CN1037818C - Method for preparing medical biologic film - Google Patents
Method for preparing medical biologic film Download PDFInfo
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- CN1037818C CN1037818C CN 95104422 CN95104422A CN1037818C CN 1037818 C CN1037818 C CN 1037818C CN 95104422 CN95104422 CN 95104422 CN 95104422 A CN95104422 A CN 95104422A CN 1037818 C CN1037818 C CN 1037818C
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Abstract
The present invention relates to a method for preparing medical materials, particularly to a method for peparing medical biologic films, which has the steps: thoroughly mixing a right amount of chitin amine solution, gelatine solution, polyoxyethylene water solution and glycerol to form gelatin pulp as a substrate; adding a right amount of Chinese medicine xanthate juice or antibacterial medicines into the substrate; spreading the substrate on a flat plate in a sterile room; naturally drying the substrate into a bisque film and then to a milky film. The present invention can be applied to a wound surface, and has the advantages of simple production process, low cost, favorable film forming performance, favorable elasticity and flexibility, favorable penetration, no toxicity and no bacteria. The present invention has the functions of bacteria resistance, inflammation relieving, etc., promotes epithelial healing, and has high medical value.
Description
The present invention relates to a kind of preparation of medical material, particularly a kind of preparation method of medical biologic film.
Medical domain is extensive use of products such as cellulose derivative, polyoxyethylene, acrylic acid, resin when the protection wound surface at present; great majority are synthetic or semi-synthetic macromolecular compound, and human body is interior, nature lacks derivant or the enzyme that decomposes these polymer substances.So effect in this respect such as natural polymer such as chitosan more and more is subject to people's attention.
The purpose of this invention is to provide that a kind of preparation technology is simple, cost is low and the preparation method of the medical biologic film of better clinical effectiveness is arranged.
Purpose of the present invention realizes with following technical scheme; At first the chitosan of 10-50 gram is dissolved in 1 liter of concentration in the described method and is in 1 one 2% the glacial acetic acid solution, getting concentration again is the 2-5% (gelatin solution of W/V, polyoxyethylene alcohol-water solution, the glycerol of 2-10% (W/V), above-mentioned four kinds of solution were according to volume ratio 40: 20: 15: 6 abundant stirring and evenly mixings, make the chitosan gel slurry as substrate; When Chinese medicine Pollen Typhae 100 gram is added water 1000ml and decocts medicine juice and be concentrated into 500ml, with the multilamellar filtered through gauze, take concoction, with chitosan gel slurry and Pollen Typhae medicine juice mixing by volume, in room temperature 20-25 ℃ sterilizing room, sprawl on flat board, becoming little yellow thickness through 48-72 hour natural drying is the thin film of 0.2-0.6mm, stand-by after low temperature, vacuum, sterilization.
Pollen Typhae medicine juice usable concentration in the described method is 10-20% (W/V) anti-microbial type medicine, 8: 1 by volume abundant mixings of chitosan gel slurry and anti-microbial type drug solution spread on the flat board in room temperature is 20-25 ℃ sterilizing room, become translucent, the milky thin film of thickness 0.2-0.6mm through 48-72 hour natural drying, stand-by after low temperature, vacuum sterilization.
The used chitosan of the present invention is a kind of ocean high molecular polysaccharide biomaterial, is the primary raw material of present artificial epithelium, has film property, breathability.
It is relatively good to have elasticity, compression resistance, pasting property during the polyvinyl alcohol film forming.
Glycerol is a kind of oily matter, can prevent sclerosis when film forming.Medical gelatin can impel the slurry film forming, increases toughness.
That the Chinese medicine Pollen Typhae has is antibiotic, antiinflammatory, effect.
The present invention can be covered in skin wound, mucosa, the shallow II of large tracts of land ° burn; nontoxic to human body; the protection wound surface is avoided environmental stimuli and pollution; has sterilization, antibacterial; promote the healing of wound surface epithelium, be convenient to clinical observation, alleviate the patient and change dressings and wait bitterly for characteristics; preparation method of the present invention is simple, cost is low, film property, resilient flexibility are good, and higher medical value is arranged.
Embodiment 1: get 30 gram chitosan and be dissolved in the glacial acetic acid aqueous solution of 2% (W/V), fully stir till the dissolving fully, the aqueous gelatin solution of 2% (W/V), the polyvinyl alcohol water solution of 5% (W/V), glycerol, above-mentioned four kinds of solution 40: 20: 15 by volume: 6 mixings, making gel slurry is substrate, get the antimicrobial drug metronidazole solution of concentration 20%, gel slurry and metronidazole solution were by 8: 1 mixings, in sterilizing room, be laid on the flat board, through 56 hours natural dryings, desirable film, thin film were translucent, milky in the time of 20 ℃.
Embodiment 2: when Chinese medicine Pollen Typhae 100 gram is added water 1000ml and decocts medicine juice and be concentrated into 500ml, use the multilamellar filtered through gauze, it is stand-by to take concoction, get gel slurry and by volume 8: 1 mixings of Pollen Typhae medicine juice among the embodiment 1, in sterilizing room, be laid on flat board, through 50 hours natural dryings, get film through low temperature in the time of 25 ℃, the vacuum stand-by film color of sterilizing is a milk yellow.
Claims (2)
1. the preparation method of a medical biologic film, it is characterized in that: at first fully to be dissolved in 1 liter of concentration be in the glacial acetic acid solution of 1-2% to the chitosan of 10-50 gram, get the gelatin solution that concentration is 2-5% again, the polyoxyethylene alcohol-water solution of 2-10%, glycerol, with above-mentioned four kinds of solution according to volume ratio 40: 20: 15: 6 abundant stirring and evenly mixings, make the chitosan gel slurry as substrate, Chinese medicine Pollen Typhae decocting becomes the medicine juice concentrated solution, with chitosan gel slurry and 8: 1 by volume mixings of Pollen Typhae medicine juice concentrated solution, sprawl on flat board in room temperature 20-25 ℃ sterilizing room, becoming little yellow thickness through 48-72 hour natural drying is the thin film of 0.2-0.6mm.
2. the preparation method of medical biologic film as claimed in claim 1, it is characterized in that: described chitosan gel slurry also can contain the anti-microbial type medicine that concentration is 10-20% (volume ratio).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95104422 CN1037818C (en) | 1995-05-01 | 1995-05-01 | Method for preparing medical biologic film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95104422 CN1037818C (en) | 1995-05-01 | 1995-05-01 | Method for preparing medical biologic film |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1112024A CN1112024A (en) | 1995-11-22 |
| CN1037818C true CN1037818C (en) | 1998-03-25 |
Family
ID=5075123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95104422 Expired - Fee Related CN1037818C (en) | 1995-05-01 | 1995-05-01 | Method for preparing medical biologic film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1037818C (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6500777B1 (en) * | 1996-06-28 | 2002-12-31 | Ethicon, Inc. | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
| CN1067281C (en) * | 1997-05-22 | 2001-06-20 | 吴湘君 | Cohesive and hydrophilic gel for medical use, and method for preparing same |
| CN1328316C (en) * | 2004-03-26 | 2007-07-25 | 杨晓霞 | Prepn process of degradable bioactive film |
| CN100411651C (en) * | 2005-06-17 | 2008-08-20 | 吴湘君 | Medical gel and its preparing method and device |
| CN1333131C (en) * | 2005-08-03 | 2007-08-22 | 高明宝 | Antibacterial mite-removing fiber product and its manufacturing method |
-
1995
- 1995-05-01 CN CN 95104422 patent/CN1037818C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1112024A (en) | 1995-11-22 |
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| PB01 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |