CN104225067B - Chinese medicine composition, preparation method and purposes for treating postmenopausal osteoporosis - Google Patents
Chinese medicine composition, preparation method and purposes for treating postmenopausal osteoporosis Download PDFInfo
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Abstract
The present invention relates to for the Chinese medicine composition for treating postmenopausal osteoporosis, preparation method and purposes.The Chinese medicine composition is made up of the 6 15 parts by weight barks of eucommia, 5 10 parts by weight raspberries and 10 12 parts by weight Semen Cuscutaes.The effect of Chinese medicine composition of the present invention has liver-kidney tonifying, strengthening the bones and muscles, the positive contracting urine of temperature, anti-aging, can improve the symptom such as soreness and weakness of waist and knees, dizzy, frequent urination, can be used successfully to treat osteoporosis in postmenopausal women.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to Chinese medicine composition and its preparation for treating postmenopausal osteoporosis
Method and purposes.
Background technology
PMO（Postmenopausal osteoporosis, POP）It is a kind of relevant with aging normal
See disease, occur mainly in postmenopausal female population.Due to estrogen deficiency, therefore bone amount is reduced and bone structure becomes
Change, thus increase bone fragility so as to be easy to fracture, and occur pain, textured bone caused by fracture, and close
And disease, even result in death.Therefore, PMO severely impacts the healthy and quality of life of the elderly,
Even shorten the life-span, increase country and family's financial resources and manpower burden.
The osteoporosis related to menopause has been very important important health care problem.1993, WHO was by osteoporosis
Disease is defined as, by systemic bone amount reduction, with the micro-structural of bone changing, causing the increase of bone fragility, thus causes fracture to be endangered
A kind of dangerous increased disease.2001, U.S. National Institutes consensus conference was proposed, osteoporosis is impaired with bone strength
The skeletal diseases being characterized, can cause fracture risk to increase.Bone strength embodies a concentrated reflection of bone density and bone mass.Osteoporosis
Pathological characteristic be bone mineral content and bone matrix composition equal proportion reduce, cortex of bone is thinning, and bone trabecula reduces, attenuated, and suffers from
During PMO, bone trabecula is broken.
Current clinical treatment is more based on estrogen supplement and calcium supplement, also there is some Chinese medicine compositions.However, existing
Traditional Chinese medicine composition formula is complicated, and preparation technology is cumbersome, and production cost is high, therefore, it is also desirable to it is more be suitable to large-scale production and
The outstanding medicine of curative effect.
The content of the invention
For solve it is above-mentioned the problems of in the prior art, the invention provides for treating postmenopausal osteoporosis
Chinese medicine composition and its production and use.
Specifically, the invention provides：
（1）A kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by by following
The Chinese medicine of proportioning is made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight.
（2）According to（1）The described Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese traditional medicine composition
Thing is made up of Chinese medicine according to the following ratio：The parts by weight of the bark of eucommia 10, the parts by weight of raspberry 10, the parts by weight of Semen Cuscutae 10.
（3）A kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by by following
The Chinese medicine of proportioning is made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 weights
Measure part.
（4）A kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by by following
The Chinese medicine of proportioning is made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, fruit of Chinese wolfberry 5-15
Parts by weight.
（5）A kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by by following
The Chinese medicine of proportioning is made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 weights
Measure part, fruit of Chinese wolfberry 5-15 parts by weight.
（6）One kind prepares basis（1）-（5）Being used for described in middle any one treats the Chinese medicine group of postmenopausal osteoporosis
The method of compound, including：
1）The Chinese medicine is water-soluble with the 50-90% (v/v) of 5 to 20 times of volumes of Chinese medicine gross weight ethanol
Liquid heating and refluxing extraction, is repeated 1-2 times, is extracted 1-3 hours every time, merges extract solution；
2）Filter the step 1）The extract solution of acquisition, so as to obtain filtrate, concentrates the filtrate until obtaining thick paste.
（7）According to（6）Described method, this method also includes：3）The thick paste is dried and fine powder is made.
（8）According to（6）Described method, this method also includes：4）The fine powder is filled into capsule, or concentration is made
Ball.
（9）According to（1）-（5）Chinese medicine composition described in middle any one is being prepared for preventing and/or treating post menopausal
Purposes in the medicine of osteoporosis.
The present invention has the advantages that compared with prior art：
1. the effect of Chinese medicine composition of the present invention has liver-kidney tonifying, strengthening the bones and muscles, the positive contracting urine of temperature, anti-aging, can change
The symptoms such as kind soreness and weakness of waist and knees, dizzy, frequent urination, can be used successfully to treat osteoporosis in postmenopausal women.
2. the formula of the Chinese medicine composition of the present invention is simple, rationally, with synergistic function, its effect is better than in formula
The combination of any one-component or any two kinds of components.
3. the Chinese medicine composition preparation method of the present invention is easy, cost is low, suitable for large-scale industrial production.
Embodiment
Below by way of the description of embodiment, the invention will be further described, but this is not the limit to the present invention
System, those skilled in the art are according to the basic thought of the present invention, and various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
The invention provides a kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese traditional medicine composition
Thing is made up of Chinese medicine according to the following ratio：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight.
Preferably, the proportioning of the Chinese medicine is：The bark of eucommia is 10 parts by weight, and raspberry is 10 parts by weight, and Semen Cuscutae is 10
Parts by weight.
The Chinese medicine composition of the present invention can also be made up of Chinese medicine according to the following ratio：Bark of eucommia 6-15 parts by weight, cover basin
Sub- 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 parts by weight.
Preferably, the proportioning of the Chinese medicine is：The bark of eucommia is 10 parts by weight, and raspberry is 10 parts by weight, and Semen Cuscutae is 10
Parts by weight, the red sage root is 6 parts by weight or 10 parts by weight.
The Chinese medicine composition of the present invention can also be made up of Chinese medicine according to the following ratio：Bark of eucommia 6-15 parts by weight, cover basin
Sub- 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, fruit of Chinese wolfberry 5-15 parts by weight.
Preferably, the proportioning of the Chinese medicine is：The bark of eucommia is 10 parts by weight, and raspberry is 10 parts by weight, and Semen Cuscutae is 10
Parts by weight, the fruit of Chinese wolfberry is 10 parts by weight.
The Chinese medicine composition of the present invention can also be made up of Chinese medicine according to the following ratio：Bark of eucommia 6-15 parts by weight, cover basin
Sub- 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 parts by weight, fruit of Chinese wolfberry 5-15 parts by weight.
Preferably, the proportioning of the Chinese medicine is：The bark of eucommia is 10 parts by weight, and raspberry is 10 parts by weight, and Semen Cuscutae is 10
Parts by weight, the red sage root is 6 parts by weight or 10 parts by weight, and the fruit of Chinese wolfberry is 10 parts by weight.
Inventors of the present invention have surprisingly found that, the Chinese medicine composition being made up of above-mentioned formula has synergistic function,
Its effect is dredged better than the combination of any one-component or any two kinds of components in formula with more excellent treatment post menopausal sclerotin
The effect of pine.
The Chinese medicine composition of the present invention is using the bark of eucommia as monarch drug in a prescription, filling liver kidney, strengthening the bones and muscles；With raspberry and Semen Cuscutae and optionally
The red sage root be ministerial drug, liver-kidney tonifying, temperature sun contracting urine, promoting blood circulation scattered silt, swelling and pain relieving；Using the optional fruit of Chinese wolfberry as adjutant, tonifying liver benefit
Kidney, anti-aging.
Various medicinal materials in the Chinese medicine composition of the present invention have the general sense of used respective name in the art.
The effect of various medicinal materials is as follows：
The bark of eucommia：For the dry bark of the Eucommiaceae plant bark of eucommia.Nature and flavor：Sweet micro-pungent, temperature.Function is cured mainly：Filling liver kidney, strengthening tendons
Bone, it is antiabortive.Spinal column ache is controlled, foot and knee flaccidity, dribbling urination, uncontrolled urination, threatened abortion is intended to fall, fetal irritability, hypertension.The bark of eucommia has
There is filling liver kidney, strengthening the bones and muscles removes internal rubbish, strengthens human body cell metabolism, prevent muscle skeleton aging, balanced human's blood
Pressure, decomposer inner cholesterol reduces body fat, recovers blood vessel elasticity, and diuresis heat-clearing, broad-spectrum antiseptic, stimulating central nervous system is carried
High white blood cell count, strengthens the remarkable efficacies such as body immunity.
Raspberry：The dry fruit of rosaceous plant rubus chingii Hu.Channel tropism：Liver；Kidney channel.Effect：Liver-kidney tonifying, controlling nocturnal emission with astringent drugs
Contracting urine, improving eyesight.Cure mainly：Thin under impotence and premature ejaculation, emission and spermatorrhea, uterus cold infertile, band, frequent micturition, which is lost, drowns, eyes dim, poliosis.
Semen Cuscutae：《Sheng Nong's herbal classic》In be listed in top grade.Its is pungent, sweet, puts down, nontoxic.Function is with curing mainly：Kidney tonifying benefit
Essence, nourishes the liver to improve visual acuity.Ache suitable for the waist and knee muscles and bones of kidney deficiency and liver, legs and feet are weak and feeble, impotence and seminal emission, crazy talk, frequent urination,
The diseases such as dripping urination, dizzy, blurring of vision, Hiccough and deaf and women are with, habitual abortion.
The red sage root：For dicotyledon Labiatae, root and rhizome is dried.Effect：Promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle,
Relieving restlessness that clears away heart-fire, nourishing blood and tranquilization.Nature and flavor：Hardship, is slightly cold.Cure mainly：With promoting blood circulation scattered silt, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving,
Coronary artery dilator, improve myocardial ischemia situation, reduce blood pressure, with all worries set aside, hypoglycemic and antibacterial of calming the nerves the effects such as, to menstruation not
Adjust, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia；Hepatosplenomegaly, the disease such as angina pectoris
Disease has certain curative effect.In addition, modern medicine is it is demonstrated experimentally that the red sage root also has anti-platelet aggregation, reduction blood viscosity and tune
The function of the inside and outside blood coagulation system of section, is a kind of safety reliable natural traditional Chinese medicine for treating cardiovascular disease again.
The fruit of Chinese wolfberry：For the dry mature fruit of plant of Solanaceae lycium barbarum.Its sweet, mild-natured work(with liver-kidney tonifying
Effect.《Compendium of Materia Medica》It is middle to say that " long term usage heavily fortified point muscles and bones, makes light of one's life by commiting suicide not old, resistance to cold and heat." traditional Chinese medical science often treated with it liver-kidney Yin deficiency, waist and knee acid
The many tears of soft, dizzy, forgetful, dizzy, blurred vision, the illness such as quench one's thirst, pass out semen.Modern pharmacology research confirms that the fruit of Chinese wolfberry can adjust body
Immunologic function, it can effectively suppress tumour growth and cell mutation, with anti-aging, anti-fatty liver, regulation blood fat and blood glucose, rush
The effect entered in terms of hematopoiesis function, and applied to clinic.
Chinese medicine composition of the present invention is preferably administered orally, and also is adapted for other administering modes, such as parenteral, sublingual gives
Medicine or oral transmucosal administration etc..
The oral delivery form of Chinese medicine composition of the present invention can be tablet, capsule, granule, pill, oral liquid, conjunction
Any conventional formulations such as agent, effervescent tablet, oral disnitegration tablet.Preferably capsule or condensed pill.
Another aspect of the present invention provide it is a kind of prepare it is of the present invention be used for treat postmenopausal osteoporosis
The method of Chinese medicine composition, including：
1）By the Chinese medicine with the Chinese medicine gross weight（Unit：g）5 to 20 times of volumes（Unit：ml）50-
90% (v/v) ethanol water heating and refluxing extraction, is repeated 1-2 times, is extracted 1-3 hours every time, merges extract solution；
2）Filter the step 1）The extract solution of acquisition, so as to obtain filtrate, concentrates the filtrate until obtaining thick paste.
The method of the present invention can also include：3）The thick paste is dried and fine powder is made.
Fine powder, which is made, to be carried out according to methods known in the art.
The method of the present invention can also include：4）The fine powder is filled into capsule, or condensed pill is made.
Pharmaceutical composition fine powder can be filled into capsule using apparatus and method commonly used in the art；If concentration is made
Ball, can be carried out using method commonly used in the art.
The present invention is further described referring to embodiment and test example, it should be appreciated that the invention is not restricted to this
A little examples.
Embodiment
In example below, mulse can be prepared according to method commonly used in the art, and can be as needed to it
Concentration is adjusted.
General preparation method can be carried out according to method commonly used in the art.
Embodiment 1
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 80 volume % of 10 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 2 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder is dispensed into capsule.
Embodiment 2：
Bark of eucommia 15g
Raspberry 5g
Semen Cuscutae 10g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 90 volume % of 20 times of amounts ethanol water, heating and refluxing extraction, extract 3 times, 1 hour every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder is dispensed into capsule.
Embodiment 3：
Bark of eucommia 6g
Raspberry 9g
Semen Cuscutae 12g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 50 volume % of 5 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 3 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder and mulse are mixed, condensed pill is prepared with general preparation method.
Embodiment 4：
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Red sage root 6g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 80 volume % of 10 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 2 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder is dispensed into capsule.
Embodiment 5：
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Red sage root 10g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 90 volume % of 20 times of amounts ethanol water, heating and refluxing extraction, extract 3 times, 1 hour every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder is dispensed into capsule.
Embodiment 6：
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Red sage root 10g
Fruit of Chinese wolfberry 10g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 50 volume % of 5 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 3 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder and mulse are mixed, condensed pill is prepared into general preparation method.
Embodiment 7：
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Fruit of Chinese wolfberry 10g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 80 volume % of 10 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 2 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder is dispensed into capsule.
Embodiment 8：
Bark of eucommia 10g
Raspberry 10g
Semen Cuscutae 10g
Fruit of Chinese wolfberry 10g
Red sage root 6g
Preparation process：
1）Weigh the bulk drug of the parts by weight；
2）Plus 50 volume % of 5 times of amounts ethanol water, heating and refluxing extraction, extract 2 times, 3 hours every time, merging was carried
Liquid is taken, is filtered to get filtrate；
3）Filtrate recycling ethanol, is concentrated into thick paste；
4）Thick paste be dry, pulverize into fine powder；
5）Fine powder and mulse are mixed, condensed pill is prepared into general preparation method.
Test example 1：Influence of the medicine of the present invention to the bone mineral density of PMO rat model
Trial drug：Chinese medicine composition made from the embodiment of the present invention 1 is suspended with distilled water.
Comparative example：Tongji University's hall XIANLING GUBAO JIAONANG（Barrenwort, teasel root, psoralea corylifolia etc.）, by the fine powder in capsule and distillation
Water is suspended.
8 monthly age cleaning grade Healthy female Wistar rats 32, body weight 250-300g.It is randomly divided into 4 groups：Normal control
Group, model control group, the administration group of the embodiment of the present invention 1, comparative example administration group, every group each 8.Extract model group, the present invention real
Apply the administration group of example 1, the bilateral ovaries of the rat of comparative example administration group.It is same to the administration group of the embodiment of the present invention 1, comparative example administration group
When gastric infusion, dosage be 2.5g medicines/kg body weight（With crude drug gauge, equivalent to 5 times of clinical dosage）.After 3 months（11
Monthly age）Each group rat is put to death, left femur, shin bone is taken out, is put in physiological saline, soft tissue is peeled off, with DPX-L type dual intensities X
Line borne densitometers determine the bone mineral density of each group rats with left femur full section, neck of femur and proximal tibia respectively.
Table 1：Influence of the medicine of the present invention to PMO rat model bone mineral density
| Group | Neck of femur | Femur full section | Proximal ends of tibia |
| Normal group | 0.376±0.028** | 0.347±0.012** | 0.408±0.051** |
| Model group | 0.257±0.076 | 0.296±0.060 | 0.303±0.019 |
| Medicine group of the present invention | 0.359±0.022** | 0.334±0.061** | 0.397±0.043** |
| Comparative example group | 0.318±0.052** | 0.302±0.019* | 0.324±0.036* |
Compared * * with model group：P ﹤ 0.05；*：P ﹥ 0.05
From experimental result, medicine of the present invention can substantially delay losing for PMO rat model bone ore deposit
Lose.
Test example 2：The evaluating drug effect of medicine of the present invention
Trial drug 1：Chinese medicine composition made from the embodiment of the present invention 1
Trial drug 2：Chinese medicine composition made from the embodiment of the present invention 4
Trial drug 3：Chinese medicine composition made from the embodiment of the present invention 6
Trial drug 4：Chinese medicine composition made from the embodiment of the present invention 7
Comparative example 1：According to the method for embodiment 1 by the bark of eucommia（10 parts by weight）With raspberry（10 parts by weight）Obtained Chinese medicine
Composition
Comparative example 2：According to the method for embodiment 1 by the bark of eucommia（10 parts by weight）With Semen Cuscutae（10 parts by weight）Obtained Chinese medicine
Composition
Comparative example 3：According to the method for embodiment 1 by the bark of eucommia（10 parts by weight）With the red sage root（10 parts by weight）Obtained Chinese medicine group
Compound
Above-mentioned trial drug 1-4 and comparative example 1-3 is utilized respectively, according to the method for test example 1 to postmenopausal osteoporosis
Disease rat model is tested.Result of the test shows that the drug effect of Chinese medicine composition is bright made from the embodiment of the present invention 1,4,6 and 7
The aobvious pharmaceutical composition better than comparative example 1-3.
Therefore, pharmaceutical composition of the invention has synergistic function.
Claims (9)
1. a kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by according to the following ratio
Chinese medicine be made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight.
2. the Chinese medicine composition according to claim 1 for being used to treat postmenopausal osteoporosis, wherein, the Chinese traditional medicine composition
Thing is made up of Chinese medicine according to the following ratio：The parts by weight of the bark of eucommia 10, the parts by weight of raspberry 10, the parts by weight of Semen Cuscutae 10.
3. a kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by according to the following ratio
Chinese medicine be made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 weight
Part.
4. a kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by according to the following ratio
Chinese medicine be made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, fruit of Chinese wolfberry 5-15 weight
Part.
5. a kind of Chinese medicine composition for being used to treat postmenopausal osteoporosis, wherein, the Chinese medicine composition is by according to the following ratio
Chinese medicine be made：Bark of eucommia 6-15 parts by weight, raspberry 5-10 parts by weight, Semen Cuscutae 10-12 parts by weight, red sage root 6-15 weight
Part, fruit of Chinese wolfberry 5-15 parts by weight.
6. a kind of Chinese traditional medicine composition for being used to treat postmenopausal osteoporosis prepared according to any one in claim 1-5
The method of thing, including：
1) Chinese medicine is added with the 50-90% (v/v) of 5 to 20 times of volumes of Chinese medicine gross weight ethanol water
Circumfluence distillation, is repeated 1-2 times, is extracted 1-3 hours every time, merges extract solution；
2) step 1 is filtered) extract solution that obtains, so as to obtain filtrate, the filtrate is concentrated until obtaining thick paste.
7. method according to claim 6, this method also includes：3) thick paste is dried and fine powder is made.
8. method according to claim 7, this method also includes：4) fine powder is filled into capsule, or concentration is made
Ball.
9. the Chinese medicine composition according to any one in claim 1-5 is being prepared for preventing and/or treating post menopausal
Purposes in the medicine of osteoporosis.
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| CN111617128A (en) * | 2020-03-12 | 2020-09-04 | 琛蓝(美国)营养制品股份有限公司 | Traditional Chinese medicine compound composition with effect of promoting bone health and preparation method and application thereof |
| CN111905022B (en) * | 2020-09-21 | 2022-03-25 | 黑龙江中医药大学 | Medicine for promoting ovulation and preparation method thereof |
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| 补肾活血法治疗绝经后骨质疏松症;张文柱等;《吉林中医药》;20041031;第24卷(第10期);第3-4页 * |
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