CN102836111B - 一种止汗组合物 - Google Patents

一种止汗组合物 Download PDF

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CN102836111B
CN102836111B CN 201210351547 CN201210351547A CN102836111B CN 102836111 B CN102836111 B CN 102836111B CN 201210351547 CN201210351547 CN 201210351547 CN 201210351547 A CN201210351547 A CN 201210351547A CN 102836111 B CN102836111 B CN 102836111B
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CN102836111A (zh
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谢玲艳
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Nantong Chuang Tao Trading Co., Ltd.
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Abstract

本发明提供一种止汗组合物，含有碳原子数为12-26的高级醇15-30份，具体为鲸蜡醇、硬脂醇、花生醇；含有分子量为400-2000的聚丙二醇3-15份；含有止汗剂20-30份，止汗剂是等份的海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂，并采用了相应的制备方法，该止汗组合物具有止汗的功效。

Description

一种止汗组合物
技术领域
本发明涉及化妆品技术领域，具体涉及一种止汗组合物。 
背景技术
止汗剂被广泛地使用，一般组合铝盐、钻盐、高级醇、挥发性聚硅氧烷等。但是，这样的止汗剂不能达到满足使用感的水平，尝试提高止汗除臭效果、并改善使用感。但是，人们还希望有更优异的止汗组合物，特别是利用传统中药。 
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供一种止汗组合物及其制备方法。 
技术方案：本发明的目的是通过如下的方案实现的： 
一种止汗组合物，含有下述组分(A)、(B)和(C)：(A)碳原子数为12-26的高级醇15-30份，具体为鲸蜡醇、硬脂醇、花生醇；(B)平均分子量为400-2000的聚丙二醇3-15份；(C)止汗剂20-30份。 
上述的止汗组合物，止汗剂是等份的海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂。 
上述止汗组合物，组分(B)是平均分子量为400-1000的聚丙二醇。 
有益效果： 
试验一、本发明对大鼠足跖部汗液分泌的影响 
1、仪器及试药本发明止汗组合物：按实施例3方法制备，大鼠灌胃器，注射器，针头，定时钟，具塞玻璃瓶(50m1)，断头台。毛果芸香碱溶液1mg/ml，10%甲醛溶液。 
2、试验动物Wistar大鼠，体重200±20g，雌雄兼用，清洁级。由上海斯莱克实验动物有限公司提供，生产许可证：SCXK(沪)2007-0005。 
3、大鼠20只，称重编号，随机分为两组，分别为毛果芸香碱组和本发明组，分别在足跖部涂抹毛果芸香碱溶液和本发明，给药后2小时，第四组于给药后1小时齐踝关节处瞬时截断双后肢，随即取下双足跖部肉垫皮肤和皮下组织各2-3.块，按常规方法固定、脱水、包埋、切片、HE染色，光学显微镜下观察各组大鼠足跖部汗腺上皮细胞内的变化，主要观察空泡的发生率，并进行计数比较，结果发现本发明对汗腺有一定的抑制作用。 
本发明对大鼠双足跖部汗腺上皮细胞形态学的影晌（χ±s，n=10） 
Figure 2012103515477100002DEST_PATH_IMAGE001
注：同模型组相比*p<0.05**<0.01 
空泡发生百分率=(空泡汗腺数/观察汗腺数)ｘ100% 
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。 
实施例1 
海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂，别取4份，粉碎，过100目筛，加鲸蜡醇15份，分子量为400的聚丙二醇3份，加热融化，混合均匀，即得。 
实施例2 
海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂，别取6份，粉碎，过100目筛，加花生醇30份，分子量为2000的聚丙二醇15份，加热融化，混合均匀，即得。 
实施例3 
海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂，别取5份，粉碎，过100目筛，加硬脂醇25份，分子量为1000的聚丙二醇8份，加热融化，混合均匀，即得。 
上述止汗剂中紫硇砂为卤化物类矿物类紫色石盐晶体Helite Violaceous，其余均为药典品种。 

Claims (2)

1.一种止汗组合物，其特征在于，含有下述组分(A)、(B)和(C)：(A)碳原子数为12-26的高级醇15-30份，具体为鲸蜡醇、硬脂醇、花生醇；(B)平均分子量为400-2000的聚丙二醇3-15份；(C)止汗剂20-30份，止汗剂是等份的海螵蛸、煅龙骨、煅牡蛎、明矾和紫硇砂。
2.如权利要求1所述的止汗组合物，其特征在于，组分(B)是平均分子量为400-1000的聚丙二醇。
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