CN102772745B - 一种治疗癌症的中药制剂及其制备方法 - Google Patents
一种治疗癌症的中药制剂及其制备方法 Download PDFInfo
- Publication number
- CN102772745B CN102772745B CN2012102975473A CN201210297547A CN102772745B CN 102772745 B CN102772745 B CN 102772745B CN 2012102975473 A CN2012102975473 A CN 2012102975473A CN 201210297547 A CN201210297547 A CN 201210297547A CN 102772745 B CN102772745 B CN 102772745B
- Authority
- CN
- China
- Prior art keywords
- radix
- herba
- cancer
- rhizoma
- fructus
- Prior art date
Links
- 201000011510 cancer Diseases 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 50
- 239000000843 powder Substances 0.000 claims abstract description 28
- 239000002775 capsule Substances 0.000 claims abstract description 19
- 229940079593 drugs Drugs 0.000 claims abstract description 18
- 239000008187 granular material Substances 0.000 claims abstract description 17
- 210000000582 Semen Anatomy 0.000 claims description 23
- 238000007796 conventional method Methods 0.000 claims description 12
- 239000006286 aqueous extract Substances 0.000 claims description 11
- 241000628997 Flos Species 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 241000271039 Agkistrodon Species 0.000 claims description 4
- 241000269417 Bufo Species 0.000 claims description 4
- 241000903946 Clematidis Species 0.000 claims description 4
- 241000660877 Coridius Species 0.000 claims description 4
- 241000218176 Corydalis Species 0.000 claims description 4
- 241001489978 Eupolyphaga Species 0.000 claims description 4
- 239000009526 Fructus Akebiae Substances 0.000 claims description 4
- 240000008397 Ganoderma lucidum Species 0.000 claims description 4
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims description 4
- 241001312741 Gekko swinhonis Species 0.000 claims description 4
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 4
- 241000237903 Hirudo Species 0.000 claims description 4
- 239000009636 Huang Qi Substances 0.000 claims description 4
- 241001269712 Laggera Species 0.000 claims description 4
- 241000283956 Manis Species 0.000 claims description 4
- 241000124079 Mylabris Species 0.000 claims description 4
- 241001057584 Myrrha Species 0.000 claims description 4
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 4
- 241000180649 Panax notoginseng Species 0.000 claims description 4
- 241001250596 Pleione Species 0.000 claims description 4
- 241000195474 Sargassum Species 0.000 claims description 4
- 241000131808 Scolopendra Species 0.000 claims description 4
- 241000522620 Scorpio Species 0.000 claims description 4
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300' height='300' x='0' y='0'> </rect>
<text x='138' y='170' class='atom-0' style='font-size:40px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >A</text>
<text x='165.6' y='170' class='atom-0' style='font-size:40px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >s</text>
<path d='M 187.992,150 L 187.984,149.828 L 187.962,149.657 L 187.926,149.489 L 187.874,149.325 L 187.809,149.166 L 187.731,149.012 L 187.64,148.867 L 187.536,148.729 L 187.421,148.601 L 187.296,148.483 L 187.16,148.377 L 187.017,148.282 L 186.865,148.201 L 186.707,148.132 L 186.544,148.078 L 186.377,148.037 L 186.207,148.012 L 186.035,148 L 185.863,148.004 L 185.692,148.023 L 185.523,148.056 L 185.357,148.103 L 185.197,148.165 L 185.042,148.24 L 184.894,148.328 L 184.754,148.429 L 184.624,148.541 L 184.504,148.664 L 184.394,148.797 L 184.297,148.939 L 184.212,149.088 L 184.14,149.245 L 184.082,149.407 L 184.038,149.573 L 184.008,149.743 L 183.994,149.914 L 183.994,150.086 L 184.008,150.257 L 184.038,150.427 L 184.082,150.593 L 184.14,150.755 L 184.212,150.912 L 184.297,151.061 L 184.394,151.203 L 184.504,151.336 L 184.624,151.459 L 184.754,151.571 L 184.894,151.672 L 185.042,151.76 L 185.197,151.835 L 185.357,151.897 L 185.523,151.944 L 185.692,151.977 L 185.863,151.996 L 186.035,152 L 186.207,151.988 L 186.377,151.963 L 186.544,151.922 L 186.707,151.868 L 186.865,151.799 L 187.017,151.718 L 187.16,151.623 L 187.296,151.517 L 187.421,151.399 L 187.536,151.271 L 187.64,151.133 L 187.731,150.988 L 187.809,150.834 L 187.874,150.675 L 187.926,150.511 L 187.962,150.343 L 187.984,150.172 L 187.992,150 L 185.992,150 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 187.992,168.455 L 187.984,168.283 L 187.962,168.112 L 187.926,167.944 L 187.874,167.779 L 187.809,167.62 L 187.731,167.467 L 187.64,167.321 L 187.536,167.184 L 187.421,167.056 L 187.296,166.938 L 187.16,166.831 L 187.017,166.737 L 186.865,166.655 L 186.707,166.587 L 186.544,166.532 L 186.377,166.492 L 186.207,166.466 L 186.035,166.455 L 185.863,166.459 L 185.692,166.477 L 185.523,166.51 L 185.357,166.558 L 185.197,166.619 L 185.042,166.695 L 184.894,166.783 L 184.754,166.883 L 184.624,166.995 L 184.504,167.118 L 184.394,167.251 L 184.297,167.393 L 184.212,167.543 L 184.14,167.699 L 184.082,167.861 L 184.038,168.028 L 184.008,168.197 L 183.994,168.369 L 183.994,168.541 L 184.008,168.712 L 184.038,168.882 L 184.082,169.048 L 184.14,169.21 L 184.212,169.366 L 184.297,169.516 L 184.394,169.658 L 184.504,169.791 L 184.624,169.914 L 184.754,170.026 L 184.894,170.126 L 185.042,170.215 L 185.197,170.29 L 185.357,170.351 L 185.523,170.399 L 185.692,170.432 L 185.863,170.45 L 186.035,170.454 L 186.207,170.443 L 186.377,170.417 L 186.544,170.377 L 186.707,170.322 L 186.865,170.254 L 187.017,170.172 L 187.16,170.078 L 187.296,169.971 L 187.421,169.853 L 187.536,169.725 L 187.64,169.588 L 187.731,169.442 L 187.809,169.289 L 187.874,169.13 L 187.926,168.965 L 187.962,168.797 L 187.984,168.626 L 187.992,168.455 L 185.992,168.455 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 187.992,131.545 L 187.984,131.374 L 187.962,131.203 L 187.926,131.035 L 187.874,130.87 L 187.809,130.711 L 187.731,130.558 L 187.64,130.412 L 187.536,130.275 L 187.421,130.147 L 187.296,130.029 L 187.16,129.922 L 187.017,129.828 L 186.865,129.746 L 186.707,129.678 L 186.544,129.623 L 186.377,129.583 L 186.207,129.557 L 186.035,129.546 L 185.863,129.55 L 185.692,129.568 L 185.523,129.601 L 185.357,129.649 L 185.197,129.71 L 185.042,129.785 L 184.894,129.874 L 184.754,129.974 L 184.624,130.086 L 184.504,130.209 L 184.394,130.342 L 184.297,130.484 L 184.212,130.634 L 184.14,130.79 L 184.082,130.952 L 184.038,131.118 L 184.008,131.288 L 183.994,131.459 L 183.994,131.631 L 184.008,131.803 L 184.038,131.972 L 184.082,132.139 L 184.14,132.301 L 184.212,132.457 L 184.297,132.607 L 184.394,132.749 L 184.504,132.882 L 184.624,133.005 L 184.754,133.117 L 184.894,133.217 L 185.042,133.305 L 185.197,133.381 L 185.357,133.442 L 185.523,133.49 L 185.692,133.523 L 185.863,133.541 L 186.035,133.545 L 186.207,133.534 L 186.377,133.508 L 186.544,133.468 L 186.707,133.413 L 186.865,133.345 L 187.017,133.263 L 187.16,133.169 L 187.296,133.062 L 187.421,132.944 L 187.536,132.816 L 187.64,132.679 L 187.731,132.533 L 187.809,132.38 L 187.874,132.221 L 187.926,132.056 L 187.962,131.888 L 187.984,131.717 L 187.992,131.545 L 185.992,131.545 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 187.992,150 L 187.984,149.828 L 187.962,149.657 L 187.926,149.489 L 187.874,149.325 L 187.809,149.166 L 187.731,149.012 L 187.64,148.867 L 187.536,148.729 L 187.421,148.601 L 187.296,148.483 L 187.16,148.377 L 187.017,148.282 L 186.865,148.201 L 186.707,148.132 L 186.544,148.078 L 186.377,148.037 L 186.207,148.012 L 186.035,148 L 185.863,148.004 L 185.692,148.023 L 185.523,148.056 L 185.357,148.103 L 185.197,148.165 L 185.042,148.24 L 184.894,148.328 L 184.754,148.429 L 184.624,148.541 L 184.504,148.664 L 184.394,148.797 L 184.297,148.939 L 184.212,149.088 L 184.14,149.245 L 184.082,149.407 L 184.038,149.573 L 184.008,149.743 L 183.994,149.914 L 183.994,150.086 L 184.008,150.257 L 184.038,150.427 L 184.082,150.593 L 184.14,150.755 L 184.212,150.912 L 184.297,151.061 L 184.394,151.203 L 184.504,151.336 L 184.624,151.459 L 184.754,151.571 L 184.894,151.672 L 185.042,151.76 L 185.197,151.835 L 185.357,151.897 L 185.523,151.944 L 185.692,151.977 L 185.863,151.996 L 186.035,152 L 186.207,151.988 L 186.377,151.963 L 186.544,151.922 L 186.707,151.868 L 186.865,151.799 L 187.017,151.718 L 187.16,151.623 L 187.296,151.517 L 187.421,151.399 L 187.536,151.271 L 187.64,151.133 L 187.731,150.988 L 187.809,150.834 L 187.874,150.675 L 187.926,150.511 L 187.962,150.343 L 187.984,150.172 L 187.992,150 L 185.992,150 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85' height='85' x='0' y='0'> </rect>
<text x='35.0455' y='53.5909' class='atom-0' style='font-size:23px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >A</text>
<text x='51.0409' y='53.5909' class='atom-0' style='font-size:23px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >s</text>
<path d='M 66.1039,42 L 66.0996,41.9004 L 66.0867,41.8015 L 66.0655,41.704 L 66.0359,41.6088 L 65.9982,41.5164 L 65.9527,41.4277 L 65.8998,41.3431 L 65.8398,41.2635 L 65.7732,41.1893 L 65.7004,41.1211 L 65.622,41.0594 L 65.5387,41.0046 L 65.4509,40.9572 L 65.3594,40.9176 L 65.2648,40.886 L 65.1679,40.8626 L 65.0693,40.8476 L 64.9697,40.8412 L 64.87,40.8433 L 64.7709,40.854 L 64.673,40.8732 L 64.5771,40.9008 L 64.484,40.9364 L 64.3943,40.98 L 64.3086,41.0311 L 64.2277,41.0894 L 64.1521,41.1544 L 64.0823,41.2257 L 64.0189,41.3027 L 63.9624,41.3848 L 63.9132,41.4716 L 63.8716,41.5622 L 63.8379,41.6561 L 63.8124,41.7525 L 63.7953,41.8508 L 63.7868,41.9501 L 63.7868,42.0499 L 63.7953,42.1492 L 63.8124,42.2475 L 63.8379,42.3439 L 63.8716,42.4378 L 63.9132,42.5284 L 63.9624,42.6152 L 64.0189,42.6973 L 64.0823,42.7743 L 64.1521,42.8456 L 64.2277,42.9106 L 64.3086,42.9689 L 64.3943,43.02 L 64.484,43.0636 L 64.5771,43.0992 L 64.673,43.1268 L 64.7709,43.146 L 64.87,43.1567 L 64.9697,43.1588 L 65.0693,43.1524 L 65.1679,43.1374 L 65.2648,43.114 L 65.3594,43.0824 L 65.4509,43.0428 L 65.5387,42.9954 L 65.622,42.9406 L 65.7004,42.8789 L 65.7732,42.8107 L 65.8398,42.7365 L 65.8998,42.6569 L 65.9527,42.5723 L 65.9982,42.4836 L 66.0359,42.3912 L 66.0655,42.296 L 66.0867,42.1985 L 66.0996,42.0996 L 66.1039,42 L 64.9448,42 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 66.1039,46.6364 L 66.0996,46.5367 L 66.0867,46.4378 L 66.0655,46.3404 L 66.0359,46.2451 L 65.9982,46.1528 L 65.9527,46.064 L 65.8998,45.9795 L 65.8398,45.8998 L 65.7732,45.8256 L 65.7004,45.7574 L 65.622,45.6957 L 65.5387,45.641 L 65.4509,45.5936 L 65.3594,45.554 L 65.2648,45.5223 L 65.1679,45.4989 L 65.0693,45.484 L 64.9697,45.4775 L 64.87,45.4797 L 64.7709,45.4904 L 64.673,45.5096 L 64.5771,45.5371 L 64.484,45.5728 L 64.3943,45.6163 L 64.3086,45.6675 L 64.2277,45.7257 L 64.1521,45.7907 L 64.0823,45.862 L 64.0189,45.939 L 63.9624,46.0212 L 63.9132,46.1079 L 63.8716,46.1986 L 63.8379,46.2924 L 63.8124,46.3889 L 63.7953,46.4871 L 63.7868,46.5865 L 63.7868,46.6862 L 63.7953,46.7856 L 63.8124,46.8839 L 63.8379,46.9803 L 63.8716,47.0742 L 63.9132,47.1648 L 63.9624,47.2515 L 64.0189,47.3337 L 64.0823,47.4107 L 64.1521,47.482 L 64.2277,47.547 L 64.3086,47.6053 L 64.3943,47.6564 L 64.484,47.6999 L 64.5771,47.7356 L 64.673,47.7631 L 64.7709,47.7823 L 64.87,47.793 L 64.9697,47.7952 L 65.0693,47.7888 L 65.1679,47.7738 L 65.2648,47.7504 L 65.3594,47.7188 L 65.4509,47.6791 L 65.5387,47.6317 L 65.622,47.577 L 65.7004,47.5153 L 65.7732,47.4471 L 65.8398,47.3729 L 65.8998,47.2932 L 65.9527,47.2087 L 65.9982,47.1199 L 66.0359,47.0276 L 66.0655,46.9323 L 66.0867,46.8349 L 66.0996,46.736 L 66.1039,46.6364 L 64.9448,46.6364 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 66.1039,37.3636 L 66.0996,37.264 L 66.0867,37.1651 L 66.0655,37.0677 L 66.0359,36.9724 L 65.9982,36.8801 L 65.9527,36.7913 L 65.8998,36.7068 L 65.8398,36.6271 L 65.7732,36.5529 L 65.7004,36.4847 L 65.622,36.423 L 65.5387,36.3683 L 65.4509,36.3209 L 65.3594,36.2812 L 65.2648,36.2496 L 65.1679,36.2262 L 65.0693,36.2112 L 64.9697,36.2048 L 64.87,36.207 L 64.7709,36.2177 L 64.673,36.2369 L 64.5771,36.2644 L 64.484,36.3001 L 64.3943,36.3436 L 64.3086,36.3947 L 64.2277,36.453 L 64.1521,36.518 L 64.0823,36.5893 L 64.0189,36.6663 L 63.9624,36.7485 L 63.9132,36.8352 L 63.8716,36.9258 L 63.8379,37.0197 L 63.8124,37.1161 L 63.7953,37.2144 L 63.7868,37.3138 L 63.7868,37.4135 L 63.7953,37.5129 L 63.8124,37.6111 L 63.8379,37.7076 L 63.8716,37.8014 L 63.9132,37.8921 L 63.9624,37.9788 L 64.0189,38.061 L 64.0823,38.138 L 64.1521,38.2093 L 64.2277,38.2743 L 64.3086,38.3325 L 64.3943,38.3837 L 64.484,38.4272 L 64.5771,38.4629 L 64.673,38.4904 L 64.7709,38.5096 L 64.87,38.5203 L 64.9697,38.5225 L 65.0693,38.516 L 65.1679,38.5011 L 65.2648,38.4777 L 65.3594,38.446 L 65.4509,38.4064 L 65.5387,38.359 L 65.622,38.3043 L 65.7004,38.2426 L 65.7732,38.1744 L 65.8398,38.1002 L 65.8998,38.0205 L 65.9527,37.936 L 65.9982,37.8472 L 66.0359,37.7549 L 66.0655,37.6596 L 66.0867,37.5622 L 66.0996,37.4633 L 66.1039,37.3636 L 64.9448,37.3636 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
<path d='M 66.1039,42 L 66.0996,41.9004 L 66.0867,41.8015 L 66.0655,41.704 L 66.0359,41.6088 L 65.9982,41.5164 L 65.9527,41.4277 L 65.8998,41.3431 L 65.8398,41.2635 L 65.7732,41.1893 L 65.7004,41.1211 L 65.622,41.0594 L 65.5387,41.0046 L 65.4509,40.9572 L 65.3594,40.9176 L 65.2648,40.886 L 65.1679,40.8626 L 65.0693,40.8476 L 64.9697,40.8412 L 64.87,40.8433 L 64.7709,40.854 L 64.673,40.8732 L 64.5771,40.9008 L 64.484,40.9364 L 64.3943,40.98 L 64.3086,41.0311 L 64.2277,41.0894 L 64.1521,41.1544 L 64.0823,41.2257 L 64.0189,41.3027 L 63.9624,41.3848 L 63.9132,41.4716 L 63.8716,41.5622 L 63.8379,41.6561 L 63.8124,41.7525 L 63.7953,41.8508 L 63.7868,41.9501 L 63.7868,42.0499 L 63.7953,42.1492 L 63.8124,42.2475 L 63.8379,42.3439 L 63.8716,42.4378 L 63.9132,42.5284 L 63.9624,42.6152 L 64.0189,42.6973 L 64.0823,42.7743 L 64.1521,42.8456 L 64.2277,42.9106 L 64.3086,42.9689 L 64.3943,43.02 L 64.484,43.0636 L 64.5771,43.0992 L 64.673,43.1268 L 64.7709,43.146 L 64.87,43.1567 L 64.9697,43.1588 L 65.0693,43.1524 L 65.1679,43.1374 L 65.2648,43.114 L 65.3594,43.0824 L 65.4509,43.0428 L 65.5387,42.9954 L 65.622,42.9406 L 65.7004,42.8789 L 65.7732,42.8107 L 65.8398,42.7365 L 65.8998,42.6569 L 65.9527,42.5723 L 65.9982,42.4836 L 66.0359,42.3912 L 66.0655,42.296 L 66.0867,42.1985 L 66.0996,42.0996 L 66.1039,42 L 64.9448,42 Z' style='fill:#000000;fill-rule:evenodd;fill-opacity:1;stroke:#000000;stroke-width:0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;' />
</svg>
 [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000008517 radix Trichosanthis Substances 0.000 claims description 4
- 239000009490 scorpio Substances 0.000 claims description 4
- 241000255791 Bombyx Species 0.000 claims description 3
- 241000717739 Boswellia sacra Species 0.000 claims description 3
- 241001251068 Formica fusca Species 0.000 claims description 3
- 239000004863 Frankincense Substances 0.000 claims description 3
- 240000008669 Hedera helix Species 0.000 claims description 3
- 229940097275 Indigo Drugs 0.000 claims description 3
- 240000007871 Indigofera tinctoria Species 0.000 claims description 3
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 3
- 241000237636 Pheretima Species 0.000 claims description 3
- 241000222640 Polyporus Species 0.000 claims description 3
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 3
- 239000010271 massa medicata fermentata Substances 0.000 claims description 3
- 239000002689 soil Substances 0.000 claims description 3
- 230000001954 sterilising Effects 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 7
- 206010006187 Breast cancer Diseases 0.000 abstract description 5
- 206010008342 Cervix carcinoma Diseases 0.000 abstract description 4
- 206010017758 Gastric cancer Diseases 0.000 abstract description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract description 4
- 201000010881 cervical cancer Diseases 0.000 abstract description 4
- 231100000486 side effect Toxicity 0.000 abstract description 4
- 230000001717 pathogenic Effects 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 201000011549 stomach cancer Diseases 0.000 abstract description 3
- 238000005728 strengthening Methods 0.000 abstract description 3
- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 241001116498 Taxus baccata Species 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 244000052769 pathogens Species 0.000 abstract description 2
- 240000003301 Agrimonia eupatoria Species 0.000 abstract 1
- 241001269715 Laggera pterodonta Species 0.000 abstract 1
- 229940100688 Oral Solution Drugs 0.000 abstract 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 abstract 1
- 241000915604 Scutellaria barbata Species 0.000 abstract 1
- 235000000125 common agrimony Nutrition 0.000 abstract 1
- 201000004101 esophageal cancer Diseases 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 10
- 239000008280 blood Substances 0.000 description 5
- 210000004369 Blood Anatomy 0.000 description 4
- 230000001225 therapeutic Effects 0.000 description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 3
- 210000000496 Pancreas Anatomy 0.000 description 3
- 231100000614 Poison Toxicity 0.000 description 3
- 201000005619 esophageal carcinoma Diseases 0.000 description 3
- 210000000056 organs Anatomy 0.000 description 3
- 201000008275 breast carcinoma Diseases 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 208000007502 Anemia Diseases 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 240000000218 Cannabis sativa Species 0.000 description 1
- 239000003390 Chinese drug Substances 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010022114 Injury Diseases 0.000 description 1
- 210000004185 Liver Anatomy 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 231100000494 adverse effect Toxicity 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 230000003821 menstrual periods Effects 0.000 description 1
- 230000003340 mental Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N p-acetaminophenol Chemical compound data:image/svg+xml;base64,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 data:image/svg+xml;base64,PD94bWwgdmVyc2lvbj0nMS4wJyBlbmNvZGluZz0naXNvLTg4NTktMSc/Pgo8c3ZnIHZlcnNpb249JzEuMScgYmFzZVByb2ZpbGU9J2Z1bGwnCiAgICAgICAgICAgICAgeG1sbnM9J2h0dHA6Ly93d3cudzMub3JnLzIwMDAvc3ZnJwogICAgICAgICAgICAgICAgICAgICAgeG1sbnM6cmRraXQ9J2h0dHA6Ly93d3cucmRraXQub3JnL3htbCcKICAgICAgICAgICAgICAgICAgICAgIHhtbG5zOnhsaW5rPSdodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rJwogICAgICAgICAgICAgICAgICB4bWw6c3BhY2U9J3ByZXNlcnZlJwp3aWR0aD0nODVweCcgaGVpZ2h0PSc4NXB4JyB2aWV3Qm94PScwIDAgODUgODUnPgo8IS0tIEVORCBPRiBIRUFERVIgLS0+CjxyZWN0IHN0eWxlPSdvcGFjaXR5OjEuMDtmaWxsOiNGRkZGRkY7c3Ryb2tlOm5vbmUnIHdpZHRoPSc4NScgaGVpZ2h0PSc4NScgeD0nMCcgeT0nMCc+IDwvcmVjdD4KPHBhdGggY2xhc3M9J2JvbmQtMCcgZD0nTSAzLjM2MzY0LDQ0LjEyIEwgMTUuOTQ2LDQwLjc0ODUnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTEnIGQ9J00gMTcuMjA0Miw0MS4wODU3IEwgMTguNDQ0NCwzNi40NTczJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC0xJyBkPSdNIDE4LjQ0NDQsMzYuNDU3MyBMIDE5LjY4NDYsMzEuODI5JyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojRTg0MjM1O3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC0xJyBkPSdNIDE0LjY4NzgsNDAuNDExNCBMIDE1LjkyNzksMzUuNzgzJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC0xJyBkPSdNIDE1LjkyNzksMzUuNzgzIEwgMTcuMTY4MSwzMS4xNTQ3JyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojRTg0MjM1O3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC0yJyBkPSdNIDE1Ljk0Niw0MC43NDg1IEwgMTkuNDg4Niw0NC4yOTEyJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC0yJyBkPSdNIDE5LjQ4ODYsNDQuMjkxMiBMIDIzLjAzMTMsNDcuODMzOCcgc3R5bGU9J2ZpbGw6bm9uZTtmaWxsLXJ1bGU6ZXZlbm9kZDtzdHJva2U6IzQyODRGNDtzdHJva2Utd2lkdGg6MS4wcHg7c3Ryb2tlLWxpbmVjYXA6YnV0dDtzdHJva2UtbGluZWpvaW46bWl0ZXI7c3Ryb2tlLW9wYWNpdHk6MScgLz4KPHBhdGggY2xhc3M9J2JvbmQtMycgZD0nTSAyNy4yODI2LDQ5LjM4OTkgTCAzMi41MTA5LDQ3Ljk4OScgc3R5bGU9J2ZpbGw6bm9uZTtmaWxsLXJ1bGU6ZXZlbm9kZDtzdHJva2U6IzQyODRGNDtzdHJva2Utd2lkdGg6MS4wcHg7c3Ryb2tlLWxpbmVjYXA6YnV0dDtzdHJva2UtbGluZWpvaW46bWl0ZXI7c3Ryb2tlLW9wYWNpdHk6MScgLz4KPHBhdGggY2xhc3M9J2JvbmQtMycgZD0nTSAzMi41MTA5LDQ3Ljk4OSBMIDM3LjczOTMsNDYuNTg4JyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC00JyBkPSdNIDM3LjczOTMsNDYuNTg4IEwgNDEuMTEwNywzNC4wMDU2JyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC00JyBkPSdNIDQwLjc2MTUsNDUuMzc0OSBMIDQzLjEyMTUsMzYuNTY3Mycgc3R5bGU9J2ZpbGw6bm9uZTtmaWxsLXJ1bGU6ZXZlbm9kZDtzdHJva2U6IzNCNDE0MztzdHJva2Utd2lkdGg6MS4wcHg7c3Ryb2tlLWxpbmVjYXA6YnV0dDtzdHJva2UtbGluZWpvaW46bWl0ZXI7c3Ryb2tlLW9wYWNpdHk6MScgLz4KPHBhdGggY2xhc3M9J2JvbmQtMTAnIGQ9J00gMzcuNzM5Myw0Ni41ODggTCA0Ni45NTAyLDU1Ljc5ODknIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTUnIGQ9J00gNDEuMTEwNywzNC4wMDU2IEwgNTMuNjkzMSwzMC42MzQyJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC02JyBkPSdNIDUzLjY5MzEsMzAuNjM0MiBMIDYyLjkwNCwzOS44NDUxJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC02JyBkPSdNIDUzLjIzMjYsMzMuODU4IEwgNTkuNjgwMiw0MC4zMDU3JyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC03JyBkPSdNIDYyLjkwNCwzOS44NDUxIEwgNjguMTMyNCwzOC40NDQyJyBzdHlsZT0nZmlsbDpub25lO2ZpbGwtcnVsZTpldmVub2RkO3N0cm9rZTojM0I0MTQzO3N0cm9rZS13aWR0aDoxLjBweDtzdHJva2UtbGluZWNhcDpidXR0O3N0cm9rZS1saW5lam9pbjptaXRlcjtzdHJva2Utb3BhY2l0eToxJyAvPgo8cGF0aCBjbGFzcz0nYm9uZC03JyBkPSdNIDY4LjEzMjQsMzguNDQ0MiBMIDczLjM2MDgsMzcuMDQzMycgc3R5bGU9J2ZpbGw6bm9uZTtmaWxsLXJ1bGU6ZXZlbm9kZDtzdHJva2U6I0U4NDIzNTtzdHJva2Utd2lkdGg6MS4wcHg7c3Ryb2tlLWxpbmVjYXA6YnV0dDtzdHJva2UtbGluZWpvaW46bWl0ZXI7c3Ryb2tlLW9wYWNpdHk6MScgLz4KPHBhdGggY2xhc3M9J2JvbmQtOCcgZD0nTSA2Mi45MDQsMzkuODQ1MSBMIDU5LjUzMjYsNTIuNDI3NScgc3R5bGU9J2ZpbGw6bm9uZTtmaWxsLXJ1bGU6ZXZlbm9kZDtzdHJva2U6IzNCNDE0MztzdHJva2Utd2lkdGg6MS4wcHg7c3Ryb2tlLWxpbmVjYXA6YnV0dDtzdHJva2UtbGluZWpvaW46bWl0ZXI7c3Ryb2tlLW9wYWNpdHk6MScgLz4KPHBhdGggY2xhc3M9J2JvbmQtOScgZD0nTSA1OS41MzI2LDUyLjQyNzUgTCA0Ni45NTAyLDU1Ljc5ODknIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+CjxwYXRoIGNsYXNzPSdib25kLTknIGQ9J00gNTYuOTcxLDUwLjQxNjggTCA0OC4xNjMzLDUyLjc3NjgnIHN0eWxlPSdmaWxsOm5vbmU7ZmlsbC1ydWxlOmV2ZW5vZGQ7c3Ryb2tlOiMzQjQxNDM7c3Ryb2tlLXdpZHRoOjEuMHB4O3N0cm9rZS1saW5lY2FwOmJ1dHQ7c3Ryb2tlLWxpbmVqb2luOm1pdGVyO3N0cm9rZS1vcGFjaXR5OjEnIC8+Cjx0ZXh0IHg9JzE3LjUxNzQnIHk9JzMxLjE2NjInIGNsYXNzPSdhdG9tLTInIHN0eWxlPSdmb250LXNpemU6NnB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6I0U4NDIzNScgPk88L3RleHQ+Cjx0ZXh0IHg9JzIzLjM1NjknIHk9JzUyLjk1OTUnIGNsYXNzPSdhdG9tLTMnIHN0eWxlPSdmb250LXNpemU6NnB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6IzQyODRGNCcgPk48L3RleHQ+Cjx0ZXh0IHg9JzIzLjM1NjknIHk9JzU4LjIzOTUnIGNsYXNzPSdhdG9tLTMnIHN0eWxlPSdmb250LXNpemU6NnB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6IzQyODRGNCcgPkg8L3RleHQ+Cjx0ZXh0IHg9JzczLjY4NjQnIHk9JzM5LjQ3MzcnIGNsYXNzPSdhdG9tLTgnIHN0eWxlPSdmb250LXNpemU6NnB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6I0U4NDIzNScgPk88L3RleHQ+Cjx0ZXh0IHg9Jzc3LjgyNjQnIHk9JzM5LjQ3MzcnIGNsYXNzPSdhdG9tLTgnIHN0eWxlPSdmb250LXNpemU6NnB4O2ZvbnQtc3R5bGU6bm9ybWFsO2ZvbnQtd2VpZ2h0Om5vcm1hbDtmaWxsLW9wYWNpdHk6MTtzdHJva2U6bm9uZTtmb250LWZhbWlseTpzYW5zLXNlcmlmO3RleHQtYW5jaG9yOnN0YXJ0O2ZpbGw6I0U4NDIzNScgPkg8L3RleHQ+Cjwvc3ZnPgo= CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 230000000505 pernicious Effects 0.000 description 1
- 230000001737 promoting Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissues Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
Abstract
本发明涉及一种治疗癌症的中药制剂，是由紫杉、半枝莲、仙鹤草、臭灵丹等110味原料药材制成的药剂。所述的药剂是口服液、颗粒、散剂、胶囊、冲剂及片剂。本发明采用了110味中药，君臣佐使合理搭配，兼顾方方面面，起到了对癌症标本兼治的作用。本发明采用的原料药为常用的普通中药，制作成本低，副作用小。本发明具有可有效增强自身免役力、攻邪而不伤正的优点，且起效快，疗效高，治愈率高，复发率较低，标本兼治，安全可靠。本发明可治疗各种类型的癌症，特别是肺癌、胃癌、肝癌、食道癌、胰腺癌、宫颈癌及乳腺癌。
Description
一种治疗癌症的中药制剂及其制备方法
技术领域
[0001] 本发明涉及一种用中药制备的治疗癌症的中药制剂及其制备方法，具体的是ー种治疗癌症的中药制剂及其制备方法。
背景技术
[0002] 癌症是世界上严重危害人们身体健康的重大疾病。在因疾病死亡的人群中因癌症死亡的约占四分之一。据世界卫生组织报告全球癌症发病率有逐年增高的趋势。据专家预测，至2020年全世界癌症新发病例将达2000万，将有1200万人死于癌症。癌症巳成为人类的一大杀手。
[0003] 癌症具有发病机理复杂，病情变化快，容易转移，治疗效果差的特点。目前西医治疗癌症的方法主要是手术切除，这种方法是将病灶处的组织切除，这种方法相对于保守疗法治愈率高，对患者身体伤害较大，危险性较高。采用放疗或化疗的方法杀死癌细胞的方法也较常用，但在杀死癌细胞的同时也会将部份正常细胞杀死，这种方法副作用大，治疗费用高，治愈率低。采用中药治疗癌症也是ー种重要的方法，中药治疗癌症较为安全，副作用小，费用较低，其缺点是治疗时间长、疗效差、治愈率也较低。
[0004]目前各种各样的癌症繁杂而各异，且尚未有统一而规范的结论，癌症具有顽固性、转移性、危害性、死亡率高的特性，用传统的中医药治疗癌症也需要不断探索和发展。
发明内容
[0005] 本发明的目的在于提出一种新的能有效治疗癌症的中药制剂，具体的是ー种治疗癌症的中药制剂及其制备方法的技术方案。
[0006] 本发明的技术方案为，`一种治疗癌症的中药制剂，其特征在于它是由下述重量份配比的原料药材制成的药剂:
[0007] 紫杉6-150 半枝莲6-150 仙鹤草6-150 臭灵丹6-150
[0008] 鸡血藤6-150 夏枯草6-150 白花蛇舌草6_150益母草6_150
[0009] 土鳖虫6-150 土茯苓6-120 延胡索6-120 蒲公英6-100
[0010] 丹參6-100 威灵仙6-100 金银花6-100 石见穿6-100
[0011] 土牛膝6-100 薏仁6-100 鹅不食草6-100 王不留行6-100
[0012] 海藻6 — 100 黄芪6-100 鸡矢藤6-100 白毛藤6-100
[0013] 三七6 — 100 山慈菇6-100 核桃树枝6-100 紫草6-100
[0014]地龙 6-100 扁豆 6-100 莪术 6-100 山楂 6-100
[0015] 败酱草6-100 茜草6-100 灵芝草6-100 泽漆6-100
[0016] 一枝黄花6-60路路通6-60 黄药子6 — 60 九香虫6-60
[0017] 获茶6-60 阜角刺6-60 沉香6-60 八月札6 — 60
[0018] 香附6 —60 郁金6-60 三棱6-60 当归6-60
[0019] 何首乌6-60 川芎6-60 喜树6_60 绞股蓝3_60[0020] 乳香6-60 没药6-60 五灵脂6-60 僵蚕6-60
[0021] 土大黄6 — 60 丹皮6-60 赤芍6 — 60 虎杖6-60
[0022] 重楼6 — 60 天花粉6-60 栝楼6_60 昆布6_60
[0023] 玄参6 — 60 天南星3-60 石上柏6-100 紫花地丁 6-60
[0024] 生地6-60 神曲6-60 青蒿6 — 60 络石藤6-60
[0025] 猪苓6-60 海蛤壳6-60 半夏6-60 大黄3-60
[0026] 木香36-60 青黛6-30 枳壳6 — 30 桂枝3-30
[0027] 大青叶6-30 柴胡6 — 30 桃仁6-30
[0028] 白花蛇6-30 白芥子6-30 蚂蚁1-30 露蜂房6-30
[0029] 海浮石6-30 牡砺6-30 瓦楞子6_30 麝香1_30
[0030] 穿山甲3-30 连翘6-30 全蝎1_30 川楝子1_30
[0031] 木通1-30 车前子1-30 红花3-15 黄柏6-15
[0032] 白英6 — 15 海螵蛸6-15 蜈蚣1-15 水蛭0.6-6
[0033]壁虎 1-6 斑蝥 0.03-0.1 蟾蜍 0.01-0.06 藤黄 0.01-0.06
[0034]蜣螂 0.1-0.6 马 钱子 0.01-0.6 砒石 0.01-0.6。
[0035] 所述的药剂是口服液、颗粒、散剂、胶囊、冲剂及片剂。
[0036] 所述的散剂由以下步骤制成:
[0037] (I)将原料药按常规方法制为含水量为10%的水提取液；
[0038] (2)将步骤(I)得到的水提取液干燥、粉碎、过至少200目筛，取筛下物为提取散剂。
[0039] 所述的片剂、颗粒剂、冲剂或胶囊由以下步骤制成:
[0040] (I)将原料药按常规方法制为含水量为10%的水提取液；
[0041] (2)将步骤(I)得到的水提取液干燥、粉碎、过至少200目筛，取筛下物为提取散剂
[0042] (3)按常规方法用步骤(2)制得的提取散剂制为片剂、颗粒剂、冲剂或胶囊。
[0043] 所述的片剂、颗粒剂、冲剂或胶囊由以下步骤制成:
[0044] (I)将权利要求1所述的原料药筛去灰土，粉碎，
[0045] ( 2 )过至少200目筛，
[0046] (3)取筛下物，消毒灭菌，为生粉散剂，
[0047]按常规方法用步骤(3)制得的生粉散剂制为片剂、颗粒剂、冲剂或胶囊。
[0048] 本发明主要根据传统中医学辨正施治的原理，集众医家所长，广采博收民间及民族地区奇药妙方，并基于现代医学对癌症的发病机理的认识及治疗原则，经长期诊疗病例的临床实践总结而成。中医治疗癌症是以辩病与辩证相结合，面对错综复杂的各种症状进行治疗。中医认为癌症最基本的特点是正虚邪实。本发明以扶正培本为主，首先辨清阴阳气血盛衰，再辨别五脏虚损及脏腑的相互关系，采用五脏分补的方法扶正培本，主要采用仙鹤草、鸡血藤、黄芪、当归、何首乌等中药补气血、固本。中医认为癌症的发生与气机运行失调有关，气机不畅，则津液气血运行代谢障碍，积而成癌。本发明采用紫衫、半枝莲、臭灵丹、夏枯草、白花蛇色草、土鳖虫、威灵仙、石见穿、海藻、山慈菇、核桃树枝、灵芝草、泽漆、一枝黄花、黄药子、九香虫、八月札、喜树、天花粉、穿山甲、全蝎、白英、海螵蛸、蜈蚣、水蛭、壁虎、斑蝥、蟾蜍、藤黄、蜣螂、马钱子、砒石等药物化癌消肿、以毒攻毒。中医认为癌症的发生多与肿块与瘀血有关，本发明的方中采用了益母草、丹參、土牛膝、王不留行、三七、山楂、茜草、三棱、当归、没药、丹皮、赤芍、玄參、生地、桃仁、红花等中药活血化瘀、软坚散结。本发明采用了清热解毒的中药成份土茯苓、蒲公英、金银花、意仁、败酱草、青蒿、枳壳、半夏、大黄、柴胡、白介子等。本发明采用止疼的中药成分延胡索、鸡矢藤、沉香、香附、郁金、木香、麝香等成分。本发明采用了 110味中药，君臣佐使合理搭配，兼顾方方面面，起到了对癌症标本兼治的作用。本发明采用的原料药为常用的普通中药，制作成本低，副作用小。本发明具有可有效增强自身免役力、攻邪而不伤正的优点，且起效快，疗效高，治愈率高，复发率较低，标本兼治，安全可靠。本发明可治疗各种类型的癌症，特别是肺癌、胃癌、肝癌、食道癌、胰腺癌、宫颈癌及乳腺癌。
[0049] 本发明的100例临床观察报告
[0050] 病例资料:全部病例均经病理及影象学检查，确诊为早、中、晩期癌症，其中肺癌26例，胃癌24例，肝癌9例，食道癌8例，胰腺癌3例，乳腺癌19例，宫颈癌11例。
[0051] 治疗方法:用本发明实施例1-5制备的ロ服液毎次10_20ml，日服3次，或用本发明实施例1-5制备的提取散剂制备的片剂、颗粒、提取散剂、胶囊、冲剂等，使用其中ー种，每次3-20克，日服3-5次，也可用本发明实施例1-5制备的生粉散剂或生粉散剂制成的片齐U、颗粒、生粉散剂、胶囊、冲剂等其中ー种，毎次5-20克日服3-5次，各种剂型可交替使用，儿童减半。治疗30天为ー疗程，轻症1-3个疗程，重症3-6个疗程。婴幼儿、孕妇、妇女月经期、年老体质极度虚弱患者禁用。
[0052] 服药期间7-10天观察一次，主要观察症状、体症改善情况及不良反应。治疗前后均查血压、心脏、肝、肾功能和尿常规。治疗结束两周内到医院复查病情。
[0053] 疗效标准:中草药治疗恶性肿瘤的疗效判断标准(《肿瘤中西医综合治疗》陈世伟张利民主编2001年7月出版第748页)
[0054] 治愈:症状、客 观检查阳性体症完全消失，恢复一定劳动能力，连续3年以上无复发者。
[0055] 临床治愈:症状及客观检查阳性症象消失，恢复一定劳动能力，I级:连续观察I年以上无复发者；2级:连续观察半年至I年无复发者；3级:连续观察2-6个月无复发者。
[0056] 显效:症状基本消失，癌灶缩小一半以上，其他客观检查有明显好转；1级:观察半年以上不再发展者；2级:观察2-6个月不再发展者。
[0057] 有效:种症状有所改善，癌灶基本稳定，观察I个月以上者。
[0058] 无效:症状及客观检查无改善，或有短期改善，而又迅速恶化者。
[0059] 治疗效果:服药I 一 6个疗程后,治愈患者为11例，治愈率11% ;临床治愈者22例，临床治愈率22% ;显效患者为28例，显效率28% ;有效患者为31人，有效率31%。无效患者8例，无效率8%。在治疗过程中未见明显药物不良反应。
[0060] 经米用本发明的药物治愈者中存活时间最长的:肺癌17年，胃癌11年,肝癌5年，食道癌8年，胰腺癌4年，乳腺癌15年，宫颈癌13年。
[0061] 其中，云南省会泽县杨姓患者，男，47岁，2000年经本地大医院诊断为恶性皮肤癌，在本地大医院治疗6年，并作了 4次手术，终被判定为无治。服本发明的药物提取散剤、胶囊、冲剂轮换使用，6个疗程后完全治愈，连续观察6年无复发。
[0062] 昆明女患者，经本地大医院诊断为右侧乳腺癌，手模可触及包块10*20，未做手木。服本发明的药物提取散剂、胶囊、冲剂轮换使用，6个疗程后包快软化，连续观察15年无复发，身体健康、精神状态良好。
具体实施方式
[0063] 各实施例按表I备料，
[0064] 1、颗粒、散剂、胶囊、冲剂及片剂等口服剂的治疗癌症的中药制剂的制备方法由以下步骤制成:
[0065] (I)将表I中的原料药按常规方法制为含水量为10%的水提取液；
[0066] (2)按常规方法用步骤(I)制得的水提取液制为口服液；
[0067] (3)将步骤(I)得到的水提取液浓缩、干燥、粉碎、过至少200目筛，取筛下物为提取散剂，包装，每袋5-10克 ；
[0068] (4)按常规方法用步骤(3)制得的提取散剂制为片剂、颗粒剂、冲剂或胶囊，颗粒剂每袋含药物散剂，2-10克；胶囊，每粒0.2-1克；冲剂，每袋含药物提取散剂3-10克；片齐U，每片含药物提取散剂0.2-1克。
[0069] 2、生粉散剂由以下步骤制成:
[0070] (I)将表I中的原料药筛去灰土，粉碎，
[0071] (2)过至少200目筛，
[0072] (3)取筛下物，消毒灭菌，为生粉散剂，包装，每袋5 — 10克。
[0073] (4)按常规方法用步骤(3)制得的生粉散剂制为片剂、颗粒剂、冲剂或胶囊。
[0074]表 I
[0075]
Claims (5)
1.一种治疗癌症的中药制剂，其特征在于它是由下述重量份配比的原料药材制成的药剂: 紫杉6-150 半枝莲6-150 仙鹤草6-150 臭灵丹6-150 鸡血藤6-150 夏枯草6-150 白花蛇舌草6-150益母草6-150 土鳖虫6-150 土茯苓6-120 延胡索6-120 蒲公英6-100 丹參6-100 威灵仙6-100 金银花6-100 石见穿6-100 土牛膝6-100 薏仁6-100 鹅不食草6-100 王不留行6-100 海藻6 — 100 黄芪6-100 鸡矢藤6-100 白毛藤6-100 三七6 — 100 山慈菇6-100 核桃树枝6-100 紫草6-100 地龙6-100 扁豆6-100 莪术6-100 山楂6-100 败酱草6-100 茜草6-100 灵芝草6-100 泽漆6-100 一枝黄花6-60路路通6-60 黄药子6 — 60 九香虫6_60 茯苓6-60 皂角刺6-60 沉香6-60 八月札6 — 60 香附6 — 60 郁金6-60 三棱6-60 当归6-60 何首乌6-60 川芎6-60 喜树6-60 绞股蓝3_60 乳香6-60 没药6-60 五灵脂6-60 僵蚕6_60 土大黄6 — 60 丹皮6-60 赤芍6 — 60 虎杖6_60 重楼6 — 60 天花粉6-60 栝.楼6-60 昆布6_60 玄參6 — 60 天南星3-60 石上柏6-100 紫花地丁 6_60 生地6-60 神曲6-60 青蒿6 — 60 络石藤6_60 猪苓6-60 海蛤壳6-60 半夏6-60 大黄3_60 木香36-60 青黛6-30 枳壳6 — 30 桂枝3_30 大青叶6-30 柴胡6 — 30 桃仁6-30 白花蛇6-30 白芥子6-30 蚂蚁1-30 露蜂房6-30 海浮石6-30 牡砺6-30 瓦楞子6-30 麝香1_30 穿山甲3-30 连翘6-30 全蝎1-30 川楝子1-30 木通1-30 车前子1-30 红花3-15 黄柏6-15 白英6 — 15 海螵蛸6-15 蜈蚣1-15 水蛭0.6-6 壁虎 1-6 斑蝥 0.03-0.1 蟾蜍 0.01-0.06 藤黄 0.01-0.06 蜣螂0.1-0.6马钱子0.01-0.6石比石0.01-0.6。
2.根据权利要求1所述的ー种治疗癌症的中药制剂，其特征在于，所述的药剂是ロ服液、颗粒、散剤、胶囊、冲剂及片剂。
3.根据权利要求1或2所述的ー种治疗癌症的中药制剂的制备方法，其特征在于所述的散剂由以下步骤制成: (1)将原料药按常规方法制为含水量为10%的水提取液， (2)将步骤(I)得到的水提取液干燥、粉碎、过至少200目筛，取筛下物为提取散剤。
4.根据权利要求1或2所述的ー种治疗癌症的中药制剂的制备方法，其特征在于所述的片剂、颗粒剂、冲剂或胶囊由以下步骤制成: (I)将原料药按常规方法制为含水量为10%的水提取液，(2)将步骤(I)得到的水提取液干燥、粉碎、过至少200目筛，取筛下物为提取散剂， (3)按常规方法用步骤(2)制得的提取散剂制为片剂、颗粒剂、冲剂或胶囊。
5.根据权利要求1或2所述的一种治疗癌症的中药制剂的制备方法，其特征在于所述的片剂、颗粒剂、冲剂或胶囊由以下步骤制成: (1)将权利要求1所述的原料药筛去灰土，粉碎， (2)过至少200目筛， (3)取筛下物，消毒灭菌，为生粉散剂， (4)按常规方法 用步骤(3)制得的生粉散剂制为片剂、颗粒剂、冲剂或胶囊。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102975473A CN102772745B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗癌症的中药制剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012102975473A CN102772745B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗癌症的中药制剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102772745A CN102772745A (zh) | 2012-11-14 |
| CN102772745B true CN102772745B (zh) | 2013-12-04 |
Family
ID=47118001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012102975473A CN102772745B (zh) | 2012-08-21 | 2012-08-21 | 一种治疗癌症的中药制剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102772745B (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071104B (zh) * | 2013-01-21 | 2015-01-07 | 戴玲玲 | 一种治疗中晚期胰腺癌的中药复方制剂 |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041109B (zh) * | 2012-11-29 | 2014-07-02 | 宁国市中医肿瘤医院 | 一种扁竹测治疗肺癌的丸剂 |
| CN103041293B (zh) * | 2012-11-29 | 2014-04-09 | 宁国市中医肿瘤医院 | 一种治疗阴虚内热型肺癌的中药汤剂 |
| CN103055266B (zh) * | 2013-01-17 | 2014-06-18 | 郭玉玲 | 一种治疗肝癌的中药组合物及其制备方法 |
| CN103110891B (zh) * | 2013-02-06 | 2014-05-28 | 河南中医学院 | 一种治疗乳腺增生及乳腺癌的中药 |
| CN103127398B (zh) * | 2013-03-08 | 2014-07-16 | 张流治 | 一种治疗癌症的中药及其制备方法 |
| CN103251882A (zh) * | 2013-03-08 | 2013-08-21 | 崔树华 | 一种治疗肿瘤的药物组合物 |
| CN103251880B (zh) * | 2013-03-08 | 2015-07-22 | 翁捷 | 一种治疗肿瘤的药物组合物及其制备方法 |
| CN103550291A (zh) * | 2013-05-06 | 2014-02-05 | 侯进怀 | 一种中药抗癌配方及制备使用方法 |
| CN103230490B (zh) * | 2013-05-08 | 2014-08-20 | 鄂宝福 | 一种治疗肝肿瘤的中药散剂 |
| CN103271971B (zh) * | 2013-06-17 | 2014-07-23 | 岳耀忠 | 一种治疗癌性疼痛的药剂 |
| CN103301352B (zh) * | 2013-06-27 | 2014-10-15 | 王松华 | 一种治疗淋巴瘤的中药组合物 |
| CN103385973B (zh) * | 2013-07-12 | 2015-04-15 | 贵州鸿德中药开发有限公司 | 一种治疗肝癌的苗药及制备方法 |
| CN103386056B (zh) * | 2013-07-27 | 2014-11-26 | 刘颖 | 抗肿瘤中药片剂及其制备方法 |
| CN103550673A (zh) * | 2013-07-30 | 2014-02-05 | 卢金贵仙 | 一种治疗原发性肝癌的中药组合物 |
| CN103566058B (zh) * | 2013-10-22 | 2017-01-04 | 重庆市中药研究院 | 一种双青组合药物、制备方法及其应用 |
| CN103550607B (zh) * | 2013-10-28 | 2015-04-29 | 韩永涛 | 一种治疗绒毛膜上皮癌的中药组合物 |
| CN103623354B (zh) * | 2013-12-09 | 2015-07-01 | 逄锦忠 | 一种治疗腹膜后滤泡树突细胞肉瘤的中药制剂 |
| CN103656041B (zh) * | 2013-12-11 | 2016-04-20 | 钟彩云 | 一种治疗宫颈癌的中药 |
| CN103638091B (zh) * | 2013-12-11 | 2016-05-25 | 北京紫云堂中医门诊部(普通合伙) | 一种用于治疗肿瘤的中药组合物及其制备方法 |
| CN103611091B (zh) * | 2013-12-11 | 2016-04-27 | 东莞市东卓中天生物科技有限公司 | 一种治疗胰腺癌的中药组合物 |
| CN103751632A (zh) * | 2013-12-14 | 2014-04-30 | 潘清水 | 治疗乳腺癌的药物 |
| CN103736006A (zh) * | 2013-12-14 | 2014-04-23 | 潘清水 | 治疗胃癌的药物 |
| CN103655823B (zh) * | 2013-12-23 | 2016-06-22 | 丽水市莲都区吴一波畲医畲药开发研究所 | 一种治疗萎缩性胃炎的中草药组合物及其制备方法 |
| CN103705897B (zh) * | 2014-01-03 | 2016-04-13 | 陈延玲 | 一种癌症止疼膏药 |
| CN103705685B (zh) * | 2014-01-14 | 2014-07-09 | 朱平 | 一种治疗产后缺乳的中药制剂 |
| CN104784244B (zh) * | 2014-01-20 | 2019-11-15 | 中国中医科学院中药研究所 | 一种治疗肿瘤的中药复方制剂 |
| CN103920090A (zh) * | 2014-03-19 | 2014-07-16 | 罗金 | 一种治疗附件囊肿的中药组合物 |
| CN103908613A (zh) * | 2014-04-03 | 2014-07-09 | 荆振海 | 一种治疗黑色素瘤的中药药剂及制备方法 |
| CN103948821A (zh) * | 2014-04-17 | 2014-07-30 | 刘德清 | 一种抗肠癌中草药药物组合物 |
| CN104042973A (zh) * | 2014-05-15 | 2014-09-17 | 李兴尧 | 一种抗肿瘤中药微生物发酵制剂及其制备方法和应用 |
| CN104001149A (zh) * | 2014-05-27 | 2014-08-27 | 刘存兵 | 一种治疗放射损伤中药组合物及其制备方法 |
| CN104096172A (zh) * | 2014-07-08 | 2014-10-15 | 张永杰 | 一种抗恶性肿瘤的中药制剂 |
| CN104288259A (zh) * | 2014-07-24 | 2015-01-21 | 田章纪 | 一种治疗乳腺病的中药配方及其丸剂的制作方法 |
| CN104189339A (zh) * | 2014-07-29 | 2014-12-10 | 刘庆芳 | 一种肺癌病人的保健配方 |
| CN104352515A (zh) * | 2014-09-22 | 2015-02-18 | 新乡医学院 | 治疗胃癌的药物组合物及其应用 |
| CN104367822A (zh) * | 2014-11-05 | 2015-02-25 | 山东瑞康生命科技有限公司 | 一种治疗乳腺癌肝郁气滞证的中药及制备方法 |
| CN104491613A (zh) * | 2014-12-11 | 2015-04-08 | 青岛大学附属医院 | 一种治疗胃肠道肿瘤的中药配方 |
| CN104510835A (zh) * | 2014-12-23 | 2015-04-15 | 青岛市城阳区人民医院 | 一种治疗肠道肿瘤的中药配方 |
| CN104667075A (zh) * | 2014-12-31 | 2015-06-03 | 青岛大学附属医院 | 一种治疗肝癌的中药配方及其制备方法 |
| CN104707047B (zh) * | 2015-04-13 | 2015-12-02 | 马建 | 一种治疗肺癌的外用药物及其制备方法 |
| CN104784562B (zh) * | 2015-05-11 | 2016-03-23 | 马建 | 一种治疗乳腺癌的外用药物及其制备方法 |
| CN104857436B (zh) * | 2015-05-18 | 2018-05-01 | 南京中医药大学 | 具有抗肝癌活性的中药复方组合物及其制备方法和应用 |
| CN104922599B (zh) * | 2015-07-03 | 2018-04-13 | 黑龙江中医药大学 | 一种用于改善因使用吉非替尼治疗胰腺癌引起的出血性膀胱炎的中药组合物及其制备方法 |
| CN105079263A (zh) * | 2015-08-08 | 2015-11-25 | 易善发 | 石上柏中药组合物及使用方法 |
| CN105168259A (zh) * | 2015-10-16 | 2015-12-23 | 四川和济健康管理有限公司 | 预防和/或治疗肿瘤的中药配方组合物及中药制剂和应用 |
| CN105233166A (zh) * | 2015-11-05 | 2016-01-13 | 青岛麦瑞特医药技术有限公司 | 一种治疗胰腺癌的中药及其制备方法 |
| CN105477451A (zh) * | 2016-01-08 | 2016-04-13 | 董仲璧 | 一种治疗癌症及癌症疼痛、发热的中药组合物 |
| CN105833220B (zh) * | 2016-04-22 | 2019-11-08 | 中国人民解放军第二军医大学 | 一种辅助治疗妇科恶性肿瘤的中药组合物及用途 |
| CN105853923A (zh) * | 2016-05-17 | 2016-08-17 | 王德玉 | 一种治疗早期宫颈癌的纯中药制剂 |
| CN110507751A (zh) * | 2019-09-25 | 2019-11-29 | 魏艳 | 一种控癌丸及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101670071A (zh) * | 2009-09-25 | 2010-03-17 | 卢速江 | 治疗癌症的中药制剂及其制备方法 |
-
2012
- 2012-08-21 CN CN2012102975473A patent/CN102772745B/zh active IP Right Grant
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071104B (zh) * | 2013-01-21 | 2015-01-07 | 戴玲玲 | 一种治疗中晚期胰腺癌的中药复方制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102772745A (zh) | 2012-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101703708B (zh) | 一种治疗类风湿关节炎、痛风的中药制剂及其制备方法 | |
| CN101690764B (zh) | 治疗心脑血管病的中药及其制备方法 | |
| CN101637585B (zh) | 治疗银屑病的中药制剂及其制备方法 | |
| CN103341004B (zh) | 一种治疗月经后期的中药组合物 | |
| CN101843787B (zh) | 一种治疗前列腺增生的中药 | |
| CN100460008C (zh) | 治疗癌症的中药组合物 | |
| CN103536758B (zh) | 一种治疗阴虚盗汗的中药组合物 | |
| CN103041312A (zh) | 具有抗肿瘤作用的中药组合物及其制备方法和应用 | |
| CN103550532B (zh) | 一种治疗心悸的中药组合物 | |
| CN101843773B (zh) | 一种治疗肝硬化的中药 | |
| CN103316205B (zh) | 用于治疗缺铁性贫血的中药及制备方法 | |
| CN102772745B (zh) | 一种治疗癌症的中药制剂及其制备方法 | |
| CN103990081A (zh) | 一种中药组合物及其在制备治疗婴幼儿黄疸药物中的用途 | |
| CN103705866A (zh) | 一种治疗月经过少的中药组合物 | |
| CN104922543A (zh) | 一种治疗闭经的药物组合物及其制备方法 | |
| CN104383115A (zh) | 一种治疗冠心病的中药制剂及其制备方法 | |
| CN102988672A (zh) | 一种治疗月经不调的中药组合物 | |
| CN101670071A (zh) | 治疗癌症的中药制剂及其制备方法 | |
| CN104940810A (zh) | 一种治疗心绞痛的中药组合物 | |
| CN102552454A (zh) | 治疗糖尿病足的中药 | |
| CN103142865A (zh) | 一种治疗高血压的中药 | |
| CN102210820A (zh) | 一种治疗白血病的中药组合物 | |
| CN102188583A (zh) | 中药治疗不孕 | |
| CN103784890A (zh) | 一种治疗骨病的中药组合物 | |
| CN101972386A (zh) | 一种治疗糖尿病痛风的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |