh air; Another selection is that effective component extracting is made novel air freshener from natural plants.From relevant Chinese medicine, effective component extracting is made the air freshener of high-efficiency environment friendly, in current domestic and international market, still belongs to initiative industry project, has development prospect.For Chinese medicine air fresh bacteriostat, there is antibacterium and pathogenic dermatophytes, the present market of Chinese medicine air fresh bacteriostat of the effect such as Prevention eczema, skin pruritus, scabies is also rare.
Summary of the invention
The object of this invention is to provide and a kind ofly take pure Chinese medicine and extract preparation as raw material, can fresh air, repel mosquitoes and flies, again can prophylactic air fresh bacteriostat.
The preparation method of above-mentioned air fresh bacteriostat is provided, and is another goal of the invention of the present invention.
Chinese medicine air fresh bacteriostat of the present invention is that the component by following parts by weight is that raw material is made:
The further raw material components (parts by weight) of Chinese medicine air fresh bacteriostat of the present invention is:
The optimum raw material components (parts by weight) of Chinese medicine air fresh bacteriostat of the present invention is:
The present invention makes concentrating agents by above-mentioned Chinese medicine air-freshing bacteria inhibition liquid and uses.
The preparation method of the pure Chinese medicine air fresh bacteriostat concentrating agents of the present invention is that Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Flos Caryophylli, Cortex Phellodendri, Radix Gentianae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Herba Andrographis and Flos Chrysanthemi Indici are mixed according to described parts by weight, with alcoholic solution, soak extraction, collect rear fill in filtrate and make.
The concrete preparation method of the pure Chinese medicine air fresh bacteriostat concentrating agents of the present invention comprises the following steps:
(1) pretreatment of raw material: Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Flos Caryophylli, Cortex Phellodendri, Radix Gentianae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Herba Andrographis and Flos Chrysanthemi Indici are cleaned standby;
(2) alcohol extractions: by pretreated raw material according to the mixing of weighing of above-mentioned parts by weight, according to the volume of 8～10 times of raw material gross weights, prepare the ethanol of mass concentration 75%, first in mixed material, add the above-mentioned ethanol that accounts for whole volumes 1/2～2/3, under room temperature, soak after one week and filter, filtrate is left in fluid reservoir;
(3) secondary alcohol extraction: the filtering residue with remaining ethanol after to an alcohol extraction carries out soak at room temperature, soaks after one week and filters, and filtrate is mixed with an alcohol extraction filtrate;
(4) fill: filtrate is carried out to fill.
The present invention can also make above-mentioned Chinese medicine air-freshing bacteria inhibition liquid spray and use.
The concrete grammar that the present invention makes spray using Chinese medicine air fresh bacteriostat be in the Chinese medicine air fresh bacteriostat of fill directly filling compressed air as propellant, to enable to form vaporific, reach spray effect.Because the present invention adds the chemical propellant such as propane, butane or dimethyl ether, guaranteed that product life-time service of the present invention is also nontoxic to human body.
Owing to having adopted technique scheme, the invention has the beneficial effects as follows:
In the main raw material of Chinese medicine that Chinese medicine air fresh bacteriostat of the present invention is used, mainly being extracted into of Radix Sophorae Flavescentis is divided into alkaloids composition, this composition all has obvious bacteriostasis to escherichia coli, golden Portugal bacterium, Bacillus proteus, dysentery bacterium and multiple pathogenic dermatophytes, while is because of the effect of its heat clearing and damp drying, parasite killing, normal decocting liquid external, for treatment and the prevention of pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection; In Radix Isatidis, contain the compositions such as sinigrin, indanol glycosides, isatin and sitosterol, its alcohol water-leach liquor all has obvious inhibitory action to gram negative bacteria and positive bacteria, simultaneously can excited endothelial system after absorption of human body, strengthen leukocytes phagocytic ability, improve body defence capability; Herba Taraxaci can obtain the effective ingredient such as Herba Taraxaci saponin, taraxacin and taraxacin through ethanol extraction, and these effective ingredient Dui Jin Portugal bacterium, Hemolytic streptococcus, mucositis bacterium and influenza virus have stronger inhibitory action; The alcohol extraction effective ingredient of Flos Caryophylli is fragrant phenol, β-Flos Caryophylli alkene, has antibacterial, worm-expelling effect; The effective ingredient of Cortex Phellodendri is mainly the flavones ingredients such as the alkaloids such as berberine and flavone Radix Hyperici Monogyni (Herba Hyperici Monogyni), except the multiple pathogenic dermatophytess such as the antibacterials such as staphylococcus aureus, streptococcus pneumoniae and acrothesium floccosum are had stronger inhibitory action, also has the effect of antiallergic action simultaneously, in addition, Cortex Phellodendri has heat clearing and damp drying, and pathogenic fire purging is except steaming, the effect of detoxification sore treatment, can decocting liquid washout be used for sore swollen toxin, treatment and the prevention of skin eczema pruritus etc.; Radix Gentianae water logging agent has inhibitory action in various degree to multiple pathogenic dermatophytes and bacillus pyocyaneus, dysentery bacterium, staphylococcus aureus etc., its bitter in the mouth is cold in nature, heat clearing and damp drying, can externally applied anti-inflammation antipruritic, the contained gentiopicrin of Radix Gentianae also has higher toxicity to plasmodium in addition; Fructus Cnidii removing dampness and killing parasites, dispelling wind for relieving itching, can decocting liquid outer for pudendal pruritus swell and ache, treatment and the prevention of rheumatic arthralgia, eczema scabies, the in vitro tests of its contained osthole, bergapton and isopimpinellin shows, staphylococcus aureus, bacillus pyocyaneus, dermatophytosis etc. are had to strong activity, and its contained xanthotoxol also has stronger antiinflammatory and analgesic effect; Rhizoma Smilacis Glabrae removing damp-heat, let out turbid removing toxic substances, easing joint movement, can external prevent and treat damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, the limbs contracture due to syphilis and mercurialism, bones and muscles pain etc., modern pharmacological research shows, Rhizoma Smilacis Glabrae all has obvious bacteriostasis to staphylococcus, A type and group B streptococcus etc.; Herba Andrographis cures mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., and external can be treated furuncle toxic swelling, trauma infection contamination etc.; Flos Chrysanthemi Indici containing can be widely used in treatment furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, the disease such as dizzy of having a headache.There is again good hypotensive effect, can be used for the auxiliary treatment of hypertension simultaneously.
The present invention selects fragrant odour, and the natural Chinese medicine with sterilizing fungistatic effect is raw material, extracts its effective ingredient and makes air fresh bacteriostat, and filling compressed air is as propellant, not only production method is simple, easy to use, and after using to human body without any murder by poisoning.
Through the results show, product of the present invention has powerful dissipation effect to harmful bacterias such as staphylococcus aureus, influenza virus, escherichia coli, can effectively prevent the generation of influenza and epidemic disease, can substitute chemosynthesis air freshener and insect aerosol in the market, the place that the crowd is dense, easily cause cross infection such as be widely used in hotel, office building, room, army, school, hospital, car.
The specific embodiment
Below in conjunction with embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.In addition should be understood that those skilled in the art can make various changes or modifications the present invention after having read the content of the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
Take that to manufacture the spray product that 10,000 bottles of net capacity are 500mL be example, according to following weight, be ready to raw material of Chinese medicine: Radix Isatidis 108Kg, Radix Sophorae Flavescentis 45Kg, Herba Taraxaci 70Kg, Flos Caryophylli 35Kg, Cortex Phellodendri 32Kg, Radix Gentianae 9Kg, Fructus Cnidii 7Kg, Rhizoma Smilacis Glabrae 8Kg, Herba Andrographis 35Kg and Flos Chrysanthemi Indici 48Kg.
Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Flos Caryophylli, Cortex Phellodendri, Radix Gentianae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Herba Andrographis and Flos Chrysanthemi Indici are mixed, the ethanol 2000L that adds mass concentration 75%, under room temperature, airtight immersion, after one week, filters out filtrate, leaves in fluid reservoir stand-by.The alcoholic solution 1350L that adds again mass concentration 75% in filtering residue, under room temperature, airtight immersion is one week, filters out filtrate, mixes with an alcohol extraction filtrate, obtains altogether alcohol extract 3000L.
The ethanol 2000L that adds again mass concentration 40%, obtains containing the alcohol extract 5000L that alcohol mass concentration is 60%, and dress is filled with, and filling compressed air in tank, packs and put in storage after the assay was approved simultaneously.
Embodiment 2
Take that to manufacture the concentrating agents product that 10,000 bottles of net capacity are 500mL be example, according to following weight, be ready to raw material of Chinese medicine: Radix Isatidis 110Kg, Radix Sophorae Flavescentis 40Kg, Herba Taraxaci 75Kg, Flos Caryophylli 35Kg, Cortex Phellodendri 30Kg, Radix Gentianae 9Kg, Fructus Cnidii 7Kg, Rhizoma Smilacis Glabrae 8Kg, Herba Andrographis 30Kg and Flos Chrysanthemi Indici 45Kg.
Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Flos Caryophylli, Cortex Phellodendri, Radix Gentianae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Herba Andrographis and Flos Chrysanthemi Indici are mixed, the ethanol 2000L that adds mass concentration 75%, under room temperature, airtight immersion, after one week, filters out filtrate, leaves in fluid reservoir stand-by.The ethanol 1350L that adds again mass concentration 75% in filtering residue, under room temperature, airtight immersion is one week, filters out filtrate, mixes with an alcohol extraction filtrate, obtains altogether alcohol extract 3000L.
The ethanol 2000L that adds again mass concentration 40%, obtains containing the alcohol extract 5000L that alcohol mass concentration is 60%, and dress is filled with, after the assay was approved packing warehouse-in.
The present invention is according to < < disinfection technology standard > > (version in 2002), under testing conditions separately, the bacteriostasis property to Chinese medicine air fresh bacteriostat of the present invention detects respectively, and concrete testing result is as follows.
The quality 5% ethanol dilution liquid of A, Chinese medicine air fresh bacteriostat of the present invention is 3.76 * 10 to concentration
4bacteria suspension effect 2min for the coli test of cfu/mL, each the equal > 95% of bacteriostasis rate, product has bacteriostasis for escherichia coli.
B, Chinese medicine air fresh bacteriostat quality of the present invention 5% ethanol dilution liquid are 1.80 * 10 to concentration
4the staphylococcus aureus of cfu/mL bacteria suspension effect 2min for test, each the equal > 95% of bacteriostasis rate, product has stronger bacteriostasis for staphylococcus aureus.
C, Chinese medicine air fresh bacteriostat quality of the present invention 5% ethanol dilution liquid are 2.02 * 10 to concentration
4the Candida albicans of cfu/mL bacteria suspension effect 2min for test, each the equal > 97% of bacteriostasis rate, product has bacteriostasis for Candida albicans.
D, Chinese medicine air fresh bacteriostat quality of the present invention 5% ethanol dilution liquid are after 45 ℃ are incubated 90 days, bacteria suspension effect 2min for staphylococcus aureus is tested, each the equal > 90% of bacteriostasis rate, bacteria suspension effect 2min for escherichia coli, Candida albicans are tested, each the equal > 75% of bacteriostasis rate, there is no significant difference with the fungistatic effect before depositing, show the fungistatic effect of escherichia coli, staphylococcus aureus, Candida albicans stable.
Actual case
Inventor selects certain liang kindergarten to do drug study contrast of the present invention, experimental group and matched group have respectively 50 4-6 year children, experimental group is used Chinese medicine air fresh bacteriostat of the present invention every day in classroom, and matched group is not used any air fresh bacteriostat.In swine flu autumn prevailing, use Chinese medicine air fresh bacteriostat of the present invention, no one flu.And have 26 people in matched group, there is flu-like symptom.
Claims (3)
1. a Chinese medicine air fresh bacteriostat, is characterized in that being made by the preparation method comprising the steps:
(1) pretreatment of raw material: Radix Isatidis, Radix Sophorae Flavescentis, Herba Taraxaci, Flos Caryophylli, Cortex Phellodendri, Radix Gentianae, Fructus Cnidii, Rhizoma Smilacis Glabrae, Herba Andrographis and Flos Chrysanthemi Indici are cleaned standby; The parts by weight of above-mentioned raw materials are:
(2) alcohol extractions: by pretreated raw material according to the mixing of weighing of above-mentioned parts by weight, according to raw material gross weight 8-10 volume doubly, prepare the ethanol of mass concentration 75%, first in mixed material, add the above-mentioned ethanol that accounts for whole volume 1/2-2/3, under room temperature, soak after one week and filter, filtrate is left in fluid reservoir;
(3) secondary alcohol extraction: the filtering residue with remaining ethanol after to an alcohol extraction carries out soak at room temperature, soaks after one week and filters, and filtrate is mixed with an alcohol extraction filtrate;
(4) fill: filtrate is carried out to fill.
2. Chinese medicine air fresh bacteriostat according to claim 1, is characterized in that the parts by weight of described raw material are:
3. Chinese medicine air fresh bacteriostat according to claim 2, is characterized in that the parts by weight of described raw material are:
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| CN105192006A (en) * | 2015-09-07 | 2015-12-30 | 蚌埠龙达农业专业合作社 | Sterilization and disinfection incense for free-range chicken house and preparation method thereof |
| CN105165920A (en) * | 2015-09-07 | 2015-12-23 | 蚌埠龙达农业专业合作社 | Local chicken farm sterilization disinfectant and preparation method of local chicken farm sterilization disinfectant |
| CN105727337A (en) * | 2016-02-17 | 2016-07-06 | 广西大学 | Traditional Chinese medicine antimicrobial air freshener and preparation method thereof |
| CN106234483A (en) * | 2016-08-03 | 2016-12-21 | 安徽省华凯轻工科技有限公司 | A kind of plant source draft antibacterial |
| CN108498386A (en) * | 2018-05-21 | 2018-09-07 | 广东省中药研究所 | A kind of mosquito repellent composition and preparation method thereof |
| CN108722099B (en) * | 2018-06-06 | 2019-12-24 | 德州德运环保科技股份有限公司 | Environment-friendly deodorant with bacteriostatic action and preparation method thereof |
| CN112121116A (en) * | 2020-10-27 | 2020-12-25 | 天津国际生物医药联合研究院 | Natural plant active factor antibacterial atomizing agent and preparation method thereof |
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| JP3830960B1 (en) * | 2005-08-12 | 2006-10-11 | 建仁 河乃 | Hair growth substance |
| CN101391108B (en) * | 2008-10-31 | 2013-05-08 | 山西振东制药股份有限公司 | Traditional Chinese medicine air fresh bacteriostat and preparation method thereof |
| CN102450285A (en) * | 2010-10-26 | 2012-05-16 | 成都顺发消洗科技有限公司 | Traditional Chinese drug air refreshing agent and preparation method thereof |
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