CN108653111B - Acne removing cream and preparation method thereof - Google Patents
Acne removing cream and preparation method thereof Download PDFInfo
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- CN108653111B CN108653111B CN201810852382.9A CN201810852382A CN108653111B CN 108653111 B CN108653111 B CN 108653111B CN 201810852382 A CN201810852382 A CN 201810852382A CN 108653111 B CN108653111 B CN 108653111B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses acne-removing cream and a preparation method thereof. The acne-removing cream comprises the following active ingredients: coptis chinensis extract, lithospermum extract, loquat leaf extract and spiraea ulmaria extract. The active component of the acne-removing cream disclosed by the invention adopts the extract compatibility of natural plants, and the combination of the coptis extract, the lithospermum extract, the loquat leaf extract and the spiraea ulmaria extract has a good acne-removing effect, takes effect quickly, does not leave scars and has a good treatment effect on acne caused by various reasons. The acne-removing cream disclosed by the invention is simple in preparation method, wide in raw material source and suitable for large-scale industrial production.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to acne removing cream and a preparation method thereof.
Background
Acne, commonly known as whelk, is a common disease in dermatology, is a chronic skin disease which occurs in pilosebaceous glands, is frequently generated in the parts with abundant sebaceous glands, such as the head, the face, the neck, the chest and the back, and according to statistics, about 85 percent of people in the adolescence stage suffer from acne with different degrees. Scars caused by acne seriously affect the appearance of a patient, further have adverse effects on the psychology of the patient, along with the development of the society, the health concept of people is more and more mature, and the existing method for treating acne mainly comprises a traditional Chinese medicine therapy, a western medicine therapy and a combined traditional Chinese and western medicine therapy; the therapeutic medicine comprises broad-spectrum antibiotic, antiandrogen, tretinoin, vitamin A, corticosteroid hormone, Chinese medicinal compound, etc. Western medicine therapy mainly depends on antibiotic treatment, has a quick curative effect, but easily causes propionibacterium acnes to generate drug resistance, is difficult to radically treat, has certain side effects and is easy to generate dependence; the traditional Chinese medicine therapy mainly regulates endocrine, and the curative effect is slow; at present, the treatment effect of the combination of traditional Chinese medicine and western medicine is reported to be better, the curative effect is short, but most of the traditional Chinese medicine treatment needs to be taken orally, the types of external cosmetics are less, and acne-removing effect additives from natural sources are less.
Patent 201610626122.0 discloses an anti-acne cream. It is composed of A, B, C, D, E, F, G, and the total weight of the components is 100 parts; the A is OLIVEM1000, isomeric hexadecane, thiaketone, DC-345, 2EHP and EMT-10, and the A comprises the following components by weight: 1.5-4 parts, 2-6 parts, 0.1-0.6 part, 1.5-4 parts, 1-4 parts and 0.5-2 parts; the B is water, carbomer 940, EDTA-2Na, methyl paraben and allantoin which are respectively prepared from the following components in parts by weight: 40-60 parts, 0.3-0.6 part, 0.1-0.5 part, 0.1-0.3 part and 0.2-1 part; the C is water, a compound amino acid humectant, propylene glycol, Tai Gemeitin or rhododendron acid or vitamin B6 and vitamin B3, and the components are respectively 10-20 parts, 2-8 parts, 0.8-3 parts and 1-8 parts by weight; the D is lactobionic acid and accounts for 0.5 to 3 parts by weight; the E is kuh-seng stemonin which accounts for 1 to 6 parts by weight; the F is MTI and accounts for 0.1 part by weight; the medicine G is acne killer, and is prepared from 0.3-4 parts by weight of the components. The acne-removing cream has complex components and high preparation cost, and is easy to relapse after healing.
Patent 201710204492.X discloses a traditional Chinese medicine acne removing cream. Is prepared by decocting the following raw material medicines in parts by weight: 10 parts of dandelion, 5 parts of wild chrysanthemum flower, 5 parts of patrinia, 3 parts of clove, 3 parts of forsythia, 1 part of rabdosia rubescens, 2 parts of chamomile essential oil and 1 part of tea tree oil essential oil. The traditional Chinese medicine acne removing cream has high viscosity, is not easy to clean after use, and has slow treatment effect.
Disclosure of Invention
The invention aims to provide acne-removing cream and a preparation method thereof.
The acne-removing cream comprises the following active ingredients: coptis chinensis extract, lithospermum extract, loquat leaf extract and spiraea ulmaria extract.
The extraction method of the coptis chinensis extract comprises the following steps: pulverizing Coptidis rhizoma, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of nano montmorillonite, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The extraction method of the lithospermum extract comprises the following steps: pulverizing radix Arnebiae, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The extraction method of the loquat leaf extract comprises the following steps: pulverizing folium Eriobotryae into coarse powder, placing into a distillation container, adding 3-8 times of water by weight, and soaking for 0.5-2 hr; heating rapidly to boil, maintaining for 10-40min, connecting reflux condenser tube, collecting condensate to obtain distillate, and evaporating distillate to obtain powdery substance.
The extraction method of the spiraea ulmaria extract comprises the following steps: soaking fresh flowers of spiraea ulmaria in 6-12 times of water for 1-3 hr, decocting for 1-3 hr, filtering to obtain filtrate, and evaporating to obtain powdery substance.
The active ingredients of the acne-removing cream also comprise a spilanthol leaf extract.
The extraction method of the spilanthol leaf extract comprises the following steps: pulverizing flos Helianthi, extracting under reflux at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The acne-removing cream also comprises a pharmaceutically acceptable auxiliary agent, wherein the mass ratio of the auxiliary agent to the active ingredients is 100: (3-8); the auxiliary agent comprises the following substances in parts by weight: 8-12 parts of glycerol, 8-12 parts of butanediol, 1-3 parts of dipotassium glycyrrhizinate, 2-5 parts of glyceryl stearate, 1-3 parts of isostearic acid and 15-25 parts of water.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 1-3 parts of dipotassium glycyrrhizinate according to parts by weight, adding 15-25 parts of water, heating to 55-65 ℃, and stirring for 10-20 min;
(2) cooling to 45-50 deg.C, adding 2-5 parts of glyceryl stearate and 1-3 parts of isostearic acid, and stirring for 10-20 min;
(3) cooling to room temperature, adding 8-12 parts of glycerol, 8-12 parts of butanediol and 1-4 parts of active ingredients of the acne cream, and continuously stirring for 10-20min to obtain the acne cream.
The active ingredients of the acne-removing cream are as follows by weight: the coptis chinensis extract: and (3) extracting the lithospermum: loquat leaf extract: meadowsweet extract ═ 1: (0.5-2): (0.5-2): (0.5-2).
The invention has the beneficial effects that: the active component of the acne-removing cream disclosed by the invention adopts the extract compatibility of natural plants, and the combination of the coptis extract, the lithospermum extract, the loquat leaf extract and the spiraea ulmaria extract has a good acne-removing effect, takes effect quickly, does not leave scars and has a good treatment effect on acne caused by various reasons. The acne-removing cream disclosed by the invention is simple in preparation method, wide in raw material source and suitable for large-scale industrial production.
Detailed Description
The present invention is further illustrated by the following specific examples.
The preparation method of the active ingredients of the acne cream in the following examples is as follows:
the extraction method of the coptis extract comprises the following steps: pulverizing Coptidis rhizoma, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, and extracting at 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of nano montmorillonite, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The extraction method of the lithospermum extract comprises the following steps: pulverizing radix Arnebiae, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze for 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The extraction method of the loquat leaf extract comprises the following steps: pulverizing folium Eriobotryae into coarse powder, placing into a distillation container, adding 5 times of water by weight, and soaking for 1 hour; heating rapidly to boil, maintaining for 30min, connecting reflux condenser tube, collecting condensate to obtain distillate, and evaporating distillate to obtain powdery substance.
The extraction method of the spiraea ulmaria extract comprises the following steps: soaking fresh flowers of spiraea ulmaria in water 8 times the weight of the fresh flowers for 2 hours, decocting the flowers in a decocting container for 2 hours, filtering the decoction to obtain filtrate, and evaporating the filtrate to dryness to obtain powdery substances.
The extraction method of the spilanthol leaf extract comprises the following steps: pulverizing flos Helianthi, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze for 5000r.min-1Centrifuging for 10min, collecting supernatant, adding diatomaceous earth5 parts, stirring uniformly, drying at low temperature, grinding, performing Soxhlet extraction with methanol, evaporating the extracting solution in a water bath, and preparing the traditional Chinese medicine composition.
Example 1
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract, 0.5g of spiraea ulmaria extract and 20g of water.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, folium Eriobotryae extract 0.5g, and flos Spiraeae Fortunei extract 0.5g, and stirring for 15 min.
Example 2
An acne-removing cream is composed of the following materials: 8g of glycerol, 8g of butanediol, 1g of dipotassium glycyrrhizinate, 3g of glyceryl stearate, 1g of isostearic acid, 0.4g of coptis chinensis extract, 0.4g of lithospermum extract, 0.4g of loquat leaf extract, 0.4g of spiraea ulmaria extract and 18g of water.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 1g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 55 ℃, and stirring for 10 min;
(2) cooling to 45 ℃, adding 3g of glyceryl stearate and 1g of isostearic acid, and continuing stirring for 10 min;
(3) cooling to room temperature, adding glycerol 8g, butanediol 8g, Coptidis rhizoma extract 0.4g, radix Arnebiae extract 0.4g, folium Eriobotryae extract 0.4g, and flos Spiraeae Fortunei extract 0.4g, and stirring for 10 min.
Example 3
An acne-removing cream is composed of the following materials: 12g of glycerol, 12g of butanediol, 3g of dipotassium glycyrrhizinate, 5g of glyceryl stearate, 3g of isostearic acid, 0.6g of coptis chinensis extract, 0.6g of lithospermum extract, 0.6g of loquat leaf extract, 0.6g of spiraea ulmaria extract and 25g of water.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 3g of dipotassium glycyrrhizinate according to parts by weight, adding 25g of water, heating to 65 ℃, and stirring for 20 min;
(2) cooling to 50 ℃, adding 5g of glyceryl stearate and 3g of isostearic acid, and continuing stirring for 20 min;
(3) cooling to room temperature, adding 12g of glycerol, 12g of butanediol, 0.6g of rhizoma coptidis extract, 0.6g of lithospermum extract, 0.6g of folium eriobotryae extract and 0.6g of spiraea ulmaria extract, and continuously stirring for 20min to obtain the traditional Chinese medicine.
Example 4
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract, 0.5g of spiraea ulmaria extract, 0.5g of spilanthol flower extract and 20g of water.
The extraction method of the spilanthol leaf extract comprises the following steps: pulverizing flos Helianthi, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze for 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, folium Eriobotryae extract 0.5g, flos Spiraeae Fortunei extract 0.5g, and flos Helianthi extract 0.5g, and stirring for 15 min.
Example 5
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract, 0.5g of spiraea ulmaria extract, 0.5g of fiveleaf akebia extract and 20g of water.
The extraction method of the extract of the fiveleaf akebia comprises the following steps: pulverizing herba Indigoferae Incarnatae, extracting under reflux at normal pressure for 3 times, filtering the extractive solution with gauze for 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, folium Eriobotryae extract 0.5g, flos Spiraeae Fortunei extract 0.5g, and herba Indigoferae Incarnatae extract 0.5g, and stirring for 15 min.
Example 6
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract, 0.5g of spiraea ulmaria extract, 0.5g of Indigofera tinctoria extract and 20g of water.
The extraction method of the Sichuan Indigofera tinctoria extract comprises the following steps: pulverizing herba Indigoferae Incarnatae, extracting under reflux at normal pressure for 3 times, filtering the extractive solution with gauze for 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, folium Eriobotryae extract 0.5g, flos Spiraeae Fortunei extract 0.5g, and caulis et folium Indigoferae Sichuan of that.
Comparative example 1
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract and 20g of water.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, and folium Eriobotryae extract 0.5g, and stirring for 15 min.
Comparative example 2
An acne-removing cream is composed of the following materials: 10g of glycerol, 10g of butanediol, 2g of dipotassium glycyrrhizinate, 4g of glyceryl stearate, 2g of isostearic acid, 0.5g of coptis chinensis extract, 0.5g of lithospermum extract, 0.5g of loquat leaf extract, 0.5g of spiraea ulmaria extract and 20g of water.
The extraction method of the coptis chinensis extract comprises the following steps: pulverizing Coptidis rhizoma, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, and extracting at 5000r.min-1Centrifuging for 10min, collecting supernatant, adding 5 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
The preparation method of the acne-removing cream comprises the following steps:
(1) taking 2g of dipotassium glycyrrhizinate according to parts by weight, adding 20g of water, heating to 60 ℃, and stirring for 15 min;
(2) cooling to 48 ℃, adding 4g of glyceryl stearate and 2g of isostearic acid, and continuing stirring for 15 min;
(3) cooling to room temperature, adding glycerol 10g, butanediol 10g, Coptidis rhizoma extract 0.5g, radix Arnebiae extract 0.5g, folium Eriobotryae extract 0.5g, and flos Spiraeae Fortunei extract 0.5g, and stirring for 15 min.
Experimental example 1: concentration test for inhibiting Propionibacterium acnes Activity
The concentration is 6X 10 per ml8cfu of colony forming Propionibacterium acnes suspension, inoculated into the active substance-coated agar plates of examples 1-6 and comparative examples 1-2, respectively (concentration gradient set at 3.13mg/mL, 6.25mg/mL, 12.5mg/mL, 25mg/mL, 50mg/mL, 100mg/mL, respectively), and the plates were incubated at 37 ℃ for 3 days in an anaerobic environment to count the minimum concentration (MIC) capable of inhibiting bacteria. The results are shown in Table 1:
TABLE 1 MIC of groups for Propionibacterium acnes
Note: + is positive and has bacteriostasis; negative, no bacteriostatic effect.
As can be seen from Table 1, the minimum inhibitory concentrations of examples 1-3 are 25mg/mL, the inhibitory concentration of example 4 is 12.5mg/mL, and compared with example 1, the other experimental conditions are the same, only the active component of example 4 is added with the spilanthol herb extract, so that the spilanthol herb extract is proved to have the effect of inhibiting propionibacterium acnes; the bacteriostatic concentration of example 5 is 6.25mg/mL, which is the minimum MIC value in each group of experiments, compared with the active component of example 1, the rest are the same, only the extra-thin Indigofera tinctoria extract is added in example 5, and the effect of inhibiting propionibacterium acnes by the extra-thin Indigofera extract is proved; example 6 compared to example 5, only the extract of Indigofera tinctoria was used instead of the extract of Indigofera tinctoria, and the minimum inhibitory concentration was 25mg/mL, which is lower than that of example 6 and equivalent to example 1, so that the extract of Indigofera tinctoria did not inhibit Propionibacterium acnes; comparative example 1 found no bacteriostatic effect, and only a small amount of spiraea ulmaria extract was added as compared with the active substance of example 1, demonstrating that spiraea ulmaria extract has the effect of inhibiting propionibacterium acnes and is an irreplaceable key substance in the composition; comparative example 2 did not find bacteriostatic effect, and compared with example 1, it was only the extraction method of the coptidis rhizoma extract, which indicates that the coptidis rhizoma extract is an irreplaceable key substance in the composition, and the extraction method thereof is the only method of key.
Experimental example 2: test for reducing number of active sebaceous glands on forehead of face
The anti-acne creams prepared in the examples 1-6 and the comparative examples 1-2 are compared with a blank sample without the addition of active substances and the addition of auxiliary materials for testing, 3 tested persons with mixed and oily skin in each group of volunteers are tested, the test persons are aged 20-30 years and used for 2 times every day, the tested parts are smeared on the forehead of the face by 2g of the anti-acne cream every day, and the smearing area is 5cm2After 14 days, the quantitative ratio change of the frontal sebum line of the face was measured using a special sebum adhesive tape. The test results are shown in table 2:
TABLE 2
Note: represents P < 0.05; represents P < 0.01.
As can be seen from Table 2, the sebaceous gland numbers of examples 1-3 and example 6 were reduced comparably without significant difference, and the percentage of sebaceous gland number reduction of examples 4-5 was significantly higher than that of example 1(P <0.05), and the percentage of sebaceous gland number reduction of comparative example 1 was significantly lower than that of example 1(P < 0.01).
Experimental example 3: typical case
Wangzhi, male, age 25, inflammatory papules, pustules, nodules, and cysts, the inflammatory papules being red and varying in diameter from 1-5 mm; the pustules are consistent in size and are filled with white pus; the diameter of the nodule is more than 5 mm, and the nodule can feel hard and painful when touched; the cyst is located deeper and filled with a mixture of pus and blood. After the acne-removing cream of the invention in the embodiment 1 is applied, the symptoms are relieved after 1 month, and the acne-removing cream is cured after 4 months.
Zhao, a woman in age 21, comedo and pimple, sebaceous cyst of different size containing viscous pus with blood, and ulcerated to form sinus and scar called cystic acne. After the acne-removing cream of the invention in the embodiment 5 is applied, the symptoms are relieved after 1 month, and the acne-removing cream is cured after 3 months.
Claims (8)
1. The acne-removing cream is characterized by comprising the following active ingredients: coptis chinensis extract, lithospermum extract, loquat leaf extract and spiraea ulmaria extract; the mass ratio of the coptis extract to the lithospermum extract to the loquat leaf extract to the spiraea ulmaria extract is 1: (0.5-2): (0.5-2): (0.5-2);
the extraction method of the coptis chinensis extract comprises the following steps: pulverizing Coptidis rhizoma, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of nano montmorillonite, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
2. The acne cream according to claim 1, wherein the lithospermum extract is extracted by the following method: pulverizing radix Arnebiae, reflux-extracting under heating at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
3. The acne cream according to claim 1, wherein the loquat leaf extract is extracted by the following method: pulverizing folium Eriobotryae into coarse powder, placing into a distillation container, adding 3-8 times of water by weight, and soaking for 0.5-2 hr; heating rapidly to boil, maintaining for 10-40min, connecting reflux condenser tube, collecting condensate to obtain distillate, and evaporating distillate to obtain powdery substance.
4. The acne cream according to claim 1, wherein the extraction method of the spiraea ulmaria extract comprises the following steps: soaking fresh flowers of spiraea ulmaria in 6-12 times of water for 1-3 hr, decocting for 1-3 hr, filtering to obtain filtrate, and evaporating to obtain powdery substance.
5. The anti-acne cream according to claim 1, wherein the active ingredients of the anti-acne cream further comprise spilanthol camomile extract.
6. The acne cream according to claim 5, wherein the extraction method of the spilanthol herb extract comprises the following steps: pulverizing flos Helianthi, extracting under reflux at normal pressure for 3 times, filtering the extractive solution with gauze, 4000--1Centrifuging for 8-12min, collecting supernatant, adding 3-8 parts of diatomaceous earth, stirring, oven drying at low temperature, grinding, performing Soxhlet extraction with methanol, and evaporating the extractive solution in water bath to dryness.
7. The acne cream according to claim 1, further comprising a pharmaceutically acceptable auxiliary agent, wherein the mass ratio of the auxiliary agent to the active ingredients is 100: (3-8); the auxiliary agent comprises the following substances in parts by weight: 8-12 parts of glycerol, 8-12 parts of butanediol, 1-3 parts of dipotassium glycyrrhizinate, 2-5 parts of glyceryl stearate, 1-3 parts of isostearic acid and 15-25 parts of water.
8. The preparation method of the acne-removing cream disclosed by claim 1 is characterized by comprising the following steps of:
(1) taking 1-3 parts of dipotassium glycyrrhizinate according to parts by weight, adding 15-25 parts of water, heating to 55-65 ℃, and stirring for 10-20 min;
(2) cooling to 45-50 deg.C, adding 2-5 parts of glyceryl stearate and 1-3 parts of isostearic acid, and stirring for 10-20 min;
(3) cooling to room temperature, adding 8-12 parts of glycerol, 8-12 parts of butanediol and 1-4 parts of active ingredients of the acne cream, and continuously stirring for 10-20min to obtain the acne cream.
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| KR100827513B1 (en) * | 2007-04-10 | 2008-05-06 | 진도군 | A method for composition manufacturing having multiplication suppression capability of harmful microbe from lithospermum erythrohizon and the composition |
| CN107137481A (en) * | 2017-06-06 | 2017-09-08 | 王建宇 | A kind of clearing heat and detoxicating Whelk-eliminating paste and preparation method thereof |
| CN108310156A (en) * | 2018-05-10 | 2018-07-24 | 刘杨 | A kind of Chinese medicine composition and preparation method thereof for treating paediatrics diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR100827513B1 (en) * | 2007-04-10 | 2008-05-06 | 진도군 | A method for composition manufacturing having multiplication suppression capability of harmful microbe from lithospermum erythrohizon and the composition |
| CN107137481A (en) * | 2017-06-06 | 2017-09-08 | 王建宇 | A kind of clearing heat and detoxicating Whelk-eliminating paste and preparation method thereof |
| CN108310156A (en) * | 2018-05-10 | 2018-07-24 | 刘杨 | A kind of Chinese medicine composition and preparation method thereof for treating paediatrics diarrhea |
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