CA2786525A1 - Methods and compositions for applying moxifloxacin to the ear - Google Patents
Methods and compositions for applying moxifloxacin to the ear Download PDFInfo
- Publication number
- CA2786525A1 CA2786525A1 CA2786525A CA2786525A CA2786525A1 CA 2786525 A1 CA2786525 A1 CA 2786525A1 CA 2786525 A CA2786525 A CA 2786525A CA 2786525 A CA2786525 A CA 2786525A CA 2786525 A1 CA2786525 A1 CA 2786525A1
- Authority
- CA
- Canada
- Prior art keywords
- moxifloxacin
- formulation
- tympanic membrane
- moxigel
- middle ear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 title claims abstract description 158
- 239000000203 mixture Substances 0.000 title claims abstract description 142
- 238000000034 method Methods 0.000 title claims abstract description 48
- 210000000959 ear middle Anatomy 0.000 claims abstract description 123
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29301910P | 2010-01-07 | 2010-01-07 | |
| US61/293,019 | 2010-01-07 | ||
| PCT/US2011/020531 WO2011085209A2 (en) | 2010-01-07 | 2011-01-07 | Methods and compositions for applying moxifloxacin to the ear |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2786525A1 true CA2786525A1 (en) | 2011-07-14 |
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| CA2786525A Abandoned CA2786525A1 (en) | 2010-01-07 | 2011-01-07 | Methods and compositions for applying moxifloxacin to the ear |
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| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| EP3995160A1 (en) * | 2012-06-28 | 2022-05-11 | The Administrators of the Tulane Educational Fund | Selectively polymerizable compositions |
| CN103869033B (zh) * | 2012-12-14 | 2016-10-05 | 南京长澳医药科技有限公司 | 一种液相色谱法分离测定盐酸莫西沙星及其杂质的方法 |
| JP6255134B1 (ja) * | 2016-11-02 | 2017-12-27 | ヴェローチェ・バイオファーマ・エルエルシー | 耳炎の治療のための組成物および方法 |
| US20210177751A1 (en) * | 2017-12-08 | 2021-06-17 | The Johns Hopkins University | Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces |
| CN108593696B (zh) * | 2018-04-26 | 2020-11-03 | 南京明捷生物医药检测有限公司 | 一种利用定量核磁测定多肽中三氟乙酸残留的方法 |
| CN117045593B (zh) * | 2023-09-19 | 2024-05-28 | 上海市第六人民医院 | 一种用于慢性中耳炎治疗的抗菌温敏水凝胶及其制备方法和应用 |
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|---|---|---|---|---|
| US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6740664B2 (en) * | 1998-09-30 | 2004-05-25 | Alcon, Inc. | Methods for treating otic and ophthalmic infections |
| AR020661A1 (es) * | 1998-09-30 | 2002-05-22 | Alcon Lab Inc | Una composicion farmaceutica topica oftalmica, otica o nasal y el uso de la misma para la manufactura de un medicamento |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| JP2008523060A (ja) * | 2004-12-10 | 2008-07-03 | アルコン，インコーポレイティド | 耳感染の処置のための組成物 |
| WO2009142719A2 (en) * | 2008-05-19 | 2009-11-26 | Massachusetts Institute Of Technology | Tympanic membrane permeating ear drops and uses thereof |
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2011
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- 2011-01-07 CA CA2786525A patent/CA2786525A1/en not_active Abandoned
- 2011-01-07 US US13/520,519 patent/US20120289541A1/en not_active Abandoned
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- 2011-01-07 EP EP11732210.7A patent/EP2521547B1/en not_active Not-in-force
- 2011-01-07 HR HRP20171592TT patent/HRP20171592T1/hr unknown
- 2011-01-07 CN CN2011800127647A patent/CN102791270A/zh active Pending
- 2011-01-07 CN CN201610909298.7A patent/CN106309356A/zh not_active Withdrawn
- 2011-01-07 AU AU2011204275A patent/AU2011204275B2/en not_active Ceased
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- 2011-01-07 MX MX2012007928A patent/MX337419B/es active IP Right Grant
- 2011-01-07 SI SI201131326T patent/SI2521547T1/en unknown
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- 2011-01-07 PT PT117322107T patent/PT2521547T/pt unknown
- 2011-01-07 ES ES11732210.7T patent/ES2644826T3/es active Active
- 2011-01-07 RU RU2012133568/15A patent/RU2576029C2/ru not_active IP Right Cessation
- 2011-01-07 KR KR1020187005804A patent/KR20180027611A/ko not_active Ceased
- 2011-01-07 EP EP17186323.6A patent/EP3305280A1/en not_active Withdrawn
- 2011-01-07 KR KR1020127020775A patent/KR101835895B1/ko not_active Expired - Fee Related
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2012
- 2012-07-06 CL CL2012001835A patent/CL2012001835A1/es unknown
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2016
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2017
- 2017-10-18 CY CY20171101086T patent/CY1119493T1/el unknown
- 2017-12-21 JP JP2017245040A patent/JP2018076352A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20151105 |
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| FZDE | Discontinued |
Effective date: 20200114 |