CN102805816A - Drug composition for treating senium primary osteoarthritis and preparation method thereof - Google Patents
Drug composition for treating senium primary osteoarthritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug composition for treating primary knee joint osteoarthritis and a preparation method thereof. The drug composition comprises the following 20 medicines of ground beeltle, rheum officinale, pseudo-ginseng, corydalis tuber, sangusis draconis, teasel root, golden cypress, frankincense, myrrh, wadalee-gum-tree, asarum, homalomena occulta, edible tulip, rhizoma alismatis, and antelope horn, elecampane, rhizoma bletillae, radix angelicae, cassia twig, and notopterygium root. The prepared externally used paste has good functions of relieving swelling and pain, and relaxing tendons and activating collaterals, can be used for treating arthralgia, swelling and inhibited bending and stretching caused by knee joint osteoarthritis, and has better clinical effects.
Description
Technical field
The invention belongs to medical technical field, exactly, relate to a kind of Chinese medicine pharmaceutical composition of treating degenerative osteoarthritis and preparation method thereof.
Background technology
Degenerative osteoarthritis (Osteoarthritis OA) claims osteoarthritis again, be a kind of common with arthralgia, swelling, stiff and lopsided be the osteoarthritis of characteristics.Osteoarthritis can take place in the whole body joint, knee joint especially, and its sickness rate accounts for osteoarthritis patient's 40%.The degeneration gonarthritis is that one of common chronic degenerative joint disease of middle-aged and elderly people, particularly middle aged and aged women are seen especially.Osteoarthritis is that a kind of degeneration with articular cartilage, destruction and hyperosteogeny are the chronic joint disease of characteristic, belongs to Chinese medicine " rheumatism involving the bone ", " knee joint numbness " category.The most common with arthralgia, hyperosteogeny and limitation of activity clinically, the morbidity of osteoarthritis does not have region and race difference, and age, obesity, inflammation, wound and inherited genetic factors maybe be relevant with the generation of primary disease.This disease is often loose and lopsided with the joint, is to begin from the articular cartilage degenerative change, and then involves sclerotin, periosteum, joint capsule, and form hyperosteogeny, causes the gonalgia, swelling, deformity and dysfunction, so be referred to as the degeneration gonarthritis.The degeneration gonarthritis is that common in older people is sick, has a strong impact on bodily fuctions's activity, and work and life are affected greatly.
The degenerative osteoarthritis Therapeutic Method is more, and doctor trained in Western medicine generally adopts the antalgic and inflammation relieving method to treat, and adopts the method for operation to treat to late period, and antalgic and inflammation relieving chemistry medical instrument has certain side effect, and operation then needs higher expense and brings misery to the patient.External therapy of Chinese herb (comprise smoked, wash, apply ointment or plaster etc.) can be eliminated joint capsule and synovial membrane inflammation effectively, and the joint accretion of loosening is removed muscle spasm; Improve microcirculation in the bone; Reduce intra-osteal pressure, therefore, Chinese medicine is used in treatment osteoarthritis aspect outward and has better analgesia damp eliminating effect; Aspect the elimination hydrarthrosis curative effect preferably also being arranged, especially obvious for the more person's curative effect of hydrarthrosis.
Osteoarthritis is divided into two kinds of constitutional and Secondary cases.The change of constitutional osteoarthritis shows as cartilage matrix protein polysaccharide biosynthesis and decomposes unusually; Chondrocyte can not synthesize hyaluronic acid and the poly-glucosamine that has backbone normally; Consequent short chain proteoglycan polymer is overflowed from the collagen RF, causes the articular cartilage local softening, follows the string, wearing and tearing and structural deterioration.The Secondary cases bone close scorching be mainly wound, motion wearing and tearing and bear a heavy burden due to cartilage damage and cause the osteoarthritis reaction of the adjacent skeleton in joint.
Morbidity that it is generally acknowledged knee joint osseous arthritis is to begin from cartilage surface, and main cause is articular cartilage wearing and tearing and joint Metabolic disorder.Articular lamella exist for the cartilage surface that joint motion provides an anti-wear, lower resistance, make the joint can bear certain compressive stress and shearing force, and activity is freely.Because various impairment factors, the fibrin electrodeposition substance covers articular cartilage, influences the articular cartilage metabolism, causes the cartilage degeneration; Wherein collagen fiber expose, and form villous fibril, even volume-diminished, make cartilage surface coarse; The deliquescing that tarnishes, that continues the crack occurs, and cartilage surface is softening to break, and comes off and disappears; Reactive hyperosteogeny and hyperosteogeny appear in exposed surface of bone under the impact of alternate stress, propagation, calcification phenomenon occur at tendon, joint capsule and the ligament place of adhering to.More than change the normal nutrition and the function that all can influence the joint, cause the regression of bone property to take place.But Chinese medicine external relaxing muscles and tendons and activating QI and blood in the collateral, the reduction joint is intrinsic pressure, the characteristics of regulating and improving local microcirculation is arranged, and can alleviate muscular spasm, alleviates the stimulation to nerve, alleviates ABNORMAL STRESS and concentrates the destruction to joint and cartilage thereof.Chinese medicine has long history to the understanding of osteoarthritis, and the many theoretical point views in control are consistent with the result of study of modern medicine trend, as diminishes inflammation, improves joint surrounding tissue microcirculation, delay cartilage degeneration etc.In the knee joint osseous arthritis treatment, the traditional Chinese medical science has not only solved the infringement of local patholoic change, and can reach the treating both the principal and secondary aspects of a disease purpose through regulating general body state.
Summary of the invention
The object of the present invention is to provide a kind of constitutional knee osteoarthritis onset pharmaceutical composition external preparation rapid, easy to use of treating.Pharmaceutical preparation of the present invention also can be used for the degeneration osteoarthritis at other positions of health except that can be used for the constitutional knee osteoarthritis.
Another purpose of the present invention also is to provide a kind of preparation of pharmaceutical formulations method of treating the constitutional knee osteoarthritis.
The present invention realizes through following technical scheme:
Treatment constitutional degenerative osteoarthritis pharmaceutical composition of the present invention is by weight ratio:
Eupolyphaga Seu Steleophaga 2-10 part Radix Et Rhizoma Rhei 2-10 part Radix Notoginseng 1-3 part Rhizoma Corydalis 2-10 part
Sanguis Draxonis 1-3 part Radix Dipsaci 2-10 part Cortex Phellodendri 2-10 part Olibanum 1-3 part
Myrrha 1-3 share tea 1-3 part Herba Asari 1-5 part Rhizoma Homalomenae 1-7 part
Pseudobulbus cremastrae seu pleiones 1-7 part Rhizoma Alismatis 1-5 part Cornu Saigae Tataricae 1-7 part Radix Aucklandiae 1-3 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 1-3 part Radix Angelicae Dahuricae 1-3 part Ramulus Cinnamomi 1-3 part Rhizoma Et Radix Notopterygii 1-3 part.
The preferred weight proportioning is:
9 parts of 3 parts of Rhizoma Corydalis of 10 portions of Radix Notoginseng of 9 parts of Radix Et Rhizoma Rhei of Eupolyphaga Seu Steleophaga
3 parts of 10 parts of Olibanums of 10 portions of Cortex Phellodendris of 3 parts of Radix Dipsacis of Sanguis Draxonis
6 parts of 4.5 parts of Rhizoma Homalomenaes of 3 parts of Herba Asaris of Myrrha 3 share tea
3 parts of 6 parts of Radix Aucklandiae of 4.5 parts of Cornu Saigae Tataricae of 6 portions of Rhizoma Alismatis of Pseudobulbus cremastrae seu pleiones
3 parts of 3 portions of Rhizoma Et Radix Notopterygiis of 3 parts of Ramulus Cinnamomi of 3 parts of Radixs Angelicae Dahuricae of Pseudobulbus Bletillae (Rhizoma Bletillae).
Pharmaceutical composition external preparation of the present invention can prepare through following method:
1, gets 3 parts of 3 portions of Rhizoma Et Radix Notopterygiis of 10 parts of Olibanums of 10 portions of Cortex Phellodendris of 3 parts of Radix Dipsacis of 9 parts of Sanguis Draxonis of 3 parts of Rhizoma Corydalis of 10 portions of Radix Notoginseng of 9 parts of Radix Et Rhizoma Rhei of Eupolyphaga Seu Steleophaga, 3 parts of Ramulus Cinnamomi of 3 parts of Radixs Angelicae Dahuricae of 3 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) of 6 parts of Radix Aucklandiae of 4.5 parts of Cornu Saigae Tataricae of 6 portions of Rhizoma Alismatis of 6 parts of Pseudobulbus cremastrae seu pleiones of 4.5 parts of Rhizoma Homalomenaes of 3 parts of Herba Asaris of 3 parts of Myrrhas, 3 share tea; Prepare each medicine by above-mentioned weight portion, subsequent use;
2, Olibanum, Myrrha, Sanguis Draxonis, the catechu with the counterweight ratio is ground into fine powder;
3, Radix Notoginseng, the pure one-tenth of Cornu Saigae Tataricae powder impalpable powder with above-mentioned fine powder facing-up, sieve mixing.
4, all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei etc. 14 flavor is given as one thinks fit cataclasmly, gets vegetable oil, puts pot internal heating to 300 ℃, and refining is to dripping into pearl; Add Plumbum preparatium, stir, be placed to 100 ℃, add ten four Chinese medicine materials such as Radix Et Rhizoma Rhei; Kept 24 hours at 100 ℃, pull medicinal residues out, receive cream, form tender cream.Other gets vegetable oil, and heating is fried withered in 200 ℃ of oil cauldrons with above-mentioned ten four Chinese medicine slags, removes slag, and filters, and to dripping into pearl, adds Plumbum preparatium in 300 ℃ of refinings, stirs, and cream is soaked in the water.Get cream, with the slow fire fusing, add Six-element fine powders such as Olibanum again, stir, the stand is formed on the cloth, processes externally used paste and promptly gets externally used paste of the present invention.
Said plant oil phase is selected from a kind of in Oleum Arachidis hypogaeae semen, soybean oil, hydrogenated corn oil, the Oleum sesami;
Externally used paste of the present invention is used for the treatment of degeneration osteoarthritis, and particularly constitutional knee joint joint inflammation has better therapeutic effect.
Further specify effect of the present invention with Test Example below.
Clinical trial data
Used external preparation of the present invention (lot number: 941016) treatment knee joint osseous arthritis 100 examples, matched group 40 examples adopted dog skin plaster to compare, the contrast clinical efficacy from 1994 to 1996.
Divide into groups: 140 routine constitutional knee osteoarthritis patients are divided into two groups at random, adopt the method for clinical control to carry out Comparison of therapeutic.
The treatment group: constitutional knee joint osseous arthritis patient 100 examples, adopt external preparation of the present invention to paste patient's knee joint before, inside and outside three positions;
The dog skin plaster matched group: constitutional knee joint osseous arthritis patient 40 examples, adopt dog skin plaster plaster patient knee joint before, inside and outside three positions.
The efficacy evaluation method:
Curative effect all adopts unified standard to judge respectively mainly with pain, swelling, function limitation, numb limbs and tense tendons and dizzy five clinical manifestations and sign before and after the treatment, will be decided to be a week course of treatment, changes medicine one time in per two days, carries out the evaluation and the statistics of curative effect.
(1), pain degree is judged
With the judgement of 0-10 as pain degree, 0 is no pain, and 1-3 is a mild pain, and 4-6 is a moderate pain, is severe pain greater than 7
(2), swelling deciding degree
Slightly: suspicious swelling; Moderate: clear and definite swelling; Severe: obviously swelling.
(3), function limitation deciding degree
Slightly: limited slightly; Moderate: obviously limited; Severe: seriously limited.
Curative effect determinate standard:
Clinical cure: the basic or complete obiteration of symptom after the medication does not influence daily life and work.
Produce effects: fall two degree
Effectively: once fall
Invalid: a week does not have change after the medication.
The result:
Table 1, external preparation dog skin plaster of the present invention treatment knee joint osseous arthritis observed result
The specific embodiment
Following examples are done further elaboration to the present invention, but do not limit the scope of the invention.
The preparation of embodiment 1. external plaster agent of the present invention
(1), get Eupolyphaga Seu Steleophaga 90g, Radix Et Rhizoma Rhei 100g, Radix Notoginseng 30g, Rhizoma Corydalis 90g, Sanguis Draxonis 30g, Radix Dipsaci 100g, Cortex Phellodendri 100g, Olibanum 30g, medicine 30g, catechu 30g, Herba Asari 45g, Rhizoma Homalomenae 60g, Pseudobulbus cremastrae seu pleiones 60g, rush down 45g, Cornu Saigae Tataricae 60g, Radix Aucklandiae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Radix Angelicae Dahuricae 30g, Ramulus Cinnamomi 30g, Rhizoma Et Radix Notopterygii 30g; Prepare each medicine by above-mentioned weight portion, subsequent use;
(2), Olibanum, Myrrha, Sanguis Draxonis, the catechu with the counterweight ratio is ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae powder are pure becomes impalpable powder, with above-mentioned fine powder facing-up, sieve mixing;
(4), 14 flavors such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get Oleum sesami 2500g, put pot internal heating to 300 ℃, refining is to dripping into pearl; Add Plumbum preparatium 500g, stir, be placed to 100 ℃, add ten four Chinese medicine materials such as Radix Et Rhizoma Rhei; Kept 24 hours at 100 ℃, pull medicinal residues out, receive cream, form tender cream.Other gets Oleum sesami 2500g, and heating is fried withered in 200 ℃ of oil cauldrons with above-mentioned ten four Chinese medicine slags, removes slag, and filters, and to dripping into pearl, adds Plumbum preparatium 1250g in 300 ℃ of refinings, stirs, and cream is soaked in the water.Get cream, with the slow fire fusing, add Six-element fine powders such as Olibanum again, stir, the stand is formed on the cloth, processes externally used paste and promptly gets externally used paste of the present invention.
The preparation of embodiment 2. external plaster agent
(1), gets Eupolyphaga Seu Steleophaga 100g, Radix Et Rhizoma Rhei 100g, Radix Notoginseng 30g, Rhizoma Corydalis 100g, Sanguis Draxonis 30g, Radix Dipsaci 100g, Cortex Phellodendri 100g, Olibanum 30g, Myrrha 30g, catechu 30g, Herba Asari 50g, Rhizoma Homalomenae 70g, Pseudobulbus cremastrae seu pleiones 70g, Rhizoma Alismatis 50g, Cornu Saigae Tataricae 70g, Radix Aucklandiae 30g, Pseudobulbus Bletillae (Rhizoma Bletillae) 30g, Radix Angelicae Dahuricae 30g, Ramulus Cinnamomi 30g, Rhizoma Et Radix Notopterygii 30g; Prepare each medicine by above-mentioned weight portion, subsequent use;
(2), Olibanum, Myrrha, Sanguis Draxonis, the catechu with the counterweight ratio is ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae powder are pure becomes impalpable powder, with above-mentioned fine powder facing-up, sieve mixing.
(4), 14 flavors such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get soybean oil, put pot internal heating to 300 ℃, refining is to dripping into pearl; Add Plumbum preparatium, stir, be placed to 100 ℃, add ten four Chinese medicine materials such as Radix Et Rhizoma Rhei; Kept 24 hours at 100 ℃, pull medicinal residues out, receive cream, form tender cream.Other gets soybean oil, and above-mentioned ten four Chinese medicine slags are fried withered in 200 ℃ of oil cauldrons, removes slag, and filters, and to dripping into pearl, adds Plumbum preparatium in 300 ℃ of refinings, stirs, and cream is soaked in the water.Get cream, with the slow fire fusing, add Six-element fine powders such as Olibanum again, stir, the stand is formed on the cloth, processes externally used paste and promptly gets externally used paste of the present invention.
The preparation of embodiment 3. external plaster agent
(1), gets Eupolyphaga Seu Steleophaga 20g, Radix Et Rhizoma Rhei 20g, Radix Notoginseng 10g, Rhizoma Corydalis 20g, Sanguis Draxonis 10g, Radix Dipsaci 20g, Cortex Phellodendri 20g, Olibanum 10g, Myrrha 10g, catechu 10g, Herba Asari 10g, Rhizoma Homalomenae 10g, Pseudobulbus cremastrae seu pleiones 10g, Rhizoma Alismatis 10g, Cornu Saigae Tataricae 10g, Radix Aucklandiae 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Angelicae Dahuricae 10g, Ramulus Cinnamomi 10g, Rhizoma Et Radix Notopterygii 10g; Prepare each medicine by above-mentioned weight portion, subsequent use;
(2), Olibanum, Myrrha, Sanguis Draxonis, the catechu with the counterweight ratio is ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae powder are pure becomes impalpable powder, with above-mentioned fine powder facing-up, sieve mixing.
(4), 14 flavors such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get Oleum Brassicae campestris, put pot internal heating to 300 ℃, refining is to dripping into pearl; Add Plumbum preparatium, stir, be placed to 100 ℃, add ten four Chinese medicine materials such as Radix Et Rhizoma Rhei; Kept 24 hours at 100 ℃, pull medicinal residues out, receive cream, form tender cream.Other gets Oleum Brassicae campestris, and heating is fried withered in 200 ℃ of oil cauldrons with above-mentioned ten four Chinese medicine slags, removes slag, and filters, and to dripping into pearl, adds Plumbum preparatium in 300 ℃ of refinings, stirs, and cream is soaked in the water.Get cream, with the slow fire fusing, add Six-element fine powders such as Olibanum again, stir, the stand is formed on the cloth, processes externally used paste and promptly gets externally used paste of the present invention.
Claims (5)
1. pharmaceutical composition of treating degenerative osteoarthritis is characterized in that this pharmaceutical composition processed by following raw material medicaments:
Eupolyphaga Seu Steleophaga 2-10 part Radix Et Rhizoma Rhei 2-10 part Radix Notoginseng 1-3 part Rhizoma Corydalis 2-10 part
Sanguis Draxonis 1-3 part Radix Dipsaci 2-10 part Cortex Phellodendri 2-10 part Olibanum 1-3 part
Myrrha 1-3 share tea 1-3 part Herba Asari 1-5 part Rhizoma Homalomenae 1-7 part
Pseudobulbus cremastrae seu pleiones 1-7 part Rhizoma Alismatis 1-5 part Cornu Saigae Tataricae 1-7 part Radix Aucklandiae 1-3 part
Pseudobulbus Bletillae (Rhizoma Bletillae) 1-3 part Radix Angelicae Dahuricae 1-3 part Ramulus Cinnamomi 1-3 part Rhizoma Et Radix Notopterygii 1-3 part.
2. pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition processed by following raw material medicaments:
9 parts of 3 parts of Rhizoma Corydalis of 10 portions of Radix Notoginseng of 9 parts of Radix Et Rhizoma Rhei of Eupolyphaga Seu Steleophaga
3 parts of 10 parts of Olibanums of 10 portions of Cortex Phellodendris of 3 parts of Radix Dipsacis of Sanguis Draxonis
6 parts of 4.5 parts of Rhizoma Homalomenaes of 3 parts of Herba Asaris of Myrrha 3 share tea
3 parts of 6 parts of Radix Aucklandiae of 4.5 parts of Cornu Saigae Tataricae of 6 portions of Rhizoma Alismatis of Pseudobulbus cremastrae seu pleiones
3 parts of 3 portions of Rhizoma Et Radix Notopterygiis of 3 parts of Ramulus Cinnamomi of 3 parts of Radixs Angelicae Dahuricae of Pseudobulbus Bletillae (Rhizoma Bletillae).
3. according to claim 1 or claim 2 preparation of drug combination method is characterized in that preparing according to the following steps:
(1) get Eupolyphaga Seu Steleophaga, big Rhizoma soulieae vaginatae Rhizoma Corydalis Sanguis Draxonis Radix Dipsaci Cortex Phellodendri, Olibanum, Myrrha, catechu, Herba Asari, Rhizoma Homalomenae, Pseudobulbus cremastrae seu pleiones, Rhizoma Alismatis, Cornu Saigae Tataricae, the Radix Aucklandiae, Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Ramulus Cinnamomi, Rhizoma Et Radix Notopterygii, prepare each medicine by last weight portion proportioning, subsequent use;
(2), Olibanum, Myrrha, Sanguis Draxonis, the catechu with the counterweight ratio is ground into fine powder;
(3), Radix Notoginseng, Cornu Saigae Tataricae powder are pure becomes impalpable powder, with above-mentioned fine powder facing-up, sieve mixing.
(4), 14 flavors such as all the other Eupolyphaga Seu Steleophagas, Radix Et Rhizoma Rhei give as one thinks fit cataclasmly, get vegetable oil, put pot internal heating to 300 ℃, refining is to dripping into pearl; Add Plumbum preparatium, stir, be placed to 100 ℃, add ten four Chinese medicine materials such as Radix Et Rhizoma Rhei; Kept 24 hours at 100 ℃, pull medicinal residues out, receive cream, form tender cream.Other gets vegetable oil, and heating is fried withered in 200 ℃ of oil cauldrons with above-mentioned ten four Chinese medicine slags, removes slag, and filters, and to dripping into pearl, adds Plumbum preparatium in 300 ℃ of refinings, stirs, and cream is soaked in the water.Get cream, with the slow fire fusing, add Six-element fine powders such as Olibanum again, stir, the stand is formed on the cloth, processes externally used paste and promptly gets.
4. like the application of the described pharmaceutical composition of claim 1-3 on preparation treatment constitutional osteoarthritis medicine.
5. application as claimed in claim 4 is characterized in that preparing the application on the treatment constitutional knee joint osteoarthrosis medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115779055A (en) * | 2022-12-02 | 2023-03-14 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine composition for treating closed soft tissue injury or degenerative osteoarthritis and application thereof |
| CN115837057A (en) * | 2022-10-31 | 2023-03-24 | 北京修成药业有限公司 | Acupoint plaster for treating myasthenia gravis and using method thereof |
-
2012
- 2012-08-23 CN CN201210301715.1A patent/CN102805816B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 国家药品监督管理局: "《国家药品中药标准 骨伤科分册》", 31 December 2002 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115837057A (en) * | 2022-10-31 | 2023-03-24 | 北京修成药业有限公司 | Acupoint plaster for treating myasthenia gravis and using method thereof |
| CN115779055A (en) * | 2022-12-02 | 2023-03-14 | 中国人民解放军总医院第七医学中心 | Traditional Chinese medicine composition for treating closed soft tissue injury or degenerative osteoarthritis and application thereof |
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