CN105998283B - Traditional Chinese medicine liniment for treating papular urticaria and preparation method thereof - Google Patents
Traditional Chinese medicine liniment for treating papular urticaria and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a traditional Chinese medicine liniment for treating papular urticaria and a preparation method thereof, wherein the traditional Chinese medicine liniment comprises the following raw material medicines in parts by weight: 10-20 parts of mint, 10-20 parts of camphor, 20-40 parts of radix sophorae flavescentis, 10-20 parts of schizonepeta, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of purslane, 10-20 parts of perilla leaf, 10-20 parts of dried orange peel, 10-20 parts of radix puerariae and 10-20 parts of liquorice. The preparation method comprises pulverizing the above materials into Chinese medicinal granules; putting into a glass container, adding ethanol, mixing uniformly, carrying out ultrasonic treatment, sealing the glass container, and soaking to obtain a soaked mixture; filtering the soaked mixture to obtain filtrate and residue, adding ethanol into the residue, centrifuging, collecting supernatant, and mixing with the filtrate to obtain Chinese medicinal extractive solution; concentrating the Chinese medicinal extractive solution to obtain Chinese medicinal liniment for treating papular urticaria. The traditional Chinese medicine composition has a remarkable curative effect on the papular urticaria, and has the characteristics of good curative effect, small side effect and low recurrence rate.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine liniment for treating papular urticaria and a preparation method thereof.
Background
Papular urticaria is also known as urticaria lichen and infant lichen. Is a common allergic skin disease of infants and children, and adults can also suffer from the allergic skin disease, which is often seen in spring and autumn. Most attacks are primarily related to the allergic reactions caused by insect bites such as mosquitoes, bed bugs, fleas, lice, mites, midges and the like after the bite. Skin lesions are usually localized in the trunk, on the sides of the limbs, and in clusters or scattered in the body. The red wheal-like lesion from mung bean to peanut kernel is slightly fusiform, small blisters are usually formed at the top end, some blisters become hemispherical raised tension large blisters shortly after occurrence, the content is clear, and no red halo exists around the blisters. The skin is pale red or brownish, and some rashes are harder large papules with chestnut grains and become large like wheal after scratching. Both new and old rashes often coexist. Generally, the infant patients have obvious red swelling and blister, often severe itching and influence sleep. Scratching can cause secondary infections.
Western medicine for treating papular urticaria is characterized in that antihistamine is taken for whole body treatment, and antibiotics are added for an infected person as required; topical treatment with corticosteroids is usually carried out by the administration of neomycin
Ointment, impetigo paste, polifeprosan, 0.02 furacilin solution, etc. The western medicines have great side effects, are easy to cause the body to generate drug resistance, are easy to relapse, and are particularly cautious to the administration of the western medicines for children.
The traditional Chinese medicine for treating the papular urticaria has various traditional Chinese medicine formulas, but most of the formulas use a large amount of traditional Chinese medicines for dispelling wind, killing parasites and eliminating pathogenic factors, and the dosage of the traditional Chinese medicines for dispelling blood and regulating qi is small, so that the treatment effect can be achieved, but the aim of comprehensively conditioning the physical condition of a patient cannot be achieved. Some formulas adopt a large number of different traditional Chinese medicines, wherein most of the traditional Chinese medicines have surplus and cannot fully exert the efficacy, but the medication cost is increased, and some traditional Chinese medicines are rare medicinal materials, so that the treatment cost is obviously increased.
Disclosure of Invention
Aiming at the current situation of treatment of the papular urticaria, the invention aims to provide a traditional Chinese medicine liniment for treating the papular urticaria, which has good effect and small side effect.
The invention relates to a traditional Chinese medicine liniment for treating papular urticaria, which comprises the following raw material medicines in parts by weight: 10-20 parts of mint, 10-20 parts of camphor, 20-40 parts of radix sophorae flavescentis, 10-20 parts of schizonepeta, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of purslane, 10-20 parts of perilla leaf, 10-20 parts of dried orange peel, 10-20 parts of radix puerariae and 10-20 parts of liquorice.
Further, the traditional Chinese medicine liniment for treating the papular urticaria is characterized by comprising the following components in parts by weight: the traditional Chinese medicine comprises the following raw material medicines in parts by weight: 15 parts of mint, 15 parts of camphor, 30 parts of radix sophorae flavescentis, 15 parts of schizonepeta, 15 parts of divaricate saposhnikovia root, 15 parts of purslane, 15 parts of perilla leaf, 15 parts of dried orange peel, 15 parts of radix puerariae and 15 parts of liquorice.
Further, the preparation method of the traditional Chinese medicine liniment for treating the papular urticaria, which is disclosed by the invention, comprises the following steps of:
step one, according to the weight parts of all raw materials in the traditional Chinese medicine liniment for treating the papular urticaria, mint, camphor, radix sophorae flavescentis, herba schizonepetae, radix sileris, purslane, perilla leaves, pericarpium citri reticulatae, radix puerariae and liquorice are respectively taken, mixed and crushed into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, putting the traditional Chinese medicine particles obtained in the step one into a glass container, adding ethanol water solution which is 3-4 times of the mass of the traditional Chinese medicine particles and has the volume concentration of 75-95%, uniformly mixing, carrying out ultrasonic treatment at the frequency of 15-30kHz for 20-40min, sealing the glass container, and soaking for 3-5 days to obtain a soaked mixture for later use;
step three, filtering the mixture obtained in the step two after soaking to obtain filtrate and filter residue; adding ethanol water solution with the volume concentration of 75-95% 1-2 times of the filter residue, mixing, and centrifuging to obtain supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath at the temperature of 50-60 ℃ for 20-30min, and cooling to room temperature to prepare the traditional Chinese medicine liniment for treating the papular urticaria.
Further, the traditional Chinese medicine liniment for treating the papular urticaria is a tincture.
The using method and the dosage of the traditional Chinese medicine liniment are determined according to the age, physical condition, mild symptoms and other factors of a patient, and are preferably as follows: the tincture is dipped with sterilized cotton swab and applied to the rash 3-4 times per day, and the application frequency can be properly reduced or increased according to the severity of symptoms. One week is a treatment course.
Has the advantages that:
1. the radix sophorae flavescentis and the divaricate saposhnikovia root have the effects of clearing heat, drying dampness, dispelling wind and killing insects; mint and schizonepeta herb have the effects of dispelling wind, relieving itching, promoting eruption and diminishing inflammation; the camphor can detoxify, avoid dirt, reduce swelling and relieve pain, and has mild local anesthetic effect; the liquorice tonifies the spleen and qi, clears away heat and toxic materials, can relieve the toxicity and the intensity of the medicines and blends the medicines; the dried orange peel and the purslane have the effects of clearing away heat and toxic materials, dissipating blood and eliminating swelling; su Ye can release exterior, dispel cold, regulate qi and harmonize nutrient; kudzuvine root can dispel pathogenic heat from yangming-warm disease. The medicines in the invention act synergistically, radix sophorae flavescentis and radix sileris are used for clearing heat and drying dampness, schizonepeta and radix puerariae are used for relieving itching, promoting eruption and diminishing inflammation, the radix sileris, mint and camphor are used for clearing body fluid and relieving pain, meanwhile, the dried orange peel and the purslane are used for dissipating blood and reducing swelling, and finally, the liquorice is used for harmonizing the medicines to play the functions of dissipating wind, activating blood, removing dampness and relieving itching together, so that the traditional Chinese medicine composition has a remarkable curative effect on papular urticaria, the cure rate reaches 98.67%, and the cure rate reaches 78.67% in one course of treatment, and has the characteristics of good curative effect, easiness in.
2. In the preparation process of the traditional Chinese medicine liniment for treating the papular urticaria, the ethanol extraction is adopted to reduce the leaching of impurities such as mucus, starch, protein and the like in the medicinal materials. The solubility of ethanol is between polar and non-polar, and can dissolve some components which are soluble in water and some components which are dissolved in a non-polar solvent. Ethanol also has pharmacological effects. However, when the concentration of ethanol is too high, water-soluble pigments, resins, etc. are not easily removed, and when the concentration of ethanol is too low, impurities such as polysaccharides, proteins, and inorganic salts are not easily removed. Therefore, the ethanol with the concentration of 75-95% is used as the solvent of the raw material medicines, so that the effective components can be separated out to a greater extent, and the treatment effect of the traditional Chinese medicine liniment for treating the papular urticaria is improved.
3. In the preparation process of the traditional Chinese medicine liniment for treating the papular urticaria, the raw material medicines are crushed into coarse particles, and are further crushed by ultrasonic waves, in the process, the special effects of strong vibration, high acceleration, strong cavitation effect, stirring and the like generated by the ultrasonic waves are utilized, the cells of the plant medicinal materials can be damaged, and the solvent permeates into the cells of the medicinal materials, so that chemical components in the medicinal materials are dissolved in the solvent, the treatment effect of the traditional Chinese medicine liniment for treating the papular urticaria is greatly improved, and the treatment period is obviously shortened.
Detailed Description
The present invention will be further described with reference to specific examples.
Example 1: a traditional Chinese medicine liniment for treating papular urticaria is prepared by the following steps:
step one, taking 10g of mint, 15g of camphor, 20g of radix sophorae flavescentis, 15g of herba schizonepetae, 15g of radix saposhnikoviae, 10g of purslane, 20g of perilla leaf, 10g of dried orange peel, 10g of radix puerariae and 10g of liquorice, mixing and crushing into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, putting the traditional Chinese medicine particles obtained in the step one into a glass bottle, adding 400ml of 75% ethanol, uniformly mixing, carrying out ultrasonic treatment for 20min by adopting 15kHz ultrasonic waves, sealing the glass bottle, and soaking for 3 days to obtain a soaked mixture for later use;
step three, filtering the soaked mixture obtained in the step two by using 500-mesh gauze to obtain filtrate and filter residues; adding 100ml of 75% ethanol into the filter residue, centrifuging for 2min at 200g, and collecting the supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath with the temperature of 55 ℃ for 20min, and cooling to room temperature to obtain the traditional Chinese medicine liniment for treating the papular urticaria.
Example 2: a traditional Chinese medicine liniment for treating papular urticaria is prepared by the following steps:
taking 15g of mint, 15g of camphor, 30g of radix sophorae flavescentis, 15g of herba schizonepetae, 15g of radix saposhnikoviae, 15g of purslane, 15g of perilla leaf, 15g of dried orange peel, 15g of radix puerariae and 15g of liquorice, mixing and crushing into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, filling the traditional Chinese medicine particles obtained in the step one into a glass bottle, adding 400ml of 95% ethanol, uniformly mixing, carrying out ultrasonic treatment for 20min by adopting 20kHz ultrasonic waves, sealing the glass bottle, and soaking for 3 days to obtain a soaked mixture for later use;
step three, filtering the soaked mixture obtained in the step two by using 500-mesh gauze to obtain filtrate and filter residues; adding 100ml of 95% ethanol into the filter residue, centrifuging for 2min at 200g, and collecting the supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath with the temperature of 55 ℃ for 30min, and cooling to room temperature to obtain the traditional Chinese medicine liniment for treating the papular urticaria.
Example 3: a traditional Chinese medicine liniment for treating papular urticaria is prepared by the following steps:
taking 15g of mint, 20g of camphor, 35g of radix sophorae flavescentis, 20g of herba schizonepetae, 20g of radix saposhnikoviae, 10g of purslane, 15g of perilla leaf, 20g of dried orange peel, 10g of radix puerariae and 10g of liquorice, mixing and crushing into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, filling the traditional Chinese medicine particles obtained in the step one into a glass bottle, adding 450ml of 80% ethanol, uniformly mixing, carrying out ultrasonic treatment for 30min by adopting 25kHz ultrasonic waves, sealing the glass bottle, and soaking for 4 days to obtain a soaked mixture for later use;
step three, filtering the soaked mixture obtained in the step two by using 500-mesh gauze to obtain filtrate and filter residues; adding 150ml of 80% ethanol into the filter residue, centrifuging for 2min at 200g, and collecting the supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath at 50 ℃ for 25min, and cooling to room temperature to obtain the traditional Chinese medicine liniment for treating the papular urticaria.
Example 4: a traditional Chinese medicine liniment for treating papular urticaria is prepared by the following steps:
step one, taking 20g of mint, 10g of camphor, 40g of radix sophorae flavescentis, 10g of schizonepeta, 10g of radix saposhnikoviae, 20g of purslane, 10g of perilla leaf, 20g of dried orange peel, 20g of radix puerariae and 20g of liquorice, mixing and crushing into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, filling the traditional Chinese medicine particles obtained in the step one into a glass bottle, adding 600ml of 85% ethanol, uniformly mixing, carrying out ultrasonic treatment for 25min by adopting 30kHz ultrasonic waves, sealing the glass bottle, and soaking for 5 days to obtain a soaked mixture for later use;
step three, filtering the soaked mixture obtained in the step two by using 500-mesh gauze to obtain filtrate and filter residues; adding 200ml of 85% ethanol into the filter residue, centrifuging 200g for 2min, and collecting the supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath at 60 ℃ for 20min, and cooling to room temperature to obtain the traditional Chinese medicine liniment for treating the papular urticaria.
And (3) clinical observation:
1. the treatment method comprises the following steps: the tincture is dipped with sterilized cotton swab and applied to the rash 3-4 times per day, and the application frequency can be properly reduced or increased according to the severity of symptoms. One week is a treatment course.
2. Treatment evaluation criteria: and (3) healing: the pruritus disappears, the rash subsides, and no recurrence occurs within 1 year. The method has the following advantages: the pruritus disappears, the rash subsides, and the rash recurs within 1 year. And (4) invalidation: itching is not continuous, new skin lesions are formed.
3. The treatment effect is as follows: after 75 cases of treatment, 70 cases (93.33%) were cured, 4 cases (5.33%) were effective, and 1 case (1.33%) was ineffective. One course of treatment is 59 cases (78.67%), 2-3 courses of treatment are 14 cases (18.67%), and 4 courses of treatment are 1 case (1.33%).
4. Clinical typical cases:
clinical case 1: yang Shi, female, 2 years old, head, face and limbs appeared red ball type small rash, which was extremely itchy and relieved after applying the medicine, and the symptoms disappeared after 1 week. After 3 weeks, the itching disappeared and the rash subsided. No relapse occurs in 1 year of follow-up visit after drug withdrawal.
Clinical case 2: wangzhi, female, age 12, red and small rash on limbs, extreme itching, remitting after applying the medicine and disappearance of symptoms after 1 week. After 3 weeks, the itching disappeared and the rash subsided. No relapse occurs in 1 year of follow-up visit after drug withdrawal.
Clinical case 3: tan Shi in China, male, 11 years old, red wheal-like papule from mung bean to peanut kernel in waist, small blister at the top, intolerable pruritus, symptom relief after medicine application, lasting medicine application for 1 week, pruritus disappearance, and skin rash crusting. After 3 weeks, the itching disappeared and the rash subsided. No relapse occurs in 1 year of follow-up visit after drug withdrawal.
Claims (2)
1. A traditional Chinese medicine liniment for treating papular urticaria is characterized in that: the traditional Chinese medicine comprises the following raw material medicines in parts by weight: 10-20 parts of mint, 10-20 parts of camphor, 20-40 parts of radix sophorae flavescentis, 10-20 parts of schizonepeta, 10-20 parts of divaricate saposhnikovia root, 10-20 parts of purslane, 10-20 parts of perilla leaf, 10-20 parts of dried orange peel, 10-20 parts of radix puerariae and 10-20 parts of liquorice;
the traditional Chinese medicine liniment for treating papular urticaria is prepared by adopting the following preparation method, and the preparation method comprises the following steps:
step one, according to the weight parts of all raw materials in the traditional Chinese medicine liniment for treating the papular urticaria, mint, camphor, radix sophorae flavescentis, herba schizonepetae, radix sileris, purslane, perilla leaves, pericarpium citri reticulatae, radix puerariae and liquorice are respectively taken, mixed and crushed into traditional Chinese medicine particles of 100 meshes and 200 meshes for later use;
step two, putting the traditional Chinese medicine particles obtained in the step one into a glass container, adding ethanol water solution which is 3-4 times of the mass of the traditional Chinese medicine particles and has the volume concentration of 75-95%, uniformly mixing, carrying out ultrasonic treatment at the frequency of 15-30kHz for 20-40min, sealing the glass container, and soaking for 3-5 days to obtain a soaked mixture for later use;
step three, filtering the mixture obtained in the step two after soaking to obtain filtrate and filter residue; adding ethanol water solution with the volume concentration of 75-95% 1-2 times of the filter residue, mixing, and centrifuging to obtain supernatant; mixing the obtained supernatant with the filtrate to obtain Chinese medicinal extractive solution, and placing in a glass container;
and step four, placing the glass container filled with the traditional Chinese medicine extracting solution in the step three in a water bath at the temperature of 50-60 ℃ for 20-30min, and cooling to room temperature to prepare the traditional Chinese medicine liniment for treating the papular urticaria.
2. The traditional Chinese medicine liniment for treating papular urticaria of claim 1, wherein: the traditional Chinese medicine comprises the following raw material medicines in parts by weight: 15 parts of mint, 15 parts of camphor, 30 parts of radix sophorae flavescentis, 15 parts of schizonepeta, 15 parts of divaricate saposhnikovia root, 15 parts of purslane, 15 parts of perilla leaf, 15 parts of dried orange peel, 15 parts of radix puerariae and 15 parts of liquorice.
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2016
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| CN102631647A (en) * | 2012-03-23 | 2012-08-15 | 王莲芬 | Chinese patent medicine mixture for treating acute urticaria |
| CN104258181A (en) * | 2014-09-22 | 2015-01-07 | 彭阳 | Traditional Chinese medicine preparation for treating acute urticaria |
| CN105287717A (en) * | 2015-12-07 | 2016-02-03 | 广东伊茗药业有限公司 | Externally applied preparation composition for treating mosquito bites and insect bites and preparation method of external preparation composition |
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