CN102973492A - Chitosan hydrogel for treating haemorrhoids and preparation method thereof - Google Patents
Chitosan hydrogel for treating haemorrhoids and preparation method thereof Download PDFInfo
- Publication number
- CN102973492A CN102973492A CN2011102581161A CN201110258116A CN102973492A CN 102973492 A CN102973492 A CN 102973492A CN 2011102581161 A CN2011102581161 A CN 2011102581161A CN 201110258116 A CN201110258116 A CN 201110258116A CN 102973492 A CN102973492 A CN 102973492A
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- China
- Prior art keywords
- chitosan
- water
- carbomer
- aquagel
- solution
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001661 Chitosan Polymers 0.000 title claims abstract description 42
- 208000014617 hemorrhoid Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000017 hydrogel Substances 0.000 title abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 29
- 229960001631 carbomer Drugs 0.000 claims abstract description 29
- 239000000243 solution Substances 0.000 claims description 27
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 20
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 13
- 230000008961 swelling Effects 0.000 claims description 11
- 230000006196 deacetylation Effects 0.000 claims description 4
- 238000003381 deacetylation reaction Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 2
- 201000007772 internal hemorrhoid Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 11
- 244000052616 bacterial pathogen Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000003431 cross linking reagent Substances 0.000 abstract description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000000499 gel Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000005461 lubrication Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 210000002255 anal canal Anatomy 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses chitosan hydrogel for treating haemorrhoids and a preparation method thereof. The chitosan hydrogel for treating haemorrhoids comprises: 0.1 to 10% of chitosan, 0.1 to 2.0% of carbomer, 0.5 to 4.0% of triethylamine and the balance water. Chitosan and carbomer gel are directly mixed and the mixture is prepared into the chitosan hydrogel at a normal temperature without a cross-linking agent. The preparation method is simple. The chitosan hydrogel for treating haemorrhoids has effects of inhibiting a plurality of bacteria, can be cured into a film on the surface of haemorrhoids thereby effectively isolating haemorrhoids from pathogenic bacteria in the intestine, and has an effect of lubrication and thus the chitosan hydrogel can eliminate haemorrhoid clinical symptoms and cure haemorrhoids.
Description
Technical field
The present invention relates to a kind of aquagel for the treatment of hemorrhoid.The invention still further relates to the preparation method of described aquagel.
Background technology
A kind of common multiple disease of hemorrhoid is under the human body rectum end mucosa and anal canal skin under venous plexus the formed soft vein of expansion and flexing group occurs.The product of existing treatment hemorrhoid in the market mostly is oral formulations and externally used paste, and externally used paste can directly act on the blood stasis surface, but unguentum film property in vivo is relatively poor, and the continuous action time is shorter, can not effectively isolate the enteral pathogenic bacterium.Gel is a kind of novel bionic technology preparation; it is inserted in the anorectal; can in anorectal, disperse immediately; closely stick with the anorectal inwall; form layer protecting film on the blood stasis surface simultaneously; persistent period reaches 24 hours, effectively isolates pathogenic bacterium in the anorectal, and the stimulation to blood stasis is less when defecation simultaneously.
Chitosan is polymerized by N-acetyl group-D-glucopyranose amine; it is the alkaline polysaccharide of unique a large amount of existence in the biosphere; have the characteristics such as have no side effect, good biocompatibility, degradable, source are abundant, chitosan and derivant thereof have good biocidal property and film property.
Summary of the invention
Purpose of the present invention, just provide a kind of aquagel that any cross-linking agent can be used for treating hemorrhoid that do not contain, the characteristics of have the antibacterial hemostasis of collection, dwindling blood stasis, good film-forming property, longer duration, biological degradability is good, and the effect of existing convergence blood stasis has again the effect of isolating pathogenic bacterium in the anorectal.
Aquagel of the present invention, made by following component by weight percentage:
Chitosan 0.1% ~ 10%
Carbomer 0.1% ~ 2%
Triethanolamine 0.1% ~ 4%
All the other are water.
Described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%.
The preparation method of above-mentioned aquagel is:
(1) gets the raw materials ready by said components and percentage by weight, water is divided into 2 parts, with standby carbomer (Carbomer molecular structure :-[CH2-CH-] N-COOH) evenly be sprinkling upon the water surface of a water, room temperature hold over night or heating in water bath 0.5 ~ 3h, make its abundant swelling, obtain carbomer solution;
(2) in another part water, add standby chitosan and obtain chitosan solution, then join in the carbomer solution;
(3) under the stirring condition, slowly drip standby triethanolamine in step (2) gained mixed solution, pH is 6.0 ~ 8.0 to the aquagel system, leaves standstill 30min final vacuum de-bubbled, can make aquagel.
The beneficial effect of the relative prior art of the present invention is:
(1) the present invention does not contain any cross-linking agent, can make under the room temperature, and preparation method is easy.
(2) the aquagel preparation of the present invention length of holding time, suppress and time of isolation pathogenic bacterium
Long.
(3) aquagel pH value of the present invention is similar to the anorectal road, and non-stimulated and bad sensation almost more can not destroyed the balance of normal flora in the anorectal road.
The specific embodiment
Below be embodiments of the invention.
Embodiment one
With carbomer 0.103 g(≈ 0.1%) be sprinkling upon uniformly on the water surface of 50 ml water, hold over night makes its complete swelling; With chitosan 1 g(≈ 1%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution, add gradually triethanolamine 2 ml(≈ 2% under the stirring condition), fully stirring and making its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment two
With carbomer 1 g(≈ 1%) be sprinkling upon uniformly on the water surface of 50 ml water, hold over night makes its complete swelling; With chitosan 1 g(≈ 1%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution, add gradually triethanolamine 2 ml(≈ 2% under the stirring condition), fully stirring and making its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment three
With carbomer 2.1g(≈ 2%) be sprinkling upon uniformly on the water surface of 50 ml water, hold over night makes its complete swelling; With chitosan 1 g(≈ 0.95%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution, add gradually triethanolamine 2 ml(≈ 1.9% under the stirring condition), fully stirring and making its mix homogeneously, the pH value of gained solution is 7.0.Leave standstill 30 min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment four
With carbomer 0.5 g(≈ 0.5%) be sprinkling upon uniformly on the water surface of 50 ml water, hold over night makes its complete swelling; With chitosan 0.1 g(≈ 0.1%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution; Add gradually triethanolamine 1.5 ml(≈ 1.5% under the stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment five
Carbomer 0.5 g is sprinkling upon on the water surface of 50 ml water uniformly, and hold over night makes its complete swelling; Chitosan 2 g are dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution; Add gradually triethanolamine 1.5 ml under the stirring condition, fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment six
With carbomer 0.5 g(≈ 0.4%) be sprinkling upon uniformly on the water surface of 50 ml water, hold over night makes its complete swelling; With chitosan 11.3 g(≈ 10%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution; Add gradually triethanolamine 1.5 ml(≈ 1.3% under the stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment seven
With carbomer 0.2 g(≈ 0.2%) be sprinkling upon uniformly on the water surface of 50 ml water, heating in water bath 0.5 ~ 3h makes its complete swelling; With chitosan 8 g(≈ 7.3%) be dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution, described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%; Add gradually triethanolamine 0.1 ml(≈ 0.1% under the stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment eight
Carbomer 2 g are sprinkling upon on the water surface of 50 ml water uniformly, and hold over night makes its complete swelling.Chitosan 5 g are dissolved in the 50 ml water, obtain chitosan solution, then join in the carbomer solution; Add gradually triethanolamine 0.5 ml under the stirring condition, fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Embodiment nine
With carbomer 0.6 g(≈ 0.6%) be sprinkling upon uniformly on the water surface of 50 ml water, heating in water bath 0.5 ~ 3h makes its complete swelling.With chitosan 0.2 g(≈ 0.2%) be dissolved in the 50 ml water, obtain chitosan solution, described chitosan is low-molecular weight chitoglycan or chitosan derivatives, molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%, then joins in the carbomer solution; Add gradually triethanolamine 4.5ml(≈ 4% under the stirring condition), fully stir and make its mix homogeneously; Leave standstill 30min final vacuum de-bubbled under the room temperature, can make aquagel.
Claims (4)
1. aquagel for the treatment of hemorrhoid is characterized in that being made by following component by weight percentage:
Chitosan 0.1% ~ 10%
Carbomer 0.1% ~ 2%
Triethanolamine 0.1% ~ 4%
All the other are water.
2. aquagel according to claim 1, it is characterized in that: described chitosan is low-molecular weight chitoglycan or chitosan derivatives, and molecular weight ranges is 5000 ~ 50000, and deacetylation is 60% ~ 100%.
3. according to claim 1 and 2 the preparation method of described aquagel, step is as follows:
(1) water is divided into 2 parts, carbomer evenly is sprinkling upon the water surface of a water, room temperature hold over night or heating in water bath 0.5 ~ 3h make its abundant swelling obtain carbomer solution;
(2) in another part water, add the chitosan dissolving and obtain chitosan solution, then join in step (1) the gained carbomer solution;
(3) under the stirring condition, in step (2) gained mixed solution, slowly drip triethanolamine.
4. an aquagel as claimed in claim 1 is applied to the treatment of internal hemorrhoid, external hemorrhoid and mixed hemorrhoid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110258116.1A CN102973492B (en) | 2011-09-02 | 2011-09-02 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110258116.1A CN102973492B (en) | 2011-09-02 | 2011-09-02 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102973492A true CN102973492A (en) | 2013-03-20 |
| CN102973492B CN102973492B (en) | 2015-04-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110258116.1A Active CN102973492B (en) | 2011-09-02 | 2011-09-02 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
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| Country | Link |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948661A (en) * | 2014-04-29 | 2014-07-30 | 安徽徽科生物工程技术有限公司 | Medicine combination for treating gynecological diseases, prostatic diseases or anorectal diseases, and application for same |
| CN103948660A (en) * | 2014-04-29 | 2014-07-30 | 安徽徽科生物工程技术有限公司 | Medical biological dressing suppository for treating gynecological diseases, diseases of prostate or anorectal diseases and application thereof |
| CN104027448A (en) * | 2014-04-16 | 2014-09-10 | 广西信业生物技术有限公司 | Chitosan gel and preparation method thereof |
| WO2014187361A1 (en) * | 2013-05-23 | 2014-11-27 | Taiwan Hopax Chems. Mfg. Co., Ltd. | Composition for enhancing intestine metabolism |
| CN104188896A (en) * | 2014-08-25 | 2014-12-10 | 漳州片仔癀药业股份有限公司 | Chitosan polyelectrolyte composite gel as well as preparation method and applications thereof |
| CN104523452A (en) * | 2014-12-22 | 2015-04-22 | 闽南师范大学 | Preparation method of antibacterial carboxylation chitosan complex gel |
| CN105169456A (en) * | 2015-08-25 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Medical biological hydrogel functional dressing for hemorrhoid and preparation method thereof |
| CN108853167A (en) * | 2018-09-13 | 2018-11-23 | 广州润虹医药科技股份有限公司 | A kind of hemorrhoid composition containing chitosan, preparation method and applications |
| CN112999339A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Lysozyme gel and preparation method and application thereof |
-
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- 2011-09-02 CN CN201110258116.1A patent/CN102973492B/en active Active
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014187361A1 (en) * | 2013-05-23 | 2014-11-27 | Taiwan Hopax Chems. Mfg. Co., Ltd. | Composition for enhancing intestine metabolism |
| CN104027448A (en) * | 2014-04-16 | 2014-09-10 | 广西信业生物技术有限公司 | Chitosan gel and preparation method thereof |
| CN104027448B (en) * | 2014-04-16 | 2015-12-09 | 东莞市达庆医疗器械有限公司 | A kind of chitosan gel rubber and preparation method thereof |
| CN103948661A (en) * | 2014-04-29 | 2014-07-30 | 安徽徽科生物工程技术有限公司 | Medicine combination for treating gynecological diseases, prostatic diseases or anorectal diseases, and application for same |
| CN103948660A (en) * | 2014-04-29 | 2014-07-30 | 安徽徽科生物工程技术有限公司 | Medical biological dressing suppository for treating gynecological diseases, diseases of prostate or anorectal diseases and application thereof |
| CN103948661B (en) * | 2014-04-29 | 2017-08-11 | 安徽徽科生物工程技术有限公司 | Pharmaceutical composition and its application for treating gynecological disease, prostatic disorders or anorectal disease |
| CN104188896A (en) * | 2014-08-25 | 2014-12-10 | 漳州片仔癀药业股份有限公司 | Chitosan polyelectrolyte composite gel as well as preparation method and applications thereof |
| CN104523452A (en) * | 2014-12-22 | 2015-04-22 | 闽南师范大学 | Preparation method of antibacterial carboxylation chitosan complex gel |
| CN104523452B (en) * | 2014-12-22 | 2017-11-17 | 闽南师范大学 | A kind of preparation method of antibacterial type carboxyl chitosan plural gel |
| CN105169456A (en) * | 2015-08-25 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | Medical biological hydrogel functional dressing for hemorrhoid and preparation method thereof |
| CN108853167A (en) * | 2018-09-13 | 2018-11-23 | 广州润虹医药科技股份有限公司 | A kind of hemorrhoid composition containing chitosan, preparation method and applications |
| CN112999339A (en) * | 2019-12-19 | 2021-06-22 | 陕西康乐实业有限公司 | Lysozyme gel and preparation method and application thereof |
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| Publication number | Publication date |
|---|---|
| CN102973492B (en) | 2015-04-29 |
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