CN102813753B - Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene - Google Patents
Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene Download PDFInfo
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Abstract
The invention relates to a nutritional food and a medicine, and especially relates to a composition which can alleviate the eye fatigue, improve the eyesight, reduce the blood fat and nourish the liver and the kidney, has no toxic side effects and is suitable for long-term taking. The composition comprises the following components, by weight, 100-900 parts of Cistanche deserticola or Cistanche deserticola, and one or several of 200-1000 parts of chrysanthemum, 200-2000 parts of taurine, 5-30 parts of lycopene or 5-30 parts of astaxanthin or 100-900 parts of grape pip, 2.5-15 parts of beta-carotene or a Dunaliella salina extract, and 6-30 parts of xanthophyll.
Description
Technical field
The present invention relates to nutraceutical and medicine, particularly relate to a kind of compositions that can alleviate eyestrain, improve vision, improving eyesight and effect for reducing blood fat.
Background technology
Along with TV, popularizing of microcomputer, stay up late in addition, tired, the bad shortage with eye custom and nutrient, cause visual deterioration, optic nerve fatigue, so that myopia, hypermetropia, increasing of the ophthalmics such as astigmatism, affect our quality of life, the Chinese Traditional Medicines of existing a lot of protection and treatment visual deterioration, as contain Herba Dendrobii, the Radix Rehmanniae, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Semen Plantaginis, Rhizoma Alismatis, Fructus Schisandrae Chinensis, the Rhizoma Anemarrhenae, the Chinese medicine of the compositions such as Cortex Phellodendri, but the alleviation of vision need to be very long a period of time, and this class medicine is taken for a long time and can be caused stomach discomfort, impact digestion waits side effect, be not suitable for long-term taking and the drawback such as be difficult for adhering to, also has beta-carotene, phylloxanthin, taurine, Flos Chrysanthemis etc. can improvement and vision protection and the material that has no side effect, but the effect of taking separately slowly, especially to often stay up late and chronic fatigue due to visual deterioration without obvious effect, very weak to the effect of fatigue alleviating.
Raising along with people's living standard, high fat kind food intake dose increases, the hobby of tobacco and wine, the rate that causes fat is soaring year by year, also have the quickening of rhythm of life, the increase of stress, diet and daily life irregular, cause physical function disorder, dysbolism of blood fat, make hyperlipidemia become epidemic diseases now.Research datas show in a large number, and hyperlipidemia is the risk factor of apoplexy, coronary heart disease, myocardial infarction, sudden death.In addition, hyperlipidemia is also an important risk factor that promotes hypertension, impaired glucose tolerance, diabetes.So must pay much attention to the harm of hyperlipidemia, positive prevention and treatment.The medicine of blood fat reducing has a lot, and Western medicine has lovastatin, pravastatin, aspirin, holds and cut down Ta Ting and atorvastatin etc.Chinese medicine class contains the Chinese medicine preparation such as Fructus Crataegi, Radix Scrophulariae, Rhizoma Polygoni Cuspidati, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Rhizoma Alismatis, Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, but the side effect of Western medicine lipid lowerers long-term taking is large, and Liver and kidney stomach function regulating is had to obvious side effect, is difficult for taking for a long time.Chinese medicine class taking dose is large, takes for a long time and also has obvious side effect, can cause discomfort, dyspepsia and the chronic lesion to Liver and kidney of stomach, and the many expenses of dose are large and patient such as is difficult for adhering at the defect.The lycopene in addition with antioxidation and lipid-reducing function, can slow down the development of cardiovascular disease, safety and having no side effect, but the effect of taking is separately slow, and the effect without conditioning viscera function, and hyperlipemia is conventionally with hepatic and renal function imbalance, deficient, organ function disorder causes again abnormalities of sugar/lipid metabolism, makes blood fat be difficult to decline.
To sum up, need a kind ofly to alleviate eyestrain, improve vision, improving eyesight and effect for reducing blood fat and have no side effect, be applicable to long-term taking and can nurse one's health the product of hepatic and renal function.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, a kind of function that can nurse one's health Liver and kidney when effectively alleviating eyestrain, improving vision, improving eyesight and effect for reducing blood fat is provided, strengthen and to improve the effect of vision or blood fat reducing, and have no side effect, be applicable to long-term taking, have the compositions of preventive and therapeutic action.Said composition is characterised in that and contains Herba Cistanches or Herba Cynomorii; and contain Flos Chrysanthemi and taurine, phylloxanthin, beta-carotene or TANZAOSU, lycopene or astaxanthin or wherein one or more of Semen Vitis viniferae; described compositions is by invigorating the liver and kidney and improve vision or effect for reducing blood fat combination; nursed one's health organ function; strengthened immunity, capability of resistance to radiation and the enhancing effect for reducing blood fat of eyes, and had no side effect and applicable long-term taking.
Liver and kidney is the major organs of each internal organs of dredging, Liver and kidney void can cause spleen YANG deficiency, make taste operation disorderly, the metabolic function of liver is not normal, lipid metabolism and transformation function are stagnated, cause wetting, expectorant, the pathological changes such as drink, with advancing age, the multinomial physiological function of body is also faded thereupon, liver wherein, renal function and carbohydrate metabolism, microcirculations etc. must be affected, occur that endocrine and lipid metabolism are chaotic, hepatic and renal function goes down, these factors have affected the normal composition of blood, and then broken the normal physicochemical characteristics of blood, make the proportion of blood, viscosity, there is change in osmotic pressuries etc., cause the change of blood self circulation law, gradually occur that hemorheological characteristics is abnormal.So conditioning hepatic and renal function is conciliation and improves the basic of blood viscosity.
Eye is first of face, close with relationship between Zang-Fu and channels-collaterals.The large puzzled opinion > of < < Ling Shu Miraculous Pivot or Divine Axis > says: " the essence of five ZANG-organs and six FU-organs gas is noted in order on all and smart for it." eye why look all things on earth, bright autumn hair, distinguishes color, all relies and moistens foster in vital essence.If internal organs imbalance of YIN and YANG, can cause oculopathy, and among internal organs, Liver and kidney is the closest with the relation of eye.The traditional Chinese medical science is said liver storing blood, has one's ideas straightened out in eye, and blood i.e. essence, and the bad store blood function that affects liver of liver function reduces its blood, and deficiency of liver-blood and can not nourishing in order causes the ophthalmics such as visual deterioration such as dry and astringent dim-sighted, the nyctalopia of eyes, myopia.Kidney storing essence, the raw marrow of essence, marrow leads in brain, in order system, leads in brain, and essence is the material base of the various functional activities of human body." order person, the essence of five ZANG-organs and six FU-organs also ".Kidney essense is by self-restraint edema with the liver involved, the physiology contact of upper Ji heart-fire and Jin Mu interpromoting relation in five elements, to each internal organs play moist, moisten foster effect, so nutrition eyes combine with adjusting and reinforcing liver and kidney function, be treatment and the ideal chose that prevents ophthalmic vision protection.
Herba Cistanches
Herba Cistanches is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche, has the function of kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Modern study protects the liver and improves sexual function effect, and kind has Herba Cistanches, Cistanche Tubulosa, Saline Cistanche Herb, Herba Boschniakiae Rossicae, Xinjiang Sha east Herba Cistanches, spends salt Herba Cistanches etc. in vain.
Herba Cynomorii
Herba Cynomorii, has another name called Herba Cynomorii, a kind of parasitic plant, medicine another name ground ball top, rust iron staff, Songaria Cynomorium Herb, useful smart Xing Yang, moisturizes nourishing muscle and tendon, large nourishing YIN gas, benefiting essence-blood, profit stool effect Herba Cynomorii and Herba Cistanches have play the same tune on different musical instruments wonderful, and the two is sweet in the mouth matter profit warm in nature all, returns kidney and large intestine channel, equal energy kidney-replenishing, nourishing kidney-yin, benefiting essence-blood, loosening bowel to relieve constipation, with the available insufficiency of kidney-YANG of controlling, the sexual impotence of blood and essence asthenia, infertile, soreness of the waist and knees, the unable grade of muscles and bones disease.
Flos Chrysanthemi
Flos Chrysanthemi, sweet, bitter, be slightly cold, Here it is medicine chrysanthemum, can be divided into 4 large classes medicine chrysanthemum, spends chrysanthemum, Flos Chrysanthemi, Flos Chrysanthemi flower and Flos Chrysanthemi four classes in vain, and Flos Chrysanthemi is returned lung, Liver Channel, loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.Medicinal part: head inflorescence effective ingredient: Flos Chrysanthemi flavone.
Beta-carotene
Beta-carotene is a kind of green and yellow vegetable of being extensively present in, the natural carotenoid in fruit.Beta-carotene is joined end to end and is formed by the two keys of 4 isoprene, belongs to tetraterpenes compound, respectively has 1 β-purple trailing plants ketone ring at the two ends of molecule, and center burst can produce 2 vitamin A molecules, has conjugation between a plurality of pairs of keys and two key.Beta-carotene can be produced by chemosynthesis, plant extract and 3 kinds of methods of microorganism fermentation, according to mode of production difference, is divided into chemosynthesis beta-carotene and the large class of natural beta-carotin two.
Beta-carotene has the title of vitamin a source, is a kind of important human body physiological function active substance.There are protection eyes, improve the multiple efficacies such as vision, removing toxic substances, antioxidation.
Phylloxanthin
Phylloxanthin is a kind of important antioxidant, a member for carotenoid family (the natural fat-soluble pigment of finding in one group of plant), have another name called " plant progesterone ", at occurring in nature and zeaxanthin, jointly exist, at present, on market, the phylloxanthin of selling is mainly derived from the deep processing of fresh Flos Tagetis Erectae.Phylloxanthin is one of main pigment forming eye retina macular region; human body cannot be manufactured; must be by being rich in the meal supplement of phylloxanthin; phylloxanthin is as antioxidant and photoprotection; can promote the regeneration of rhodopsin in retina cell; laser high myopia and detachment of retina can be prevented, and vision, vision protection can be promoted.
Taurine
Taurine claims again beta-amino ethyl sulfonic acid, separates the earliest, therefore gain the name in Calculus Bovis.Taurine has different physiological roles, is the requisite a kind of nutrient of health.The rich content of taurine in brain, widely distributed, can obviously promote the nervous system especially growth promoter of optic nerve and cell proliferation, differentiation, and be dose dependent, in cranial nerve cell growth course, plays an important role.In the mankind's eye retina, also have a large amount of taurines, so supplementation of taurine is also most important for people's eyes.If lack taurine, can cause its retinal degeneration, long-term lacking, eventually to blind.So ophthalmic can be prevented and treat to supplementation of taurine, protection eyes and vision enhancing effect.
Lycopene
Lycopene is a kind of of carotenoid, due to the earliest from Fructus Lycopersici esculenti separation make, therefore claim " lycopene ".The oxidation resistance of lycopene is 3.2 times of carotene, is 100 times of vitamin E, and human body cannot be manufactured lycopene, need from meals, absorb, and lycopene is playing an important role aspect reduction lipoprotein oxidation.It is reported, oral natural lycopene, can make serum cholesterol be down to below 5.20 mM/ls, and lycopene is used for preventing and treating hypercholesterolemia and hyperlipidemia, can slow down the development of cardiovascular disease.Lycopene can be removed the free radical in human body most effectively, keeps cell homergy, anti-aging in advance.
Astaxanthin
Astaxanthin is from river crayfish shell, and a kind of Red carotenoids of finding in Concha Ostreae and salmon can be with protein bound blue or green, blue in vivo.Similar with lycopene, there are equally antioxidation, blood fat reducing, the effect of prevention cardiovascular and cerebrovascular disease.
TANZAOSU
Halophila Chlorophyta, Chlorophyceae, volvocales, salt alga section, Halophila, is a kind of unicellular Eukaryotic Algae, is one of eukaryote of the salt tolerant found up to now, is also life entity blank the earliest.Nineteen ninety, world NI classified algae extrats bata-carotene as the core theme of meeting in the research of the wide application of medical circle, thereby had caused showing great attention to of the interior medical expert of worldwide and expert's biology.Associated Press in 1991 classifies the effect of algae extrats bata-carotene as the third-largest scientific and technological engineering in the large science and technology in the world ten then., in TANZAOSU, being rich in the required multiple natural nutrient of health as materials such as beta-carotene, TANZAOSU can obviously improve body disease-resistant, immunity and antioxidation, prevents and treats cataract, improve vision.
Semen Vitis viniferae
Grape seed extract OPC has superpower oxidation resistance, 50 times of vitamin e, energy delaying aging, prevention of arterial sclerosis, also the title that has skin vitamin, is 20 times of vitamin C, and research is found, Semen Vitis viniferae extract has the free radical of removing, antioxidation, blood fat reducing, blood pressure lowering, suppresses the formation effect of thrombosis.
According to the present invention; a kind of compositions is provided, has comprised: the lycopene of the Flos Chrysanthemi of the Herba Cistanches of 100-900 weight portion or Herba Cynomorii and 200-1000 weight portion and the taurine of 200-2000 weight portion, 5-30 weight portion or the Semen Vitis viniferae of 5-30 weight portion astaxanthin or 100-900 weight portion are, the phylloxanthin of the beta-carotene of 2.5-15 weight portion or TANZAOSU, 6-30 weight portion, wherein one or more.Described compositions has the effect of alleviating eyestrain, improving vision, improving eyesight and blood fat reducing, and the compositions that has no side effect of applicable long-term taking.
According to an aspect of the present invention, compositions of the present invention can be applicable to medicine, such as making pharmaceutically acceptable all solid-state or liquid dosage forms such as tablet, capsule, granule, powder, unguentum, pill, oral liquid and teabag.Said composition realizes above-mentioned all kinds of dosage form adjuvant used and consumption is acceptable in dosage form and meets national adjuvant and the consumption that food additive is added to standard.
According to an aspect of the present invention, compositions of the present invention also can be applicable to food, for example, for take oil as basic food, as margarine, mayonnaise, peanut butter, or for water sample food, fruit drink for example, sports drink and bland etc., and add all kinds of Mel, sugar, various pollen, all kinds of Folium Camelliae sinensis and tea polyphenols, all kinds of nuts, in fruit and mixed grain rice, as Semen Juglandis, Semen Sesami, Semen arachidis hypogaeae, Semen Armeniacae Amarum, Semen sojae atricolor, Semen setariae, Semen Phaseoli, Fructus Jujubae, Fructus anacardii, Passifolra edulis, Arillus Longan, Fructus Vitis viniferae, in Semen Ziziphi Spinosae etc., make and can improve vision or blood fat reducing and the functional food of the effect of invigorating blood circulation.
In a specific embodiment, described Herba Cistanches is selected from orobanchaceae plant cistanche class, Cistanche Tubulosa, Saline Cistanche Herb, Herba Boschniakiae Rossicae, Xinjiang Sha east Herba Cistanches, spend a kind of in salt Herba Cistanches etc. in vain, comprise the former raw material of its Herba Cistanches, Herba Cistanches extract, its physiologically acceptable salt and derivant thereof.
In a specific embodiment, described Herba Cynomorii comprises the former raw material of Herba Cynomorii, Herba Cynomorii extract, its physiologically acceptable salt and derivant thereof.
In a specific embodiment, the Flos Chrysanthemi of telling comprises spends chrysanthemum, Flos Chrysanthemi, Flos Chrysanthemi flower and Flos Chrysanthemi in vain, comprises the former raw material of its Flos Chrysanthemi, Flos Chrysanthemi extract, its physiologically acceptable salt and derivant thereof.
In a specific embodiment, the phylloxanthin of telling also, containing the Flos Tagetis Erectae of phylloxanthin, comprises its primary raw material, Flos Tagetis Erectae extract, its physiologically acceptable salt and derivant thereof.
According to a further aspect in the invention, compositions of the present invention also can contain Fructus Lycii, Armillaria mellea, Flos Jasmini Sambac, Semen Cassiae, Radix Notoginseng, Folium Ginkgo, the Radix Astragali, Radix Codonopsis or Radix Ginseng or Radix Panacis Quinquefolii, Radix Angelicae Sinensis, Herba Melissae officinalis, Flos Osmanthi Fragrantis, wherein one or more of lavandula angustifolia.Fructus Lycii has invigorating the liver and kidney, blood-enriching tranquillizing, and promoting the production of body fluid to quench thirst effect, has synergism with Herba Cistanches, is of value to and improves vision and conditioning cardiovascular and cerebrovascular vessel; Soothing the liver, regulating the flow of Qi and the middle Jiao effect that Flos Jasmini Sambac has, can alleviate the greasy property of Herba Cistanches, has inflammation-dimishing and eye brightening effect simultaneously; Semen Cassiae clearing away heat and cooling blood, can alleviate the warm-heat effect of Herba Cistanches; The effect of invigorating blood circulation of Radix Notoginseng and Folium Ginkgo, can improve the blood circulation of eye and brain, promotes its recovery; The Radix Astragali, Radix Codonopsis or Radix Ginseng or Radix Panacis Quinquefolii and Radix Angelicae Sinensis have the effect of benefiting qi and nourishing blood, can supplement eyes and brain nutrition, make it be difficult for more afterwards recurrence; Armillaria mellea, lavandula angustifolia have the effect of the suppressing the hyperactive liver that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., removing obstruction in the collateral to relieve pain, can alleviate the dizziness headache that visual deterioration and hyperlipidemia etc. cause; Asthenia and dizzy symptom that the fragrant refreshment of Herba Melissae officinalis and Flos Osmanthi Fragrantis, relieving spasm to stop pain effect can contribute to alleviating asthenopia and cerebral anoxia to cause.
According to another aspect of the invention, compositions of the present invention also can contain one or more and derivant thereof of multivitamin, trace element, aminoacid, albumen, peptide apoplexy due to endogenous wind, vitamin comprises: vitamin B1, B2, B12, B6, vitamin C, vitamin E, vitamin AD, folic acid etc.; Trace element comprises: ferrum, zinc, copper, selenium, magnesium etc.; Albumen, aminoacid, peptide class comprise all kinds of animal and vegetable protein and Chicken Albumin, immunoglobulin, metallothionein (MT), earthworm protein (fibrin thrombolytic enzyme), ferritin, casein, phycocyanin, nucleic acid, aminoacids complex, aspartic acid, lysine, polypeptide, dipeptides, glutathion, blood pressure lowering peptide.Because vitimin supplement, trace element and immune protein can improve the nutrition of body and strengthen immunologic function, be conducive to the recovery of disease.
Present composition the kidney invigorating and liver heat removing and eyesight improving, nutrition eyes or antioxidation blood fat reducing are combined; mend-clear-adjust-foster combination; strengthened it and alleviated the effect of eyestrain, improving eyesight and blood fat reducing, and strengthened hepatic and renal function, made the sufficient operation of its essence and blood strong; that each internal organs play is moist, moisten foster effect; strengthened lipid metabolism and transformation function, made eyes obtain more effectively nourishing and protection, make blood fat fast and safety fall back to normal level; and safely, have no side effect, be applicable to long-term taking.
The specific embodiment
By the following examples, further illustrate the present invention, yet experimental example of the present invention and embodiment are only for illustrating the present invention, should by any way described embodiment is not interpreted as the scope of the invention is limited.
Unless otherwise indicated, the present invention's each composition raw material used is commercial available.
The preparation of embodiment 1 present composition
Utilizing the material of listing in following table is raw material, and evenly mixing can be prepared some compositionss of the present invention.It should be understood that the additive-based required adjuvant of available prior art as required makes the composition product of pharmaceutically acceptable all solid-state or liquid dosage forms such as tablet, capsule, granule, powder, cream, ball, oral liquid and teabag.
| Example | Raw material |
| 1 | 100 grams of Herba Cistanches extracts; 2000 grams of taurines; 2000 grams of Flos Chrysanthemi extracts |
| 2 | 900 grams of Herba Cistanches extracts; 200 grams of taurines; 200 grams of Flos Chrysanthemi extracts |
| 3 | 400 grams of Herba Cistanches extracts; 1000 grams of taurines; 1000 grams of Flos Chrysanthemi extracts |
| 4 | 100 grams of Herba Cistanches extracts; 30 grams of phylloxanthins |
| 5 | 900 grams of Herba Cistanches extracts; 6 grams of phylloxanthins |
| 6 | 400 grams of Herba Cistanches extracts; 15 grams of phylloxanthins |
| 7 | 100 grams of Herba Cistanches extracts; 15'-dioxygenase gram |
| 8 | 900 grams of Herba Cistanches extracts; 2.5 grams of beta-carotene |
| 9 | 400 grams of Herba Cistanches extracts; 10 grams of beta-carotene |
| 10 | 100 grams of Herba Cistanches extracts; 30 grams of lycopenes |
| 11 | 400 grams of Herba Cistanches extracts; 12 grams of lycopenes |
| 12 | 900 grams of Herba Cistanches extracts; 5 grams of lycopenes |
Embodiment 2 present compositions are alleviated eyestrain and are acted on experiment
Clinical data: choose 32 routine patients, male 20 examples, female's 12 examples, 18 years old 9 example, 35 years old 16 example, 46-55 year 7 examples; Occupation: teacher's 7 examples, student's 16 examples, 6 examples that crash, peasant's 9 examples; Myopia 20 examples, hypermetropia 6 examples, astigmatic 6 examples; Intraocular pressure 32 examples are all normal, with slight dizziness, and blurred vision, eye muscle strength is weak uneven; Course of disease elder 3 years, short person 6 days.Method: above 32 routine patients are divided into 4 groups at random, is respectively of the present invention group of 24 examples, divides 3 groups, every group of compositions that gives respectively example 1,2,3 preparations of the present invention, and dosage, for everyone 2 grams/day, is taken at twice; Matched group 8 examples, compositions for Flos Chrysanthemi extract and taurine, ratio and preparation be with ratio and the preparation method of this example 1,2,3 ZHONGJUHUA and taurine, and dosage is for observing therapeutic outcome after 30 days for everyone 2 grams/day: cure as transference cure 50 minutes above no abnormalities feels of continuous operation; Effectively for symptom, substantially disappear, continuous operation is effectively remission without significant discomfort sense in 25 minutes, 10 minutes no abnormalities feels of continuous operation; Invalid unchanged for symptom after medication, the results are shown in Table 1
Table 1 present composition is alleviated the Comparison of therapeutic of eyestrain's effect
Conclusion: the present composition is obviously better than matched group.
Embodiment 3 present compositions improve vision effect experiment
Clinical data: choose 48 routine patients, male 29 examples, 58 eyes, female's 19 examples, 36 eyes, age 34-50 year, occupation: teacher's 23 examples, student's 17 examples, peasant's 8 examples; Myopia 20 examples, hypermetropia 15 examples, astigmatic 13 examples; Intraocular pressure 48 examples are all normal, and statistics is logarithmic visual acuity chart and criterion, course of disease elder 2 years, and short person 6 days, all case table of logarithm detect as≤2 row.Method: above 48 routine patients are divided into 4 groups at random, is respectively of the present invention group of 36 examples, divides 3 groups, every group of 12 examples, give respectively in example 4,5,6 of the present invention the compositions of preparation, and dosage is that example 4 is everyone 130 mg/day, 5,6 groups of examples, for everyone 500 mg/day, are taken at twice; Matched group 12 examples, are independent phylloxanthin group, and dosage is 20 mg/day, take at twice and within 30 days, observe afterwards the line number variation that the rear vision for the treatment of improves, and cure: >=6 row, and effective: 4-5 is capable, effectively: >=3 row are invalid :≤2 row; In Table 2
Table 2 present composition improves the Comparison of therapeutic of vision effect
Conclusion: the present composition is obviously better than matched group, illustrates that the present composition is better than independent phylloxanthin group.
Embodiment 4 present composition Herba Cistanchess and phylloxanthin combination improve vision effect experiment
Clinical data: choose 40 routine patients, male 20 examples, 49 eyes, female's 20 examples, 48 eyes, age 26-49 year, occupation: teacher's 21 examples, 9 examples that crash, peasant's 10 examples; Myopia 17 examples, hypermetropia 7 examples, astigmatic 16 examples; Intraocular pressure 40 examples are all normal, and statistics is logarithmic visual acuity chart and criterion, course of disease elder 2 years, and short person 6 days, all case table of logarithm detect as≤2 row.Method: above 48 routine patients are divided into 4 groups at random, is respectively of the present invention group of 36 examples, divides 3 groups, gives respectively the compositions of preparation in example 7,8,9 of the present invention, and dosage is example 7 everyone 150 mg/day, and example 8,9 everyone 500 mg/day, take at twice; Matched group 12 examples, are independent phylloxanthin group, and dosage is 15 mg/day, takes at twice; Within 30 days, observe afterwards the line number that vision improves after treatment and change, during treatment, avoid long-time reading, see TV, online, avoid and eat maror, cure: >=6 row, effective: 4-5 is capable, effectively: >=3 row are invalid :≤2 row; In Table 3
Table 3 present composition improves the experiment of vision effect contrast
| Group | Number of cases | Natural law | Dosage/day | Recovery from illness | Effective | Effectively | Invalid | Total effective rate % |
| Matched group | 10 | 30 | 15 milligrams | 2 | 2 | 1 | 5 | 50 |
| 7 groups of examples | 10 | 30 | 150 milligrams | 3 | 3 | 1 | 3 | 70 |
| 8 groups of examples | 10 | 30 | 500 milligrams | 4 | 2 | 2 | 2 | 80 |
| 9 groups of examples | 10 | 30 | 500 milligrams | 4 | 3 | 2 | 1 | 90 |
Conclusion: the present composition is obviously better than matched group, illustrates that the present composition is better than independent phylloxanthin group.
The effect for reducing blood fat experiment of embodiment 5 present compositions
Clinical data: choose this experimental example 88 examples, be divided at random 4 groups, of the present invention group totally 3 groups is respectively 10,11,12 groups of examples, every group of 22 examples, sex: female's 30 examples, male 36 examples, the course of disease was at 6 months-3 years; 1 group of 22 example of matched group, female's 9 examples, male 13 examples, age 50-73 year, the course of disease 7 months-2 years; Method is, matched group gives everyone 20 milligrams/day of single product lycopene groups, take at twice, of the present invention group of compositions that gives respectively preparation in example 10,11,12,10 groups everyone 125 milligrams/day, 11,12 groups everyone 500 milligrams/day of examples, take at twice, it is 1 course for the treatment of that each group is 30 days, after 2 courses for the treatment of, adds up curative effect.All cases all meet the standard of the Chinese cardiovascular magazine of < < > > aberrant angiogenesis Preventing Countermeasures special topic group < < aberrant angiogenesis control suggestion > > in 1997 formulation above: under normal diet, twice lipids detection in 3 weeks, being diagnosed as the one that meets following condition can make a definite diagnosis: 1. blood fat T-CHOL (TC) > 5.72mmol/L; 2., triacylglycerol (TG) < 1.70mmol/L; 3. HDL-C (HDL-C) < 1.04mmol/L; Get rid of the hypercholesterolemia patient of family and in 5 months, using the patient who affects blood lipid metabolism medicine.Efficacy determination: effective is lipids detection TC decline >=20% or TG decline >=40% or HDL-C rising >=0.26mmol/L.Effective: lipids detection TC decline >=10% or TG decline >=20% but < 40% or HDL-C rising >=0.103mmol/L but < 0.26mmmol/L.Invalid for not reaching effective standard.Comparison of therapeutic is in Table 4
The effect for reducing blood fat Comparison of therapeutic of table 4 present composition
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate % |
| Matched group | 22 | 7 | 6 | 9 | 59.09 |
| 10 groups of examples | 22 | 7 | 10 | 5 | 77.27 |
| 11 groups of examples | 22 | 9 | 10 | 3 | 86.36 |
| 12 groups of examples | 22 | 8 | 10 | 4 | 81.81 |
Result: of the present invention group of curative effect is better than matched group.
Other embodiment
Utilize the experiment of other proportionings repetitions embodiment 2-5 in the scope of the invention, contrast with corresponding reference examples, all can obtain identical/similar result (data are not shown), compositions of the present invention is alleviated eyestrain, order and blood fat reducing (data are not shown).
The present invention only be take above-described embodiment and is set forth as example, and other proportionings of the concrete proportioning shown in embodiment and the unshowned present composition all can be used for the present invention and they all can realize technique effect of the present invention.
Claims (2)
1. the blurred vision that the compositions of being prepared by Herba Cistanches extract, taurine and Flos Chrysanthemi extract is caused by eye muscle strength imbalance in preparation treatment, the application in asthenopic medicine, wherein in compositions, the content of Herba Cistanches extract is 400g, taurine 1000g, Flos Chrysanthemi extract 1000g.
2. application as claimed in claim 1, the dosage form of wherein said medicine is capsule, granule, powder, unguentum, oral liquid or teabag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159682.1A CN102813753B (en) | 2012-05-22 | 2012-05-22 | Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210159682.1A CN102813753B (en) | 2012-05-22 | 2012-05-22 | Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102813753A CN102813753A (en) | 2012-12-12 |
| CN102813753B true CN102813753B (en) | 2014-02-26 |
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| CN201210159682.1A Expired - Fee Related CN102813753B (en) | 2012-05-22 | 2012-05-22 | Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103380839A (en) * | 2013-06-29 | 2013-11-06 | 安徽皖山食品有限公司 | Eye-protecting tea drink and preparation method thereof |
| CN103446569A (en) * | 2013-09-05 | 2013-12-18 | 李树森 | Formula and preparation method of astaxanthin with thrombolysis effect |
| CN104041822A (en) * | 2014-07-03 | 2014-09-17 | 吴润瑞 | Composition with health care effect and preparation method of composition |
| TWI650131B (en) * | 2014-07-03 | 2019-02-11 | 杏輝藥品工業股份有限公司 | Cistanche tubulosa extract for the preparation of medicines or foods for the protection of ocular cells |
| CN104783181A (en) * | 2015-04-10 | 2015-07-22 | 钱绍祥 | Astaxanthin-containing composition and preparation method thereof |
| CN105233274A (en) * | 2015-09-30 | 2016-01-13 | 孟令刚 | Oral composition containing cistanche and enzymes |
| CN105124339A (en) * | 2015-10-21 | 2015-12-09 | 吉林省普蓝高科技有限公司 | Blueberry fruitcake used for relieving asthenopia and preparing technology thereof |
| CN109288051A (en) * | 2017-12-01 | 2019-02-01 | 天津地天科技发展有限公司 | A kind of Ricipe for health care food of cordyceps and ginseng prevention kind tumor seven kinds of raw materials of anti-aging |
| CN108308493A (en) * | 2018-01-25 | 2018-07-24 | 江苏神华药业有限公司 | A kind of anti-fatigue solid beverage and preparation method of astaxanthin-containing |
| CN109007635A (en) * | 2018-08-13 | 2018-12-18 | 万光瑞 | A kind of improving eyesight benefit brain composition and the preparation method and application thereof |
| CN111053248A (en) * | 2018-10-16 | 2020-04-24 | 东莞市维康医疗投资有限公司 | Earthworm protein oral liquid and preparation method thereof |
| CN109331143B (en) * | 2018-10-30 | 2022-07-08 | 河西学院 | A herba cistanches Deserticolae composition and its preparation method |
| CN111686169A (en) * | 2019-03-11 | 2020-09-22 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition with function of relieving visual fatigue and preparation method and application thereof |
| CN111450200A (en) * | 2020-04-21 | 2020-07-28 | 富诺健康股份有限公司 | Composition with function of relieving visual fatigue and preparation method thereof |
| CN113261619A (en) * | 2021-05-07 | 2021-08-17 | 天津朗诺宠物食品有限公司 | Freeze-dried tear mark removing staple food for pet cats and preparation method thereof |
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| CN102188604A (en) * | 2010-03-09 | 2011-09-21 | 贺光民 | Medicament for treating myopia and presbyopia |
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| CN101081049A (en) * | 2006-06-02 | 2007-12-05 | 王耀锋 | Green grape health tea |
| CN102188604A (en) * | 2010-03-09 | 2011-09-21 | 贺光民 | Medicament for treating myopia and presbyopia |
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