Background technology
Skin is as the first physiology defence line of human body and maximum organ, and the moment participates in the functional activity of body, maintains the unity of opposites of body and natural environment, and any abnormal conditions of body also can reflect at skin surface.
A lot of dermatosis is all the outward manifestation of viscera disease, i.e. a lot of dermatosis, and its basic reason is at internal organs.Such as: cutaneous manifestations of psoriasis, vitiligo, allergic prurigo, lupus erythematosus, internal organs cancerous protuberance etc., be toxin, the organism metabolic disorder of, pathogenic microorganism infection abnormal with cell division and generation thereof, immunologic function is unbalance, endocrine regulation, free radical toxin dysbolismus are relevant, even has indirect or direct relation with spirit, neural pathological change.
Skin possesses the Physiological protection function of almost Perfect: as barrier action, sensation, regulate body temperature, Absorption, secretion and Excretion etc., safeguard body healthy in, play very important effect.
In dermatosis, skin infection and allergic dermatitis account for major part, but along with old man's dermatoses of aging degeneration change, skin carcinoma etc. are also important dermatosiss, should be noted the various skin barrier causing side effect because of Drug therapy disease in addition.China has a large population, and it is also many to suffer from dermopathic patient.
From pathology, cannot treat different things as the same because dermatosis is of a great variety, western medical treatment dermatosis instant effect, but easily recur bounce-back, mainly because with the addition of caused by hormone in medicine, so the recurrence bounce-back making a lot of conditions of patients toss about, and increase the weight of time by time, thus cause the confidence losing treatment.The traditional Chinese medical science adopts traditional Chinese medical herbal treatment, and especially to the dermatosis chronic disease of chronic disease, have extraordinary curative effect, by clinical verification, it serves to show and got the nod, Development of Chinese Medicine is included into national development strategy for this reason.
Application number be CN201210126195.5 application discloses a kind of Multi-herb antibacterial liquid, it is characterized in that it is the medicament be made up of following 39 kinds of Chinese herbal medicine raw material by weight ratio: a kind of Multi-herb antibacterial liquid, it is characterized in that, the preferred composition of described Multi-herb antibacterial liquid and weight portion thereof: Radix Angelicae Dahuricae 15g, Rhizoma Alpiniae Officinarum 10g, Cortex Cinnamomi 10g, Pericarpium Zanthoxyli 10g, described medicine also comprises following composition and weight thereof: Borneolum Syntheticum 10g, Herba Menthae 9g, Cinnabaris 10g, Herba Schizonepetae 15g, Folium Artemisiae Argyi 20g, Radix Arnebiae (Radix Lithospermi) 11g, Flos Lonicerae 20g, Flos Sophorae 10g, Flos Carthami 20g, Radix Sophorae Flavescentis 10g, Radix Astragali 20g, Radix Angelicae Sinensis 16g, Cortex Phellodendri 15g, Cortex Lycii 10g, favus skin 20g, Radix Scutellariae 15g, Radix Saposhnikoviae 10g, Herba Asari 12g, Ramulus Mori 10g, Fructus Forsythiae 7g, Rhizoma Atractylodis 10g, Periostracum Cicadae 10g, Cortex Pseudolaricis 10g, Zaocys 10g, Agkistrodon 8g, Radix Isatidis 15g, Rhizoma Coptidis 10g, Fructus Cnidii 10g, Herba Ephedrae 15g, Radix Stemonae 10g, Semen Coicis 12g, Radix Et Rhizoma Rhei 15g, Mylabris 7g, Fructus Gleditsia 10g, the former degree edible distillate spirit of 200ml.
A kind of Multi-herb antibacterial liquid disclosed in above-mentioned patent documentation, its usage is for directly embrocating on surface, skin damage place, and only simple for illing skin, the assimilation effect of skin to medicine is poor, cures the symptoms, not the disease often; Containing a large amount of wine in formula, strong to skin irritation; And medicament categories is too much, component is more, and the impact mutually pind down is larger, find optimal balance point very difficult; For large-area dermatosis, by the Measures compare trouble of smearing.
Summary of the invention
In order to solve the problems of the prior art, the object of this invention is to provide a kind of good antimicrobial effect, without hormone and western medicine composition, safe, effective, nontoxic, corrosion-free, have no side effect, to skin without any zest, the stifling antibacterial liquid that can realize the treating both the principal and secondary aspects of a disease to dermatosis.
For achieving the above object, the present invention by the following technical solutions: a kind of stifling antibacterial liquid, the component of this stifling antibacterial liquid and the weight portion of corresponding component as follows:
Old vinegar 2000 weight portion;
Antibacterial 10 weight portion;
Glacial acetic acid 100 weight portion.
Preferred scheme, described stifling antibacterial liquid also comprises following 9 kinds of components: Fructus Momordicae, Fructus Cannabis, Solanum muricatum, Radix Scutellariae, Cortex Dictamni, Fructus Cnidii, Flos Chrysanthemi Indici, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), the Fructus Kochiae, and shared by described above 9 kinds of components, weight portion is 18 weight portions.
Preferred scheme further, described stifling antibacterial liquid also comprises Radix Sophorae Flavescentis, and weight portion shared by described Radix Sophorae Flavescentis is 36 weight portions.
Further preferred scheme, described stifling antibacterial liquid also comprises Ramulus et folium taxi cuspidatae, and weight portion shared by described Ramulus et folium taxi cuspidatae is 12 weight portions.
Described stifling antibacterial liquid also comprises Cortex Phellodendri and Herba Houttuyniae, and shared by described Cortex Phellodendri and Herba Houttuyniae, weight portion is 24 weight portions.
Described stifling antibacterial liquid also comprises Pericarpium Zanthoxyli and Rhizoma Zingiberis Recens, and shared by described Pericarpium Zanthoxyli and Rhizoma Zingiberis Recens, weight portion is 16 weight portions.
The raw materials used Chinese herbal medicine being safely, having no side effect of a kind of stifling antibacterial liquid of the present invention, the beautiful kylin board old vinegar that old vinegar selects pollution-free food company limited of peaches and plums village, Nantong to produce is food grade vinegar, product to skin without any stimulation; And raw material is after stifling, the active ingredient of Chinese medicine exists in the form of an ion, and ion infiltrates skin, enters the object that can reach disease therapy in body better; Human body is in stifling process, and skin temperature can raise, and the blood capillary of skin can be expanded, blood circulation speeds, and facilitates the metabolism of skin and body, facilitate simultaneously arthroncus disappear and promote organize regeneration capacity, energy allaying tiredness, gives comfortable feel; The irritability of the peripheral nerve of skin can be reduced, alleviate the anxiety of skin.The stifling antibacterial liquid of the present invention's one in use, can reach good health-care effect while curing the disease, takes stopgap measures and effect a permanent cure to disease.
Detailed description of the invention
One, embodiment 1, takes old vinegar (food grade, pollution-free food company limited of peaches and plums village, Nantong beautiful kylin board old vinegar) 2000 grams, antibacterial 10 grams, glacial acetic acid 100 restrains the present invention fumigates antibacterial liquid.
Two, embodiment 2, take Fructus Momordicae 18 grams, Fructus Cannabis 18 grams, Solanum muricatum 18 grams, Radix Sophorae Flavescentis 36 grams, Radix Scutellariae 18 grams, Cortex Phellodendri 24 grams, Cortex Dictamni 18 grams, Fructus Cnidii 18 grams, Flos Chrysanthemi Indici 18 grams, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 18 grams, Herba Houttuyniae 24 grams, Ramulus et folium taxi cuspidatae 12 grams, the Fructus Kochiae 18 grams, 16 grams, Pericarpium Zanthoxyli, 16 grams, Rhizoma Zingiberis Recens, old vinegar 2000 grams (food grade, pollution-free food company limited of peaches and plums village, Nantong beautiful kylin board old vinegar), 100 grams, glacial acetic acid (CP level), antibacterial 10 restrain the present invention fumigates antibacterial liquid.
Three, embodiment 3, take Fructus Momordicae 18 grams, Fructus Cannabis 18 grams, Solanum muricatum 18 grams, Radix Sophorae Flavescentis 36 grams, Radix Scutellariae 18 grams, Cortex Phellodendri 24 grams, Cortex Dictamni 18 grams, Fructus Cnidii 18 grams, Flos Chrysanthemi Indici 18 grams, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 18 grams, Herba Houttuyniae 24 grams, Ramulus et folium taxi cuspidatae 12 grams, the Fructus Kochiae 18 grams, 16 grams, Pericarpium Zanthoxyli, 16 grams, Rhizoma Zingiberis Recens, old vinegar 2000 grams of (food grade, pollution-free food company limited of peaches and plums village, Nantong beautiful kylin board old vinegar), 100 grams, glacial acetic acid (CP level), antibacterial 10 restrain the present invention fumigates antibacterial liquid, get 400 grams and do skin test test:
(1), test objective: detect with rabbit the skin wound repair that surface contact causes, and shift the mankind onto, but the reflection of the result of the test skin irritation that representative sample is inreal is dangerous.
(2), control sample:
Negative control 0.9% chloride injection water
Positive control 20% sodium lauryl sulphate
(3), pilot system is differentiated:
Belong to and planting: the purebred White Rabbit of New Zealand White
Quantity: 3
Sex: male
Weight: on-test body weight be not less than 2.0kg
Health status: health does not use, just grow up
Raise: raise in cage by group, carry out identifier number, test code number, test start date
Animal is differentiated: bitter in the mouth acid dyeing
Cage: plastic cages
Duration of trial: under experimental enviroment 7 days
(4), raising and maintenance:
Animal origin: lake, Suzhou High-Tech Zone town experimental animal Science and Technology Ltd.
Bedding and padding: NA
Feedstuff: test full-valence pellet feed (lake, Suzhou High-Tech Zone town experimental animal Science and Technology Ltd.)
Water: tap water
Room temperature: 17-25 degree Celsius
Relative humidity: 30-70%
Illumination: need 12 h light every day, full spectrum daylight lamp
Personnel: testing staff has corresponding detection qu alification
(in food, water, noiseless test data pollutant exist)
(5), route of administration: test specimen directly and rabbit back contact skin, is considered to optimum contact mode.
(6), test method: test and unhairing process was carried out to back part of animal coating area in first 24 hours, unhairing scope is left and right, back each 3cm x 3cm, as test and look-out station, getting tested material 0.5ml is coated on the plucked skin in left side (2.5cm x 2.5cm), cover with two-layer gauze and one deck oilpaper, ensure fully to contact with skin; Right side is blank negative control.Application time 4 hours, after sticking end, goes out tested material with warm water clean coating position.
(7), result is observed: perusal in 1 hour, 24 hours, 48 hours after removal tested material also records coating part with or without the situation such as erythema and edema, carries out dermoreaction scoring by table 1.
Table 1 skin wound repair standards of grading
(8), evaluation of result: temporally some the scoring of 3 animals to be added, divided by number of animals, obtain the skin wound repair integral mean value (stimulation index) of different time points, get wherein the highest skin irritation index, evaluate the rank of animal skin stimulus intensity by table 1.
(9), result is observed: after removing tested material, each time point observes the reaction of animal local skin, and rabbit coating tested material side and control sides have been showed no local erythema, edema etc.Be 0 to the highest skin irritation index of rabbit.In table 2.
Table 2 dermoreaction result is observed
Skin irritation positive control is as table 3:
The reactive contrast of table 3 skin irritation sun
Note: positive control carries out once for every 6 months, and skin irritation index is 5.4.
(10), conclusion: under this experimental condition, test specimen is fumigated antibacterial liquid and do not find skin wound repair on rabbit skin, shows that the stifling antibacterial liquid of the present invention's one is safe, non-stimulated, can relievedly use.
Four, embodiment 4, take Fructus Momordicae 18 grams, Fructus Cannabis 18 grams, Solanum muricatum 18 grams, Radix Sophorae Flavescentis 36 grams, Radix Scutellariae 18 grams, Cortex Phellodendri 24 grams, Cortex Dictamni 18 grams, Fructus Cnidii 18 grams, Flos Chrysanthemi Indici 18 grams, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 18 grams, Herba Houttuyniae 24 grams, Ramulus et folium taxi cuspidatae 12 grams, the Fructus Kochiae 18 grams, 16 grams, Pericarpium Zanthoxyli, 16 grams, Rhizoma Zingiberis Recens, old vinegar 2000 grams of (food grade, pollution-free food company limited of peaches and plums village, Nantong beautiful kylin board old vinegar), 100 grams, glacial acetic acid (CP level), antibacterial 10 is restrained the present invention fumigates antibacterial liquid, get this stifling antibacterial liquid 400 and do aging front product Micro biological Tests respectively, bacteriostasis property is tested, product physical and chemical inspection and aging rear product bacteriostasis property inspection, censorship tests to general large (Shanghai) standard technique Services Co., Ltd, assay sees the following form respectively:
(1), aging front product Micro biological Tests the results are shown in Table 4
The aging front product Micro biological Tests result of table 4
(2), aging front bacteriostasis property result of the test is in table 5
The aging front bacteriostasis property result of the test of table 5
(3), aging front product physical and chemical inspection the results are shown in Table 6
The aging front product physical and chemical inspection result of table 6
Sequence number |
Test item |
Unit |
Detection method |
Testing result |
Detection limit |
1 |
PH |
/ |
" disinfection technology standard " (version in 2002) |
3.04 |
/ |
(4), aging rear product bacteriostasis property assay is in table 7
The aging rear product bacteriostasis property assay of table 7
Above-mentioned each assay shows, the stifling antibacterial liquid good antimicrobial effect of the present invention's one, antibacterial stable, its antibacterial active ingredient has certain infiltration and nursing role to stifling area skin, is the desirable antibacterial external used medicine of skin.