CN102934797A - Trepang capsule and preparation process thereof - Google Patents
Trepang capsule and preparation process thereof Download PDFInfo
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- CN102934797A CN102934797A CN2012104208118A CN201210420811A CN102934797A CN 102934797 A CN102934797 A CN 102934797A CN 2012104208118 A CN2012104208118 A CN 2012104208118A CN 201210420811 A CN201210420811 A CN 201210420811A CN 102934797 A CN102934797 A CN 102934797A
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Abstract
The invention relates to a trepang capsule and a preparation process thereof. The trepang capsule is composed of 500-1000 parts of trepang, 50-100 parts of gingko, 50-80 parts of acanthopanax leaf, 50-80 parts of folium cortex eucommiae; 50-80 parts of hawthorn, 50-80 parts of Chinese date, 50-80 parts of Chinese wolfberry, 10-20 parts of fructus momordicae, 50-80 parts of calcium gluconate, and 50-80 parts of vitamin C. The preparation process comprises the following eleven steps: raw material purification, vacuum freeze drying, coarse cracking, superfine grinding, microwave auxiliary enzymolysis, enzyme deactivation, filtration, desalting, auxiliary seasoning processing, material proportioning and pelletization, as well as sterilization and packing. The obtained trepang capsule is reasonable in formulation composition and stable in property, has blood sugar decreasing and blood pressure reducing efficacy, and is especially prominent in blood fat reducing efficacy.
Description
Technical field
The present invention relates to a kind of beche-de-mer capsules and preparation technology thereof.
Background technology
Sea cucumber belongs to the Echinodermata Holothuroidea, and the whole world has sea cucumber kind more than 1100 at present approximately, wherein can be edible about 40 kinds; China has sea cucumber more than 140 to plant approximately, wherein have about 20 kinds can be edible, 10 kinds of sea cucumbers have higher commodity value.Before centuries, China people just think that sea cucumber is not only a kind of delicacies, but also are a kind of tonic nutriments.China Ming Dynasty thanks between year in Wanli year and starts system work " five assorted ancient sacrificial utensils " just relevant for the record of sea cucumber: " sea cucumber, beach, the east area of the Liao River, coextensive with eastern and southern Liaoning Province has it, its benefit warm in nature, sufficient enemy joins, therefore named sea cucumber ".
Sea cucumber is the animality health food of high nutrition, high protein, and its nutritional labeling is mainly sterol and Triterpenoids.Research in recent years tentative confirmation Stichopus Japonicus Acidic Mucopolysaccharide has antitumor and blood coagulation resisting function, and the contained holothurin of actinopyga agassizi is inhibited to the S180 mouse tumor, and sea cucumber also has the Antiarthritic effect in addition, and old man's arthralgia is had curative effect.
The defective of prior art has: one, in the processing of traditional sea cucumber, sea cucumber is pulverized with enzymolysis process incomplete, thereby destroys the nutritional labeling in the sea cucumber, reduces the health-care efficacy of sea cucumber.Two, sea cucumber preparation nutritional labeling is more single, and formulating is less, and mouthfeel and nutritive value are all lower.
Summary of the invention
The invention provides a kind of prescription and preparation technology thereof of beche-de-mer capsules, as a kind of prescription capsule, it had both kept the main nutrient composition in the sea cucumber, compatible with other functional health care foods again, prescription is reasonable, process stabilizing, and health-care effect is outstanding, definite reducing blood lipid, blood sugar and blood pressure effect are arranged, and wherein effect for reducing blood fat is particularly outstanding.
Technical scheme is as follows:
Beche-de-mer capsules of the present invention, consisted of sea cucumber 500-1000 part wherein, ginkgo 50-100 part by sea cucumber, ginkgo, acanthopanax, folium cortex eucommiae, hawthorn, date, matrimony vine, Momordica grosvenori, calcium gluconae and vitamin C, Leaves of Hippophae L 50-80 part, lotus leaf 50-80 part, hawthorn 50-80 part, date 50-80 part, matrimony vine 50-80 part, Momordica grosvenori 10-20 part, calcium gluconae 50-80 part, vitamin C 50-80 part.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: with the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
2, vacuum freeze drying: the sea cucumber that cleans up is carried out freeze drying, and cryogenic temperature is-20～-25 ℃, and vacuum is 5-15Pa, snap frozen 2-3h, 60-70 ℃ of freeze-drying final temperature.
3, coarse crushing: the sea cucumber after the freeze drying is put into pulverizer, pulverize 10-30min, cross 60 mesh sieves, obtain thick sea cucumber powder.
4, ultramicro grinding: first the sea cucumber meal is carried out ultramicro grinding by airslide disintegrating mill, time 2-3h obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out nanometer by the high speed shear ultrafine crusher and pulverize, grinding time is 3-5h.
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with the 1:5-10 mass ratio, obtain sea cucumber milk, the compound protease of accurate weighing sea cucumber weight 0.3-0.4% (pepsin: bromelain=2:1), put into the container that cleans up through pure water, add after an amount of pure water dissolves compound protease, put into enzymatic vessel together with sea cucumber milk, in intensity is the microwave environment of 500-1000W, leave standstill 1-2min.
6, the enzyme that goes out: after enzymolysis is finished, with enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out; After finishing the deactivation of enzyme, to the enzymatic vessel stopped heating, enzymolysis liquid is cooled to rapidly normal temperature; The enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
7, filter: the enzymolysis liquid after will lowering the temperature is used first the centrifugal 20min of generic centrifuge, filters, and gets filtrate, and the centrifugal 20min of low temperature ultrahigh speed filters filtrate for later use.
8, desalination: with filtrate by nanofiltration with except freshen; Residue and then mistake 100 mesh sieves obtain sea cucumber extract.
9, processing auxiliary material baste:
Get the ginkgo blade at 2-3 age, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the ginkgo leaf meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets ginkgo leaf powder.
Get the wilsonii blade at 3 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the acanthopanax meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets the acanthopanax powder.
Get above Eucommia ulmoides Oliv. leaves of 10 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 20KW, 2450MHz condition microwave 10 minutes are again in 150 ℃ of baking oven bakings 15 seconds, 4 ℃ of coolings, pulverize, cross 80 mesh sieves, get the folium cortex eucommiae meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets Eucommia Leaf Powder.
Get hawthorn, soak 60min, then adopt the decocting cooking method to extract, extracts 3 times, add water and doubly measure and be respectively 14 times, 12 times and 12 times, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method drying namely gets haw thorn extract.
Get date, oven dry is pulverized, and crosses 60 mesh sieves, gets jujube powder; Jujube powder is put into extraction equipment for fat, adopt the absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after the degreasing backflow is added 20 times of water gagings soak, behind adjusting pH8, the immersion 80min, take the Microwave Extraction method to extract jujube powder, time 5min namely gets Fructus Jujubae extract.
Get matrimony vine, decocted 2 hours with 8 times of water gagings first, decocted 1.5 hours with 6 times of water gagings, merge decocting liquid twice, film evaporation method is flung to moisture, reduction vaporization dry (0.1MPa, 20 ℃), and reduction vaporization dry (0.1MPa, 20 ℃) namely gets wolfberry fruit extract.
Get Momordica grosvenori, oven dry is pulverized, and crosses 60 mesh sieves, gets mangosteen powder; Add 30 times of water gagings, ultrasonic wave extracts 3 times under 50 ℃ of conditions, each 5min, and operating frequency 53KHz, power 150W merges three times filtrate, and the film drying method is dry, namely gets Fructus Monordicae extract.。
With above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in the jacketed pan, heats in ultrasonic environment, and ultrasonic frequency is 20-30KHz, and boiling temperature is 95-100 ℃, and the time is 2-4 hour; Centrifuge with 100 order filter clothes filters, and gets the auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, and drying gets dry extract.
Add microcrystalline cellulose in quality 1:1 ratio, fully mixing is crossed 40 mesh sieves, puts the vacuum desiccator inner drying.
With 75% ethanol softwood processed, granulate with 14 eye mesh screens, in 70 ℃ of oven dry, namely get the beche-de-mer capsules particle.
11, sterilization and filling: the method that sterilization adopts pasteurization to combine with microwave sterilization.
At first product is placed 95 ℃ of conditions, sterilization 15s shifts out; Put it into again the microwave quick-reaction system and carry out microwave sterilization, power 850-1000W, time 8-15min.
In the filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Be compared with existing technology, the technology of the present invention effect comprises:
1, to choose sea cucumber be primary raw material in the present invention, and compatible with ginkgo, acanthopanax, folium cortex eucommiae, hawthorn, date, matrimony vine, Momordica grosvenori, calcium gluconae and vitamin C, and the prescription ratio has been carried out detailed screening, and prescription forms rationally, stable in properties.
2, the present invention conducts in-depth research sea cucumber pulverizing and enzymolysis process, has significantly improved the bioavilability of sea cucumber, has fully kept the main nutrient composition of sea cucumber.
3, the present invention has carried out system research to the pulverizing extraction process of ginkgo, acanthopanax, folium cortex eucommiae, hawthorn, date, matrimony vine and Momordica grosvenori, by technology such as ultramicro grinding, makes the rapidly stripping of its active ingredient, improves extraction efficiency.
4, the present invention conducts in-depth research the product sterilization process, so that can reach sterilization effect, but the retained product nutritional labeling is not destroyed again.
5, gained beche-de-mer capsules of the present invention has definite reducing blood lipid, hypoglycemic and blood pressure reduction effect, and wherein blood fat reducing function is especially outstanding.
The specific embodiment
Below in conjunction with specific embodiment technical solution of the present invention is described in detail.
Embodiment 1:
Prescription forms:
500 parts of sea cucumbers, 50 parts of ginkgoes, 50 parts of acanthopanaxes, 50 parts of folium cortex eucommiaes, 50 parts of hawthorn, 50 parts in date, 50 parts of matrimony vines, 10 parts of Momordica grosvenoris, 50 parts of calcium gluconaes, 50 parts of vitamin Cs.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: with the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
2, vacuum freeze drying: the sea cucumber that cleans up is carried out freeze drying, and cryogenic temperature is-20 ℃, and vacuum is 5Pa, snap frozen 2h, 60 ℃ of freeze-drying final temperatures.
3, coarse crushing: the sea cucumber after the freeze drying is put into pulverizer, pulverize 10min, cross 60 mesh sieves, obtain thick sea cucumber powder.
4, ultramicro grinding: first the sea cucumber meal is carried out ultramicro grinding by airslide disintegrating mill, time 2h obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out nanometer by the high speed shear ultrafine crusher and pulverize, grinding time is 3h.
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with the 1:5 mass ratio, obtain sea cucumber milk, the compound protease of accurate weighing sea cucumber weight 0.3% (pepsin: bromelain=2:1), put into the container that cleans up through pure water, add after an amount of pure water dissolves compound protease, put into enzymatic vessel together with sea cucumber milk, in intensity is the microwave environment of 500W, leave standstill 1min.
6, the enzyme that goes out: after enzymolysis is finished, with enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10min that go out; After finishing the deactivation of enzyme, to the enzymatic vessel stopped heating, enzymolysis liquid is cooled to rapidly normal temperature; The enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
7, filter: the enzymolysis liquid after will lowering the temperature is used first the centrifugal 20min of generic centrifuge, filters, and gets filtrate, and the centrifugal 20min of low temperature ultrahigh speed filters filtrate for later use.
8, desalination: with filtrate by nanofiltration with except freshen; Residue and then mistake 100 mesh sieves obtain sea cucumber extract.
9, processing auxiliary material baste:
Get the ginkgo blade at 2 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the ginkgo leaf meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets ginkgo leaf powder.
Get the wilsonii blade at 3 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the acanthopanax meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets the acanthopanax powder.
Get above Eucommia ulmoides Oliv. leaves of 10 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 20KW, 2450MHz condition microwave 10 minutes are again in 150 ℃ of baking oven bakings 15 seconds, 4 ℃ of coolings, pulverize, cross 80 mesh sieves, get the folium cortex eucommiae meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets Eucommia Leaf Powder.
Get hawthorn, soak 60min, then adopt the decocting cooking method to extract, extracts 3 times, add water and doubly measure and be respectively 14 times, 12 times and 12 times, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method drying namely gets haw thorn extract.
Get date, oven dry is pulverized, and crosses 60 mesh sieves, gets jujube powder; Jujube powder is put into extraction equipment for fat, adopt the absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after the degreasing backflow is added 20 times of water gagings soak, behind adjusting pH8, the immersion 80min, take the Microwave Extraction method to extract jujube powder, time 5min namely gets Fructus Jujubae extract.
Get matrimony vine, decocted 2 hours with 8 times of water gagings first, decocted 1.5 hours with 6 times of water gagings, merge decocting liquid twice, film evaporation method is flung to moisture, reduction vaporization dry (0.1MPa, 20 ℃), and reduction vaporization dry (0.1MPa, 20 ℃) namely gets wolfberry fruit extract.
Get Momordica grosvenori, oven dry is pulverized, and crosses 60 mesh sieves, gets mangosteen powder; Add 30 times of water gagings, ultrasonic wave extracts 3 times under 50 ℃ of conditions, each 5min, and operating frequency 53KHz, power 150W merges three times filtrate, and the film drying method is dry, namely gets Fructus Monordicae extract.。
With above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in the jacketed pan, heats in ultrasonic environment, and ultrasonic frequency is 20KHz, and boiling temperature is 95 ℃, and the time is 4 hours; Centrifuge with 100 order filter clothes filters, and gets the auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, and drying gets dry extract.
Add microcrystalline cellulose in quality 1:1 ratio, fully mixing is crossed 40 mesh sieves, puts the vacuum desiccator inner drying.
With 75% ethanol softwood processed, granulate with 14 eye mesh screens, in 70 ℃ of oven dry, namely get the beche-de-mer capsules particle.
11, sterilization and filling: the method that sterilization adopts pasteurization to combine with microwave sterilization.
At first product is placed 95 ℃ of conditions, sterilization 15s shifts out; Put it into again the microwave quick-reaction system and carry out microwave sterilization, power 850W, time 15min.
In the filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Embodiment 2:
Prescription forms:
1000 parts of sea cucumbers, 100 parts of ginkgoes, 80 parts of acanthopanaxes, 80 parts of folium cortex eucommiaes, 80 parts of hawthorn, 80 parts in date, 80 parts of matrimony vines, 20 parts of Momordica grosvenoris, 80 parts of calcium gluconaes, 80 parts of vitamin Cs.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: with the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
2, vacuum freeze drying: the sea cucumber that cleans up is carried out freeze drying, and cryogenic temperature is-25 ℃, and vacuum is 15Pa, snap frozen 3h, 70 ℃ of freeze-drying final temperatures.
3, coarse crushing: the sea cucumber after the freeze drying is put into pulverizer, pulverize 30min, cross 60 mesh sieves, obtain thick sea cucumber powder.
4, ultramicro grinding: first the sea cucumber meal is carried out ultramicro grinding by airslide disintegrating mill, time 3h obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out nanometer by the high speed shear ultrafine crusher and pulverize, grinding time is 5h.
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with the 1:10 mass ratio, obtain sea cucumber milk, the compound protease of accurate weighing sea cucumber weight 0.4% (pepsin: bromelain=2:1), put into the container that cleans up through pure water, add after an amount of pure water dissolves compound protease, put into enzymatic vessel together with sea cucumber milk, in intensity is the microwave environment of 1000W, leave standstill 2min.
6, the enzyme that goes out: after enzymolysis is finished, with enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 30min that go out; After finishing the deactivation of enzyme, to the enzymatic vessel stopped heating, enzymolysis liquid is cooled to rapidly normal temperature; The enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
7, filter: the enzymolysis liquid after will lowering the temperature is used first the centrifugal 20min of generic centrifuge, filters, and gets filtrate, and the centrifugal 20min of low temperature ultrahigh speed filters filtrate for later use.
8, desalination: with filtrate by nanofiltration with except freshen; Residue and then mistake 100 mesh sieves obtain sea cucumber extract.
9, processing auxiliary material baste:
Get the ginkgo blade at 3 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the ginkgo leaf meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets ginkgo leaf powder.
Get the wilsonii blade at 3 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the acanthopanax meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets the acanthopanax powder.
Get above Eucommia ulmoides Oliv. leaves of 10 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 20KW, 2450MHz condition microwave 10 minutes are again in 150 ℃ of baking oven bakings 15 seconds, 4 ℃ of coolings, pulverize, cross 80 mesh sieves, get the folium cortex eucommiae meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets Eucommia Leaf Powder.
Get hawthorn, soak 60min, then adopt the decocting cooking method to extract, extracts 3 times, add water and doubly measure and be respectively 14 times, 12 times and 12 times, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method drying namely gets haw thorn extract.
Get date, oven dry is pulverized, and crosses 60 mesh sieves, gets jujube powder; Jujube powder is put into extraction equipment for fat, adopt the absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after the degreasing backflow is added 20 times of water gagings soak, behind adjusting pH8, the immersion 80min, take the Microwave Extraction method to extract jujube powder, time 5min namely gets Fructus Jujubae extract.
Get matrimony vine, decocted 2 hours with 8 times of water gagings first, decocted 1.5 hours with 6 times of water gagings, merge decocting liquid twice, film evaporation method is flung to moisture, reduction vaporization dry (0.1MPa, 20 ℃), and reduction vaporization dry (0.1MPa, 20 ℃) namely gets wolfberry fruit extract.
Get Momordica grosvenori, oven dry is pulverized, and crosses 60 mesh sieves, gets mangosteen powder; Add 30 times of water gagings, ultrasonic wave extracts 3 times under 50 ℃ of conditions, each 5min, and operating frequency 53KHz, power 150W merges three times filtrate, and the film drying method is dry, namely gets Fructus Monordicae extract.。
With above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in the jacketed pan, heats in ultrasonic environment, and ultrasonic frequency is 30KHz, and boiling temperature is 100 ℃, and the time is 2 hours; Centrifuge with 100 order filter clothes filters, and gets the auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, and drying gets dry extract.
Add microcrystalline cellulose in quality 1:1 ratio, fully mixing is crossed 40 mesh sieves, puts the vacuum desiccator inner drying.
With 75% ethanol softwood processed, granulate with 14 eye mesh screens, in 70 ℃ of oven dry, namely get the beche-de-mer capsules particle.
11, sterilization and filling: the method that sterilization adopts pasteurization to combine with microwave sterilization.
At first product is placed 95 ℃ of conditions, sterilization 15s shifts out; Put it into again the microwave quick-reaction system and carry out microwave sterilization, power 1000W, time 8min.
In the filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Claims (2)
1. a beche-de-mer capsules is characterized in that, beche-de-mer capsules is made of sea cucumber, ginkgo, acanthopanax, folium cortex eucommiae, hawthorn, date, matrimony vine, Momordica grosvenori, calcium gluconae and vitamin C, sea cucumber 500-1000 part wherein, ginkgo 50-100 part, acanthopanax 50-80 part, folium cortex eucommiae 50-80 part, hawthorn 50-80 part, date 50-80 part, matrimony vine 50-80 part, Momordica grosvenori 10-20 part, calcium gluconae 50-80 part, vitamin C 50-80 part.
2. the preparation technology of a kind of beche-de-mer capsules as claimed in claim 1, it is characterized in that this preparation technology comprises purification of raw materials, vacuum freeze drying, coarse crushing, ultramicro grinding, microwave-assisted enzyme solution, the enzyme that goes out, filtration, desalination, processing auxiliary material baste, batching and granulation and sterilization and loads totally ten one steps:
(1) purification of raw materials: with the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
(2) vacuum freeze drying: the sea cucumber that cleans up is carried out freeze drying, and cryogenic temperature is-20～-25 ℃, and vacuum is 5-15Pa, snap frozen 2-3h, 60-70 ℃ of freeze-drying final temperature.
(3) coarse crushing: the sea cucumber after the freeze drying is put into pulverizer, pulverize 10-30min, cross 60 mesh sieves, obtain thick sea cucumber powder.
(4) ultramicro grinding: first the sea cucumber meal is carried out ultramicro grinding by airslide disintegrating mill, time 2-3h obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out nanometer by the high speed shear ultrafine crusher and pulverize, grinding time is 3-5h.
(5) microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with the 1:5-10 mass ratio, obtain sea cucumber milk, the compound protease of accurate weighing sea cucumber weight 0.3-0.4% (pepsin: bromelain=2:1), put into the container that cleans up through pure water, add after an amount of pure water dissolves compound protease, put into enzymatic vessel together with sea cucumber milk, in intensity is the microwave environment of 500-1000W, leave standstill 1-2min.
(6) enzyme that goes out: after enzymolysis is finished, with enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out; After finishing the deactivation of enzyme, to the enzymatic vessel stopped heating, enzymolysis liquid is cooled to rapidly normal temperature; The enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
(7) filter: the enzymolysis liquid after will lowering the temperature is used first the centrifugal 20min of generic centrifuge, filters, and gets filtrate, and the centrifugal 20min of low temperature ultrahigh speed filters filtrate for later use.
(8) desalination: with filtrate by nanofiltration with except freshen; Residue and then mistake 100 mesh sieves obtain sea cucumber extract.
(9) processing auxiliary material baste:
Get the ginkgo blade at 2-3 age, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the ginkgo leaf meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets ginkgo leaf powder.
Get the wilsonii blade at 3 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 150 ℃ of baking ovens toasted 15 seconds, 4 ℃ of coolings are pulverized, and cross 80 mesh sieves, get the acanthopanax meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets the acanthopanax powder.
Get above Eucommia ulmoides Oliv. leaves of 10 ages, 25 ℃ of water rinses spread and dry, placed 4 hours 100 ℃ of steam beatings 5 minutes, room temperature cooling in 25 ℃, 0.1MPa environment, 20KW, 2450MHz condition microwave 10 minutes are again in 150 ℃ of baking oven bakings 15 seconds, 4 ℃ of coolings, pulverize, cross 80 mesh sieves, get the folium cortex eucommiae meal, meal is dropped into fluid energy mill carry out ultramicro grinding, product is crossed 300 mesh sieves, namely gets Eucommia Leaf Powder.
Get hawthorn, soak 60min, then adopt the decocting cooking method to extract, extracts 3 times, add water and doubly measure and be respectively 14 times, 12 times and 12 times, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method drying namely gets haw thorn extract.
Get date, oven dry is pulverized, and crosses 60 mesh sieves, gets jujube powder; Jujube powder is put into extraction equipment for fat, adopt the absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after the degreasing backflow is added 20 times of water gagings soak, behind adjusting pH8, the immersion 80min, take the Microwave Extraction method to extract jujube powder, time 5min namely gets Fructus Jujubae extract.
Get matrimony vine, decocted 2 hours with 8 times of water gagings first, decocted 1.5 hours with 6 times of water gagings, merge decocting liquid twice, film evaporation method is flung to moisture, reduction vaporization dry (0.1MPa, 20 ℃), and reduction vaporization dry (0.1MPa, 20 ℃) namely gets wolfberry fruit extract.
Get Momordica grosvenori, oven dry is pulverized, and crosses 60 mesh sieves, gets mangosteen powder; Add 30 times of water gagings, ultrasonic wave extracts 3 times under 50 ℃ of conditions, each 5min, and operating frequency 53KHz, power 150W merges three times filtrate, and the film drying method is dry, namely gets Fructus Monordicae extract.。
With above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in the jacketed pan, heats in ultrasonic environment, and ultrasonic frequency is 20-30KHz, and boiling temperature is 95-100 ℃, and the time is 2-4 hour; Centrifuge with 100 order filter clothes filters, and gets the auxiliary material baste.
(10) batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, and drying gets dry extract.
Add microcrystalline cellulose in quality 1:1 ratio, fully mixing is crossed 40 mesh sieves, puts the vacuum desiccator inner drying.
With 75% ethanol softwood processed, granulate with 14 eye mesh screens, in 70 ℃ of oven dry, namely get the beche-de-mer capsules particle.
(11) sterilization and filling: the method that sterilization adopts pasteurization to combine with microwave sterilization.
At first product is placed 95 ℃ of conditions, sterilization 15s shifts out; Put it into again the microwave quick-reaction system and carry out microwave sterilization, power 850-1000W, time 8-15min.
In the filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
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