CN102822197A - 具有降低的免疫原性的bmp-7变体 - Google Patents

具有降低的免疫原性的bmp-7变体 Download PDF

Info

Publication number
CN102822197A
CN102822197A CN2010800643966A CN201080064396A CN102822197A CN 102822197 A CN102822197 A CN 102822197A CN 2010800643966 A CN2010800643966 A CN 2010800643966A CN 201080064396 A CN201080064396 A CN 201080064396A CN 102822197 A CN102822197 A CN 102822197A
Authority
CN
China
Prior art keywords
bmp
variant
variants
cell
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800643966A
Other languages
English (en)
Chinese (zh)
Inventor
M·E·帕特森
M·H·阿拉维-伊斯玛仪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of CN102822197A publication Critical patent/CN102822197A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2010800643966A 2009-12-22 2010-12-21 具有降低的免疫原性的bmp-7变体 Pending CN102822197A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28922009P 2009-12-22 2009-12-22
US61/289,220 2009-12-22
PCT/US2010/061437 WO2011087768A1 (en) 2009-12-22 2010-12-21 Bmp-7 variants with reduced immunogenicity

Publications (1)

Publication Number Publication Date
CN102822197A true CN102822197A (zh) 2012-12-12

Family

ID=43735952

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800643966A Pending CN102822197A (zh) 2009-12-22 2010-12-21 具有降低的免疫原性的bmp-7变体

Country Status (7)

Country Link
US (1) US20130190236A1 (https=)
EP (1) EP2516456A1 (https=)
JP (1) JP2013514811A (https=)
CN (1) CN102822197A (https=)
AU (1) AU2010341565A1 (https=)
CA (1) CA2785038A1 (https=)
WO (1) WO2011087768A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432423A (zh) 2014-09-26 2022-05-06 拉金德拉·萨哈伊·巴特纳格尔 用于治疗疾病和病症的NFkB活性的抑制剂
US10130678B2 (en) 2014-12-29 2018-11-20 Bioventus, LLC. Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2019148140A2 (en) * 2018-01-26 2019-08-01 Wu Joseph C Implantable biomaterials that enhance stem cell survival and function

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044838A2 (en) * 2003-11-03 2005-05-19 Genencor International, Inc. Cd4+ epitopes of bone morphogenetic proteins
WO2005097825A2 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
WO2009086131A1 (en) * 2007-12-21 2009-07-09 Stryker Corporation Bmp mutants with decreased susceptibility to noggin

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83003A (en) 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5011691A (en) 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
JPH06500466A (ja) 1990-06-15 1994-01-20 カーネギー インスチチューション オブ ワシントン Ｇｄｆ―１
US5656593A (en) 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5674844A (en) 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5849686A (en) 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6506729B1 (en) 1991-03-11 2003-01-14 Curis, Inc. Methods and compositions for the treatment and prevention of Parkinson's disease
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
DK0625989T3 (da) 1992-02-12 2000-06-26 Bioph Biotech Entw Pharm Gmbh DNA-sekvenser kodende for hidtil ukendte vækst-/differentieringsfaktorer
JPH08503198A (ja) 1992-11-03 1996-04-09 クリエイティブ バイオモレキュルズ，インコーポレイテッド Ｏｐ−３誘導形態形成
JP3645258B2 (ja) 1993-01-12 2005-05-11 ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 増殖分化因子−５
EP0678101A4 (en) 1993-01-12 1997-07-16 Univ Johns Hopkins Med FACTOR-9 OF GROWTH AND DIFFERENTIATION.
DK0690873T3 (da) 1993-03-19 2003-09-29 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-8
BR9406715A (pt) 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-11) polipeptideo de proteina-11 morfogenética de osso purificada (BMP-11) e molécula de DNA quimérica
EP0698095B1 (en) 1993-05-12 2004-04-28 Genetics Institute, LLC Bmp-10 compositions
CA2165776A1 (en) 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
EP0725796A4 (en) 1993-10-08 1999-12-01 Univ Johns Hopkins Growth differentiation factor-10
JP3300500B2 (ja) 1993-10-12 2002-07-08 新日本製鐵株式会社 疲労強度、降伏強度および被削性に優れる熱間鍛造用鋼の製造方法
DE4334646C1 (de) 1993-10-12 1994-09-29 Quinting Friedhelm Durchsichtige Analog-Zeituhr
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
DE69434651T2 (de) 1993-12-07 2007-03-08 Genetics Institute, Inc., Cambridge Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
IL114397A0 (en) 1994-07-01 1995-10-31 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF-beta-family
CA2194660C (en) 1994-07-08 2009-09-29 Se-Jin Lee Growth differentiation factor-11
WO1996014335A1 (en) 1994-11-07 1996-05-17 The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services Cartilage-derived morphogenetic proteins
US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US6846906B1 (en) 1998-10-07 2005-01-25 Stryker Corporation Modified proteins of the TGF-β superfamily, including morphogenic proteins
JP3762222B2 (ja) 1998-10-07 2006-04-05 ストライカー・コーポレーション 改変型ＴＧＦ−βスーパーファミリータンパク質
US6677432B1 (en) 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US8154581B2 (en) 2002-10-15 2012-04-10 Revolutionary Concepts, Inc. Audio-video communication system for receiving person at entrance
WO2005113585A2 (en) 2004-05-20 2005-12-01 Acceleron Pharma Inc. Modified tgf-beta superfamily polypeptides
ES2369629T3 (es) 2004-05-25 2011-12-02 Stryker Corporation Uso de op-1 para tratar defectos del cartílago.
WO2007087053A2 (en) 2005-12-22 2007-08-02 Centocor, Inc Bmp-7 variant compositions, methods and uses
US7659250B2 (en) * 2005-12-22 2010-02-09 Centocor, Inc. BMP-7 variant compositions, methods and uses
WO2008051526A2 (en) * 2006-10-23 2008-05-02 Stryker Corporation Bone morphogenetic proteins
WO2010117047A1 (ja) 2009-04-10 2010-10-14 株式会社ニコン 光学材料、光学素子、及びその製造方法
JP2011211450A (ja) 2010-03-30 2011-10-20 Victor Co Of Japan Ltd 立体映像表示装置、立体映像撮像装置および立体映像表示方法
US9507084B2 (en) 2010-12-03 2016-11-29 Ofs Fitel, Llc Single-mode, bend-compensated, large-mode-area optical fibers designed to accomodate simplified fabrication and tighter bends
US8886307B2 (en) 2012-01-30 2014-11-11 Medtronic, Inc. Adaptive cardiac resynchronization therapy
WO2013183270A1 (ja) 2012-06-07 2013-12-12 旭化成エレクトロニクス株式会社 位置検出装置
US9298469B2 (en) 2012-06-15 2016-03-29 International Business Machines Corporation Management of multiple nested transactions
US9405290B1 (en) 2013-01-17 2016-08-02 Kla-Tencor Corporation Model for optical dispersion of high-K dielectrics including defects
JP6154215B2 (ja) 2013-06-28 2017-06-28 株式会社日立国際電気 半導体装置の製造方法、基板処理装置およびプログラム
US9170581B2 (en) 2013-09-30 2015-10-27 Crown Equipment Limited Industrial vehicles with overhead light based localization
JP6541301B2 (ja) 2014-03-28 2019-07-10 キヤノン株式会社 ロボット装置、ロボット装置の制御方法、ロボット制御プログラム、及び記録媒体
US9411440B2 (en) 2014-08-22 2016-08-09 Qualcomm Incorporated Digital ultrasonic emitting base station
US9407762B2 (en) 2014-10-10 2016-08-02 Bank Of America Corporation Providing enhanced user authentication functionalities
US9412814B2 (en) 2014-12-24 2016-08-09 Taiwan Semiconductor Manufacturing Co., Ltd. Structure and formation method of FinFET device
US9400685B1 (en) 2015-01-30 2016-07-26 Huawei Technologies Co., Ltd. Dividing, scheduling, and parallel processing compiled sub-tasks on an asynchronous multi-core processor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044838A2 (en) * 2003-11-03 2005-05-19 Genencor International, Inc. Cd4+ epitopes of bone morphogenetic proteins
WO2005097825A2 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
WO2009086131A1 (en) * 2007-12-21 2009-07-09 Stryker Corporation Bmp mutants with decreased susceptibility to noggin

Also Published As

Publication number Publication date
CA2785038A1 (en) 2011-07-21
WO2011087768A1 (en) 2011-07-21
EP2516456A1 (en) 2012-10-31
JP2013514811A (ja) 2013-05-02
AU2010341565A1 (en) 2012-07-12
US20130190236A1 (en) 2013-07-25

Similar Documents

Publication Publication Date Title
JP5529754B2 (ja) Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体
TWI444475B (zh) 經設計之成骨蛋白類
US20140336114A1 (en) Buffers for Controlling the pH of Bone Morphogenetic Proteins
US9200048B2 (en) High activity growth factor mutants
US7026445B2 (en) Human SDF-5 protein and compositions
US6395883B1 (en) Soluble morphogenic protein complex compositions of matter
DE69333745T2 (de) Löslicher komplex morphogener proteine und zusammensetzungen davon
JP2004536056A (ja) Ｒａｎｋアンタゴニストの療法使用
US20130190236A1 (en) BMP-7 Variants with Reduced Immunogenicity
US20110224138A1 (en) Methods for treating pain induced by injuries and diseases of an articular joint
US9012401B2 (en) Growth factor mutants with improved biological activity
KR102404717B1 (ko) Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드
AU2017200239B2 (en) Designer osteogenic proteins
EP4452300A1 (en) Use of analog of c-type natriuretic peptide for the treatment of fgfr-related bone repair and bone formation impairment
Chen Recombinant human morphogenetic protein: its future role in spinal fusions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121212