CN102908462A - Isatis root particle and preparation method thereof - Google Patents
Isatis root particle and preparation method thereof Download PDFInfo
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- CN102908462A CN102908462A CN2012104755020A CN201210475502A CN102908462A CN 102908462 A CN102908462 A CN 102908462A CN 2012104755020 A CN2012104755020 A CN 2012104755020A CN 201210475502 A CN201210475502 A CN 201210475502A CN 102908462 A CN102908462 A CN 102908462A
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- radix isatidis
- isatis root
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- steviosin
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Abstract
The invention relates to an isatis root particle and a preparation method thereof. The isatis root particle is composed of 10-20 parts of isatis root, 10-15 parts of folium isatidis, 10-20 parts of dextrin, 2-5 parts of liquorice, 1-3 parts of honeysuckle, 0.1-0.5 parts of vitamin C and 0.1-0.2 parts of steviosin. The preparation method is that the isatis root, the folium isatidis, the liquorice and the honeysuckle are washed by clean water to be placed in a 60-80 DEG C drying oven for drying and smashing; an ethanol solution is added, and 120 W ultrasonic wave is used for extracting and centrifuging to obtain supernatant liquor; membrane filtration is carried out on the supernatant liquor, and decompression and concentration are carried out to obtain an extractive; and the extractive, vitamin, steviosin and dextrin are evenly mixed, and freeze drying is carried out after palletizing. The isatis root particle is rich in active ingredients, can be used for treating diseases such as tepidity fever, wind-heat type common cold, headache and dermexanthesis, and is good in curative effect, stable in quality and free of side effects.
Description
Technical field
The present invention relates to a kind of Radix Isatidis granule, be specifically related to a kind of have heat-clearing and toxic substances removing, the sharp larynx effect of removing heat from blood, can cure Chinese medicine of the diseases such as warm fever, anemopyretic cold, headache, dermexanthesis and preparation method thereof, belong to the Chinese drug preparation technique field.
Background technology
Radix Isatidis begins to be stated from Shennong's Herbal, and heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving function are arranged, and is usually used in viral and bacterial infection.Along with going deep into of research, people extract from Radix Isatidis and have isolated more chemical composition, found widely pharmacological action, water soluble ingredient wherein (organic acid, aminoacid, polysaccharide etc.) has the effects such as antiviral, antifungal and immunomodulating, and there is very important effect the aspect such as liposoluble constituent (indigo, indirubin etc.) is antibacterial at it, anticoagulant, antiinflammatory, anti-bacteria endotoxin.Radix Isatidis granule is got through water extraction, precipitate with ethanol, granulation by chromatogram of Radix Isatidis, because clinical efficacy is definite, " Chinese pharmacopoeia is recorded to be gone through version.Its preparation technology is: decoct with water twice, merge extractive liquid, is concentrated in right amount, adds ethanol and makes and contain the alcohol amount and reach 60%, and precipitation is got the supernatant Recycled ethanol, and is concentrated, adds adjuvant and granulates and get final product.Because it is longer to receive the heat time heating time of alcohol after the water extraction behind the concentrated and precipitate with ethanol, thus larger to the destruction of effective ingredient, liposoluble constituent possible loss more than 90% in concentration process in the extracting solution.Therefore there is irrationality in its preparation technology, should give Improvement and perfection.
The present invention not only improves technique, and adopts new prescription, and product is rich in active component, and good effect, has no side effect at steady quality.
Summary of the invention
The purpose of this invention is to provide a kind of Radix Isatidis granule, have heat-clearing and toxic substances removing, the sharp larynx effect of removing heat from blood, can be used for curing the diseases such as warm fever, anemopyretic cold, headache, dermexanthesis.
Another object of the present invention provides a kind of preparation method of Radix Isatidis granule.
For realizing the purpose of foregoing invention, the technical scheme that the present invention takes is as follows:
A kind of Radix Isatidis granule is comprised of the component of following weight portion:
10 ~ 20 parts of Radix Isatidis
10 ~ 15 parts of Folium Isatidiss
10 ~ 20 parts in dextrin
2 ~ 5 parts in Radix Glycyrrhizae
1 ~ 3 part of Flos Lonicerae
0.1 ~ 0.5 part of vitamin C
0.1 ~ 0.2 part of steviosin;
A kind of preparation method of Radix Isatidis granule comprises the steps:
(1) put into 60 ~ 80 ℃ of baking ovens after 1 ~ 3 part of 10 ~ 20 parts of Radix Isatidis, 10 ~ 15 parts of Folium Isatidiss, 2 ~ 5 parts in Radix Glycyrrhizae, Flos Lonicerae are cleaned up with clear water, dry to moisture below 10%, then pulverize, cross 50 mesh sieves;
(2) powder of step (1) gained being added 5 ~ 10 times of volume fractions is 40% alcoholic solution, centrifugal after the ultrasound wave that applies 120W extracts 10 ~ 15min under 40 ℃ of conditions, gets supernatant;
(3) be that the inorganic ceramic film of 50nm carries out membrane filtration with supernatant with the aperture, the concentrated extract that obtains of filtrate decompression;
(4) with the extract in the step (3) and 0.1 ~ 0.5 part of vitamin C, 0.1 ~ 0.2 part of steviosin, dextrin 10 ~ 20 mix homogeneously, carry out lyophilization after the granulation and get final product.
The invention has the beneficial effects as follows:
(1) product is rich in active component, can be used for treating the diseases such as warm fever, anemopyretic cold, headache, dermexanthesis, and good effect, has no side effect at steady quality;
(2) adopt ultrasonic technology to extract, the time is short, and efficient is high; Adopt membrane filtration technique to filter, can effectively carry out purification, keep to greatest extent effective ingredient.
The specific embodiment
Below by example the present invention is described in further details, these examples only are used for illustrating the present invention, do not limit the scope of the invention.
Embodiment 1
Radix Isatidis granule is comprised of the component of following weight portion:
10 parts of Radix Isatidis
10 parts of Folium Isatidiss
10 parts in dextrin
2 parts in Radix Glycyrrhizae
1 part of Flos Lonicerae
0.1 part of vitamin C
0.1 part of steviosin;
The preparation method of Radix Isatidis granule comprises the steps:
(1) put into 60 ℃ of baking ovens after 1 part of 10 parts of Radix Isatidis, 10 parts of Folium Isatidiss, 2 parts in Radix Glycyrrhizae, Flos Lonicerae are cleaned up with clear water, dry to moisture below 10%, then pulverize, cross 50 mesh sieves;
(2) powder of step (1) gained being added 5 times of volume fractions is 40% alcoholic solution, centrifugal after the ultrasound wave that applies 120W extracts 10min under 40 ℃ of conditions, gets supernatant;
(3) be that the inorganic ceramic film of 50nm carries out membrane filtration with supernatant with the aperture, the concentrated extract that obtains of filtrate decompression;
(4) with the extract in the step (3) and 0.1 part of vitamin C, 0.1 part of steviosin, 10 parts of mix homogeneously of dextrin, carry out lyophilization after the granulation and get final product.
Embodiment 2
Radix Isatidis granule is comprised of the component of following weight portion:
15 parts of Radix Isatidis
13 parts of Folium Isatidiss
15 parts in dextrin
3 parts in Radix Glycyrrhizae
2 parts of Flos Loniceraes
0.3 part of vitamin C
0.15 part of steviosin;
The preparation method of Radix Isatidis granule comprises the steps:
(1) put into 70 ℃ of baking ovens after 2 parts of 15 parts of Radix Isatidis, 13 parts of Folium Isatidiss, 3 parts in Radix Glycyrrhizae, Flos Lonicerae are cleaned up with clear water, dry to moisture below 10%, then pulverize, cross 50 mesh sieves;
(2) powder of step (1) gained being added 8 times of volume fractions is 40% alcoholic solution, centrifugal after the ultrasound wave that applies 120W extracts 8min under 40 ℃ of conditions, gets supernatant;
(3) be that the inorganic ceramic film of 50nm carries out membrane filtration with supernatant with the aperture, the concentrated extract that obtains of filtrate decompression;
(4) with the extract in the step (3) and 0.3 part of vitamin C, 0.15 part of steviosin, 15 parts of mix homogeneously of dextrin, carry out lyophilization after the granulation and get final product.
Embodiment 3
Radix Isatidis granule is comprised of the component of following weight portion:
20 parts of Radix Isatidis
15 parts of Folium Isatidiss
20 parts in dextrin
5 parts in Radix Glycyrrhizae
3 parts of Flos Loniceraes
0.5 part of vitamin C
0.2 part of steviosin;
The preparation method of Radix Isatidis granule comprises the steps:
(1) put into 80 ℃ of baking ovens after 3 parts of 20 parts of Radix Isatidis, 15 parts of Folium Isatidiss, 5 parts in Radix Glycyrrhizae, Flos Lonicerae are cleaned up with clear water, dry to moisture below 10%, then pulverize, cross 50 mesh sieves;
(2) powder of step (1) gained being added 10 times of volume fractions is 40% alcoholic solution, centrifugal after the ultrasound wave that applies 120W extracts 15min under 40 ℃ of conditions, gets supernatant;
(3) be that the inorganic ceramic film of 50nm carries out membrane filtration with supernatant with the aperture, the concentrated extract that obtains of filtrate decompression;
(4) with the extract in the step (3) and 0.5 part of vitamin C, 0.2 part of steviosin, 20 parts of mix homogeneously of dextrin, carry out lyophilization after the granulation and get final product.
Claims (2)
1. Radix Isatidis granule, it is characterized in that: the component by following weight portion forms:
10 ~ 20 parts of Radix Isatidis
10 ~ 15 parts of Folium Isatidiss
10 ~ 20 parts in dextrin
2 ~ 5 parts in Radix Glycyrrhizae
1 ~ 3 part of Flos Lonicerae
0.1 ~ 0.5 part of vitamin C
0.1 ~ 0.2 part of steviosin.
2. the method for the preparation of Radix Isatidis granule claimed in claim 1 is characterized in that: comprise the steps:
(1) put into 60 ~ 80 ℃ of baking ovens after 1 ~ 3 part of 10 ~ 20 parts of Radix Isatidis, 10 ~ 15 parts of Folium Isatidiss, 2 ~ 5 parts in Radix Glycyrrhizae, Flos Lonicerae are cleaned up with clear water, dry to moisture below 10%, then pulverize, cross 50 mesh sieves;
(2) powder of step (1) gained being added 5 ~ 10 times of volume fractions is 40% alcoholic solution, centrifugal after the ultrasound wave that applies 120W extracts 10 ~ 15min under 40 ℃ of conditions, gets supernatant;
(3) be that the inorganic ceramic film of 50nm carries out membrane filtration with supernatant with the aperture, the concentrated extract that obtains of filtrate decompression;
(4) with the extract in the step (3) and 0.1 ~ 0.5 part of vitamin C, 0.1 ~ 0.2 part of steviosin, dextrin 10 ~ 20 mix homogeneously, carry out lyophilization after the granulation and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104755020A CN102908462A (en) | 2012-11-22 | 2012-11-22 | Isatis root particle and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104755020A CN102908462A (en) | 2012-11-22 | 2012-11-22 | Isatis root particle and preparation method thereof |
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| CN102908462A true CN102908462A (en) | 2013-02-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758914A (en) * | 2015-04-28 | 2015-07-08 | 黄佩霞 | Medicined diet formula capable of improving colds and preparation method of medicined diet formula |
| CN104971322A (en) * | 2015-06-11 | 2015-10-14 | 钟兴欢 | Chinese wampee fruit tablet for clearing and moistening throat |
| CN106109573A (en) * | 2016-06-17 | 2016-11-16 | 广东和平君乐药业有限公司 | A kind of compound isatis root granules and production technology thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843659A (en) * | 2010-06-08 | 2010-09-29 | 中国人民解放军第三○二医院 | Traditional Chinese medicine granular formulation for preventing and treating influenza and preparation method thereof |
-
2012
- 2012-11-22 CN CN2012104755020A patent/CN102908462A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843659A (en) * | 2010-06-08 | 2010-09-29 | 中国人民解放军第三○二医院 | Traditional Chinese medicine granular formulation for preventing and treating influenza and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| HARRI HEMILA，等: "维生素C与感冒：对Chalmers综述的分析", 《中国临床营养杂志》, vol. 11, no. 1, 31 March 2003 (2003-03-31), pages 59 - 61 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758914A (en) * | 2015-04-28 | 2015-07-08 | 黄佩霞 | Medicined diet formula capable of improving colds and preparation method of medicined diet formula |
| CN104971322A (en) * | 2015-06-11 | 2015-10-14 | 钟兴欢 | Chinese wampee fruit tablet for clearing and moistening throat |
| CN106109573A (en) * | 2016-06-17 | 2016-11-16 | 广东和平君乐药业有限公司 | A kind of compound isatis root granules and production technology thereof |
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Application publication date: 20130206 |