CN102805816B - Drug composition for treating senium primary osteoarthritis and preparation method thereof - Google Patents
Drug composition for treating senium primary osteoarthritis and preparation method thereof Download PDFInfo
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- CN102805816B CN102805816B CN201210301715.1A CN201210301715A CN102805816B CN 102805816 B CN102805816 B CN 102805816B CN 201210301715 A CN201210301715 A CN 201210301715A CN 102805816 B CN102805816 B CN 102805816B
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Abstract
The invention discloses a drug composition for treating primary knee joint osteoarthritis and a preparation method thereof. The drug composition comprises the following 20 medicines of ground beeltle, rheum officinale, pseudo-ginseng, corydalis tuber, sangusis draconis, teasel root, golden cypress, frankincense, myrrh, wadalee-gum-tree, asarum, homalomena occulta, edible tulip, rhizoma alismatis, and antelope horn, elecampane, rhizoma bletillae, radix angelicae, cassia twig, and notopterygium root. The prepared externally used paste has good functions of relieving swelling and pain, and relaxing tendons and activating collaterals, can be used for treating arthralgia, swelling and inhibited bending and stretching caused by knee joint osteoarthritis, and has better clinical effects.
Description
Technical field
The invention belongs to medical technical field, exactly, relate to a kind of Traditional Chinese medicine composition for the treatment of degenerative osteoarthritis and preparation method thereof.
Background technology
Degenerative osteoarthritis (Osteoarthritis, OA) claims again osteoarthritis, is a kind of common taking arthralgia, swelling, the stiff and lopsided osteoarthritis as feature.Can there is osteoarthritis in whole body joint, especially knee joint, and its sickness rate accounts for 40% of Human Osteoarthritis.Degenerative knee is one of common chronic degenerative joint disease of middle-aged and elderly people, and particularly middle aged and aged women is common especially.Osteoarthritis is a kind of degeneration taking articular cartilage, destruction and the hyperosteogeny chronic joint disease as feature, belongs to Chinese medicine " rheumatism involving the bone ", " knee joint numbness " category.The most common with arthralgia, hyperosteogeny and limitation of activity clinically, the morbidity of osteoarthritis is without region and race difference, and age, obesity, inflammation, wound and inherited genetic factors may be relevant with the generation of primary disease.This disease is often loose and lopsided with joint, is from articular cartilage degenerative change, and then involves sclerotin, periosteum, joint capsule, and form hyperosteogeny, causes the gonalgia, swelling, deformity and dysfunction, therefore be referred to as degenerative knee.Degenerative knee is old people's commonly encountered diseases, has a strong impact on bodily fuctions's activity, and work and life are affected greatly.
Degenerative osteoarthritis Therapeutic Method is more, and doctor trained in Western medicine generally adopts antalgic and inflammation relieving method to treat, and adopts the method for operation to treat to late period, and antalgic and inflammation relieving chemical drugs has certain side effect, and operation needs higher expense and brings misery to patient.External therapy of Chinese herb (comprise smoked, wash, apply ointment or plaster etc.) can be eliminated joint capsule and synovial membrane inflammation effectively, the joint accretion of loosening, remove muscle spasm, improve microcirculation in bone, reduce intra-osteal pressure, therefore, Chinese medicine external has better analgesia damp eliminating effect aspect treatment osteoarthritis, also having good curative effect aspect elimination hydrarthrosis, especially obvious for the more person's curative effect of hydrarthrosis.
Osteoarthritis is divided into two kinds of constitutional and Secondary cases.Spontaneous osteoarthritis change shows as cartilage matrix protein polysaccharide biosynthesis and decomposes abnormal, chondrocyte can not synthesize hyaluronic acid and the poly-glucosamine normally with backbone, consequent short chain proteoglycan polymer is overflowed from collagen network structure, causes articular cartilage local softening, follows the string, wearing and tearing and structural deterioration.Secondary cases bone close scorching be mainly wound, motion wearing and tearing and bear a heavy burden due to cartilage damage and cause the osteoarthritis reaction of the adjacent skeleton in joint.
Morbidity that it is generally acknowledged knee joint osseous arthritis is from cartilage surface, and main cause is articular cartilage wearing and tearing and joint Metabolic disorder.Existing for joint motion the cartilage surface of an anti-wear, lower resistance being provided of articular lamella, make joint can bear certain compressive stress and shearing force, and activity freely.Due to various impairment factors, fibrin electrodeposition substance covers articular cartilage, affects metabolism of articular cartilage, cause cartilage degeneration, wherein collagen fiber expose, and form villous fibril, even volume-diminished, makes cartilage surface coarse, and deliquescing tarnishes, then there is crack, cartilage surface is softening to break, and comes off and disappears, and reactive hyperosteogeny and hyperosteogeny appear in exposed surface of bone under the impact of alternate stress, there is propagation, calcification phenomenon at tendon, joint capsule and the ligament place of adhering to.More than change normal nutrition and the function that all can affect joint, cause bone regression to occur.Chinese medicine external can relaxing muscles and tendons and activating QI and blood in the collateral, reduces intra-articular pressure, has the feature that regulates and improve local microcirculation, and can alleviate muscular spasm, alleviates neural stimulation, alleviates ABNORMAL STRESS and concentrates the destruction to joint and cartilage thereof.Chinese medicine has long history to the understanding of osteoarthritis, and the result of study trend of many theoretical point views and modern medicine in control is consistent, as diminishes inflammation, improves periarticular and organize microcirculation, delay cartilage degeneration etc.In knee joint osseous arthritis treatment, the traditional Chinese medical science has not only solved the infringement of local patholoic change, and can be by regulating general body state to reach treating both the principal and secondary aspects of a disease object.
Summary of the invention
The object of the present invention is to provide a kind of Of Primary Osteoarthritis Of Knee onset pharmaceutical composition external preparation rapid, easy to use for the treatment of.Pharmaceutical preparation of the present invention, except can be used for Of Primary Osteoarthritis Of Knee, also can be used for the degeneration osteoarthritis at other positions of health.
Another object of the present invention is also to provide a kind of pharmaceutical preparation preparation method for the treatment of Of Primary Osteoarthritis Of Knee.
The present invention is achieved through the following technical solutions:
Treatment constitutional degenerative osteoarthritis pharmaceutical composition of the present invention is by weight ratio:
Eupolyphaga Seu Steleophaga 2-10 part Radix Et Rhizoma Rhei 2-10 part Radix Notoginseng 1-3 part Rhizoma Corydalis 2-10 part
Sanguis Draxonis 1-3 part Radix Dipsaci 2-10 part Cortex Phellodendri 2-10 part Olibanum 1-3 part
Myrrha 1-3 share tea 1-3 part Herba Asari 1-5 part Rhizoma Homalomenae 1-7 part
Pseudobulbus cremastrae seu pleiones 1-7 part Rhizoma Alismatis 1-5 part Cornu Saigae Tataricae 1-7 part Radix Aucklandiae 1-3 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 1-3 part Radix Angelicae Dahuricae 1-3 part Ramulus Cinnamomi 1-3 part Rhizoma Et Radix Notopterygii 1-3 part.
Preferred weight proportioning is:
9 parts of 3 parts of Rhizoma Corydalis of 10 portions of Radix Notoginseng of 9 parts of Radix Et Rhizoma Rhei of Eupolyphaga Seu Steleophaga
3 parts of 10 parts of Olibanums of 10 portions of Cortex Phellodendris of 3 parts of Radix Dipsacis of Sanguis Draxonis
6 parts of 4.5 parts of Rhizoma Homalomenaes of 3 parts of Herba Asaris of Myrrha 3 share tea
3 parts of 6 parts of Radix Aucklandiae of 4.5 parts of Cornu Saigae Tataricae of 6 portions of Rhizoma Alismatis of Pseudobulbus cremastrae seu pleiones
3 parts of 3 portions of Rhizoma Et Radix Notopterygiis of 3 parts of Ramulus Cinnamomi of 3 parts of Radixs Angelicae Dahuricae of Pseudobulbus Bletillae (Rhizoma Bletillae).
Pharmaceutical composition external preparation of the present invention can be prepared by the following method:
1, get 3 parts of 3 portions of Rhizoma Et Radix Notopterygiis of 10 parts of Olibanums of 10 portions of Cortex Phellodendris of 3 parts of Radix Dipsacis of 9 parts of Sanguis Draxonis of 3 parts of Rhizoma Corydalis of 10 portions of Radix Notoginseng of 9 parts of Radix Et Rhizoma Rhei of Eupolyphaga Seu Steleophaga, 3 parts of Ramulus Cinnamomi of 3 parts of Radixs Angelicae Dahuricae of 3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 6 parts of Radix Aucklandiae of 4.5 parts of Cornu Saigae Tataricae of 6 portions of Rhizoma Alismatis of 6 parts of Pseudobulbus cremastrae seu pleiones of 4.5 parts of Rhizoma Homalomenaes of 3 parts of Herba Asaris of 3 parts of Myrrhas, 3 share tea, prepare each medicine by above-mentioned weight portion, for subsequent use;
2, the Olibanum of counterweight ratio, Myrrha, Sanguis Draxonis, catechu are ground into fine powder;
3, Radix Notoginseng, Cornu Saigae Tataricae shatter poling fine powder, with above-mentioned fine powder facing-up, sieve, and mix.
4,14 tastes such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei are given as one thinks fit cataclasmly, get vegetable oil, put in pot and are heated to 300 DEG C, and refining is to dripping into pearl, add Plumbum preparatium, stir evenly, be placed to 100 DEG C, add the ten four Chinese medicine materials such as Radix Et Rhizoma Rhei, keep 24 hours at 100 DEG C, pull medicinal residues out, receive cream, form tender cream.Separately get vegetable oil, heating, above-mentioned ten four Chinese medicine slags are fried withered in 200 DEG C of oil cauldrons, remove slag, filter, in 300 DEG C of refinings to dripping into pearl, add Plumbum preparatium, stir evenly, cream is soaked in water.Get cream, with slow fire fusing, then add the Six-element fine powders such as Olibanum, stir evenly, sharing, on cloth, is made externally used paste and is obtained externally used paste of the present invention.
Described plant oil phase is selected from the one in Oleum Arachidis hypogaeae semen, soybean oil, hydrogenated corn oil, Oleum sesami;
Externally used paste of the present invention is for the treatment of degeneration osteoarthritis, and particularly constitutional knee joint joint inflammation has good therapeutic effect.
Further illustrate effect of the present invention with test example below.
Clinical trial data
Used external preparation of the present invention (lot number: 941016) treatment knee joint osseous arthritis 100 examples, matched group 40 examples adopt dog skin plaster to compare, contrast clinical efficacy from 1994 to 1996.
Grouping: 140 routine Of Primary Osteoarthritis Of Knee patients are divided into two groups at random, adopt the method for clinical control to carry out Comparison of therapeutic.
Treatment group: constitutional knee osteoarthritis patients 100 examples, adopt that external preparation of the present invention pastes before patient's knee joint, inside and outside three positions;
Dog skin plaster matched group: constitutional knee osteoarthritis patients 40 examples, adopt before dog skin plaster plaster patient knee joint, inside and outside three positions.
Efficacy evaluation method:
Curative effect, mainly with pain, swelling, function limitation, numb limbs and tense tendons and dizzy five clinical manifestations and sign, all adopts unified standard to judge respectively before and after treatment, will be decided to be one week the course for the treatment of, within every two days, changes medicine one time, carries out evaluation and the statistics of curative effect.
(1), pain degree is judged
Judgement using 0-10 as pain degree, 0 is without pain, and 1-3 is mild pain, and 4-6 is moderate pain, is greater than 7 for severe pain
(2), swelling deciding degree
Slight: suspicious swelling; Moderate: clear and definite swelling; Severe: obvious tumefaction.
(3), function limitation deciding degree
Slight: slightly limited; Moderate: obviously limited; Severe: seriously limited.
Curative effect determinate standard:
Clinical cure: after medication, symptom disappears substantially or completely, does not affect daily life and work.
Effective: to fall two degree
Effective: once to fall
Invalid: after medication, one week nothing changes.
Result:
Table 1, external preparation dog skin plaster of the present invention treatment knee joint osseous arthritis observed result
Detailed description of the invention
The present invention is further elaborated for following examples, but do not limit the scope of the invention.
The preparation of embodiment 1. external patch unguentum of the present invention
(1), get Eupolyphaga Seu Steleophaga 90g, Radix Et Rhizoma Rhei 100g, Radix Notoginseng 30g, Rhizoma Corydalis 90g, Sanguis Draxonis 30g, Radix Dipsaci 100g, Cortex Phellodendri 100g, Olibanum 30g, medicine 30g, catechu 30g, Herba Asari 45g, Rhizoma Homalomenae 60g, Pseudobulbus cremastrae seu pleiones 60g, rush down 45g, Cornu Saigae Tataricae 60g, Radix Aucklandiae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Radix Angelicae Dahuricae 30g, Ramulus Cinnamomi 30g, Rhizoma Et Radix Notopterygii 30g, prepare each medicine by above-mentioned weight portion, for subsequent use;
(2), the Olibanum of counterweight ratio, Myrrha, Sanguis Draxonis, catechu are ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae shatter poling fine powder, with above-mentioned fine powder facing-up, sieves, mix;
(4), 14 tastes such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei are given as one thinks fit cataclasm, get Oleum sesami 2500g, put in pot and be heated to 300 DEG C, refining is to dripping into pearl, add Plumbum preparatium 500g, stir evenly, be placed to 100 DEG C, add the ten four Chinese medicine materials such as Radix Et Rhizoma Rhei, keep 24 hours at 100 DEG C, pull medicinal residues out, receive cream, form tender cream.Separately get Oleum sesami 2500g, heating, above-mentioned ten four Chinese medicine slags are fried withered in 200 DEG C of oil cauldrons, remove slag, filter, in 300 DEG C of refinings to dripping into pearl, add Plumbum preparatium 1250g, stir evenly, cream is soaked in water.Get cream, with slow fire fusing, then add the Six-element fine powders such as Olibanum, stir evenly, sharing, on cloth, is made externally used paste and is obtained externally used paste of the present invention.
The preparation of embodiment 2. external patch unguentum
(1), get Eupolyphaga Seu Steleophaga 100g, Radix Et Rhizoma Rhei 100g, Radix Notoginseng 30g, Rhizoma Corydalis 100g, Sanguis Draxonis 30g, Radix Dipsaci 100g, Cortex Phellodendri 100g, Olibanum 30g, Myrrha 30g, catechu 30g, Herba Asari 50g, Rhizoma Homalomenae 70g, Pseudobulbus cremastrae seu pleiones 70g, Rhizoma Alismatis 50g, Cornu Saigae Tataricae 70g, Radix Aucklandiae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Radix Angelicae Dahuricae 30g, Ramulus Cinnamomi 30g, Rhizoma Et Radix Notopterygii 30g, prepare each medicine by above-mentioned weight portion, for subsequent use;
(2), the Olibanum of counterweight ratio, Myrrha, Sanguis Draxonis, catechu are ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae shatter poling fine powder, with above-mentioned fine powder facing-up, sieves, mix.
(4), 14 tastes such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get soybean oil, put in pot and are heated to 300 DEG C, refining is to dripping into pearl, add Plumbum preparatium, stir evenly, be placed to 100 DEG C, add the ten four Chinese medicine materials such as Radix Et Rhizoma Rhei, keep 24 hours at 100 DEG C, pull medicinal residues out, receive cream, form tender cream.Separately get soybean oil, above-mentioned ten four Chinese medicine slags are fried withered in 200 DEG C of oil cauldrons, remove slag, filter, in 300 DEG C of refinings to dripping into pearl, add Plumbum preparatium, stir evenly, cream is soaked in water.Get cream, with slow fire fusing, then add the Six-element fine powders such as Olibanum, stir evenly, sharing, on cloth, is made externally used paste and is obtained externally used paste of the present invention.
The preparation of embodiment 3. external patch unguentum
(1), get Eupolyphaga Seu Steleophaga 20g, Radix Et Rhizoma Rhei 20g, Radix Notoginseng 10g, Rhizoma Corydalis 20g, Sanguis Draxonis 10g, Radix Dipsaci 20g, Cortex Phellodendri 20g, Olibanum 10g, Myrrha 10g, catechu 10g, Herba Asari 10g, Rhizoma Homalomenae 10g, Pseudobulbus cremastrae seu pleiones 10g, Rhizoma Alismatis 10g, Cornu Saigae Tataricae 10g, Radix Aucklandiae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Angelicae Dahuricae 10g, Ramulus Cinnamomi 10g, Rhizoma Et Radix Notopterygii 10g, prepare each medicine by above-mentioned weight portion, for subsequent use;
(2), the Olibanum of counterweight ratio, Myrrha, Sanguis Draxonis, catechu are ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae shatter poling fine powder, with above-mentioned fine powder facing-up, sieves, mix.
(4), 14 tastes such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get Oleum Brassicae campestris, put in pot and are heated to 300 DEG C, refining is to dripping into pearl, add Plumbum preparatium, stir evenly, be placed to 100 DEG C, add the ten four Chinese medicine materials such as Radix Et Rhizoma Rhei, keep 24 hours at 100 DEG C, pull medicinal residues out, receive cream, form tender cream.Separately get Oleum Brassicae campestris, heating, above-mentioned ten four Chinese medicine slags are fried withered in 200 DEG C of oil cauldrons, remove slag, filter, in 300 DEG C of refinings to dripping into pearl, add Plumbum preparatium, stir evenly, cream is soaked in water.Get cream, with slow fire fusing, then add the Six-element fine powders such as Olibanum, stir evenly, sharing, on cloth, is made externally used paste and is obtained externally used paste of the present invention.
Claims (2)
1. the application of pharmaceutical composition on preparation treatment spontaneous osteoarthritis medicine, prescription and preparation method that described pharmaceutical composition is concrete are as follows:
Eupolyphaga Seu Steleophaga 90g Radix Et Rhizoma Rhei 100g Radix Notoginseng 30g Rhizoma Corydalis 90g
Sanguis Draxonis 30g Radix Dipsaci 100g Cortex Phellodendri 100g Olibanum 30g
Myrrha 30g catechu 30g Herba Asari 45g Rhizoma Homalomenae 60g
Pseudobulbus cremastrae seu pleiones 60g Rhizoma Alismatis 45g Cornu Saigae Tataricae 60g Radix Aucklandiae 30g
Pseudobulbus Bletillae (Rhizoma Bletillae) 30g Radix Angelicae Dahuricae 30g Ramulus Cinnamomi 30g Rhizoma Et Radix Notopterygii 30g
Method for making: above 20 taste medical materials, Olibanum, Myrrha, Sanguis Draxonis, catechu are ground into fine powder; Radix Notoginseng, Cornu Saigae Tataricae shatter poling fine powder, with above-mentioned fine powder facing-up, sieve, and mix; 14 tastes such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei are given as one thinks fit cataclasm; Get Oleum sesami 2500g, put in pot and be heated to 300 DEG C, refining, to dripping into pearl, adds Plumbum preparatium 500g, stirs evenly, and is placed to 100 DEG C, adds the ten four Chinese medicine materials such as Radix Et Rhizoma Rhei, keeps 24 hours at 100 DEG C, pulls medicinal residues out, receives cream, forms tender cream; Separately get Oleum sesami 2500g, heating, above-mentioned ten four Chinese medicine slags are fried withered in 200 DEG C of oil cauldrons, remove slag, filter, in 300 DEG C of refinings to dripping into pearl, add Plumbum preparatium 1250g, stir evenly, cream is soaked in water; Get cream, with slow fire fusing, then add the Six-element fine powders such as Olibanum, stir evenly, sharing, on cloth, to obtain final product.
2. the application of pharmaceutical composition as claimed in claim 1, is characterized in that the application on its preparation treatment constitutional knee joint osseous arthritis medicine.
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| CN201210301715.1A CN102805816B (en) | 2012-08-23 | 2012-08-23 | Drug composition for treating senium primary osteoarthritis and preparation method thereof |
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| CN115779055A (en) * | 2022-12-02 | 2023-03-14 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine composition for treating closed soft tissue injury or degenerative osteoarthritis and application thereof |
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