CN102973492B - Chitosan hydrogel for treating haemorrhoids and preparation method thereof - Google Patents
Chitosan hydrogel for treating haemorrhoids and preparation method thereof Download PDFInfo
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- CN102973492B CN102973492B CN201110258116.1A CN201110258116A CN102973492B CN 102973492 B CN102973492 B CN 102973492B CN 201110258116 A CN201110258116 A CN 201110258116A CN 102973492 B CN102973492 B CN 102973492B
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Abstract
The invention discloses chitosan hydrogel for treating haemorrhoids and a preparation method thereof. The chitosan hydrogel for treating haemorrhoids comprises: 0.1 to 10% of chitosan, 0.1 to 2.0% of carbomer, 0.5 to 4.0% of triethylamine and the balance water. Chitosan and carbomer gel are directly mixed and the mixture is prepared into the chitosan hydrogel at a normal temperature without a cross-linking agent. The preparation method is simple. The chitosan hydrogel for treating haemorrhoids has effects of inhibiting a plurality of bacteria, can be cured into a film on the surface of haemorrhoids thereby effectively isolating haemorrhoids from pathogenic bacteria in the intestine, and has an effect of lubrication and thus the chitosan hydrogel can eliminate haemorrhoid clinical symptoms and cure haemorrhoids.
Description
Technical field
The present invention relates to a kind of aquagel for the treatment of hemorrhoid.The invention still further relates to the preparation method of described aquagel.
Background technology
A kind of common multiple disease of hemorrhoid is under human rectum's end mucosa and under anal canal skin, the soft vein group expanded and flexing is formed occurs venous plexus.The product of existing treatment hemorrhoid mostly in the market is oral formulations and externally used paste, and externally used paste can directly act on blood stasis surface, but unguentum film property is in vivo poor, and the continuous action time is shorter, can not effectively isolate enteral pathogenic bacterium.Gel is a kind of novel bionic technology preparation; inserted in anorectal; can disperse in anorectal immediately; with anorectal inwall close adhesion; form layer protecting film on blood stasis surface simultaneously; persistent period reaches 24 hours, and effectively pathogenic bacterium in isolation anorectal, simultaneously less to the stimulation of blood stasis when defecation.
Chitosan is polymerized by N-acetyl group-D-glucopyranose amine; it is unique a large amount of alkaline polysaccharide existed in biosphere; have have no side effect, the feature such as good biocompatibility, degradable, abundance, Chitosan-phospholipid complex has good biocidal property and film property.
Summary of the invention
Object of the present invention, just be to provide a kind of aquagel that not can be used for treating hemorrhoid containing any cross-linking agent, there is the antibacterial hemostasis of collection, reduce the feature of blood stasis, good film-forming property, persistent period is long, biological degradability is good, the effect of existing convergence blood stasis, has again the effect of pathogenic bacterium in isolation anorectal.
Aquagel of the present invention, be made up of following component by weight percentage:
Chitosan 0.1% ~ 10%
Carbomer 0.1% ~ 2%
Triethanolamine 0.1% ~ 4%
All the other are water.
Described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%.
The preparation method of above-mentioned aquagel is:
(1) get the raw materials ready by said components and percentage by weight, water is divided into 2 parts, standby carbomer (Carbomer molecular structure :-[-CH2-CH-] N-COOH) is evenly sprinkling upon the water surface of a water, room temperature hold over night or heating in water bath 0.5 ~ 3h, make it fully swelling, obtain carbomer solution;
(2) in another part of water, add standby chitosan and obtain chitosan solution, then join in carbomer solution;
(3) under stirring condition, in step (2) gained mixed solution, slowly drip standby triethanolamine, be 6.0 ~ 8.0 to aquagel system pH, leaves standstill 30min final vacuum de-bubbled, can obtain aquagel.
The beneficial effect of hinge structure of the present invention is:
(1) the present invention is not containing any cross-linking agent, and can obtain under room temperature, preparation method is easy.
(2) aquagel preparation of the present invention is held time length, suppress and isolation pathogenic bacterium time comparatively
Long.
(3) aquagel pH value of the present invention is similar to anorectal road, and almost non-stimulated and bad sensation, more can not destroy the balance of normal flora in anorectal road.
Detailed description of the invention
Be below embodiments of the invention.
Embodiment one
By carbomer 0.103 g(≈ 0.1%) be sprinkling upon on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; By chitosan 1 g(≈ 1%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution, under stirring condition, add triethanolamine 2 ml(≈ 2% gradually), fully stir and make its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment two
By carbomer 1 g(≈ 1%) be sprinkling upon on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; By chitosan 1 g(≈ 1%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution, under stirring condition, add triethanolamine 2 ml(≈ 2% gradually), fully stir and make its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment three
By carbomer 2.1g(≈ 2%) be sprinkling upon on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; By chitosan 1 g(≈ 0.95%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution, under stirring condition, add triethanolamine 2 ml(≈ 1.9% gradually), fully stir and make its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment four
By carbomer 0.5 g(≈ 0.5%) be sprinkling upon on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; By chitosan 0.1 g(≈ 0.1%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution; Triethanolamine 1.5 ml(≈ 1.5% is added gradually under stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment five
Be sprinkling upon by carbomer 0.5 g on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; Chitosan 2 g is dissolved in 50 ml water, obtains chitosan solution, then join in carbomer solution; Add triethanolamine 1.5 ml under stirring condition gradually, fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment six
By carbomer 0.5 g(≈ 0.4%) be sprinkling upon on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling; By chitosan 11.3 g(≈ 10%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution; Triethanolamine 1.5 ml(≈ 1.3% is added gradually under stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment seven
By carbomer 0.2 g(≈ 0.2%) be sprinkling upon on the water surface of 50 ml water uniformly, heating in water bath 0.5 ~ 3h, makes its complete swelling; By chitosan 8 g(≈ 7.3%) be dissolved in 50 ml water, obtain chitosan solution, then join in carbomer solution, described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%; Triethanolamine 0.1 ml(≈ 0.1% is added gradually under stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment eight
Be sprinkling upon by carbomer 2 g on the water surface of 50 ml water uniformly, hold over night, makes its complete swelling.Chitosan 5 g is dissolved in 50 ml water, obtains chitosan solution, then join in carbomer solution; Add triethanolamine 0.5 ml under stirring condition gradually, fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Embodiment nine
By carbomer 0.6 g(≈ 0.6%) be sprinkling upon on the water surface of 50 ml water uniformly, heating in water bath 0.5 ~ 3h, makes its complete swelling.By chitosan 0.2 g(≈ 0.2%) be dissolved in 50 ml water, obtain chitosan solution, described chitosan is low-molecular weight chitoglycan or chitosan derivatives, molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%, then joins in carbomer solution; Triethanolamine 4.5ml(≈ 4% is added gradually under stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under room temperature, can aquagel be obtained.
Claims (3)
1. treat an aquagel for hemorrhoid, it is characterized in that being made up of following component by weight percentage:
Chitosan 0.1% ~ 10%
Carbomer 0.1% ~ 2%
Triethanolamine 0.1% ~ 4%
All the other are water.
2. aquagel according to claim 1, is characterized in that: described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%.
3. the preparation method of the aquagel according to claim 1 or 2, step is as follows:
(1) water is divided into 2 parts, carbomer is evenly sprinkling upon the water surface of a water, room temperature hold over night or heating in water bath 0.5 ~ 3h, make it fully swellingly obtain carbomer solution;
(2) in another part of water, add chitosan dissolving obtain chitosan solution, then join in step (1) gained carbomer solution;
(3), under stirring condition, in step (2) gained mixed solution, slowly triethanolamine is dripped.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110258116.1A CN102973492B (en) | 2011-09-02 | 2011-09-02 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
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| CN201110258116.1A CN102973492B (en) | 2011-09-02 | 2011-09-02 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
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| CN102973492A CN102973492A (en) | 2013-03-20 |
| CN102973492B true CN102973492B (en) | 2015-04-29 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201509419A (en) * | 2013-05-23 | 2015-03-16 | Taiwan Hopax Chems Mfg Co Ltd | Composition for enhancing intestine metabolism |
| CN104027448B (en) * | 2014-04-16 | 2015-12-09 | 东莞市达庆医疗器械有限公司 | A kind of chitosan gel rubber and preparation method thereof |
| CN103948661B (en) * | 2014-04-29 | 2017-08-11 | 安徽徽科生物工程技术有限公司 | Pharmaceutical composition and its application for treating gynecological disease, prostatic disorders or anorectal disease |
| CN103948660B (en) * | 2014-04-29 | 2017-08-11 | 安徽徽科生物工程技术有限公司 | Medical bio bressing suppository and its application for treating gynecological disease, prostatic disorders or anorectal disease |
| CN104188896A (en) * | 2014-08-25 | 2014-12-10 | 漳州片仔癀药业股份有限公司 | Chitosan polyelectrolyte composite gel as well as preparation method and applications thereof |
| CN104523452B (en) * | 2014-12-22 | 2017-11-17 | 闽南师范大学 | A kind of preparation method of antibacterial type carboxyl chitosan plural gel |
| CN105169456B (en) * | 2015-08-25 | 2018-06-01 | 东莞市达庆医疗器械有限公司 | A kind of medical bio hemorrhoid hydrogel functional dressing and preparation method thereof |
| CN108853167A (en) * | 2018-09-13 | 2018-11-23 | 广州润虹医药科技股份有限公司 | A kind of hemorrhoid composition containing chitosan, preparation method and applications |
| CN112999339A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Lysozyme gel and preparation method and application thereof |
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2011
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