CN103948660B - Medical bio bressing suppository and its application for treating gynecological disease, prostatic disorders or anorectal disease - Google Patents
Medical bio bressing suppository and its application for treating gynecological disease, prostatic disorders or anorectal disease Download PDFInfo
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Abstract
The invention provides a kind of medical bio bressing suppository and its application for being used to treat gynecological disease, prostatic disorders or anorectal disease.The medical bio bressing suppository includes main ingredient and auxiliary material, and main ingredient includes Echinacea element and chitosan.The present invention first applies Echinacea element in externally applied drug, relative to medicine for oral administration, can directly reach diseased region and dosage is less, it is achieved that preferably therapeutic effect；Using the good biocompatibility of chitosan, the effective administration concentration of holding is played to Echinacea element, extends the synergistic effects such as drug treating time, even if Echinacea element is mutually merged with chitosan, and be adsorbed in illing skin or mucomembranous surface formation protective layer；In addition, the defence capability of the generation of glucosaminidase and the growth of fibroblast, lifting skin or mucous membrane can also more effectively be stimulated by being adsorbed in the Echinacea element of skin or mucomembranous surface；Echinacea element can also stimulating immune system, the quantity and activity of increase leucocyte, the therapeutic effect of lifting independent medication.
Description
Technical field
The present invention relates to biomedicine field, in particular to one kind be used to treating gynecological disease, prostatic disorders or
The medical bio bressing suppository of anorectal disease and its application.
Background technology
The traditional Chinese medical science its " with lower disease " refers mainly to gynaecological disease, and other two class belongs to the " disease below waistband in today's society
Suffer from ", such as prostatosis of male and the anorectal disease that has of men and women, above-mentioned disease is all the vast national common disease of puzzlement, many
Morbidity.Many of which chronic inflammation is referred to as " precancerous lesion ", canceration probability 1.2~3.8%.
The characteristics of above-mentioned each disease is that morbidity is extensive, and the course of disease is long, when it is good when it is bad, be difficult to cure.Although targeted drug is
Number is many, and with obvious drug effect is generally chemical synthetic drug and antibiotics, the production of said medicine and uses
Cheng Zhonghui produces pollution to environment, to patient's toxic side effect, also there is the problem of inducing the resistance to the action of a drug or drug resistance.
Echinacea is composite family (Asteraceae) genus echinacea (achinacea, also known as Echinacea) plant, originates in north
U.S., is widely used, and be generally considered tool by the Echinacea element (or purple cone extract) of its extraction in US and European
There is immunological enhancement, containing various active composition, the immunocyte vigor such as leucocyte in human body can be pierced, improve human body itself and exempt from
Epidemic disease power.At present, the application to Echinacea element is also substantially used for improving the health food of body immunity, or and other
Chinese herbal medicine is used in mixed way, and is used as adjuvant.
The content of the invention
The present invention is intended to provide a kind of medical bio bressing for being used to treat gynecological disease, prostatic disorders or anorectal disease
Suppository and its application, have toxic side effect with the medicine for solving gynecological disease, prostatic disorders or anorectal disease in the prior art
The problem of.
To achieve these goals, according to an aspect of the invention, there is provided a kind of be used to treat gynecological disease, prostatitis
The medical bio bressing suppository of gland disease or anorectal disease, the medical bio bressing suppository includes main ingredient and auxiliary material, and main ingredient includes
Echinacea element and chitosan.
Further, the content of above-mentioned Echinacea element is 0.05~5wt% of medical bio bressing suppository, and chitosan contains
Measure as 0.1~5wt% of medical bio bressing suppository.
Further, the content of above-mentioned Echinacea element is 0.1~2.0wt% of medical bio bressing suppository, chitosan
Content is 0.5~2.5wt% of medical bio bressing suppository.
Further, above-mentioned main ingredient is made up of chitosan and Echinacea element.
Further, above-mentioned medical bio bressing suppository is 1~5g suppository.
Further, above-mentioned auxiliary material includes glycerine, carbomer, EDTA, ethylene glycol, triethanolamine and/or benzoic acid.
According to another aspect of the present invention there is provided a kind of above-mentioned medical bio bressing suppository treatment gynecological disease,
Application in the medicine of prostatic disorders or anorectal disease.
Further, said medicine is treatment bacterial vaginitis, colpomycosis, trichomonas vaginitis, Combination
Vaginitis, cervicitis, prostatitis, hypertrophy of the prostate, hyperplasia of prostate, the medicine of internal piles or mixed hemorrhoid.
Apply the technical scheme of the present invention, Echinacea element therein belongs to plant extracts, does not have toxic side effect to human body,
And the present invention first applies Echinacea element in externally applied drug, relative to medicine for oral administration, can directly reach diseased region and dosage
It is less, it is achieved that the therapeutic effect become apparent.In medical bio bressing suppository, the gel of chitosan formation is as just
The colloid of electric charge, can largely be adsorbed, the germ that aggegation is negatively charged, block its metabolic activity and breeding, until disintegration；Meanwhile,
Using the good biocompatibility of chitosan, the effective administration concentration of holding, extension drug treating time etc. are played to Echinacea element
Synergistic effect, even if Echinacea element is mutually merged with chitosan, and is adsorbed in illing skin or mucomembranous surface and is formed protective layer,
Chitosan therein can prevent the invasion of bacterium and virus, such as suppress, kill the Candida albicans for being difficult to tackle and golden Portugal
Bacterium, moreover it is possible to be that epidermal cell and profitable strain provide nutrition, promotes itself to repair and microecological balance；In addition, being adsorbed in skin
Or the Echinacea element of mucomembranous surface can not only preferably suppress hyaluronidase activity, blocking virus particle to host cell
Attach with intrusion, and can also more effectively stimulate the generation of glucosaminidase and the growth of fibroblast, promote skin,
The defence capability of the nutrition and reparation of mucomembranous cell, lifting skin or mucous membrane；Further, Echinacea element can stimulate siberian crabapple
System, increase leucocyte quantity and activity, strengthen macrophage phagocytic activity, promote lymphokine for example interferon, interleukin,
The secretion of TNF, and then improve the therapeutic effect of independent medication.
Embodiment
It should be noted that in the case where not conflicting, the feature in embodiment and embodiment in the application can phase
Mutually combination.The present invention is described in detail below in conjunction with embodiment.
The present invention it is a kind of preferred embodiment in there is provided one kind be used for treat gynecological disease, prostatic disorders or
The medical bio bressing suppository of anorectal disease, the medical bio bressing suppository includes main ingredient and auxiliary material, and main ingredient includes Echinacea element
And chitosan.
Echinacea element in above-mentioned medical bio bressing suppository belongs to plant extracts, does not have toxic side effect to human body, and
The present invention Echinacea element is applied in externally applied drug first, relative to medicine for oral administration, diseased region can be directly reached and dosage compared with
It is few, it is achieved that the therapeutic effect become apparent.In medical bio bressing suppository, the gel of chitosan formation is used as positive electricity
The colloid of lotus, can largely be adsorbed, the germ that aggegation is negatively charged, block its metabolic activity and breeding, until disintegration；Meanwhile, profit
With the good biocompatibility of chitosan, the effective administration concentration of holding is played to Echinacea element, extension drug treating time etc. increases
Effect is acted on, even if Echinacea element is mutually merged with chitosan, and is adsorbed in illing skin or mucomembranous surface formation protective layer, its
In chitosan can prevent the invasion of bacterium and virus, such as suppress, kill and be difficult to the Candida albicans and S. aureus L-forms that tackle,
It can also be that epidermal cell and profitable strain provide nutrition, promote itself to repair and microecological balance；In addition, being adsorbed in skin or viscous
The Echinacea element on film surface can not only preferably suppress the attaching of hyaluronidase activity, blocking virus particle to host cell
With intrusion, and the generation of glucosaminidase and the growth of fibroblast can also be more effectively stimulated, promote skin, mucous membrane
The defence capability of the nutrition and reparation of cell, lifting skin or mucous membrane；Further, Echinacea element can stimulating immune system,
Increase the quantity and activity of leucocyte, strengthen the phagocytic activity of macrophage, promote lymphokine such as interferon, interleukin, swell
The secretion of tumor necrosis factor, and then improve the therapeutic effect of independent medication.
In addition, for above-mentioned medical bio bressing suppository, the present invention is sent out by long-term biological test and clinical test
It is existing, as the Echinacea element of main ingredient composition and the consumption of chitosan it is not to control curative effect in above-mentioned medical bio bressing suppository more
Fruit is more obvious, and then it is determined has an amount ranges of good efficacy, and the content of wherein Echinacea element is medical bio bressing
0.05~5wt% of suppository, the content of chitosan is 0.1~5wt% of medical bio bressing suppository.
Further, the factor of comprehensive medicinal cost, the absorbability of medicine and the aspect of drug effect three, preferably above-mentioned Echinacea
The content of element is 0.1~2.0wt% of medical bio bressing suppository, and the content of chitosan is the 0.5 of medical bio bressing suppository
~2.5wt%.
The main ingredient composition of the pharmaceutical composition of the present invention can include the effective component in addition to Echinacea element and chitosan
To realize the application in a variety of disease medicaments are treated, the present invention is preferably applied in this hair with chitosan and Echinacea element for main ingredient
In the medical bio bressing suppository of bright treated disease.
For the handling characteristics of suppository, preferably above-mentioned medical bio bressing suppository is 1~5g suppository.
The auxiliary material of aforementioned pharmaceutical compositions includes stabilizer and emulsifying agent, and stabilizer and emulsifying agent therein can be used
This area conventional stabilizer and emulsifying agent, such as glycerine, carbomer, EDTA, ethylene glycol, triethanolamine or benzoic acid.
There is provided a kind of above-mentioned medical bio bressing suppository in treatment woman in another preferred embodiment of the present invention
Application in the medicine of section's disease, prostatic disorders or anorectal disease.
Further preferred said medicine is treatment bacterial vaginitis, colpomycosis, trichomonas vaginitis, Combination
Vaginitis, cervicitis, prostatitis, hypertrophy of the prostate, hyperplasia of prostate, the medicine of internal piles or mixed hemorrhoid.
Beneficial effects of the present invention are further illustrated below with reference to embodiment and comparative example.
The preparation of medical bio bressing suppository：
Embodiment 1
By 1880 grams of polyethylene glycol1500Be heated to molten state, then thereto add fineness be 100 mesh more than, 500 mesh with
Under Echinacea element, chitosan, carbomer940Each 40 grams are stirred to form suspension, and the suspension is injected into suppository mould
In, about 1000,2 grams every of suppository are cooled down to obtain, the medical bio bressing suppository of embodiment 1 is used as.
Embodiment 2
By 1870 grams of polyethylene glycol1500Molten state is heated to, Echinacea plain 10 grams, chitosan 20 are then added thereto
Gram, 100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, as
The medical bio bressing suppository of embodiment 2.
Embodiment 3
By 1850 grams of polyethylene glycol1500Be heated to molten state, then thereto add Echinacea element 1 gram, 50 grams of chitosan,
100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, be used as reality
Apply the medical bio bressing suppository of example 3.
Embodiment 4
By 1860 grams of polyethylene glycol1500Be heated to molten state, then thereto add Echinacea element 2 grams, 40 grams of chitosan,
100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, be used as reality
Apply the medical bio bressing suppository of example 4.
Embodiment 5
By 1800 grams of polyethylene glycol1500Molten state is heated to, Echinacea plain 100 grams, chitosan 2 are then added thereto
Gram, 100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, as
The medical bio bressing suppository of embodiment 5.
Embodiment 6
By 1800 grams of polyethylene glycol1500Molten state is heated to, Echinacea plain 1 gram, chitosan 100 are then added thereto
Gram, 100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, as
The medical bio bressing suppository of embodiment 6.
Embodiment 7
By 1870 grams of polyethylene glycol1500Molten state is heated to, Echinacea plain 20 grams, chitosan 10 are then added thereto
Gram, 100 grams of carbomer fine powder.Injected after stirring in suppository mould, cool down to obtain about 1000,2 grams every of suppository, as
The medical bio bressing suppository of embodiment 7.
Comparative example 1
By 1860 grams of polyethylene glycol1500Molten state is heated to, 40 grams of chitosan, carbomer fine powder are then added thereto
100 grams.After stirring inject suppository mould in, cool down to obtain about 1000,2 grams every of suppository, as a comparison case 1 it is medical
Biological dressing suppository.
Comparative example 2
By 1800 grams of polyethylene glycol1500Molten state is heated to, 100 grams of chitosan, carbomer fine powder are then added thereto
100 grams.After stirring inject suppository mould in, cool down to obtain about 1000,2 grams every of suppository, as a comparison case 2 it is medical
Biological dressing suppository.
Comparative example 3
By 1860 grams of polyethylene glycol1500Molten state is heated to, Echinacea plain 40 grams, carbomer fine powder are then added thereto
100 grams.After stirring inject suppository mould in, cool down to obtain about 1000,2 grams every of suppository, as a comparison case 3 it is medical
Biological dressing suppository.
Comparative example 4
By 1800 grams of polyethylene glycol1500Molten state is heated to, 100 grams of Echinacea element, carbomer are then added thereto thin
100 grams of powder.Injected after stirring in suppository mould, cool down to obtain about 1000, the doctor of 2 grams every of suppository, as a comparison case 4
Use biological dressing suppository.
The content of Echinacea element and chitosan is shown in Table 1 in the biological dressing suppository of embodiment 1 to 7 and comparative example 1 to 4.
Table 1
| Echinacea element (wt%) | Chitosan (wt%) | |
| Embodiment 1 | 2.0 | 2.0 |
| Embodiment 2 | 0.5 | 1.0 |
| Embodiment 3 | 0.05 | 2.5 |
| Embodiment 4 | 0.1 | 2.0 |
| Embodiment 5 | 5 | 0.1 |
| Embodiment 6 | 0.05 | 5 |
| Embodiment 7 | 1.0 | 0.5 |
| Comparative example 1 | -- | 2.0 |
| Comparative example 2 | -- | 5.0 |
| Comparative example 3 | 2.0 | -- |
| Comparative example 4 | 5.0 | -- |
Found after animal experiment test is carried out to the medicine of above-described embodiment 1 to 7 and comparative example 1 to 4, embodiment 1 to 7
Gel preparation be respectively provided with obvious therapeutic effect to Combination vaginitis, prostatitis and mixed hemorrhoid, and comparative example 1 to 4
Gel preparation does not play obvious therapeutic effect to Combination vaginitis, prostatitis and mixed hemorrhoid, further relates to, this hair
Echinacea element and chitosan in bright pharmaceutical composition serve synergistic function, in treatment gynecological disease, prostate disease
There is good application prospect in the medicine of disease or anorectal disease.
Clinical test
For gynecological disease：
Embodiment 8
Clinically vaginitis, virus in patients with cervicitis totally 240.Advise before sleeping every night and to be covered with disposable hand (finger) by embodiment 1
Suppository fills in affected part, daily one.Using curative effect is evaluated by clinical rating scales after 7 days, evaluation result is shown in Table 2.
Table 2
From Table 2, it can be seen that the suppository of embodiment 1 is 98.4% to the effective percentage of bacterial vaginitis, mycotic is cloudy
The scorching effective percentage in road is 95%, and the effective percentage of Combination vaginitis is 98.3%, and the effective percentage of cervicitis is 93.3%, merges total
Effective percentage is 96.3%.
Embodiment 9
Select clinically Combination vaginitis, virus in patients with cervicitis totally 60.Advising will be upper with disposable hand (finger) set before sleeping every night
State the suppository feeding vagina depths of embodiment 2.With one before sleeping every night.Using curative effect is evaluated by clinical rating scales after 7 days, comment
Valency the results are shown in Table 3.
Table 3
The gel of the low dosage main ingredient of embodiment 2 is to the effective percentage for mixing vaginitis it can be seen from the data in table 3
60%, the effective percentage of cervicitis is 46.7%, and it is 53.3% to merge total effective rate.
For prostatic disorders：
Embodiment 10
Clinically prostatitis, hypertrophy of the prostate, hyperplasia patient totally 60.Advise it every night should with disposable hand (finger) set
This medical one feeding anus deep of suppository, 7 days as one therapeutic course.Curative effect is evaluated with reference to clinical scale, evaluation result is shown in Table 4.
Table 4
As can be seen from Table 4, the suppository of embodiment 1 is to prostatitic efficient for 86.7%, hypertrophy of the prostate, increasing
Raw effective percentage is 86.7%, and total effective rate is 86.7%.
Embodiment 11
Clinically internal piles, mixed hemorrhoid patient totally 120.Advise its every night before chamber with disposable hand (finger) set by embodiment 1
One piece of suppository fills in anus, and medication is evaluated after 7 days with reference to clinical evaluation standard, and evaluation result is shown in Table 5.
Table 5
As can be seen from Table 5, the suppository of embodiment 1 is 95.9% to the total effective rate of internal piles, mixed hemorrhoid.
Above-mentioned data are analyzed it can be found that the medical bio bressing suppository of the application is in treatment gynecological disease, preceding
Obvious therapeutic effect has been played in the medicine of row gland disease or anorectal disease, and the therapeutic effect of embodiment 1 becomes apparent.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (3)
1. a kind of medical bio bressing suppository for being used to treat gynecological disease, prostatic disorders or anorectal disease, it is characterised in that
The medical bio bressing suppository is prepared from using following methods：By 1880 grams of polyethylene glycol1500Molten state is heated to, then
Thereto add fineness be 100 mesh more than, Echinacea element, chitosan, carbomer below 500 mesh940Each 40 grams of shapes that stir
Into suspension, the suspension is injected in suppository mould, 1000,2 grams every of suppository is cooled down to obtain.
2. the medical bio bressing suppository described in a kind of claim 1 is preparing treatment gynecological disease, prostatic disorders or anal intestine
Application in the medicine of disease.
3. application according to claim 2, it is characterised in that the medicine is treatment bacterial vaginitis, mycotic the moon
Road inflammation, trichomonas vaginitis, Combination vaginitis, cervicitis, prostatitis, hypertrophy of the prostate, hyperplasia of prostate, internal piles or mixed
Close the medicine of hemorrhoid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410178692.9A CN103948660B (en) | 2014-04-29 | 2014-04-29 | Medical bio bressing suppository and its application for treating gynecological disease, prostatic disorders or anorectal disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410178692.9A CN103948660B (en) | 2014-04-29 | 2014-04-29 | Medical bio bressing suppository and its application for treating gynecological disease, prostatic disorders or anorectal disease |
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| Publication Number | Publication Date |
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| CN103948660A CN103948660A (en) | 2014-07-30 |
| CN103948660B true CN103948660B (en) | 2017-08-11 |
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| CN102973492B (en) * | 2011-09-02 | 2015-04-29 | 欧世文 | Chitosan hydrogel for treating haemorrhoids and preparation method thereof |
| CN103040728A (en) * | 2013-02-03 | 2013-04-17 | 福州乾正药业有限公司 | Chitosan gel for women as well as preparation method and medical application thereof |
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