CN102791270A - 将莫西沙星应用于耳的方法和组合物 - Google Patents

将莫西沙星应用于耳的方法和组合物 Download PDF

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Publication number
CN102791270A
CN102791270A CN2011800127647A CN201180012764A CN102791270A CN 102791270 A CN102791270 A CN 102791270A CN 2011800127647 A CN2011800127647 A CN 2011800127647A CN 201180012764 A CN201180012764 A CN 201180012764A CN 102791270 A CN102791270 A CN 102791270A
Authority
CN
China
Prior art keywords
moxifloxacin
glue
moses
tackifier
mef
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800127647A
Other languages
English (en)
Chinese (zh)
Inventor
R·J·索恰克
B·W·Y·张
G·M·沃尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
University of Minnesota System
Original Assignee
Novartis AG
University of Minnesota System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44306169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102791270(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG, University of Minnesota System filed Critical Novartis AG
Priority to CN201610909298.7A priority Critical patent/CN106309356A/zh
Publication of CN102791270A publication Critical patent/CN102791270A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2011800127647A 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物 Pending CN102791270A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610909298.7A CN106309356A (zh) 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29301910P 2010-01-07 2010-01-07
US61/293,019 2010-01-07
PCT/US2011/020531 WO2011085209A2 (en) 2010-01-07 2011-01-07 Methods and compositions for applying moxifloxacin to the ear

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610909298.7A Division CN106309356A (zh) 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物

Publications (1)

Publication Number Publication Date
CN102791270A true CN102791270A (zh) 2012-11-21

Family

ID=44306169

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2011800127647A Pending CN102791270A (zh) 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物
CN201610909298.7A Withdrawn CN106309356A (zh) 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610909298.7A Withdrawn CN106309356A (zh) 2010-01-07 2011-01-07 将莫西沙星应用于耳的方法和组合物

Country Status (24)

Country Link
US (1) US20120289541A1 (enExample)
EP (2) EP2521547B1 (enExample)
JP (3) JP2013516485A (enExample)
KR (2) KR101835895B1 (enExample)
CN (2) CN102791270A (enExample)
AU (1) AU2011204275B2 (enExample)
BR (1) BR112012016809A2 (enExample)
CA (1) CA2786525A1 (enExample)
CL (1) CL2012001835A1 (enExample)
CY (1) CY1119493T1 (enExample)
DK (1) DK2521547T3 (enExample)
ES (1) ES2644826T3 (enExample)
HR (1) HRP20171592T1 (enExample)
HU (1) HUE035586T2 (enExample)
LT (1) LT2521547T (enExample)
MX (1) MX337419B (enExample)
NO (1) NO2521547T3 (enExample)
PH (1) PH12012501371A1 (enExample)
PL (1) PL2521547T3 (enExample)
PT (1) PT2521547T (enExample)
RU (2) RU2016101214A (enExample)
SI (1) SI2521547T1 (enExample)
WO (1) WO2011085209A2 (enExample)
ZA (1) ZA201205965B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
AU2013284453A1 (en) * 2012-06-28 2015-01-22 The Administrators Of The Tulane Educational Fund Selectively polymerizable compositions and methods of use in Vivo
CN103869033B (zh) * 2012-12-14 2016-10-05 南京长澳医药科技有限公司 一种液相色谱法分离测定盐酸莫西沙星及其杂质的方法
JP6255134B1 (ja) * 2016-11-02 2017-12-27 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
CN111601588A (zh) * 2017-12-08 2020-08-28 约翰霍普金斯大学 用于增强粘膜表面处活性剂运输的低渗水凝胶配制物
CN108593696B (zh) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 一种利用定量核磁测定多肽中三氟乙酸残留的方法
CN117045593B (zh) * 2023-09-19 2024-05-28 上海市第六人民医院 一种用于慢性中耳炎治疗的抗菌温敏水凝胶及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650863A (zh) * 1998-09-30 2005-08-10 阿尔康实验室公司 治疗眼、耳和鼻的抗生素组合物
US20070098679A1 (en) * 2002-11-27 2007-05-03 Regents Of The University Of Minnesota Methods and Compositions for Applying Pharmacologic Agents to the Ear
CN101072571A (zh) * 2004-12-10 2007-11-14 爱尔康公司 用于治疗耳感染的组合物
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6740664B2 (en) * 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
JP3450805B2 (ja) * 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650863A (zh) * 1998-09-30 2005-08-10 阿尔康实验室公司 治疗眼、耳和鼻的抗生素组合物
US20070098679A1 (en) * 2002-11-27 2007-05-03 Regents Of The University Of Minnesota Methods and Compositions for Applying Pharmacologic Agents to the Ear
CN101072571A (zh) * 2004-12-10 2007-11-14 爱尔康公司 用于治疗耳感染的组合物
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOSE R.ARRIETA, ET.AL.,: ""Moxifloxa cin vs amoxicillin/clavulana te in the treatment of acute sinusitis"", 《AMERICAN JOURNAL OF OTOLARYNGOLOGY–HEAD AND NECK MEDICINE AND SURGERY》 *

Also Published As

Publication number Publication date
CA2786525A1 (en) 2011-07-14
EP2521547A2 (en) 2012-11-14
CY1119493T1 (el) 2018-03-07
MX337419B (es) 2016-03-03
RU2576029C2 (ru) 2016-02-27
EP2521547B1 (en) 2017-08-16
LT2521547T (lt) 2017-12-11
MX2012007928A (es) 2012-11-22
RU2016101214A (ru) 2018-11-21
HUE035586T2 (en) 2018-05-28
WO2011085209A2 (en) 2011-07-14
JP6267246B2 (ja) 2018-01-24
EP2521547A4 (en) 2014-03-26
ES2644826T3 (es) 2017-11-30
WO2011085209A3 (en) 2011-11-17
PT2521547T (pt) 2017-11-17
EP3305280A1 (en) 2018-04-11
JP2018076352A (ja) 2018-05-17
RU2012133568A (ru) 2014-02-20
HRP20171592T1 (hr) 2018-02-09
ZA201205965B (en) 2014-01-29
AU2011204275A1 (en) 2012-08-23
KR20180027611A (ko) 2018-03-14
CL2012001835A1 (es) 2013-03-22
AU2011204275B2 (en) 2015-04-02
PH12012501371A1 (en) 2012-10-22
KR20120114344A (ko) 2012-10-16
BR112012016809A2 (pt) 2017-09-26
NO2521547T3 (enExample) 2018-01-13
US20120289541A1 (en) 2012-11-15
DK2521547T3 (da) 2017-11-20
PL2521547T3 (pl) 2018-01-31
JP2013516485A (ja) 2013-05-13
SI2521547T1 (en) 2018-02-28
CN106309356A (zh) 2017-01-11
JP2016155808A (ja) 2016-09-01
KR101835895B1 (ko) 2018-03-07

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Application publication date: 20121121