CN102823860A - Xylo-oligosaccharide tablet and preparation method thereof - Google Patents
Xylo-oligosaccharide tablet and preparation method thereof Download PDFInfo
- Publication number
- CN102823860A CN102823860A CN201210327872XA CN201210327872A CN102823860A CN 102823860 A CN102823860 A CN 102823860A CN 201210327872X A CN201210327872X A CN 201210327872XA CN 201210327872 A CN201210327872 A CN 201210327872A CN 102823860 A CN102823860 A CN 102823860A
- Authority
- CN
- China
- Prior art keywords
- xylo
- tablet
- oligosaccharide
- preparation
- oligo saccharide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to the technical field of health-care products, in particular to a xylo-oligosaccharide tablet. The xylo-oligosaccharide tablet is prepared by the following raw materials by weight: 594.5g of xylo-oligosaccharide, 53.2g of dextrin, 68g of starch, 58g of lactose, 20.6g of magnesium stearate, 35g of talcum powder, and 170.7g of povidone, wherein relative weight-average molecular mass of povidone is 2000. A preparation method of the xylo-oligosaccharide tablet comprises the steps of: evenly mixing raw materials, spraying 90% ethanol solution for moisturizing, pelletizing, drying, granulating, and tableting, and each 1000g is sprayed with 120g of ethanol solution. The xylo-oligosaccharide tablet has high dissolution rate, high dissolving speed, and high bioavailability, and can enable xylo-oligosaccharide to play a more effective role in regulating intestinal flora. In addition, the xylo-oligosaccharide tablet also has the functions of relaxing bowels, promoting defecation, improving the immunity and resisting tumor.
Description
Technical field
The present invention relates to health product technology field, particularly a kind of Xylo-oligo saccharide tablet also relates to the preparation method of Xylo-oligo saccharide tablet.
Background technology
Xylo-oligosaccharide is claimed wood oligose again.Be by 2-7 wood sugar with β-1, the general name of the straight chain compound sugar of 4-glycosidic bond be combined into, active ingredient is xylobiose, xylotriose, Xylotetrose, wooden pentasaccharides etc., is main with xylobiose and xylotriose wherein.It is be rich in xylan plant be raw material, the outstanding functional oligose of one type of effect through biochemical method is produced has the function of significant propagation beneficial bacteria of intestinal tract, has become a kind of novel green food additives at present.
Xylo-oligosaccharide is one of kind that propagation Bifidobacterium function is the strongest in the polymerization carbohydrate; Its effect property is nearly 20 times of other polymerization carbohydrates; The enzyme that does not have the hydrolysis xylo-oligosaccharide in the human gastrointestinal tract; So it can directly get into and be preferably Bifidobacterium in the large intestine and utilize, promote Bifidobacterium propagation to produce multiple organic acid simultaneously.Reduce the enteron aisle pH value, suppress harmful bacteria growing, probio is bred at enteron aisle in a large number, reach above-mentioned health-care efficacy, the health care secret place of Here it is xylo-oligosaccharide.
At present, the health food of the adjusting gastrointestinal function of the overwhelming majority is that primary and secondary effect is bigger with traditional Chinese medicine ingredients on the market, and a large amount of eating can cause feeling sick, vomit, suffer from abdominal pain, suffering from diarrhoea, also visible dizziness, walking shakiness, facial numbness etc.
Tablet is meant medicinal substances extract, medicinal substances extract are added the disk shape that medicinal material fine powder or medicinal material fine powder and the compacting of proper auxiliary materials mixing form or the preparation of special-shaped sheet.Its advantage is: the dissolution rate and the bioavilability of tablet are better usually; Dosage is accurate, and medicament contg difference is less in the tablet; Steady quality, tablet are drying solid, and some easy oxidation deterioration and deliquescent medicine can borrow dressing protect, and light, air, moisture etc. are less to its influence; Take, carry, transportation etc. is more convenient; Mechanization is produced, and output is big, and cost is low, and sanitary standard reaches easily.
Relevant Xylo-oligo saccharide tablet is also arranged on the market, but its dissolution rate is low, dissolution velocity is slow, and bioavilability is low, has restricted its application.Like application number is 200510111263.0; Name is called the Chinese invention patent application of " Xylo-oligo saccharide tablet and preparation method thereof "; Use the compacting earlier of dolomol and superfine silica gel powder or silica to add the coating agent dressing then, but parameters such as dissolution velocity, dissolution rate are not measured in flakes.
Summary of the invention
Low in order to solve above existing Xylo-oligo saccharide tablet dissolution rate, dissolution velocity is slow, the problem that bioavilability is low, and it is high to the invention provides a kind of dissolution rate, and dissolution velocity is fast, the Xylo-oligo saccharide tablet that bioavilability is high.
The invention provides the preparation method of said Xylo-oligo saccharide tablet.
The present invention realizes through following measure:
A kind of Xylo-oligo saccharide tablet, process by following materials of weight proportions:
Xylo-oligosaccharide 594.5g, dextrin 53.2g, starch 68g, lactose 68g, dolomol 20.6g, talcum powder 35g, PVP 170.7g, the average weight-molecular mass of PVP are 2000.
The preparation method of described Xylo-oligo saccharide tablet mixes raw material, sprays 90% ethanolic solution and makes it moistening, granulates oven dry, whole grain, compressing tablet, every 1000g spray ethanolic solution 120g.
Process the tablet that specification is the 1.0g/ sheet.
Xylo-oligosaccharide is characterized in being difficult to the human consumption enzyme and decomposes, and stability is very good.Even (PH=2.5-7) is heated to 100 ℃ and also do not decompose basically under acid condition, and some functional oligose decomposes next being easy to of acid condition, thereby it promotes Bifidobacterium proliferation activity to reduce.Research shows, every day oral 0.7g, two week back large intestine Bifidobacteriums ratios be increased to 17.9% from 8.9%; Every day oral 1.4g, the ratio of a week back large intestine Bifidobacterium is increased to 33% from 9%; Every day oral 3.5g, the ratios of two week back large intestine Bifidobacteriums are increased to 21.7% from 3.7%.Can find out in the above-mentioned data that xylo-oligosaccharide can make Bifidobacterium breed in a large number significantly, make probio become the enteron aisle dominant bacteria, get rid of the purpose of harmful bacterium thereby reach.
Beneficial effect of the present invention: Xylo-oligo saccharide tablet dissolution rate of the present invention is high, and dissolution velocity is fast, and bioavilability is high, and the effect that can make xylo-oligosaccharide regulate gut flora is more effectively brought into play.In addition, the present invention also has relaxing bowel, improves immunity and antineoplastic action.
The specific embodiment
For a better understanding of the present invention, further specify below in conjunction with specific embodiment.
Embodiment:
A kind of Xylo-oligo saccharide tablet, process by following materials of weight proportions:
Xylo-oligosaccharide 594.5g, dextrin 53.2g, starch 68g, lactose 58g, dolomol 20.6g, talcum powder 35g, PVP 170.7g, the average weight-molecular mass of PVP are 2000.
Above-mentioned raw materials is mixed, spray 90% ethanolic solution and make it moistening, granulate, oven dry, whole grain, compressing tablet, every 1000g raw material spray ethanolic solution 120g.
Process the tablet that specification is the 1.0g/ sheet.
Usage and dosage: these article are tablet, suitable swallowing.Every day 1 time, each 2.
The dissolution velocity experiment:
Use the hanging basket method to measure:
Measure the purified water 900ml that handles through the degassing, inject in each process container, heating makes solvent temperature remain on 37 ± 0.5 ℃, and the adjustment rotating speed makes it stable.Getting the test sample input changes in the basket, will change basket and fall in the container, picks up counting immediately, an amount of in regulation sample point draw solution during to 45 minutes, filters through 0.8 μ m miillpore filter immediately, and being sampled to filtration certainly should accomplish in 30 seconds.Get filtrating, high effective liquid chromatography for measuring, chromatographic column is Shodex sugar KS-802 internal diameter 8mm, column length 300mm, the ion-type gel column of filler granularity 6um.
The Xylo-oligo saccharide tablet that optional the foregoing description prepares 6 (1.0g/ sheets) is as experimental group, chooses answering of selling on the market and faces 6 of smooth glad board Xylo-oligo saccharide tablets (0.39g/ sheet) as control group.The manufacturer that faces smooth glad board Xylo-oligo saccharide tablet again is a Shanghai Fuxing Linxi Medicine Industry Co., Ltd; With application number is that the applicant of 200510111263.0 patent is identical; And all be film coating agent, so, infer and commercially availablely face smooth glad board Xylo-oligo saccharide tablet again and be the above-mentioned product of applying for a patent.
Mensuration result is following:
Use and observe:
(1) Lee, the woman, 46 years old, constipation, depression, forgetful, absent minded, mood were prone to fluctuation, and tablet every day of taking that embodiment 1 makes 1 time, each 2, symptom is obviously improved after 10 days, and defecation is smooth and easy, and mood is steady.
(2) Wang, the woman, 55 years old, glutted after meal, the epigastric discomfort of apocleisis, gastric disorder causing nausea vomiting, tablet every day of taking that embodiment 1 makes 1 time, each 2, the gastric disorder causing nausea symptoms of emesis disappears after 3 days, after 5 days defaecation smooth and easy, feed is normal.
(3) Lee, the woman, 26 years old, face had acne, constipation, tablet every day of taking that embodiment 1 makes 1 time, each 2, to take continuously 15 days, face acne is eliminated gradually, and skin has clear improvement, and the constipation symptom is cured.
Claims (3)
1. Xylo-oligo saccharide tablet is characterized in that being processed by following materials of weight proportions:
Xylo-oligosaccharide 594.5g, dextrin 53.2g, starch 68g, lactose 58g, dolomol 20.6g, talcum powder 35g, PVP 170.7g, the average weight-molecular mass of PVP are 2000.
2. the preparation method of the described Xylo-oligo saccharide tablet of claim 1 is characterized in that raw material is mixed, and sprays 90% ethanolic solution and makes it moistening, granulates oven dry, whole grain, compressing tablet, every 1000g raw material spray ethanolic solution 120g.
3. preparation method according to claim 2 is characterized in that processing the tablet that specification is the 1.0g/ sheet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210327872XA CN102823860A (en) | 2012-09-07 | 2012-09-07 | Xylo-oligosaccharide tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210327872XA CN102823860A (en) | 2012-09-07 | 2012-09-07 | Xylo-oligosaccharide tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102823860A true CN102823860A (en) | 2012-12-19 |
Family
ID=47327330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210327872XA Pending CN102823860A (en) | 2012-09-07 | 2012-09-07 | Xylo-oligosaccharide tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102823860A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022036121A1 (en) * | 2020-08-12 | 2022-02-17 | Pharmavite, Llc | Prebiotic composition of pectin, beta-glucan, xylooligosaccharide and/or ashwagandha and a method of improving mood |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977850A (en) * | 2005-12-08 | 2007-06-13 | 上海复星临西药业有限公司 | Xylo-oligo saccharide tablet and its preparing method |
-
2012
- 2012-09-07 CN CN201210327872XA patent/CN102823860A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977850A (en) * | 2005-12-08 | 2007-06-13 | 上海复星临西药业有限公司 | Xylo-oligo saccharide tablet and its preparing method |
Non-Patent Citations (2)
| Title |
|---|
| 郑汝华: "《片剂的制备工艺和原理》", 30 September 1991 * |
| 黄朝霞: "粉末直接压片工艺的进展", 《现代食品与药品杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022036121A1 (en) * | 2020-08-12 | 2022-02-17 | Pharmavite, Llc | Prebiotic composition of pectin, beta-glucan, xylooligosaccharide and/or ashwagandha and a method of improving mood |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101829212B (en) | Buccal tablet and preparation method thereof | |
| CN103919920A (en) | Buccal tablet retaining original ecology of wolfberry fruits and preparation process thereof | |
| CN101007071A (en) | Traditional Chinese medicine for treating acute and chronic gastroenteritis and bacterial dysentery and its processing technology | |
| CN100401920C (en) | Diet fiber composition with intestine-nourishing constipation-releving functions and its production method | |
| WO2014183508A1 (en) | Biogas residue-containing formula feed for chicken | |
| CN101238851A (en) | Chinese medicinal composition for promoting growing and fattening of meat chicken and preparation thereof | |
| CN102552871B (en) | A kind of tannalbin yeast chewable tablet and production method thereof | |
| CN102823860A (en) | Xylo-oligosaccharide tablet and preparation method thereof | |
| CN101537037B (en) | Amaranth berberine tablet and preparation method thereof | |
| CN105249441A (en) | Folium mori health care product for reducing blood glucose and preparation method thereof | |
| CN101045080A (en) | Traditional Chinese medicine prpearation for treating acute pharyngitis and its prepairng method | |
| CN105145957B (en) | A kind of health-care herbal tea beverage improving oral ulcer and preparation method thereof and detection method | |
| CN107625852A (en) | A kind of clearing heat and promoting diuresis stagnation resolvation stop-band Chinese medicine composition and its preparation technology and application | |
| CN108743809B (en) | Throat clearing composition and preparation method and application thereof | |
| CN101292735A (en) | Sorbitol buccal tablet composition and preparing method thereof | |
| CN111466579A (en) | Probiotic inulin tablet and preparation method thereof | |
| CN102085271A (en) | Composition for protecting liver | |
| CN102232974A (en) | Preparation method of Chinese medicinal granule for poultry | |
| CN101589806A (en) | A kind of solid low-energy food that is rich in dietary fiber and polyethylene glycol and preparation method thereof | |
| CN101317659A (en) | Preparation method for high-efficiency composite food cellulose based on surface finish | |
| CN101664425A (en) | Poplar flower effervescent granules for treating avian colibacillosis and preparation method thereof | |
| CN1092656A (en) | Donkey-hide gelatin beverage and preparation method thereof | |
| CN100381152C (en) | Medicinal granules of nourishing Yin and tonifying stomach, capsule and tablet preparing method | |
| CN104561187A (en) | Preparation method and application of mannose oligomer of pastry food accessory | |
| CN100398114C (en) | Composition of stachyose and bee product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20121219 |