CN103446569A - Formula and preparation method of astaxanthin with thrombolysis effect - Google Patents
Formula and preparation method of astaxanthin with thrombolysis effect Download PDFInfo
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- CN103446569A CN103446569A CN2013103984489A CN201310398448A CN103446569A CN 103446569 A CN103446569 A CN 103446569A CN 2013103984489 A CN2013103984489 A CN 2013103984489A CN 201310398448 A CN201310398448 A CN 201310398448A CN 103446569 A CN103446569 A CN 103446569A
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Abstract
The invention discloses a formula of astaxanthin with thrombolysis effect. The formula of staxanthin with thrombolysis effect comprises the following components by weight: 50mg of astaxanthin, 300g of ginger, 300g of garlic, 150g of lemon, 300g of apple vinegar and 300g of honey. The preparation method comprises the following steps of: peeling and dicing ginger, peeling garlic, mixing and the ginger and garlic and squeezing into juice; dicing lemon and squeezing into juice; mixing the ginger-garlic juice with lemon juice and stirring; adding apple vinegar and evenly mixing; heating and boiling the juice obtained in the step II; simmering, evaporating the juice to be half, and adding honey; dissolving 50mg of astaxanthin by using 90% alcohol, and adding the mixed liquid and stirring; coding and encasing. According to the formula of astaxanthin with thrombolysis effect and the preparation method thereof, the manufacturing cost is low, the economic pressure of factories and patients can be lowered, the pain of patients, caused by taking the medicine can be eliminated, the disease can be treated and the health-care purpose can be reached.
Description
Technical field
The invention belongs to thrombolytic medicine Development Techniques field, relate in particular to a kind of astaxanthin formula and preparation method with thrombolytic effect.
Background technology
Thrombosis is that blood flow is at the formed fritter in the surface of the inner face exfoliation of cardiovascular system blood vessel or mend.In variable fluid dependent form (variable flow dependent patterns), thrombosis is by insoluble fibrin, the platelet of deposition, the leukocyte gathered and the erythrocyte be absorbed in form, thrombosis is a kind of process that relates to the multifactor variation of many h and E factors interact with each other, the common patient to thrombosis quality clinically, topmost characteristics are that family history is arranged, repeated relapsing, youth, the outbreak seriousness of symptom and thrombosis position unusual.
The clinical research of arteriosclerosis and related cardiovascular disease shows, the oxidation of low density lipoprotein, LDL (LDL) is to cause arteriosclerotic major reason, in human body, LDL concentration is higher, platelet deposition makes the blood vessel obstruction blood flow rate that attenuates in addition, it is just larger that human body is suffered from arteriosclerotic risk, blood middle-high density lipoprotein (HDL) has opposite effect, it can stop arteriosclerotic generation, in blood of human body, astaxanthin is by extra-low density fat, astaxanthin atherosclerosis mechanism, albumen (VLDL), LDL and HDL carry.External and clinical trial proves every human oral 3.6mg/d astaxanthin, continuous 2 weeks, can prevent the oxidation of LDL.In addition, there is zooscopy to show, astaxanthin has in vivo remarkable rising HDL and falls the effect of LDL, wherein HDL can increase to 66.5 ± 5.1mg/dL by 49.7 original ± 3.6mg/dL, therefore infer that astaxanthin can alleviate the oxidation of apolipoprotein, can be used to prevention of arterial sclerosis, coronary heart disease and ischemic brain injury.The medicine that is different from general reduction LDL, take 1.8,3.6,14.4 and 21.6mg astaxanthin after continuous 2 weeks every day, and the time of LDL oxidation has been extended respectively 5.0%, 26.2%, 42.3% and 30.7%; But thereby the atherosis generation of prevention of arterial.
The antithrombotic therapy is to use thrombolytic drug, antiplatelet drug and anticoagulant.When formulating antithrombotic therapeutic strategy, at first it is also noted that thrombolytic drug therapy, because thrombolytic drug can be removed an established thrombosis. antithrombotic treatment is wanted variation, and this depends on that the position of getting involved is vein or arterial circulation system; The degree that blood vessel is got involved and position; Thrombotic expansion, the danger of thromboembolism or recurrence; And antithrombotic treatment and hemorrhage relative pros and cons, artificial mechanical's method of recovering vascular patency has foley's tube art and surgery embolectomy; The antithrombotic therapeutic scheme of its indication and complication and special disease kind (as myocardium infarction, venous thrombosis, lung infraction, cerebrovascular accident, the cardiac valve of reparation, arterial thrombosis) is relevant.
Existing thrombolytic drug price is high, and DeGrain, have side effects to human body, is unfavorable for human body recovery.
Summary of the invention
The purpose of the embodiment of the present invention is to provide a kind of astaxanthin formula and preparation method with thrombolytic effect, is intended to solve existing thrombolytic drug price high, and DeGrain, have side effects to human body, is unfavorable for the problem of human body recovery.
The embodiment of the present invention is achieved in that a kind of astaxanthin formula with thrombolytic effect, and this astaxanthin formula with thrombolytic effect is as follows:
Astaxanthin, Rhizoma Zingiberis Recens, Bulbus Allii, Fructus Citri Limoniae, apple vinegar, Mel;
The weight of formula components is: astaxanthin 50mg, Rhizoma Zingiberis Recens 300g, Bulbus Allii 300g, Fructus Citri Limoniae 150g, apple vinegar 300g, Mel 300g.
Another purpose of the embodiment of the present invention is to provide a kind of preparation method with astaxanthin of thrombolytic effect, and this preparation method with astaxanthin of thrombolytic effect comprises the following steps:
The peeling of step 1, Rhizoma Zingiberis Recens, stripping and slicing, garlic peeling, Rhizoma Zingiberis Recens with squeeze the juice after Bulbus Allii mixes,
Step 2, Fructus Citri Limoniae stripping and slicing are squeezed the juice, and Rhizoma Zingiberis Recens Bulbus Allii juice and Fructus Citri Limoniae juice are mixed to rear the stirring, add apple vinegar, stirring and evenly mixing;
Step 3, the juice heating that step 2 is prepared are got away, and little fire boils, and juice is evaporated to half, adds Mel;
Step 4,90 degree ethanol for the 50mg astaxanthin are dissolved, the w/v 50mg:30ml of astaxanthin and ethanol, add the mixed liquor stirring;
Step 5, stamp vanning.
Further, the time that the little fire of step 3 boils is 30 minutes,
Further, the ethanol that dissolves astaxanthin in step 4 also can substitute with Semen Maydis oil, and the w/v of astaxanthin and Semen Maydis oil is 50mg:30ml.
Astaxanthin formula and preparation method with thrombolytic effect provided by the invention, by by astaxanthin, Rhizoma Zingiberis Recens, Bulbus Allii, Fructus Citri Limoniae, apple vinegar, Mel; The weight of formula components is: astaxanthin 50mg, Rhizoma Zingiberis Recens 300g, Bulbus Allii 300g, Fructus Citri Limoniae 150g, apple vinegar 300g, Mel 300g, obtain having the astaxanthin of thrombolytic effect according to preparation process, method is simple, easy to operate, be of high nutritive value, preferably resolve existing thrombolytic drug price high, DeGrain, human body is had side effects, be unfavorable for the problem of human body recovery.In addition, cost of manufacture of the present invention is low, has alleviated producer and patient's economic pressures, has eliminated the misery when patient takes medicine, made people reach when curing the disease the health care purpose.
The accompanying drawing explanation
Fig. 1 is the flow chart of the astaxanthin preparation method with thrombolytic effect that provides of the embodiment of the present invention.
The specific embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
Fig. 1 shows the astaxanthin preparation method flow process with thrombolytic effect provided by the invention.For convenience of explanation, only show part related to the present invention.
The preparation method of the astaxanthin with thrombolytic effect that embodiments of the invention provide, this preparation method with astaxanthin of thrombolytic effect comprises the following steps:
The peeling of step 1, Rhizoma Zingiberis Recens, stripping and slicing, garlic peeling, Rhizoma Zingiberis Recens with squeeze the juice after Bulbus Allii mixes,
Step 2, Fructus Citri Limoniae stripping and slicing are squeezed the juice, and Rhizoma Zingiberis Recens Bulbus Allii juice and Fructus Citri Limoniae juice are mixed to rear the stirring, add apple vinegar, stirring and evenly mixing;
Step 3, the juice heating that step 2 is prepared are got away, and little fire boils, and juice is evaporated to half, adds Mel;
Step 4,90 degree ethanol for the 50mg astaxanthin are dissolved, the w/v 50mg:30ml of astaxanthin and ethanol, add the mixed liquor stirring;
Step 5, stamp vanning.
As a prioritization scheme of the embodiment of the present invention, the time that the little fire of step 3 boils is 30 minutes,
As a prioritization scheme of the embodiment of the present invention, the ethanol that dissolves astaxanthin in step 4 also can substitute with Semen Maydis oil, and the w/v of astaxanthin and Semen Maydis oil is 50mg:30ml.
Below in conjunction with drawings and the specific embodiments, application principle of the present invention is further described.
As shown in Figure 1, the astaxanthin preparation method with thrombolytic effect of the embodiment of the present invention comprises the following steps:
S101: Rhizoma Zingiberis Recens peeling, stripping and slicing, garlic peeling, Rhizoma Zingiberis Recens with squeeze the juice after Bulbus Allii mixes,
S102: the Fructus Citri Limoniae stripping and slicing is squeezed the juice, and Rhizoma Zingiberis Recens Bulbus Allii juice and Fructus Citri Limoniae juice are mixed to rear the stirring, adds apple vinegar, stirring and evenly mixing;
S103: the juice heating that step 2 is prepared is got away, and little fire boils, and juice is evaporated to half, adds Mel;
S104: the 50mg astaxanthin is dissolved with 90 degree ethanol, add mixed liquor to stir;
S105: stamp vanning.
Concrete steps of the present invention are:
The peeling of step 1, Rhizoma Zingiberis Recens, stripping and slicing, garlic peeling, Rhizoma Zingiberis Recens with squeeze the juice after Bulbus Allii mixes,
Step 2, Fructus Citri Limoniae stripping and slicing are squeezed the juice, and Rhizoma Zingiberis Recens Bulbus Allii juice and Fructus Citri Limoniae juice are mixed to rear the stirring, add apple vinegar, stirring and evenly mixing;
Step 3, the juice heating that step 2 is prepared are got away, and little fire boils 30 minutes, and juice is evaporated to half, adds Mel;
Step 4,90 degree ethanol for the 50mg astaxanthin are dissolved, add mixed liquor to stir; The w/v 50mg:30ml of astaxanthin and ethanol, the ethanol that dissolves astaxanthin also can substitute with Semen Maydis oil, and the w/v of astaxanthin and Semen Maydis oil is 50mg:30ml.
Step 5, stamp vanning.
Using method of the present invention is: takes 40 milliliters every morning, serve on one month, and the heart, brain, two lower limb arteriovenous, thrombosis is all removed clean.Substituted bridging and support, be careful in one's diet, the few oil of few salt, can not recur.Take again one month by above dosage, the normal 80-125 of blood pressure.
I take one month (2013.7.1 to 2013.8.1) two lower limb vein thrombus by formula and all dispose (have People hospital B ultrasonic for card) I entered People hospital (B ultrasonic show thousand pairs of lower limb vein thrombus) second day and turn the Shandong Prov. Hospital vascular surgery and treat on April 29.Does not have an operation older (79 years old), and May 9 left hospital, and is in hospital 9 days.Ate this formula from July 1, going to People hospital to do the B ultrasonic thrombosis on August 2 has not had, and it is strange that doctor feels, has now two parts of B ultrasonic can do proof.I asked that the doctor trained in Western medicine expert said that current thrombosis can't resolve, and can only do and put up a bridge and two kinds of ways of support.The traditional Chinese medical science is also helpless.If this formula is applied, the Chinese life-span obviously improves, and support and bridging, all at several ten thousand yuan, greatly reduce with this formulation cost.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any modifications of doing within the spirit and principles in the present invention, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (4)
1. the astaxanthin formula with thrombolytic effect, is characterized in that, this astaxanthin formula with thrombolytic effect is as follows:
Astaxanthin, Rhizoma Zingiberis Recens, Bulbus Allii, Fructus Citri Limoniae, apple vinegar, Mel;
The weight ratio of formula components is: astaxanthin 50mg, Rhizoma Zingiberis Recens 300g, Bulbus Allii 300g, Fructus Citri Limoniae 150g, apple vinegar 300g, Mel 300g.
2. the preparation method with astaxanthin of thrombolytic effect, is characterized in that, this preparation method with astaxanthin of thrombolytic effect comprises the following steps:
The peeling of step 1, Rhizoma Zingiberis Recens, stripping and slicing, garlic peeling, Rhizoma Zingiberis Recens with squeeze the juice after Bulbus Allii mixes,
Step 2, Fructus Citri Limoniae stripping and slicing are squeezed the juice, and Rhizoma Zingiberis Recens Bulbus Allii juice and Fructus Citri Limoniae juice are mixed to rear the stirring, add apple vinegar, stirring and evenly mixing;
Step 3, the juice heating that step 2 is prepared are got away, and little fire boils, and juice is evaporated to half, adds Mel;
Step 4,90 degree ethanol for the 50mg astaxanthin are dissolved, the w/v 50mg:30ml of astaxanthin and ethanol, add the mixed liquor stirring;
Step 5, stamp vanning.
3. the preparation method with astaxanthin of thrombolytic effect as claimed in claim 2, is characterized in that, the time that the little fire of step 3 boils is 30 minutes.
4. 50mg as claimed in claim 2 has the preparation method of the astaxanthin of thrombolytic effect, it is characterized in that, the ethanol that dissolves astaxanthin in step 4 also can substitute with Semen Maydis oil, and the w/v of astaxanthin and Semen Maydis oil is 50mg:30ml.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103783614A (en) * | 2014-02-08 | 2014-05-14 | 中国海洋大学 | Astaxanthin apple vinegar beverage and fabrication method thereof |
Citations (3)
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| US20060287391A1 (en) * | 2005-06-15 | 2006-12-21 | Yamaha Hatsudoki Kabushiki Kaisha | Phosphodiesterase inhibitor |
| CN102697825A (en) * | 2012-07-03 | 2012-10-03 | 童长虹 | Anti-aging health-care product |
| CN102813753A (en) * | 2012-05-22 | 2012-12-12 | 孟令刚 | Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060287391A1 (en) * | 2005-06-15 | 2006-12-21 | Yamaha Hatsudoki Kabushiki Kaisha | Phosphodiesterase inhibitor |
| CN102813753A (en) * | 2012-05-22 | 2012-12-12 | 孟令刚 | Composition containing Cistanche deserticola or Herba Cynomorii and combination of chrysanthemum, taurine, lycopene, xanthophyll and beta-carotene |
| CN102697825A (en) * | 2012-07-03 | 2012-10-03 | 童长虹 | Anti-aging health-care product |
Non-Patent Citations (3)
| Title |
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| YASUTO S ET AL.: "Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats", 《NUTRITION RESEARCH》 * |
| 网络: "http://hi.baidu.com/dongjizhimeng/item/11e4e40030412f9ba3df4339", 《HTTP://HI.BAIDU.COM/DONGJIZHIMENG/ITEM/11E4E40030412F9BA3DF4339》 * |
| 胡秀英: "《老年护理手册》", 31 December 2010, 科学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103783614A (en) * | 2014-02-08 | 2014-05-14 | 中国海洋大学 | Astaxanthin apple vinegar beverage and fabrication method thereof |
| CN103783614B (en) * | 2014-02-08 | 2015-12-09 | 中国海洋大学 | A kind of astaxanthin apple vinegar beverage and preparation method thereof |
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Application publication date: 20131218 |