CN102933079B - 儿茶酚-o-甲基转移酶抑制剂及其在治疗精神障碍中的用途 - Google Patents

儿茶酚-o-甲基转移酶抑制剂及其在治疗精神障碍中的用途 Download PDF

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CN102933079B
CN102933079B CN201180012413.6A CN201180012413A CN102933079B CN 102933079 B CN102933079 B CN 102933079B CN 201180012413 A CN201180012413 A CN 201180012413A CN 102933079 B CN102933079 B CN 102933079B
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hydroxyl
phenyl
alkyl
base
methyl
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CN102933079A (zh
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S.沃尔肯伯格
J.C.巴罗
S.T.哈里森
B.W.特罗特
K.K.南达
P.J.曼利
Z.赵
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Merck Sharp & Dohme LLC
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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CN201180012413.6A 2010-03-04 2011-02-28 儿茶酚-o-甲基转移酶抑制剂及其在治疗精神障碍中的用途 Expired - Fee Related CN102933079B (zh)

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US31040010P 2010-03-04 2010-03-04
US61/310400 2010-03-04
PCT/US2011/026414 WO2011109261A1 (en) 2010-03-04 2011-02-28 Inhibitors of catechol o-methyl transferase and their use in the treatment of psychotic disorders

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CN102933079A CN102933079A (zh) 2013-02-13
CN102933079B true CN102933079B (zh) 2016-02-17

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US (1) US9309199B2 (enExample)
EP (1) EP2542077A4 (enExample)
JP (1) JP5860417B2 (enExample)
KR (1) KR20130044381A (enExample)
CN (1) CN102933079B (enExample)
AU (1) AU2011223976B2 (enExample)
BR (1) BR112012021659A2 (enExample)
CA (1) CA2789474A1 (enExample)
MX (1) MX2012010188A (enExample)
RU (1) RU2563634C2 (enExample)
WO (1) WO2011109261A1 (enExample)

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RU2563634C2 (ru) 2015-09-20
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