CN102802612A - 含有5-氨基酮戊酸的固态组合物 - Google Patents

含有5-氨基酮戊酸的固态组合物 Download PDF

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Publication number
CN102802612A
CN102802612A CN2010800256075A CN201080025607A CN102802612A CN 102802612 A CN102802612 A CN 102802612A CN 2010800256075 A CN2010800256075 A CN 2010800256075A CN 201080025607 A CN201080025607 A CN 201080025607A CN 102802612 A CN102802612 A CN 102802612A
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CN
China
Prior art keywords
triglycerides
ala
solid
pharmaceutical product
solid pharmaceutical
Prior art date
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Pending
Application number
CN2010800256075A
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English (en)
Chinese (zh)
Inventor
欧迪维格·塞莱格·赫兰
格雷·斯滕斯鲁德
比约恩·克莱姆
乔恩·埃瑞克·布伦德恩
阿斯拉克·戈达尔
乔·克拉韦内斯
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Photocure ASA
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Photocure ASA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42628133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102802612(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Photocure ASA filed Critical Photocure ASA
Publication of CN102802612A publication Critical patent/CN102802612A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800256075A 2009-06-11 2010-06-11 含有5-氨基酮戊酸的固态组合物 Pending CN102802612A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09251538 2009-06-11
EP09251538.6 2009-06-11
PCT/EP2010/003531 WO2010142456A1 (en) 2009-06-11 2010-06-11 Solid compositions comprising 5-aminolevulinic acid

Publications (1)

Publication Number Publication Date
CN102802612A true CN102802612A (zh) 2012-11-28

Family

ID=42628133

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800256075A Pending CN102802612A (zh) 2009-06-11 2010-06-11 含有5-氨基酮戊酸的固态组合物

Country Status (18)

Country Link
US (1) US20120134921A1 (enExample)
EP (1) EP2440188A1 (enExample)
JP (1) JP2012529451A (enExample)
KR (1) KR20140014401A (enExample)
CN (1) CN102802612A (enExample)
AU (1) AU2010257752B2 (enExample)
BR (1) BRPI1011650A2 (enExample)
CA (1) CA2763837A1 (enExample)
CL (1) CL2011003115A1 (enExample)
CO (1) CO6480960A2 (enExample)
CR (1) CR20110649A (enExample)
MX (1) MX2011013069A (enExample)
NZ (1) NZ596946A (enExample)
PE (1) PE20120858A1 (enExample)
RU (1) RU2527328C2 (enExample)
SG (1) SG176687A1 (enExample)
WO (1) WO2010142456A1 (enExample)
ZA (1) ZA201108850B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105481946A (zh) * 2015-12-18 2016-04-13 浙江工商大学 5-氨基酮戊酸与3-羟基吡啶-4-酮的缀合物及其制备法和用途
CN107434753A (zh) * 2017-07-26 2017-12-05 南京大学 5‑氨基乙酰丙酸及其衍生物的泡腾片及其制备方法
CN108697800A (zh) * 2015-12-17 2018-10-23 光治疗Asa公司 用于膀胱癌的光动力疗法（pdt）的方法

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* Cited by examiner, † Cited by third party
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MX2012010007A (es) * 2010-03-01 2012-10-01 Photocure Asa Composiciones cosmeticas.
DE102012105512A1 (de) * 2012-06-25 2014-04-24 Hennig Arzneimittel Gmbh & Co. Kg Arzneiform zur verlängerten Freisetzung von Wirkstoffen
US20140067024A1 (en) 2012-08-30 2014-03-06 Photocure Asa Dual panel photodynamic therapy lamp
GB201221123D0 (en) 2012-11-23 2013-01-09 Photocure As Device for photodynamic treatment
CA2909826A1 (en) * 2013-03-12 2014-10-09 Applied Bioresearch, Inc. Chelation suppository for improved drug delivery
WO2016017006A1 (ja) * 2014-07-31 2016-02-04 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ カプセル製剤
JP6588193B2 (ja) * 2014-07-31 2019-10-09 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ カプセル製剤
US11623008B2 (en) * 2014-08-20 2023-04-11 Professional Compounding Centers Of America Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
US9956426B2 (en) 2015-02-26 2018-05-01 Amol Punjabi Upconverting nanoparticles
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
US10744212B2 (en) 2016-03-14 2020-08-18 General Electric Company Topical application of nerve labeling dyes for image-guided surgery
GB2546128A (en) * 2016-09-28 2017-07-12 Photocure Asa Pharamaceutical compositions comprising hexaminolevulinic acid and methods of using the same
AU2018255269B2 (en) 2017-04-17 2023-03-09 The University Of Chicago Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease
WO2019107389A1 (ja) 2017-12-01 2019-06-06 Ｓｂｉファーマ株式会社 免疫チェックポイント阻害剤による抗腫瘍効果を増強するための医薬組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1178521A (zh) * 1995-03-10 1998-04-08 光治疗公司 用作光化学疗法中的光致敏剂的5－氨基酮戊酸的酯
US20030125388A1 (en) * 2000-01-28 2003-07-03 Bruno Gander 5-Aminolevulinic acid formulation dissolved/dispersed in non-aqueous solvents
US20040234601A1 (en) * 2001-10-09 2004-11-25 Valerie Legrand Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20080227757A1 (en) * 2005-04-26 2008-09-18 Christel Muller-Goymann Formulation for dermal application

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3181062B2 (ja) * 1991-01-31 2001-07-03 帝國製薬株式会社 下部消化管崩壊経口製剤
US6492420B2 (en) * 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
EP2127642A3 (en) * 1998-08-13 2010-02-24 Cima Labs, Inc. Microemulsions as solid dosage forms for oral administration
ATE314091T1 (de) * 1999-06-09 2006-01-15 Mochida Pharm Co Ltd System für wirkstofffreisetzung im unteren verdauungstrakt
GB0018527D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Composition
GB0018528D0 (en) * 2000-07-27 2000-09-13 Photocure Asa Compounds
US7264629B2 (en) * 2001-11-09 2007-09-04 Qlt, Inc. Photodynamic therapy for the treatment of hair loss
TW577606U (en) * 2001-11-20 2004-02-21 Carry Computer Eng Co Ltd Improved structure of all-in-one silicon disk
GB0609809D0 (en) * 2006-05-17 2006-06-28 Photocure Asa Product
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1178521A (zh) * 1995-03-10 1998-04-08 光治疗公司 用作光化学疗法中的光致敏剂的5－氨基酮戊酸的酯
US20030125388A1 (en) * 2000-01-28 2003-07-03 Bruno Gander 5-Aminolevulinic acid formulation dissolved/dispersed in non-aqueous solvents
US20040234601A1 (en) * 2001-10-09 2004-11-25 Valerie Legrand Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
US20080227757A1 (en) * 2005-04-26 2008-09-18 Christel Muller-Goymann Formulation for dermal application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RYAN F.DONNELLY: "Influence of Formulation Factors on PpIX Production and Photodynamic Action of Novel ALA-loaded Microparticles", 《BIOPHARMACEUTICS & DRUG DISPOSITION》, no. 30, 31 March 2009 (2009-03-31), pages 55 - 70, XP002601528, DOI: doi:10.1002/BDD.645 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108697800A (zh) * 2015-12-17 2018-10-23 光治疗Asa公司 用于膀胱癌的光动力疗法（pdt）的方法
US11235168B2 (en) 2015-12-17 2022-02-01 Photocure Asa Method of photodynamic therapy (PDT) for bladder cancer
US11980772B2 (en) 2015-12-17 2024-05-14 Photocure Asa Method of photodynamic therapy (PDT) for bladder cancer
CN105481946A (zh) * 2015-12-18 2016-04-13 浙江工商大学 5-氨基酮戊酸与3-羟基吡啶-4-酮的缀合物及其制备法和用途
CN105481946B (zh) * 2015-12-18 2019-05-21 浙江工商大学 5-氨基酮戊酸与3-羟基吡啶-4-酮的缀合物及其制备法和用途
CN107434753A (zh) * 2017-07-26 2017-12-05 南京大学 5‑氨基乙酰丙酸及其衍生物的泡腾片及其制备方法

Also Published As

Publication number Publication date
NZ596946A (en) 2014-07-25
KR20140014401A (ko) 2014-02-06
EP2440188A1 (en) 2012-04-18
RU2527328C2 (ru) 2014-08-27
JP2012529451A (ja) 2012-11-22
BRPI1011650A2 (pt) 2016-03-22
US20120134921A1 (en) 2012-05-31
PE20120858A1 (es) 2012-08-01
CL2011003115A1 (es) 2012-06-22
CO6480960A2 (es) 2012-07-16
RU2011150920A (ru) 2013-07-20
AU2010257752A1 (en) 2012-01-12
MX2011013069A (es) 2012-02-01
AU2010257752B2 (en) 2015-04-09
ZA201108850B (en) 2013-02-27
CA2763837A1 (en) 2010-12-16
CR20110649A (es) 2012-03-22
SG176687A1 (en) 2012-01-30
WO2010142456A1 (en) 2010-12-16

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