CA2785038A1 - Bmp-7 variants with reduced immunogenicity - Google Patents

Bmp-7 variants with reduced immunogenicity Download PDF

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Publication number
CA2785038A1
CA2785038A1 CA2785038A CA2785038A CA2785038A1 CA 2785038 A1 CA2785038 A1 CA 2785038A1 CA 2785038 A CA2785038 A CA 2785038A CA 2785038 A CA2785038 A CA 2785038A CA 2785038 A1 CA2785038 A1 CA 2785038A1
Authority
CA
Canada
Prior art keywords
bmp
variant
protein
variants
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2785038A
Other languages
English (en)
French (fr)
Inventor
Marilyn Elizabeth Patterson
Moulay Hicham Alaoui-Ismaili
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Publication of CA2785038A1 publication Critical patent/CA2785038A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2785038A 2009-12-22 2010-12-21 Bmp-7 variants with reduced immunogenicity Abandoned CA2785038A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28922009P 2009-12-22 2009-12-22
US61/289,220 2009-12-22
PCT/US2010/061437 WO2011087768A1 (en) 2009-12-22 2010-12-21 Bmp-7 variants with reduced immunogenicity

Publications (1)

Publication Number Publication Date
CA2785038A1 true CA2785038A1 (en) 2011-07-21

Family

ID=43735952

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2785038A Abandoned CA2785038A1 (en) 2009-12-22 2010-12-21 Bmp-7 variants with reduced immunogenicity

Country Status (7)

Country Link
US (1) US20130190236A1 (https=)
EP (1) EP2516456A1 (https=)
JP (1) JP2013514811A (https=)
CN (1) CN102822197A (https=)
AU (1) AU2010341565A1 (https=)
CA (1) CA2785038A1 (https=)
WO (1) WO2011087768A1 (https=)

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* Cited by examiner, † Cited by third party
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CN114432423A (zh) 2014-09-26 2022-05-06 拉金德拉·萨哈伊·巴特纳格尔 用于治疗疾病和病症的NFkB活性的抑制剂
US10130678B2 (en) 2014-12-29 2018-11-20 Bioventus, LLC. Systems and methods for improved delivery of osteoinductive molecules in bone repair
WO2019148140A2 (en) * 2018-01-26 2019-08-01 Wu Joseph C Implantable biomaterials that enhance stem cell survival and function

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Also Published As

Publication number Publication date
WO2011087768A1 (en) 2011-07-21
EP2516456A1 (en) 2012-10-31
CN102822197A (zh) 2012-12-12
JP2013514811A (ja) 2013-05-02
AU2010341565A1 (en) 2012-07-12
US20130190236A1 (en) 2013-07-25

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20161221