KR101835895B1 - 목시플록사신을 귀에 도포하기 위한 방법 및 조성물 - Google Patents

목시플록사신을 귀에 도포하기 위한 방법 및 조성물 Download PDF

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Publication number
KR101835895B1
KR101835895B1 KR1020127020775A KR20127020775A KR101835895B1 KR 101835895 B1 KR101835895 B1 KR 101835895B1 KR 1020127020775 A KR1020127020775 A KR 1020127020775A KR 20127020775 A KR20127020775 A KR 20127020775A KR 101835895 B1 KR101835895 B1 KR 101835895B1
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South Korea
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formulation
moxifloxacin
thickener
eardrum
fluid
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Expired - Fee Related
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KR1020127020775A
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English (en)
Korean (ko)
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KR20120114344A (ko
Inventor
로날드 제이. 쇼우척
벨린다 더블유.와이. 청
지. 마이클 월
Original Assignee
리전츠 오브 더 유니버스티 오브 미네소타
노파르티스 아게
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Application filed by 리전츠 오브 더 유니버스티 오브 미네소타, 노파르티스 아게 filed Critical 리전츠 오브 더 유니버스티 오브 미네소타
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020127020775A 2010-01-07 2011-01-07 목시플록사신을 귀에 도포하기 위한 방법 및 조성물 Expired - Fee Related KR101835895B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29301910P 2010-01-07 2010-01-07
US61/293,019 2010-01-07
PCT/US2011/020531 WO2011085209A2 (en) 2010-01-07 2011-01-07 Methods and compositions for applying moxifloxacin to the ear

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020187005804A Division KR20180027611A (ko) 2010-01-07 2011-01-07 목시플록사신을 귀에 도포하기 위한 방법 및 조성물

Publications (2)

Publication Number Publication Date
KR20120114344A KR20120114344A (ko) 2012-10-16
KR101835895B1 true KR101835895B1 (ko) 2018-03-07

Family

ID=44306169

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187005804A Ceased KR20180027611A (ko) 2010-01-07 2011-01-07 목시플록사신을 귀에 도포하기 위한 방법 및 조성물
KR1020127020775A Expired - Fee Related KR101835895B1 (ko) 2010-01-07 2011-01-07 목시플록사신을 귀에 도포하기 위한 방법 및 조성물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020187005804A Ceased KR20180027611A (ko) 2010-01-07 2011-01-07 목시플록사신을 귀에 도포하기 위한 방법 및 조성물

Country Status (24)

Country Link
US (1) US20120289541A1 (enExample)
EP (2) EP3305280A1 (enExample)
JP (3) JP2013516485A (enExample)
KR (2) KR20180027611A (enExample)
CN (2) CN102791270A (enExample)
AU (1) AU2011204275B2 (enExample)
BR (1) BR112012016809A2 (enExample)
CA (1) CA2786525A1 (enExample)
CL (1) CL2012001835A1 (enExample)
CY (1) CY1119493T1 (enExample)
DK (1) DK2521547T3 (enExample)
ES (1) ES2644826T3 (enExample)
HR (1) HRP20171592T1 (enExample)
HU (1) HUE035586T2 (enExample)
LT (1) LT2521547T (enExample)
MX (1) MX337419B (enExample)
NO (1) NO2521547T3 (enExample)
PH (1) PH12012501371A1 (enExample)
PL (1) PL2521547T3 (enExample)
PT (1) PT2521547T (enExample)
RU (2) RU2576029C2 (enExample)
SI (1) SI2521547T1 (enExample)
WO (1) WO2011085209A2 (enExample)
ZA (1) ZA201205965B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
JP6456285B2 (ja) * 2012-06-28 2019-01-23 ジ アドミニストレイターズ オブ ザ チューレン エデュケイショナル ファンド 選択的重合性組成物およびｉｎｖｉｖｏでのその使用方法
CN103869033B (zh) * 2012-12-14 2016-10-05 南京长澳医药科技有限公司 一种液相色谱法分离测定盐酸莫西沙星及其杂质的方法
JP6255134B1 (ja) * 2016-11-02 2017-12-27 ヴェローチェ・バイオファーマ・エルエルシー 耳炎の治療のための組成物および方法
US20210177751A1 (en) * 2017-12-08 2021-06-17 The Johns Hopkins University Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
CN108593696B (zh) * 2018-04-26 2020-11-03 南京明捷生物医药检测有限公司 一种利用定量核磁测定多肽中三氟乙酸残留的方法
CN117045593B (zh) * 2023-09-19 2024-05-28 上海市第六人民医院 一种用于慢性中耳炎治疗的抗菌温敏水凝胶及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070098679A1 (en) * 2002-11-27 2007-05-03 Regents Of The University Of Minnesota Methods and Compositions for Applying Pharmacologic Agents to the Ear

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201072B1 (en) 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
AR020661A1 (es) * 1998-09-30 2002-05-22 Alcon Lab Inc Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento
US6740664B2 (en) * 1998-09-30 2004-05-25 Alcon, Inc. Methods for treating otic and ophthalmic infections
JP3450805B2 (ja) * 2000-08-08 2003-09-29 わかもと製薬株式会社 水性医薬組成物
CN101072571A (zh) * 2004-12-10 2007-11-14 爱尔康公司 用于治疗耳感染的组合物
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070098679A1 (en) * 2002-11-27 2007-05-03 Regents Of The University Of Minnesota Methods and Compositions for Applying Pharmacologic Agents to the Ear

Also Published As

Publication number Publication date
RU2012133568A (ru) 2014-02-20
EP2521547B1 (en) 2017-08-16
DK2521547T3 (da) 2017-11-20
HUE035586T2 (en) 2018-05-28
JP2013516485A (ja) 2013-05-13
EP3305280A1 (en) 2018-04-11
CA2786525A1 (en) 2011-07-14
BR112012016809A2 (pt) 2017-09-26
ES2644826T3 (es) 2017-11-30
CN102791270A (zh) 2012-11-21
NO2521547T3 (enExample) 2018-01-13
JP2016155808A (ja) 2016-09-01
KR20120114344A (ko) 2012-10-16
WO2011085209A3 (en) 2011-11-17
CY1119493T1 (el) 2018-03-07
JP2018076352A (ja) 2018-05-17
MX2012007928A (es) 2012-11-22
RU2576029C2 (ru) 2016-02-27
PH12012501371A1 (en) 2012-10-22
WO2011085209A2 (en) 2011-07-14
JP6267246B2 (ja) 2018-01-24
PL2521547T3 (pl) 2018-01-31
RU2016101214A (ru) 2018-11-21
AU2011204275A1 (en) 2012-08-23
US20120289541A1 (en) 2012-11-15
CN106309356A (zh) 2017-01-11
MX337419B (es) 2016-03-03
PT2521547T (pt) 2017-11-17
LT2521547T (lt) 2017-12-11
HRP20171592T1 (hr) 2018-02-09
EP2521547A2 (en) 2012-11-14
EP2521547A4 (en) 2014-03-26
AU2011204275B2 (en) 2015-04-02
SI2521547T1 (en) 2018-02-28
CL2012001835A1 (es) 2013-03-22
KR20180027611A (ko) 2018-03-14
ZA201205965B (en) 2014-01-29

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