CN102934819B - Trepang capsule and preparation process thereof - Google Patents
Trepang capsule and preparation process thereof Download PDFInfo
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- CN102934819B CN102934819B CN201210420808.6A CN201210420808A CN102934819B CN 102934819 B CN102934819 B CN 102934819B CN 201210420808 A CN201210420808 A CN 201210420808A CN 102934819 B CN102934819 B CN 102934819B
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Abstract
The invention relates to a trepang capsule and a preparation process thereof. The trepang capsule is composed of 500-1000 parts of trepang, 50-100 parts of rhodiola root, 50-80 parts of mulberry leaf, 50-80 parts of Chinese wolfberry; 50-80 parts of hawthorn, 50-80 parts of Chinese date, 10-20 parts of fructus momordicae, 50-80 parts of calcium gluconate, and 50-80 parts of vitamin C. The preparation process comprises the following eleven steps: raw material purification, vacuum freeze drying, coarse cracking, superfine grinding, microwave auxiliary enzymolysis, enzyme deactivation, filtration, desalting, auxiliary seasoning processing, material proportioning and pelletization, as well as sterilization and packing. The obtained trepang capsule is reasonable in formulation composition, and stable in property, has blood sugar decreasing and blood pressure reducing efficacy, and is especially prominent in blood fat reducing efficacy.
Description
Technical field
The present invention relates to a kind of beche-de-mer capsules and preparation technology thereof.
Background technology
Sea cucumber belongs to Echinodermata Holothuroidea, and the whole world approximately has sea cucumber kind more than 1100 at present, and wherein 40 kinds of left and right can be edible; China approximately has sea cucumber more than 140 to plant, wherein have about 20 kinds can be edible, 10 kinds of sea cucumbers have higher commodity value.Before centuries, China people just think that sea cucumber is not only a kind of delicacies, but also are a kind of tonic nutriments.China Ming Dynasty thanks between year in Wanli year and starts the assorted ancient sacrificial utensil > > of system work < < five just relevant for the record of sea cucumber: " sea cucumber; beach, the east area of the Liao River, coextensive with eastern and southern Liaoning Province has it; its benefit warm in nature, sufficient enemy joins, therefore named sea cucumber ".
Sea cucumber is the animality health food of high nutrition, high protein, and its nutritional labeling is mainly sterol and Triterpenoids.Research in recent years tentative confirmation Stichopus Japonicus Acidic Mucopolysaccharide has antitumor and blood coagulation resisting function, and the contained holothurin of actinopyga agassizi is inhibited to S180 mouse tumor, and sea cucumber also has Antiarthritic effect in addition, and old man's arthralgia is had to curative effect.
The defect of prior art has: one, in the processing of traditional sea cucumber, sea cucumber is pulverized with enzymolysis process incomplete, thereby destroys the nutritional labeling in sea cucumber, reduces the health-care efficacy of sea cucumber.Two, sea cucumber preparation nutritional labeling is more single, and formulating is less, and mouthfeel and nutritive value are all lower.
Summary of the invention
The invention provides a kind of formula and preparation technology thereof of beche-de-mer capsules, as a kind of formula capsule, it had both retained the main nutrient composition in sea cucumber, compatible with other functional health care foods again, formula is reasonable, process stabilizing, and health-care effect is outstanding, have definite reducing blood lipid, blood sugar and blood pressure effect, wherein effect for reducing blood fat is particularly outstanding.
Technical scheme is as follows:
Beche-de-mer capsules of the present invention, by sea cucumber, rhodiola root, mulberry leaf, matrimony vine, hawthorn, date, Momordica grosvenori, calcium gluconae and vitamin C, formed, sea cucumber 500-1000 part wherein, rhodiola root 50-100 part, mulberry leaf 50-80 part, matrimony vine 50-80 part, hawthorn 50-80 part, date 50-80 part, Momordica grosvenori 10-20 part, calcium gluconae 50-80 part, vitamin C 50-80 part.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: by the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up;
2, vacuum freeze drying: the sea cucumber cleaning up is carried out to freeze drying, and cryogenic temperature is-20～-25 ℃, and vacuum is 5-15Pa, snap frozen 2-3h, the final baking temperature of freeze-drying is 60-70 ℃;
3, coarse crushing: the sea cucumber after freeze drying is put into pulverizer, pulverize 10-30min, cross 60 mesh sieves, obtain thick sea cucumber powder;
4, ultramicro grinding: first sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with 1:5-10 mass ratio, obtain sea cucumber milk, accurately weigh the compound protease of sea cucumber weight 0.3-0.4%, described compound protease is pepsin and bromelain, pepsin: the mass ratio=2:1 of bromelain, put into the container cleaning up through pure water, after adding appropriate pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000W in intensity;
6, the enzyme that goes out: after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out; Complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature; Enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid;
7, filter: the enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters filtrate for later use;
8, desalination: by filtrate by nanofiltration with except freshen; Residue and then excessively 100 mesh sieves, obtain sea cucumber extract;
9, processing auxiliary material baste:
Get rhodiola root, mechanical lapping, gained rhodiola root meal is crossed 60 mesh sieves; Carbon dioxide supercritical extraction method is extracted rhodiola active ingredient, and wherein extraction temperature is 40 ℃, and extracting pressure is 28MPa, and entrainer is ethanol, and volume fraction 78% extracts 160 minutes; 6000 * g high speed centrifugation 15 minutes, separated solvent, evaporation drying condition is pressure 0.1MPa, 40 ℃ of temperature, obtain;
Get the mulberry leaf after first frost, 25 ℃ of water rinses, spread and dry, in 25 ℃, 0.1MPa environment, place 4 hours, 100 ℃ of steam beatings 5 minutes, room temperature is cooling, 150 ℃ of baking ovens toast 15 seconds, 4 ℃ cooling, pulverizes, and crosses 80 mesh sieves, obtain mulberry leaf meal, meal is dropped into fluid energy mill and carry out ultramicro grinding, product is crossed 300 mesh sieves, obtains mulberry leaf powder;
Get matrimony vine, first with the decocting of 8 times of matrimony vine quality, boil 2 hours, then boil 1.5 hours with the decocting of 6 times of matrimony vine quality, merge decocting liquid twice, moisture is removed in film evaporation method volatilization, and evaporation drying condition is pressure 0.1MPa, and 20 ℃ of temperature, obtain wolfberry fruit extract;
Get hawthorn, soak 60min, then adopt decocting cooking method to extract, extracts 3 times, add water quality and be respectively 14 times, 12 times and 12 times of hawthorn, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method is dried, and obtains haw thorn extract;
Get date, dry and pulverize, cross 60 mesh sieves, obtain jujube powder; Jujube powder is put into extraction equipment for fat, adopt absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after degreasing is refluxed adds the water soaking of 20 times of jujube powder quality, regulates pH to be 8, to soak after 80min, takes Microwave Extraction method to extract jujube powder, and time 5min, obtains Fructus Jujubae extract;
Get Momordica grosvenori, dry and pulverize, cross 60 mesh sieves, obtain mangosteen powder; The water that adds 30 times of mangosteen powder quality, under 50 ℃ of conditions, ultrasonic wave extracts 3 times, each 5min, operating frequency 53KHz, power 150W, merges three times filtrate, and film drying method is dry, obtains Fructus Monordicae extract;
By above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in jacketed pan, in ultrasonic environment, heats, and ultrasonic frequency is 20-30KHz, and boiling temperature is 95-100 ℃, and the time is 2-4 hour; With the centrifuge of 100 order filter clothes, filter, obtain auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, dry, obtain dry extract;
Routine 1:1 adds microcrystalline cellulose in mass ratio, fully mixes, and crosses 40 mesh sieves, puts vacuum desiccator inner drying;
With 75% ethanol softwood processed, with 14 eye mesh screens, granulate, in 70 ℃ of oven dry, obtain beche-de-mer capsules particle;
11, sterilizing and filling: the method that sterilizing adopts pasteurization to combine with microwave sterilization.
First product is placed in to 95 ℃ of conditions, sterilizing 15s, shifts out; Put it into again microwave quick-reaction system and carry out microwave sterilization, power 850-1000W, time 8-15min;
In filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Compared to the prior art, the technology of the present invention effect comprises:
1, to choose sea cucumber be primary raw material in the present invention, and compatible with rhodiola root, mulberry leaf, matrimony vine, hawthorn, date, Momordica grosvenori, calcium gluconae and vitamin C, and prescription ratio has been carried out to detailed screening, and formula forms rationally, stable in properties.
2, the present invention conducts in-depth research sea cucumber pulverizing and enzymolysis process, has significantly improved the bioavilability of sea cucumber, has fully retained the main nutrient composition of sea cucumber.
3, the present invention has carried out system research to the pulverizing extraction process of rhodiola root, mulberry leaf, matrimony vine, hawthorn, date and Momordica grosvenori, by technology such as ultramicro grinding, makes the stripping rapidly of its active ingredient, improves extraction efficiency.
4, the present invention conducts in-depth research product sterilization process, makes to reach sterilization effect, can retained product nutritional labeling not be destroyed again.
5, gained beche-de-mer capsules of the present invention, has definite reducing blood lipid, hypoglycemic and blood pressure reduction effect, and wherein blood fat reducing function is especially outstanding.
The specific embodiment
Below in conjunction with specific embodiment, technical solution of the present invention is described in detail.
Embodiment 1:
Formula forms:
500 parts of sea cucumbers, 50 parts of rhodiola roots, 50 parts, mulberry leaf, 50 parts of matrimony vines, 50 parts of hawthorn, 50 parts, date, 10 parts of Momordica grosvenoris, 50 parts of calcium gluconaes, 50 parts of vitamin Cs.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: by the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
2, vacuum freeze drying: the sea cucumber cleaning up is carried out to freeze drying, and cryogenic temperature is-20 ℃, and vacuum is 5Pa, snap frozen 2h, the final baking temperature of freeze-drying is 60 ℃.
3, coarse crushing: the sea cucumber after freeze drying is put into pulverizer, pulverize 10min, cross 60 mesh sieves, obtain thick sea cucumber powder.
4, ultramicro grinding: first sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, time 2h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3h.
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with 1:5 mass ratio, obtain sea cucumber milk, accurately weigh the compound protease (pepsin: the mass ratio=2:1 of bromelain) of sea cucumber weight 0.3%, put into the container cleaning up through pure water, after adding appropriate pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1min in the microwave environment that is 500W in intensity.
6, the enzyme that goes out: after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10min that go out; Complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature; Enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
7, filter: the enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters filtrate for later use.
8, desalination: by filtrate by nanofiltration with except freshen; Residue and then excessively 100 mesh sieves, obtain sea cucumber extract.
9, processing auxiliary material baste:
Get rhodiola root, mechanical lapping, gained rhodiola root meal is crossed 60 mesh sieves; Carbon dioxide supercritical extraction method is extracted rhodiola active ingredient, and wherein extraction temperature is 40 ℃, and extracting pressure is 28MPa, and entrainer is ethanol, and volume fraction 78% extracts 160 minutes; 6000 * g high speed centrifugation 15 minutes, separated solvent, (40 ℃, 0.1MPa), obtain evaporation drying.
Get the mulberry leaf after first frost, 25 ℃ of water rinses, spread and dry, in 25 ℃, 0.1MPa environment, place 4 hours, 100 ℃ of steam beatings 5 minutes, room temperature is cooling, 150 ℃ of baking ovens toast 15 seconds, 4 ℃ cooling, pulverizes, and crosses 80 mesh sieves, obtain mulberry leaf meal, meal is dropped into fluid energy mill and carry out ultramicro grinding, product is crossed 300 mesh sieves, obtains mulberry leaf powder.
Get matrimony vine, first with the decocting of 8 times of matrimony vine quality, boil 2 hours, then boil 1.5 hours with the decocting of 6 times of matrimony vine quality, merge decocting liquid twice, film evaporation method is flung to moisture, and evaporation drying (0.1MPa, 20 ℃), obtains wolfberry fruit extract.
Get hawthorn, soak 60min, then adopt decocting cooking method to extract, extract 3 times, amount of water is respectively 14 times, 12 times and 12 times of hawthorn quality, and extraction time is respectively 3.0h, 2.5h and 2.5h, merge three times filtrate, film drying method is dry, obtains haw thorn extract.
Get date, dry and pulverize, cross 60 mesh sieves, obtain jujube powder; Jujube powder is put into extraction equipment for fat, adopt absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after degreasing is refluxed adds the water soaking of 20 times of jujube powder quality, regulates pH to be 8, to soak after 80min, takes Microwave Extraction method to extract jujube powder, and time 5min, obtains Fructus Jujubae extract.
Get Momordica grosvenori, dry and pulverize, cross 60 mesh sieves, obtain mangosteen powder; The water that adds 30 times of mangosteen powder quality, under 50 ℃ of conditions, ultrasonic wave extracts 3 times, each 5min, operating frequency 53KHz, power 150W, merges three times filtrate, and film drying method is dry, obtains Fructus Monordicae extract.。
By above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in jacketed pan, in ultrasonic environment, heats, and ultrasonic frequency is 20KHz, and boiling temperature is 95 ℃, and the time is 4 hours; With the centrifuge of 100 order filter clothes, filter, obtain auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, dry, obtain dry extract.
Routine 1:1 adds microcrystalline cellulose in mass ratio, fully mixes, and crosses 40 mesh sieves, puts vacuum desiccator inner drying.
With 75% ethanol softwood processed, with 14 eye mesh screens, granulate, in 70 ℃ of oven dry, obtain beche-de-mer capsules particle.
11, sterilizing and filling: the method that sterilizing adopts pasteurization to combine with microwave sterilization.
First product is placed in to 95 ℃ of conditions, sterilizing 15s, shifts out; Put it into again microwave quick-reaction system and carry out microwave sterilization, power 850W, time 15min.
In filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Embodiment 2:
Formula forms:
1000 parts of sea cucumbers, 100 parts of rhodiola roots, 80 parts, mulberry leaf, 80 parts of matrimony vines, 80 parts of hawthorn, 80 parts, date, 20 parts of Momordica grosvenoris, 80 parts of calcium gluconaes, 80 parts of vitamin Cs.
The preparation technology of beche-de-mer capsules is:
1, purification of raw materials: by the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up.
2, vacuum freeze drying: the sea cucumber cleaning up is carried out to freeze drying, and cryogenic temperature is-25 ℃, and vacuum is 15Pa, snap frozen 3h, the final baking temperature of freeze-drying is 70 ℃.
3, coarse crushing: the sea cucumber after freeze drying is put into pulverizer, pulverize 30min, cross 60 mesh sieves, obtain thick sea cucumber powder.
4, ultramicro grinding: first sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, time 3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 5h.
5, microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with 1:10 mass ratio, obtain sea cucumber milk, accurately weigh the compound protease (pepsin: bromelain mass ratio=2:1) of sea cucumber weight 0.4%, put into the container cleaning up through pure water, after adding appropriate pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 2min in the microwave environment that is 1000W in intensity.
6, the enzyme that goes out: after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 30min that go out; Complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature; Enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid.
7, filter: the enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters filtrate for later use.
8, desalination: by filtrate by nanofiltration with except freshen; Residue and then excessively 100 mesh sieves, obtain sea cucumber extract.
9, processing auxiliary material baste:
Get rhodiola root, mechanical lapping, gained rhodiola root meal is crossed 60 mesh sieves; Carbon dioxide supercritical extraction method is extracted rhodiola active ingredient, and wherein extraction temperature is 40 ℃, and extracting pressure is 28MPa, and entrainer is ethanol, and volume fraction 78% extracts 160 minutes; 6000 * g high speed centrifugation 15 minutes, separated solvent, (40 ℃, 0.1MPa), obtain evaporation drying.
Get the mulberry leaf after first frost, 25 ℃ of water rinses, spread and dry, in 25 ℃, 0.1MPa environment, place 4 hours, 100 ℃ of steam beatings 5 minutes, room temperature is cooling, 150 ℃ of baking ovens toast 15 seconds, 4 ℃ cooling, pulverizes, and crosses 80 mesh sieves, obtain mulberry leaf meal, meal is dropped into fluid energy mill and carry out ultramicro grinding, product is crossed 300 mesh sieves, obtains mulberry leaf powder.
Get matrimony vine, first with the decocting of 8 times of matrimony vine quality, boil 2 hours, then boil 1.5 hours with the decocting of 6 times of matrimony vine quality, merge decocting liquid twice, film evaporation method is flung to moisture, evaporation drying (0.1MPa, 20 ℃), evaporation drying (0.1MPa, 20 ℃), obtains wolfberry fruit extract.
Get hawthorn, soak 60min, then adopt decocting cooking method to extract, extract 3 times, amount of water is respectively 14 times, 12 times and 12 times of hawthorn quality, and extraction time is respectively 3.0h, 2.5h and 2.5h, merge three times filtrate, film drying method is dry, obtains haw thorn extract.
Get date, dry and pulverize, cross 60 mesh sieves, obtain jujube powder; Jujube powder is put into extraction equipment for fat, adopt absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after degreasing is refluxed adds the water soaking of 20 times of jujube powder quality, regulates pH to be 8, to soak after 80min, takes Microwave Extraction method to extract jujube powder, and time 5min, obtains Fructus Jujubae extract.
Get Momordica grosvenori, dry and pulverize, cross 60 mesh sieves, obtain mangosteen powder; The water that adds 30 times of mangosteen powder quality, under 50 ℃ of conditions, ultrasonic wave extracts 3 times, each 5min, operating frequency 53KHz, power 150W, merges three times filtrate, and film drying method is dry, obtains Fructus Monordicae extract.
By above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in jacketed pan, in ultrasonic environment, heats, and ultrasonic frequency is 30KHz, and boiling temperature is 100 ℃, and the time is 2 hours; With the centrifuge of 100 order filter clothes, filter, obtain auxiliary material baste.
10, batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, dry, obtain dry extract.
Routine 1:1 adds microcrystalline cellulose in mass ratio, fully mixes, and crosses 40 mesh sieves, puts vacuum desiccator inner drying.
With 75% ethanol softwood processed, with 14 eye mesh screens, granulate, in 70 ℃ of oven dry, obtain beche-de-mer capsules particle.
11, sterilizing and filling: the method that sterilizing adopts pasteurization to combine with microwave sterilization.
First product is placed in to 95 ℃ of conditions, sterilizing 15s, shifts out; Put it into again microwave quick-reaction system and carry out microwave sterilization, power 1000W, time 8min.
In filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
Claims (2)
1. a beche-de-mer capsules, it is characterized in that, beche-de-mer capsules is by sea cucumber, rhodiola root, mulberry leaf, matrimony vine, hawthorn, date, Momordica grosvenori, calcium gluconae and vitamin C are made, sea cucumber 500-1000 part wherein, rhodiola root 50-100 part, mulberry leaf 50-80 part, matrimony vine 50-80 part, hawthorn 50-80 part, date 50-80 part, Momordica grosvenori 10-20 part, calcium gluconae 50-80 part, vitamin C 50-80 part, described beche-de-mer capsules adopts following technique preparation: this preparation technology comprises purification of raw materials, vacuum freeze drying, coarse crushing, ultramicro grinding, microwave-assisted enzyme solution, enzyme goes out, filter, desalination, processing auxiliary material baste, batching and granulation and sterilizing and filling be totally ten one steps:
(1) purification of raw materials: by the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up;
(2) vacuum freeze drying: the sea cucumber cleaning up is carried out to freeze drying, and cryogenic temperature is-20～-25 ℃, and vacuum is 5-15Pa, snap frozen 2-3h, the final temperature of freeze-drying is 60-70 ℃;
(3) coarse crushing: the sea cucumber after freeze drying is put into pulverizer, pulverize 10-30min, cross 60 mesh sieves, obtain thick sea cucumber powder;
(4) ultramicro grinding: first sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
(5) microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with 1:5-10 mass ratio, obtain sea cucumber milk, accurately weigh the compound protease of sea cucumber weight 0.3-0.4%, described compound protease is pepsin and bromelain, pepsin: the mass ratio=2:1 of bromelain, put into the container cleaning up through pure water, after adding appropriate pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000W in intensity;
(6) enzyme that goes out: after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out; Complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature; Enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid;
(7) filter: the enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters filtrate for later use;
(8) desalination: by filtrate by nanofiltration with except freshen; Residue and then excessively 100 mesh sieves, obtain sea cucumber extract;
(9) processing auxiliary material baste:
Get rhodiola root, mechanical lapping, gained rhodiola root meal is crossed 60 mesh sieves; Carbon dioxide supercritical extraction method is extracted rhodiola active ingredient, and wherein extraction temperature is 40 ℃, and extracting pressure is 28MPa, and entrainer is ethanol, and volume fraction 78% extracts 160 minutes; 6000 * g high speed centrifugation 15 minutes, separated solvent, evaporation drying condition is pressure 0.1MPa, 40 ℃ of temperature, obtain;
Get the mulberry leaf after first frost, 25 ℃ of water rinses, spread and dry, in 25 ℃, 0.1MPa environment, place 4 hours, 100 ℃ of steam beatings 5 minutes, room temperature is cooling, 150 ℃ of baking ovens toast 15 seconds, 4 ℃ cooling, pulverizes, and crosses 80 mesh sieves, obtain mulberry leaf meal, meal is dropped into fluid energy mill and carry out ultramicro grinding, product is crossed 300 mesh sieves, obtains mulberry leaf powder;
Get matrimony vine, first with the decocting of 8 times of matrimony vine quality, boil 2 hours, then boil 1.5 hours with the decocting of 6 times of matrimony vine quality, merge decocting liquid twice, moisture is removed in film evaporation method volatilization, and evaporation drying condition is pressure 0.1MPa, and 20 ℃ of temperature, obtain wolfberry fruit extract;
Get hawthorn, soak 60min, then adopt decocting cooking method to extract, extracts 3 times, add water quality and be respectively 14 times, 12 times and 12 times of hawthorn, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method is dried, and obtains haw thorn extract;
Get date, dry and pulverize, cross 60 mesh sieves, obtain jujube powder; Jujube powder is put into extraction equipment for fat, adopt absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after degreasing is refluxed adds the water soaking of 20 times of jujube powder quality, regulates pH to be 8, to soak after 80min, takes Microwave Extraction method to extract jujube powder, and time 5min, obtains Fructus Jujubae extract;
Get Momordica grosvenori, dry and pulverize, cross 60 mesh sieves, obtain mangosteen powder; The water that adds 30 times of mangosteen powder quality, under 50 ℃ of conditions, ultrasonic wave extracts 3 times, each 5min, operating frequency 53KHz, power 150W, merges three times filtrate, and film drying method is dry, obtains Fructus Monordicae extract;
By above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in jacketed pan, in ultrasonic environment, heats, and ultrasonic frequency is 20-30KHz, and boiling temperature is 95-100 ℃, and the time is 2-4 hour; With the centrifuge of 100 order filter clothes, filter, obtain auxiliary material baste.
(10) batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, dry, obtain dry extract;
Routine 1:1 adds microcrystalline cellulose in mass ratio, fully mixes, and crosses 40 mesh sieves, puts vacuum desiccator inner drying;
With 75% ethanol softwood processed, with 14 eye mesh screens, granulate, in 70 ℃ of oven dry, obtain beche-de-mer capsules particle;
(11) sterilizing and filling: the method that sterilizing adopts pasteurization to combine with microwave sterilization.
First product is placed in to 95 ℃ of conditions, sterilizing 15s, shifts out; Put it into again microwave quick-reaction system and carry out microwave sterilization, power 850-1000W, time 8-15min;
In filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
2. the preparation technology of a kind of beche-de-mer capsules as claimed in claim 1, it is characterized in that, this preparation technology comprises purification of raw materials, vacuum freeze drying, coarse crushing, ultramicro grinding, microwave-assisted enzyme solution, the enzyme that goes out, filtration, desalination, processing auxiliary material baste, batching and granulation and sterilizing and filling totally ten one steps:
(1) purification of raw materials: by the fresh and alive sea cucumbers of acceptance(check), along belly from first to last complete section open, gill, impurity is cleaned up;
(2) vacuum freeze drying: the sea cucumber cleaning up is carried out to freeze drying, and cryogenic temperature is-20～-25 ℃, and vacuum is 5-15Pa, snap frozen 2-3h, the final temperature of freeze-drying is 60-70 ℃;
(3) coarse crushing: the sea cucumber after freeze drying is put into pulverizer, pulverize 10-30min, cross 60 mesh sieves, obtain thick sea cucumber powder;
(4) ultramicro grinding: first sea cucumber meal is carried out to ultramicro grinding by airslide disintegrating mill, time 2-3h, obtains ultra micro sea cucumber powder; Then ultra micro sea cucumber powder is carried out to nanometer pulverizing by high speed shear ultrafine crusher, grinding time is 3-5h;
(5) microwave-assisted enzyme solution: add pure water, sea cucumber powder and water are dissolved with 1:5-10 mass ratio, obtain sea cucumber milk, accurately weigh the compound protease of sea cucumber weight 0.3-0.4%, described compound protease is pepsin and bromelain, pepsin: the mass ratio=2:1 of bromelain, put into the container cleaning up through pure water, after adding appropriate pure water that compound protease is dissolved, together with sea cucumber milk, put into enzymatic vessel, standing 1-2min in the microwave environment that is 500-1000W in intensity;
(6) enzyme that goes out: after enzymolysis completes, by enzymolysis liquid rapidly degree of intensification to 90 ℃ of enzyme 10-30min that go out; Complete after the deactivation of enzyme, enzymatic vessel is stopped to heating, enzymolysis liquid is cooled to rapidly to normal temperature; Enzymatic vessel purified rinse water, flushing liquor is put into enzymolysis liquid;
(7) filter: the enzymolysis liquid after cooling is first used to the centrifugal 20min of generic centrifuge, filter, get filtrate, the centrifugal 20min of low temperature ultrahigh speed, filters filtrate for later use;
(8) desalination: by filtrate by nanofiltration with except freshen; Residue and then excessively 100 mesh sieves, obtain sea cucumber extract;
(9) processing auxiliary material baste:
Get rhodiola root, mechanical lapping, gained rhodiola root meal is crossed 60 mesh sieves; Carbon dioxide supercritical extraction method is extracted rhodiola active ingredient, and wherein extraction temperature is 40 ℃, and extracting pressure is 28MPa, and entrainer is ethanol, and volume fraction 78% extracts 160 minutes; 6000 * g high speed centrifugation 15 minutes, separated solvent, evaporation drying condition is pressure 0.1MPa, 40 ℃ of temperature, obtain;
Get the mulberry leaf after first frost, 25 ℃ of water rinses, spread and dry, in 25 ℃, 0.1MPa environment, place 4 hours, 100 ℃ of steam beatings 5 minutes, room temperature is cooling, 150 ℃ of baking ovens toast 15 seconds, 4 ℃ cooling, pulverizes, and crosses 80 mesh sieves, obtain mulberry leaf meal, meal is dropped into fluid energy mill and carry out ultramicro grinding, product is crossed 300 mesh sieves, obtains mulberry leaf powder;
Get matrimony vine, first with the decocting of 8 times of matrimony vine quality, boil 2 hours, then boil 1.5 hours with the decocting of 6 times of matrimony vine quality, merge decocting liquid twice, moisture is removed in film evaporation method volatilization, and evaporation drying condition is pressure 0.1MPa, and 20 ℃ of temperature, obtain wolfberry fruit extract;
Get hawthorn, soak 60min, then adopt decocting cooking method to extract, extracts 3 times, add water quality and be respectively 14 times, 12 times and 12 times of hawthorn, extraction time is respectively 3.0h, 2.5h and 2.5h, merges three times filtrate, and film drying method is dried, and obtains haw thorn extract;
Get date, dry and pulverize, cross 60 mesh sieves, obtain jujube powder; Jujube powder is put into extraction equipment for fat, adopt absolute ethyl alcohol refluxing extraction 3 times, each 2h; Jujube powder after degreasing is refluxed adds the water soaking of 20 times of jujube powder quality, regulates pH to be 8, to soak after 80min, takes Microwave Extraction method to extract jujube powder, and time 5min, obtains Fructus Jujubae extract;
Get Momordica grosvenori, dry and pulverize, cross 60 mesh sieves, obtain mangosteen powder; The water that adds 30 times of mangosteen powder quality, under 50 ℃ of conditions, ultrasonic wave extracts 3 times, each 5min, operating frequency 53KHz, power 150W, merges three times filtrate, and film drying method is dry, obtains Fructus Monordicae extract;
By above-mentioned mixing of materials, and add calcium gluconae and vitamin C, the pure water of 10 times of quality soaks, and moves in jacketed pan, in ultrasonic environment, heats, and ultrasonic frequency is 20-30KHz, and boiling temperature is 95-100 ℃, and the time is 2-4 hour; With the centrifuge of 100 order filter clothes, filter, obtain auxiliary material baste.
(10) batching and granulation:
Sea cucumber feed liquid, auxiliary material baste that enzymolysis is filtered carry out proportioning in the ratio of 1:1, mix and again pass through centrifugal filtration, dry, obtain dry extract;
Routine 1:1 adds microcrystalline cellulose in mass ratio, fully mixes, and crosses 40 mesh sieves, puts vacuum desiccator inner drying;
With 75% ethanol softwood processed, with 14 eye mesh screens, granulate, in 70 ℃ of oven dry, obtain beche-de-mer capsules particle;
(11) sterilizing and filling: the method that sterilizing adopts pasteurization to combine with microwave sterilization.
First product is placed in to 95 ℃ of conditions, sterilizing 15s, shifts out; Put it into again microwave quick-reaction system and carry out microwave sterilization, power 850-1000W, time 8-15min;
In filling process, the qualified capsule product of filling should be put into constant heat storage at any time and preserve, after the complete end of lid is rolled in same batch materials filling, again carry out ethylene oxide sterilizing.
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| CN106723068A (en) * | 2016-11-14 | 2017-05-31 | 威海力元海洋生物科技有限公司 | A kind of sea cucumber lycopene selenium radioresistance capsule formula and its preparation technology |
| CN107455753A (en) * | 2017-07-05 | 2017-12-12 | 山东圣洲海洋生物科技股份有限公司 | A kind of sea cucumber peptide oral liquid and its preparation technology |
| CN107811162B (en) * | 2017-12-08 | 2021-03-02 | 玉环市五丰蒸干脱脂鱼粉厂 | Method for preparing easily-preserved whole shrimp pulp by debitterizing and enzymolysis of marine mysid shrimps and application |
| CN107821922B (en) * | 2017-12-08 | 2020-10-27 | 玉环市五丰蒸干脱脂鱼粉厂 | Method for preparing whole shrimp pulp by debitterizing and enzymolysis of marine mysid shrimp and application thereof |
| CN110575680A (en) * | 2019-09-19 | 2019-12-17 | 福建启元堂生物技术有限公司 | Method for double super-extraction of marine nutrients |
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| CN1442068A (en) * | 2003-04-03 | 2003-09-17 | 威海健方医药研究所 | Sea cucumber candy and its production method |
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