CN1061861C - Composite natural synergic essence and preparing process and use thereof - Google Patents

Abstract

The present invention belongs to a traditional Chinese medicine medical care preparation and a preparing method thereof. The traditional Chinese medicine medical care preparation is mainly formed by preparing coptis, phellodendron bark, stemona root, kuh-seng, dictamnus, dock root, gentian root, giant knotweed rhizome, glabrous greenbrier rhizome, Chinese pulsatilla root, european verbena, arnebia root, knotgrass, herba agastachis, psoralea fruit, raw licorice, dried alum and borneol, and has preparations, such as powder, liquid, tincture, paste, crystalline powder, etc. The composite natural synergy essence of the present invention can be used for the clinical prevention and adjuvant treatment for the usual diseases of the department of gynecology and the department of dermatology. The present invention can also be used for various life and productive fields, such as hygiene and disease control, air purification, washing articles, cosmetics, prevention and protection of animals and plants, corrosion prevention, refreshment, etc.

Description

Composite natural synergic essence and its production and use

The invention belongs to a kind of Chinese medicine preparation and preparation method thereof, particularly in novel medical health care products of a kind of traditional Chinese medical science tradition side of external medicine and preparation method thereof.

At present, on market for the treatment removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching, expelling pus and promoting granulation, blood stasis dispelling analgesia, anti-inflammation, the medicine that suppresses diseases such as virus and enhance immunity function is existing a lot, but generally all has problem in various degree, does not still have to press down as the similar medicament at natural component and kills antibacterial, virus, parasite, can fully extract whole pure dissolubility water solublity and volatile effective component in the prescription again, and the medicament that makes it to strengthen.Contain western medicine composition in some similar medicament for another example and have certain side effect or the like.Therefore in application, have suitable limitation, and curative effect is single.

The objective of the invention is to propose a kind of under traditional Chinese medicine theoretical direction, widely collect the length of crowd side, in conjunction with relevant expertise, and the multipurpose composite natural synergic essence that develops of the newest fruits of Chinese medicine research both at home and abroad in recent years and preparation method thereof.But its clinical practice also can be applicable to health and epidemic prevention in prevention and auxiliary treatment gynecological common frdquently encountered disease, air cleaning, articles for washing, multiple production, sphere of lifes such as anti-guarantor of cosmetics and animals and plants and anti-corrosive fresh-keeping.

Its composition of composite natural synergic essence of the present invention and percentage by weight thereof are respectively: Rhizoma Coptidis 3-5%, Cortex Phellodendri 5-7%, Radix Stemonae 3-5%, Radix Sophorae Flavescentis 5.5-7.5%, Cortex Dictamni 6-8%, Radix Rumicis 3.5-5%, Radix Gentianae 5-8%, Rhizoma Polygoni Cuspidati 8-14%, Rhizoma Smilacis Glabrae 5-8%, Radix Pulsatillae 5.6-7.2%, Herba Verbenae 5.7-7.5%, Radix Arnebiae (Radix Lithospermi) 6-8%, Herba Polygoni Avicularis 5-7%, Herba Pogostemonis 3-5%, Fructus Psoraleae 1-3%, Radix Glycyrrhizae 5-8%, dried Alumen 1-4%, Borneolum Syntheticum 0.5-3%.

The preparation method of composite natural synergic essence of the present invention is to be ground into fruit according to traditional Chinese medicine technology and up-to-date profit to draw in conjunction with development, with 18 kinds of Chinese medicines such as above-mentioned Rhizoma Coptidis is raw material, through distillation, dissolving, alcohol extraction, water carry, mix, refining liquor, powder and the tincture that forms of operation such as magnetization.Its main technique method has three, and its step branch is set forth in the back:

One, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) Herba Pogostemonis is used steam distillation, it is standby to collect distillate;

(2) make by abundant dissolved saturated aqueous solution standby with an amount of distilled water dried Alumen;

(3) it is standby Borneolum Syntheticum fully to be dissolved into saturated solution with an amount of " tween 80 ";

(4) above three kinds of solution mixings are standby;

(5) in addition with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Fructus Psoraleae, Radix Glycyrrhizae totally 15 flavor medicines grind into 30-60 order coarser powder, be incorporated into the Herba Pogostemonis residue after the distillation, by per 150 gram raw materials with the ethanol of 1500ML 60-80% after 40-60 ℃ and 1000-3000 gauss magnetic field environment inner sealing soak 6-12 hour, place 120-130 ℃ oil bath reflux 6 hours, cold filtration removes slag, and the gained medicinal liquid is standby;

(6) add an amount of distilled water in the medicinal residues that after oil bath refluxes, leach again, energising ionization was also boiled 5-10 minute, filter pressing is removed slag, gained medicinal liquid and oil bath reflux behind the gained medicinal liquid mixing of back, the processing of decolouring, and recovered alcohol, the same dried Alumen of gained medicinal liquid, the mixed liquor mixing of Borneolum Syntheticum and Herba Pogostemonis volatile matter three solution, and placed in the 1000-3000 gauss magnetic field magnetization 5-10 minute, can the fill envelope store, these manufactured goods also available " ultrasonic agitation device " carry out activation processing, and can further make extractum or crystalline powder dosage form.

Two, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) it is standby Borneolum Syntheticum to be made into saturated solution with " tween 80 ";

(2) with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Herba Pogostemonis, Fructus Psoraleae, Radix Glycyrrhizae totally 16 the flavor medicated powder be broken into 30-60 order coarser powder, dried Alumen grinds to the powder separately and sneaks into;

(3) said mixture is restrained the medical or edible ethanol that raw materials add 1500ML 75-95% by per 150, sealing was soaked 6-12 hour in 40-70 ℃ and magnetic field environment more than 1000 Gausses, put in the 120-130 ℃ of oil bath reflux again 6 hours, cooling press elimination slag, this medicinal residues reuse is handled one time with quadrat method, behind the waste gained medicinal liquid is sneaked into, the gained medicinal liquid is handled through decolouring, again with aforementioned Borneolum Syntheticum solution mixing, magnetization is 5-10 minute in the highfield more than 1000 Gausses, promptly obtains the tincture finished product.

Three, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) in the ratio in the prescription Borneolum Syntheticum and dried Alumen are distinguished each pulverization, and mixing is standby in the formulation weight ratio;

(2) with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Herba Pogostemonis, Fructus Psoraleae, Radix Glycyrrhizae totally 16 flavor medicated powder be broken into 30-100 purpose powder, by formulation weight ratio cooperation mixing;

(3) cooperate mixing to get final product 16 mixed-powders of distinguishing the flavor of medicines such as Rhizoma Coptidis in Borneolum Syntheticum in (1) and dried Alumen mixed-powder and (2).

Composite natural synergic essence of the present invention has antibiotic widely, antiviral and some parasitic effect, and its content prescription novelty, compatibility is reasonable, and is safe and reliable, practical.Through the most up-to-date techniques method; many effects that whole effective ingredient of each constituent in the prescription are fully extracted; the multipurpose composite natural synergic essence; can effectively press down and kill various bacteria; (its minimal effective concentration is 1: 50-1: 400) for virus and parasite; various skin disease and the men and women front and back pudendum disease that causes because of them had prevention and auxiliary treatment effect; and has antiinflammatory; antiulcer; anti allergic reaction; protection and damaged tissue repair; remove effects such as pathological product and disintegrate pathological tissue; can be used for strengthening and increasing various health; sterilization; epidemic prevention; washing; beauty treatment; health care; auxiliary treatment; the effect and the purposes of articles for use such as anti-guarantor of animals and plants and anti-corrosive fresh-keeping are with a wide range of applications and good society and economic benefit.

The gynopathic medicine of the control that composite natural synergic essence of the present invention is made, evaluate through expert testimony and to think and adhere to pure Chinese medicinal preparation, can avoid unexpected reaction, and through the modern pharmacology analysis, contain in the prescription outside the composition of killing parasites for relieving itching, anti-inflammation, the composition of anti-hepatitis virus and AISD is still arranged, and consistently think that a kind of curative effect is reliable, novel medical health care products of many uses, as to have no side effect.

The medicament that composite natural synergic essence of the present invention is made is thought toxic and side effects such as no any local irritant effect and sensitization through the toxicologic study result of Beijing University of Chinese Medicine.And through the research of external function of killing microorganism, to staphylococcus aureus, staphylococcus epidermidis, escherichia coli, bacillus pyocyaneus, proteus vulgaris, first, group B streptococcus, Diplococcus pneumoniae, gonococcus etc. all have obvious bactericidal action.

Embodiment 1: a kind of treatment skin and gynopathic essence preparation

Its component and percentage by weight are respectively: Rhizoma Coptidis 4.2% Cortex Phellodendri 6.4% Radix Stemonae 4.2% Radix Sophorae Flavescentis 6.4% Cortex Dictamni 6.4% Radix Rumicis 4.2% Radix Gentianae 6.4% Rhizoma Polygoni Cuspidati 12.7% Rhizoma Smilacis Glabrae 6.4% Radix Pulsatillae 6.4% Herba Verbenae 6.4% Radix Arnebiae (Radix Lithospermi) 6.4% Herba Polygoni Avicularis 6.4% Herba Pogostemonis 4.2% Fructus Psoraleae 2.5% Radix Glycyrrhizae 6.4% dried Alumen 2.5% Borneolum Syntheticum 1.5%

This preparation has heat clearing and damp drying, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching, the function of healing up sore and relieving pain, cure mainly skin and front and back pudendal pruritus, eczema, inflammation, skin infection, burn and scald injures women's leucorrhea with red and white discharge, the swelling of the vulva pain of itching can be removed women's misery, that the dosage form of this preparation has is diffusing, liquid, tincture, cream and crystalline powder etc., can be used for the affected part outward.

Embodiment 2:

The preparation method of the essence among the embodiment 1 the steps include:

(1) Borneolum Syntheticum and dried Alumen in the flavor of 18 among the embodiment 1 medicine are distinguished independent pulverization in proportion, and mixing is standby;

(2) again other 16 flavor medicine is ground into 60 purpose powder respectively, and the mixing that proportions;

(3) Borneolum Syntheticum in (1) and dried Alumen mixed-powder are put into the 16 flavor medicamental pulverata compounds of (2), facing-up, the mixing that sieves again, get final product essence of the present invention.

Embodiment 3: a kind of pure natural dipping tea

Will be by the preparation of gained among the embodiment 2, behind the ultraviolet sufficiently sterilised, every 30-50g adorns

Go in the pouch that a permeable non-woven fabrics of usefulness makes, again pouch put into the hydrophobicity paper bag,

Also can add an amount of Folium Camelliae sinensis in it, pure natural dipping tea.

Embodiment 4: a kind of natural drug sanltary towel

After will using the ultraviolet sufficiently sterilised by the essence of gained among the embodiment 2, evenly be layered on certain

On the health defat cotton sliver of specification, its thickness is about 1-1.5mm, reuse non-woven fabrics parcel

Become sanitary towel, the glue sealing of two ends and seam, and coat an adhesive sticker in seam,

Paste a paraffin paper band again, promptly get the natural drug sanltary towel.

Embodiment 5: a kind of natural curative effect cold cream

To implement Borneolum Syntheticum in the essence prescription in 1 earlier, to be made into saturated solution with " tween 80 " standby, again all the other raw material powders are broken into 60 purpose coarser powder (wherein dried Alumen is sneaked into after grinding to the powder separately), the medical alcohol or the edible ethanol that add 1500ML80% by per 150 gram raw materials, soaked 6 hours at 60 ℃ and magnetic field environment inner sealing, place 130 ℃ oil bath reflux 6 hours again, cooling press elimination slag (handle one time with quadrat method by this medicinal residues reuse, behind the waste medicinal liquid is incorporated into), the gained medicinal liquid is handled and aforementioned Borneolum Syntheticum solution mixing through decolouring again, promptly get required tincture, get its 10 parts standby.Other gets 5 parts of sodium bicarbonate, add to be heated in 250 parts of water to stir about 80 ℃ and dissolve, adding 10 parts of the tinctures and the glycerol that are somebody's turn to do " essence " again stirs for 15 parts, and along under the same direction stirring condition, slowly join and be heated in 80 ℃ of its 50 parts of stearic acid that dissolved until becoming the ointment shape, when temperature is reduced to 40 ℃ of left and right sides, add essence, mixing thoroughly the back bottling get final product natural curative effect cold cream.

Embodiment 6: a kind of sterilizing and itch-relieving hair caring aerosol

It is standby earlier the Borneolum Syntheticum in the prescription among the embodiment 1 to be made into saturated solution with " tween 80 ", again all the other raw material powders are broken into 60 order coarser powder (wherein the independent pulverization of dried Alumen is sneaked into), the ethanol that adds 1500ML80% by per 150 gram raw materials sealing in 60 ℃ and magnetic field environment was soaked 6 hours, placed 130 ℃ of oil bath reflux again 6 hours, cooling press elimination slag (handle one time with quadrat method again by these medicinal residues, behind the waste medicinal liquid is incorporated into), the gained medicinal liquid is handled through decolouring, again with aforementioned Borneolum Syntheticum solution mixing, promptly get required tincture, get 30 parts, added 3 parts of acrylic resin alkanolamines (or polyethylene pyrrole cheese alkane ketone) again, 2 parts of glycerol, 0.1 part silicone, and spice, pigment, each is an amount of for sodium benzoate, mixing, get distilled water and be added to 100 parts, get this stock solution 200ML and inject " aerosol " bottle, promptly get sterilizing and itch-relieving hair caring aerosol after charging into the propellant that accounts for stock solution volume 12% again.

Claims (5)

1, a kind of composite natural synergic essence is characterized in that its composition and percentage by weight thereof are respectively: Rhizoma Coptidis 3-5%, Cortex Phellodendri 5-7%, Radix Stemonae 3-5%, Radix Sophorae Flavescentis 5.5-7.5%, Cortex Dictamni 6-8%, Radix Rumicis 3.5-5%, Radix Gentianae 5-8%, Rhizoma Polygoni Cuspidati 8-14%, Rhizoma Smilacis Glabrae 5-8%, Radix Pulsatillae 5.6-7.2%, Herba Verbenae 5.7-7.5%, Radix Arnebiae (Radix Lithospermi) 6-8%, Herba Polygoni Avicularis 5-7%, Herba Pogostemonis 3-5%, Fructus Psoraleae 1-3%, Radix Glycyrrhizae 5-8%, dried Alumen 1-4%, Borneolum Syntheticum 0.5-3%.

2, essence as claimed in claim 1 is characterized in that its composition and percentage by weight thereof are: Rhizoma Coptidis 4.2%, Cortex Phellodendri 6.4%, the Radix Stemonae 4.2%, Radix Sophorae Flavescentis 6.4%, Cortex Dictamni 6.4%, Radix Rumicis 4.2%, Radix Gentianae 6.4%, Rhizoma Polygoni Cuspidati 12.7%, Rhizoma Smilacis Glabrae 6.4%, the Radix Pulsatillae 6.4%, Herba Verbenae 6.4%, Radix Arnebiae (Radix Lithospermi) 6.4%, Herba Polygoni Avicularis 6.4%, Herba Pogostemonis 4.2%, Fructus Psoraleae 2.5%, Radix Glycyrrhizae 6.4%, dried Alumen 2.5%, Borneolum Syntheticum 1.5%.

3, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) Herba Pogostemonis is used steam distillation, it is standby to collect distillate;

(2) make by abundant dissolved saturated aqueous solution standby with an amount of distilled water dried Alumen;

(3) it is standby Borneolum Syntheticum fully to be dissolved into saturated solution with an amount of " tween 80 ";

(4) above three kinds of solution mixings are standby;

(5) in addition with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Fructus Psoraleae, Radix Glycyrrhizae totally 15 flavor medicines grind into 30-60 order coarser powder, be incorporated into the Herba Pogostemonis residue after the distillation, by per 150 gram raw materials with the ethanol of 1500ML60-80% after 40-60 ℃ and 1000-3000 gauss magnetic field environment inner sealing soak 6-12 hour, place 120-130 ℃ oil bath reflux 6 hours, cold filtration removes slag, and the gained medicinal liquid is standby;

(6) add an amount of distilled water in the medicinal residues that after oil bath refluxes, leach again, energising ionization was also boiled 5-10 minute, filter pressing is removed slag, gained medicinal liquid and oil bath reflux behind the gained medicinal liquid mixing of back, the processing of decolouring, and recovered alcohol, the same dried Alumen of gained medicinal liquid, the mixed liquor mixing of Borneolum Syntheticum and Herba Pogostemonis volatile matter three solution, and placed in the 1000-3000 gauss magnetic field magnetization 5-10 minute, can the fill envelope store, these manufactured goods also available " ultrasonic agitation device " carry out activation processing, and can further make extractum or crystalline powder dosage form.

4, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) it is standby Borneolum Syntheticum to be made into saturated solution with " tween 80 ";

(2) with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Herba Pogostemonis, Fructus Psoraleae, Radix Glycyrrhizae totally 16 the flavor medicated powder be broken into 30-60 purpose coarser powder, dried Alumen grinds to the powder separately and sneaks into;

(3) said mixture is restrained the medical or edible ethanol that raw materials add 1500ML75-95% by per 150, sealing was soaked 6-12 hour in 40-70 ℃ and magnetic field environment more than 1000 Gausses, placed 120-130 ℃ of oil bath reflux again 6 hours, cold filtration removes slag, this medicinal residues reuse is handled one time with quadrat method, behind the waste gained medicinal liquid is sneaked into, the gained medicinal liquid is handled through decolouring, again with aforementioned Borneolum Syntheticum solution mixing, magnetization is 5-10 minute in the highfield more than 1000 Gausses, promptly obtains the tincture finished product.

5, a kind of preparation method of composite natural synergic essence, its key step comprises:

(1) in the ratio in claim 1 or 2 prescriptions Borneolum Syntheticum and dried Alumen are distinguished each pulverization, and mixing is standby by its part by weight;

(2) with Rhizoma Coptidis, Cortex Phellodendri, the Radix Stemonae, Radix Sophorae Flavescentis, Cortex Dictamni, Radix Rumicis, Radix Gentianae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, the Radix Pulsatillae, Herba Verbenae, Radix Arnebiae (Radix Lithospermi), Herba Polygoni Avicularis, Herba Pogostemonis, Fructus Psoraleae, Radix Glycyrrhizae totally 16 flavor medicated powder be broken into 30-100 purpose powder, by claim 1 or 2 formulation weight ratios cooperation mixing;

(3) cooperate mixing to get final product 16 mixed-powders of distinguishing the flavor of medicines such as Rhizoma Coptidis in Borneolum Syntheticum in (1) and dried Alumen mixed-powder and (2).