CN102949444A - Application of salvianolic acid effective part in preparing preparation for improving skin quality - Google Patents
Application of salvianolic acid effective part in preparing preparation for improving skin quality Download PDFInfo
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- CN102949444A CN102949444A CN2012102601155A CN201210260115A CN102949444A CN 102949444 A CN102949444 A CN 102949444A CN 2012102601155 A CN2012102601155 A CN 2012102601155A CN 201210260115 A CN201210260115 A CN 201210260115A CN 102949444 A CN102949444 A CN 102949444A
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- salviae miltiorrhizae
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- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- YMGFTDKNIWPMGF-QHCPKHFHSA-N Salvianolic acid A Natural products OC(=O)[C@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc2ccc(O)c(O)c2C=Cc3ccc(O)c(O)c3 YMGFTDKNIWPMGF-QHCPKHFHSA-N 0.000 title abstract 8
- YMGFTDKNIWPMGF-UCPJVGPRSA-N Salvianolic acid A Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C(=C(O)C(O)=CC=1)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 YMGFTDKNIWPMGF-UCPJVGPRSA-N 0.000 title abstract 8
- 229930183842 salvianolic acid Natural products 0.000 title abstract 8
- 239000002674 ointment Substances 0.000 claims abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 34
- 150000007965 phenolic acids Chemical class 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 19
- 229960004756 ethanol Drugs 0.000 claims description 16
- 239000012530 fluid Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 13
- 238000010936 aqueous wash Methods 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 11
- 239000000047 product Substances 0.000 claims description 10
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 6
- 238000004440 column chromatography Methods 0.000 claims description 5
- 239000000287 crude extract Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 241000594182 Sarcophaga sigma Species 0.000 claims description 2
- 229920001429 chelating resin Polymers 0.000 claims description 2
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 238000005374 membrane filtration Methods 0.000 claims description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 2
- 235000013824 polyphenols Nutrition 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 238000005406 washing Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 230000001815 facial effect Effects 0.000 abstract description 6
- 208000017520 skin disease Diseases 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 230000003796 beauty Effects 0.000 abstract description 2
- 230000003111 delayed effect Effects 0.000 abstract description 2
- 238000011031 large-scale manufacturing process Methods 0.000 abstract description 2
- 230000009759 skin aging Effects 0.000 abstract description 2
- SNKFFCBZYFGCQN-UHFFFAOYSA-N 2-[3-[3-[1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]carbonyl-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-4-yl]prop-2-enoyloxy]-3-(3,4-dihydroxyphenyl)propanoic acid Chemical compound C=1C=C(O)C=2OC(C=3C=C(O)C(O)=CC=3)C(C(=O)OC(CC=3C=C(O)C(O)=CC=3)C(O)=O)C=2C=1C=CC(=O)OC(C(=O)O)CC1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-UHFFFAOYSA-N 0.000 abstract 1
- SNKFFCBZYFGCQN-VWUOOIFGSA-N Lithospermic acid B Natural products C([C@H](C(=O)O)OC(=O)\C=C\C=1C=2[C@H](C(=O)O[C@H](CC=3C=C(O)C(O)=CC=3)C(O)=O)[C@H](OC=2C(O)=CC=1)C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 SNKFFCBZYFGCQN-VWUOOIFGSA-N 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- STCJJTBMWHMRCD-UHFFFAOYSA-N salvianolic acid B Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=O)C=Cc2cc(O)c(O)c3OC(C(C(=O)OC(Cc4ccc(O)c(O)c4)C(=O)O)c23)c5ccc(O)c(O)c5 STCJJTBMWHMRCD-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 30
- 239000010409 thin film Substances 0.000 description 7
- 206010000496 acne Diseases 0.000 description 6
- 240000007164 Salvia officinalis Species 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000005412 red sage Nutrition 0.000 description 5
- 206010048768 Dermatosis Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000014593 oils and fats Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229940099259 vaseline Drugs 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- 239000002398 materia medica Substances 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
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- 231100000252 nontoxic Toxicity 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
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- 238000012827 research and development Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- 230000002476 tumorcidal effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
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Abstract
The invention provides an application of salvianolic acid effective part in preparing a preparation for improving skin quality. The preparation is a solution agent or an ointment agent prepared from the salvianolic acid effective part as an active component and a pharmaceutic adjuvant. The content of the salvianolic acid effective part in the preparation is 10-75%. The internal and external functions of the salvianolic acid effective part with a high content of salvianolic acid B are effectively combined, so that the skin quality is improved, the skin aging is delayed and facial skin diseases such as whelk and the like are also treated. As the salvianolic acid effective part is completely water-soluble, the salvianolic acid effective part can be washed by using water and no trace is left after the use for daubing on the skin. Compared with the existing skin beauty and health products, the salvianolic acid effective part has the advantages of clear effective components, high content, high efficiency, safety, no toxicity, no sequelae, convenience for using, adaptability to all sorts of people, low price and easiness for large scale production and has a great application value.
Description
Technical field
The present invention relates to the aesthetic health care preparation, be specifically related to improve skin preparation, relate in particular to poly phenolic acid of Radix Salviae Miltiorrhizae effective site and improve application in the skin skin quality preparation in preparation.
Background technology
Along with the raising of people's living standard, also increasing to the demand of aesthetic health care preparation, especially more and more higher to the prescription that improves skin preparation.That sells in market at present improves skin skin quality preparation, although of a great variety,, the problem of existence is also many, and for example, composition is unclear, and effect is poor, and what have also has larger side effect etc.Some so-called pure Chinese medicinal preparation, complicated component wherein, effective ingredient is indefinite, causes toxic and side effects larger, easily causes allergy and Other diseases.In addition, some preparation uses trouble, and inconvenient operation is expensive.Therefore, seek effective ingredient clear and definite, content is high, safety, toxicity is little, the easy to use and low product that improves the skin skin quality of price, be society in the urgent need to.
Poly phenolic acid of Radix Salviae Miltiorrhizae effective site has showed very strong activating blood circulation to dissipate blood stasis clinically, antioxidation, anticoagulant, and suppress thrombotic effect.The poly phenolic acid of Radix Salviae Miltiorrhizae effective site that content of danshinolic acid B is high in external zoopery, has also showed very strong killing the virus, and kills antibacterial and tumoricidal function (Antiviral Research55(2002) 91-106; Food industry science and technology 07(2011) 65-66; CHINA JOURNAL OF CHINESE MATERIA MEDICA 35(2010) 389-392).Therefore, the new purposes of research and development poly phenolic acid of Radix Salviae Miltiorrhizae effective site causes concern.
Summary of the invention
Technical problem to be solved by this invention is the new purposes of research design poly phenolic acid of Radix Salviae Miltiorrhizae effective site.
The invention provides poly phenolic acid of Radix Salviae Miltiorrhizae effective site and improve application in the skin skin quality preparation in preparation.
Preparation of the present invention solution or ointment that to be poly phenolic acid of Radix Salviae Miltiorrhizae effective site make as active component and pharmaceutic adjuvant.
Preparation of the present invention on the one hand can be the oils of skin accumulation, the dust in the pore, chemical pollutant and microorganism etc., and absorption is also removed; On the other hand, poly phenolic acid of Radix Salviae Miltiorrhizae effective site and skin close contact and infiltration can be given full play to its sterilization and the function such as activating blood circulation to dissipate blood stasis, increase the vigor of each confluent monolayer cells of epidermis, and allow wrinkle of skin unfold.
The present invention adopts content of danshinolic acid B to reach the poly phenolic acid of Radix Salviae Miltiorrhizae effective site of 78%-85%, be dissolved in the ethanol water of water or 1%-90%, be prepared into solution or make ointment with pharmaceutic adjuvant, the content of poly phenolic acid of Radix Salviae Miltiorrhizae effective site in preparation is 10%-75%, is preferably 45%-75%; 10%-40% more preferably.
Content of danshinolic acid B of the present invention reaches the poly phenolic acid of Radix Salviae Miltiorrhizae effective site of 78%-85%, can number be that 201110260898.2 disclosed methods make according to Chinese patent application.
The unforeseeable effect of the present invention just is the high poly phenolic acid of Radix Salviae Miltiorrhizae effective site of content of danshinolic acid B, effect with external two aspects combines effectively in vivo, improve the skin skin quality thereby reach, delayed skin aging, and the dermatosis of face such as comedo etc. are also had therapeutical effect.
Because poly phenolic acid of Radix Salviae Miltiorrhizae effective site is fully water miscible, therefore, after smearing the skin use, is easy to water and washes away.Can significantly see after the flushing, leave no trace, the skin of processing presents compact soft and moist smooth (Fig. 1-4); Simultaneously facial some dermatosis has been carried out treating (Fig. 5-6).
With existing skin beauty health-care product relatively, this product has that effective ingredient is clear and definite, content is high, and is efficient, safety is nontoxic, no sequel is easy to use, is fit to various crowds, and inexpensive and be easy to the advantage of large-scale production, and larger using value is arranged.
Description of drawings
After the solution of Fig. 1 and Fig. 2 embodiment 1 preparation uses once, the variation before and after the face skin.The left figure of Fig. 1 and Fig. 2: the face before solution uses.Fig. 1 and Fig. 2 the right: smear face with solution, wait the moisture evaporation after, can form thin film at face, water washes away the face of thin film after 1 hour.Can find out from Fig. 1 and Fig. 2, leave no trace after thin film washes away, with comparing before the use, face skin presents oils and fats immediately to be reduced, and skin compacts soft and moist smooth.
The solution of Fig. 3 embodiment 1 preparation is smeared the once variation of rear skin of the back of the hand.Upper figure, the right hand is carried on the back in contrast, does not smear solution.Figure below, the left hand back of the body of same person is smeared with solution, and water washes away the thin film of left hand back after 2 hours.As can be seen from the figure, leave no trace after thin film washes away, with comparing of the not used thin film right hand back of the body, the skin of the left hand back of the body seem relatively compact soft and moist smooth.
The variation of face skin before and after the solution of Fig. 4 embodiment 1 preparation repeatedly uses.Left figure: the face before solution uses.Right figure: smear face with solution, operate the same, once a day, continued operation 14 days.As can be seen from the figure, solution with after leave no trace, with use before compare, solution has used 14 times, the face skin oils and fats that becomes significantly reduces, youth is compacted, soft and moist smooth, stereotype alleviates.
The ethanol water agent of preparation is having dermopathic face among Fig. 5 embodiment 2, the variation of face skin before and after using.Guo X, woman, 37 years old, grade teacher.Face has comedo, and skin is more coarse.Left figure: the face before solution uses.Right figure: smear face with solution, operate the same, once a day, each 1 hour, used continuously 10 days, skin delicate the compacting that become, soft and moist smooth, comedo almost disappears.
The ointment of Fig. 6 embodiment 3 preparations is having the dermopathic facial facial variation in front and back of using.King X, woman, 34 years old, public institution's accounting.Her skin of face oil type has comedo, and surface ratio is more coarse.Left figure: the face before ointment uses.Right figure: the ointment with preparation among the embodiment 4 is put face on the skin, uses continuously 15 days every day 3 times, and comedo fades away as a result, and it is soft and moist more smooth than compacting before using that skin also becomes.
The specific embodiment
The embodiment that the below provides, only for further specifying the present invention, they are to the present invention and do not constitute any limitation.
The poly phenolic acid of Radix Salviae Miltiorrhizae effective site powder of mentioning in the following examples, refer to that all content of danshinolic acid B reaches the dried powder of the poly phenolic acid of Radix Salviae Miltiorrhizae effective site of 78%-85%, it is number to be 201110260898.2 disclosed methods according to Chinese patent application, is made through twice column chromatography by Radix Salviae Miltiorrhizae powder.
Embodiment 1
With pressed powder 75 gram of active component of red sage root, the distilled water mixing of (embodiment 4 makes) and 50 milliliters is diluted with water to 100 milliliters again, makes aqueous solution, the centrifugal precipitation of removing, and supernatant just can directly be used as solution.During use, equably each 3.5 milliliters of solution is coated in face with face brush, wait the moisture evaporation after, can form thin film at face, keep after 1 hour, water is with its flush away, leave no trace, face namely presents oils and fats to be reduced, skin compact soft and moist smooth (Fig. 1-4).
Embodiment 2
Pressed powder 75 grams (embodiment 5 makes) with active component of red sage root, mix with 50 milliliters 20% ethanol water, be diluted to 100 milliliters with 20% ethanol water again, make its ethanol water, the centrifugal precipitation of removing, supernatant just can directly be used as solution, and all the other operations are described as embodiment 1.10 times, each 3.5 milliliters, after the use, not only improved facial skin quality, and can treat face dermatosis (Fig. 5).
Embodiment 3
Be prepared into the ointment of active component of red sage root.Material: active component of red sage root pressed powder 30 grams, 5 milliliters in (embodiment 6 makes) vaseline 65 grams and water, total amount 100 grams.Method for making: the pressed powder of getting active component of red sage root is put in the mortar, after adding 20 gram vaseline and 5 ml waters and grinding well, slowly adds remaining vaseline, grinds well to get final product again.Ointment is spread upon face, and 3 times on the one, each 1 gram through 15 days use, has obviously improved facial skin quality, and comedo is partly cured (Fig. 6).
Embodiment 4
The preparation of poly phenolic acid of Radix Salviae Miltiorrhizae effective site:
(1) 1 kilogram of Radix Salviae Miltiorrhizae powder (available from Hui nationality, 100 orders) is put in the glass column (10 * 80 centimetres), behind 3 liters of dehydrated alcohol eluting, collects fat-soluble effective site, puts aside; Be 85% ethanol water eluting again with 16 liters of concentration, after the ethanol in the effluent reclaims, residue thin up to 4 liter, membrane filtration (30 microns in filter membrane aperture).The salvia-soluble effective portion of polyphenol acid is in this filtrate, and this filtrate claims crude extract.
(2) 1,2 kilograms of the Amberlite XAD-4 macroporous resins of U.S. SIGMA company are put in the glass column (10 * 80 centimetres), use successively 4 liter 50%, 95% ethanol water to clean post, wash post with deionized-distilled water 10 the lucid yang sending up again.2, add crude extract and advance post, after the outflow, add again 1.2 liters washing post, collect this Secondary Flow fluid of merging, claim the effluent first.3, the effluent first is added post again, add again 1.2 premium on currency after the outflow and wash post, collect this Secondary Flow fluid of merging, claim effluent second.4, add 3.6 liter 15% ethanol aqueous wash post after, add again 1.2 liter of 55% ethanol aqueous wash post, collect and merge this Secondary Flow fluid, after merging with effluent second again, claim effluent the third, place and wait again column chromatography.5, add 3.6 liter of 55% ethanol aqueous wash post after, add again 1.2 premium on currency and wash post, collect to merge this Secondary Flow fluid, claim the effluent fourth, poly phenolic acid of Radix Salviae Miltiorrhizae effective site is eluted in wherein.6, effluent third is carried out macroporous resin column chromatography at above-mentioned same post.Add first 3.6 premium on currency and clean post, discard effluent.7, add effluent third and advance post, add again 1.2 premium on currency after the outflow and wash post, discard this Secondary Flow fluid.8, add 3.6 liter 15% ethanol aqueous wash post after, add again 1.2 liter of 55% ethanol aqueous wash post, discard this Secondary Flow fluid.9, add 7.2 liter 55% ethanol aqueous wash post, add again 1.2 premium on currency and wash post, collect this Secondary Flow fluid of merging, and merge with above-mentioned effluent fourth, behind the recovery ethanol wherein, the aqueous solution that stays obtains the pressed powder of final products poly phenolic acid of Radix Salviae Miltiorrhizae effective site through lyophilization, weighs 37 grams.Content of danshinolic acid B reaches 78% in the product after testing.
Embodiment 5
The preparation of poly phenolic acid of Radix Salviae Miltiorrhizae effective site: method obtains the pressed powder of final products poly phenolic acid of Radix Salviae Miltiorrhizae effective site with embodiment 4, weighs 35 grams.Content of danshinolic acid B reaches 80% in the product after testing.
Embodiment 6
The preparation of poly phenolic acid of Radix Salviae Miltiorrhizae effective site: method obtains the pressed powder of final products poly phenolic acid of Radix Salviae Miltiorrhizae effective site with embodiment 4, weighs 33 grams.Content of danshinolic acid B reaches 85% in the product after testing.
Claims (6)
1. poly phenolic acid of Radix Salviae Miltiorrhizae effective site is improved application in the skin skin quality preparation in preparation.
2. application according to claim 1 is characterized in that, described preparation solution or ointment that to be poly phenolic acid of Radix Salviae Miltiorrhizae effective site make as active component and pharmaceutic adjuvant; The content of described poly phenolic acid of Radix Salviae Miltiorrhizae effective site in preparation is 10%-75%.
3. application according to claim 2 is characterized in that, the content of described poly phenolic acid of Radix Salviae Miltiorrhizae effective site in preparation is 45%-75%.
4. application according to claim 2 is characterized in that, the content of described poly phenolic acid of Radix Salviae Miltiorrhizae effective site in preparation is 10%-40%.
5. application according to claim 1 is characterized in that, content of danshinolic acid B is 78%-85% in the described poly phenolic acid of Radix Salviae Miltiorrhizae effective site.
6. application according to claim 1 is characterized in that, described poly phenolic acid of Radix Salviae Miltiorrhizae effective site makes by following method:
(1) Radix Salviae Miltiorrhizae powder is 1 kilogram, puts in the glass column, with 3 liters of dehydrated alcohol eluting, collects fat-soluble effective site, puts aside; Be 85% ethanol water eluting again with 16 liters of concentration, after the ethanol in the effluent reclaims, residue thin up to 4 liter, membrane filtration, 30 microns in filter membrane aperture; The salvia-soluble effective portion of polyphenol acid is in filtrate, and this filtrate is crude extract;
(2) 1,2 kilograms of the Amberlite XAD-4 macroporous resins of U.S. SIGMA company are put in the glass column, use successively 4 liter 50%, 95% ethanol water to clean post, wash post with deionized-distilled water 10 the lucid yang sending up again; 2, add crude extract and advance post, after the outflow, add again 1.2 liters washing post, collect this Secondary Flow fluid of merging, be the effluent first; 3, the effluent first is added post again, add again 1.2 premium on currency after the outflow and wash post, collect this Secondary Flow fluid of merging, be effluent second; 4, add 3.6 liter 15% ethanol aqueous wash post after, add again 1.2 liter of 55% ethanol aqueous wash post, collect and merge this Secondary Flow fluid, after merging with effluent second again, be effluent the third, place and wait again column chromatography; 5, add 3.6 liter of 55% ethanol aqueous wash post after, add again 1.2 premium on currency and wash post, collect to merge this Secondary Flow fluid, be the effluent fourth, poly phenolic acid of Radix Salviae Miltiorrhizae effective site is eluted in wherein; 6, effluent third is carried out column chromatography at identical post: add first 3.6 premium on currency and clean macroporous resin column, discard effluent; 7, add effluent third and advance post, add again 1.2 premium on currency after the outflow and wash post, discard this Secondary Flow fluid; 8, add 3.6 liter 15% ethanol aqueous wash post after, add again 1.2 liter of 55% ethanol aqueous wash post, discard this Secondary Flow fluid; 9, add 7.2 liter 55% ethanol aqueous wash post, add again 1.2 premium on currency and wash post, collect this Secondary Flow fluid of merging, and merge with above-mentioned effluent fourth, behind the recovery ethanol wherein, the aqueous solution that stays obtains the pressed powder of final products poly phenolic acid of Radix Salviae Miltiorrhizae effective site through lyophilization.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210260115.5A CN102949444B (en) | 2012-07-25 | 2012-07-25 | Salvia root polyphenol acid active component improves the application in skin skin quality preparation in preparation |
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| CN201210260115.5A CN102949444B (en) | 2012-07-25 | 2012-07-25 | Salvia root polyphenol acid active component improves the application in skin skin quality preparation in preparation |
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| CN102949444B CN102949444B (en) | 2016-05-04 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853404A (en) * | 2015-01-19 | 2016-08-17 | 兰赫(上海)生物科技有限公司 | Compound used for treating acne and application thereof |
| CN109568217A (en) * | 2019-01-30 | 2019-04-05 | 广州诗美化妆品有限公司 | A kind of preparation method of Salvia root P.E and its application in anti-acne |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198062A (en) * | 2011-05-26 | 2011-09-28 | 成都中医药大学 | Red sage root mask and preparation method thereof |
| CN102274283A (en) * | 2011-09-05 | 2011-12-14 | 邵明川 | Preparation method of red-rooted salvia root active fraction |
-
2012
- 2012-07-25 CN CN201210260115.5A patent/CN102949444B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198062A (en) * | 2011-05-26 | 2011-09-28 | 成都中医药大学 | Red sage root mask and preparation method thereof |
| CN102274283A (en) * | 2011-09-05 | 2011-12-14 | 邵明川 | Preparation method of red-rooted salvia root active fraction |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853404A (en) * | 2015-01-19 | 2016-08-17 | 兰赫(上海)生物科技有限公司 | Compound used for treating acne and application thereof |
| CN109568217A (en) * | 2019-01-30 | 2019-04-05 | 广州诗美化妆品有限公司 | A kind of preparation method of Salvia root P.E and its application in anti-acne |
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| CN102949444B (en) | 2016-05-04 |
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Effective date of registration: 20231221 Address after: Room 903 and 905, 9th Floor, Building 3, Building 3, No. 1588 Shanghai Hangzhou Road, Fengxian District, Shanghai Patentee after: Qiansheng (Shanghai) Pharmaceutical Technology Co.,Ltd. Address before: Maryland, USA Patentee before: Shao Mingchuan |
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