CN105477451A - 一种治疗癌症及癌症疼痛、发热的中药组合物 - Google Patents

一种治疗癌症及癌症疼痛、发热的中药组合物 Download PDF

Info

Publication number
CN105477451A
CN105477451A CN201610008440.0A CN201610008440A CN105477451A CN 105477451 A CN105477451 A CN 105477451A CN 201610008440 A CN201610008440 A CN 201610008440A CN 105477451 A CN105477451 A CN 105477451A
Authority
CN
China
Prior art keywords
parts
radix
grams
chinese medicine
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610008440.0A
Other languages
English (en)
Inventor
董仲璧
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610008440.0A priority Critical patent/CN105477451A/zh
Publication of CN105477451A publication Critical patent/CN105477451A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/342—Adenophora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种治疗癌症及癌症疼痛、发热的中药组合物，它包含下列重量份的物质：灵芝50份、人参50份、黄芪100份、白术30份、苍术20份、茯苓30份、薏苡仁30份、赤小豆20份、山药30份、杭芍20份、桂枝15份、丹参30份、丹皮20份、山栀20份、当归20份、川芎20份、黄芩20份、延胡索20份、远志20份、黄柏20份、豪猪刺20份、地骨皮20份、合欢皮20份、桔梗10份、七叶一枝花20份、南沙参20份、仙鹤草20份、柴胡30份、乳香20份、没药20份、见肿消20份、小铜锤20份、皂角刺20份、苦地丁20份、白药子50份和黄药子50份。所述的中药不但药效确切，见效较快，而且成本较低，毒副作用较小。

Description

一种治疗癌症及癌症疼痛、发热的中药组合物
技术领域
本发明涉及医药领域，具体来说涉及一种治疗癌症及癌症疼痛、发热的中药组合物。
背景技术
慢性癌痛则是由于恶性肿瘤而引起的慢性疼痛，癌症病人的自觉症状中，疼痛发生率最高。有25％～40％初诊的恶性肿瘤患者、30～50％的癌症患者在积极治疗期间、70％～90％的患者在癌症进展期都会出现这一症状，许多癌症病人在生命的最后一段时间内不得不忍受着癌痛的极大痛苦。据调查，在我国有61.6％～69％的患者伴有癌痛，住院患者中伴有疼痛的患者占69％，其中轻度疼痛占21.5％，中度疼痛占19％，重度疼痛占28.5％。
药物治疗是癌痛治疗的主要方法。目前临床上主要应用WHO推荐的“三阶梯镇痛药”治疗方法，其治疗原则可以大致归纳为五点，即：口服、按时、按阶梯、个体化、注意具体细节。对一级(轻度)疼痛的患者来说主要选用解热镇痛剂类药如阿司匹林；对于二级(中度)疼痛应选用弱阿片类药物，如可待因；对于三级(重度)疼痛应首选强阿片类药，如吗啡片等。其治疗对于大多数患者来说，可以缓解其癌性疼痛。但是长期使用此类药物毒副作用大，最常见的有便秘、镇静、恶心呕吐、呼吸抑制等，且依赖性、成瘾性强，常常严重影响患者的生活质量。因此，如何在充分镇痛的同时又减少不必要的副作用，在目前的临床工作中变得尤为急需。
发明内容
本发明的目的是提供一种治疗癌症及癌症疼痛、发热的中药组合物。
为了实现本发明的目的，本发明提供一种治疗癌症及癌症疼痛、发热的中药组合物，它包含下列重量份的物质：灵芝50份、人参50份、黄芪100份、白术30份、苍术20份、茯苓30份、薏苡仁30份、赤小豆20份、山药30份、杭芍20份、桂枝15份、丹参30份、丹皮20份、山栀20份、当归20份、川芎20份、黄芩20份、延胡索20份、远志20份、黄柏20份、豪猪刺20份、地骨皮20份、合欢皮20份、桔梗10份、七叶一枝花20份、南沙参20份、仙鹤草20份、柴胡30份、乳香20份、没药20份、见肿消20份、小铜锤20份、皂角刺20份、苦地丁20份、白药子50份和黄药子50份。
优选地，本发明所述的治疗癌症及癌症疼痛、发热的中药组合物还包含下列重量份的物质：0.5份的3-(4-{[3-(5-氯噻吩-2-基)异噻唑-4-基]甲氧基}-3，5-二氟苯基)丙酸。
更优选地，所述中药组合物可以是片剂、分散片、胶囊剂、口服液或汤剂。
本发明还提供3-(4-{[3-(5-氯噻吩-2-基)异噻唑-4-基]甲氧基}-3，5-二氟苯基)丙酸在制备治疗癌症的药物中的用途。
所述的中药不但药效确切，见效较快，而且成本较低，毒副作用较小。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例
称取灵芝50克、人参50克、黄芪100克、白术30克、苍术20克、茯苓30克、薏苡仁30克、赤小豆20克、山药30克、杭芍20克、桂枝15克、丹参30克、丹皮20克、山栀20克、当归20克、川芎20克、黄芩20克、延胡索20克、远志20克、黄柏20克、豪猪刺20克、地骨皮20克、合欢皮20克、桔梗10克、七叶一枝花20克、南沙参20克、仙鹤草20克、柴胡30克、乳香20克、没药20克、见肿消20克、小铜锤20克、皂角刺20克、苦地丁20克、白药子50克和黄药子50克，粉碎，过100目筛，混合均匀得到粉末。
实验例
MTT(购自Sigma公司)用生理盐水溶解，配制成5mg/mL的工作液，-20℃保存；二甲基亚矾(DMSO)为西安化学试剂厂生产，分析纯。人乳腺癌细胞T47D细胞购自上海丰寿生物科技有限公司。
MTT法原理
MTT是一种能接受H+的黄色染料。在活细胞线粒体呼吸链中，琥珀酸脱氢酶和细胞色素C可使MTT的四氮唑环开裂，生成蓝紫色的formazan结晶。而死细胞中不含这种脱氢酶。Formazan结晶的生成量与活细胞数成正比，该结晶的DMSO溶液在570nm处有最大吸收峰，所以，可通过检测formazan结晶的量来评价药物对细胞增殖的影响。
选取人乳腺癌细胞T47D细胞作为受试细胞。肿瘤细胞置于恒温恒湿培养箱中进行常规培养(培养温度为于37℃、饱和湿度为5％CO2)培养至对数生长期时，收集用于抗肿瘤试验。将上述制备对数生长期的肿瘤细胞用0.02％的乙二胺四乙酸溶液进行鳌合，制成细胞悬液，收集100μL肿瘤细胞悬液加入酶标板(96孔)内，取三个孔作为重复试验。培养24h左右。
受试药物1为：称取灵芝50克、人参50克、黄芪100克、白术30克、苍术20克、茯苓30克、薏苡仁30克、赤小豆20克、山药30克、杭芍20克、桂枝15克、丹参30克、丹皮20克、山栀20克、当归20克、川芎20克、黄芩20克、延胡索20克、远志20克、黄柏20克、豪猪刺20克、地骨皮20克、合欢皮20克、桔梗10克、七叶一枝花20克、南沙参20克、仙鹤草20克、柴胡30克、乳香20克、没药20克、见肿消20克、小铜锤20克、皂角刺20克、苦地丁20克、白药子50克和黄药子50克，粉碎，加入5000毫升水，在回流的条件下加热3小时，过滤，使滤液冷却至室温，然后经过0.25μm的微孔滤膜过滤。
受试药物2为：称取3-(4-{[3-(5-氯噻吩-2-基)异噻唑-4-基]甲氧基}-3，5-二氟苯基)丙酸0.1克，加入8000毫升，超声10分钟，然后经过0.25μm的微孔滤膜过滤。
受试药物3为：取100ml的0.25μm的微孔滤膜过滤的受试药物1溶液和100ml的0.25μm的微孔滤膜过滤的受试药物2混合，即得。
取对数生长期的肿瘤细胞，将细胞密度调至2×105个/mL，按每孔200μL加到96孔细胞培养板中，于37℃通入5％CO2的培养箱中培养4h。分别取上述受试药物1、受试药物2和受试药物3，每种样品设3个平行样，同时设阳性、阴性对照，每孔加样品液或空白液各2μL，培养72h，然后每孔加MTT液10μL，继续培养4h，37℃，2000r/min离心8min，吸去上清。每孔加入DMSO各100μL在微量振荡器上振荡15min，至结晶完全溶解后，酶标仪测定每孔570nm处的吸光值(OD值)。取三孔平均OD值按IR％＝(OD对照-OD样品)/OD对照×100％来计算样品对细胞增殖的抑制率(IR％)。
采用MTT法，以阿霉素为阳性对照药(浓度为0.5μM)进行体外抗肿瘤活性评价，结果如下：
样品 OD值 抑制率％
空白组 1.13±0.05
对照组 1.05±0.03
阿霉素 0.21±0.01 80.00
受试药物1 0.53±0.01 49.52
受试药物2 0.38±0.01 63.81
受试药物3 0.48±0.01 54.29
由上述结果可见，本发明的药物对于人乳腺癌细胞T47D细胞具有体外抑制作用。

Claims (4)

1.一种治疗癌症及癌症疼痛、发热的中药组合物，其特征在于，它包含下列重量份的物质：灵芝50份、人参50份、黄芪100份、白术30份、苍术20份、茯苓30份、薏苡仁30份、赤小豆20份、山药30份、杭芍20份、桂枝15份、丹参30份、丹皮20份、山栀20份、当归20份、川芎20份、黄芩20份、延胡索20份、远志20份、黄柏20份、豪猪刺20份、地骨皮20份、合欢皮20份、桔梗10份、七叶一枝花20份、南沙参20份、仙鹤草20份、柴胡30份、乳香20份、没药20份、见肿消20份、小铜锤20份、皂角刺20份、苦地丁20份、白药子50份和黄药子50份。
2.根据权利要求1所述的治疗癌症及癌症疼痛、发热的中药组合物，其特征在于，它还包含下列重量份的物质：0.5份的3-(4-{[3-(5-氯噻吩-2-基)异噻唑-4-基]甲氧基}-3，5-二氟苯基)丙酸。
3.根据权利要求1或2所述的治疗癌症及癌症疼痛、发热的中药组合物，其特征在于，所述中药组合物可以是片剂、分散片、胶囊剂、口服液或汤剂。
4.3-(4-{[3-(5-氯噻吩-2-基)异噻唑-4-基]甲氧基}-3，5-二氟苯基)丙酸在制备治疗癌症的药物中的用途。
CN201610008440.0A 2016-01-08 2016-01-08 一种治疗癌症及癌症疼痛、发热的中药组合物 Pending CN105477451A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610008440.0A CN105477451A (zh) 2016-01-08 2016-01-08 一种治疗癌症及癌症疼痛、发热的中药组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610008440.0A CN105477451A (zh) 2016-01-08 2016-01-08 一种治疗癌症及癌症疼痛、发热的中药组合物

Publications (1)

Publication Number Publication Date
CN105477451A true CN105477451A (zh) 2016-04-13

Family

ID=55664961

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610008440.0A Pending CN105477451A (zh) 2016-01-08 2016-01-08 一种治疗癌症及癌症疼痛、发热的中药组合物

Country Status (1)

Country Link
CN (1) CN105477451A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105749187A (zh) * 2016-05-05 2016-07-13 王爱华 一种治疗乳腺癌的中药制剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646660A (zh) * 2007-02-22 2010-02-10 Irm责任有限公司 调节g蛋白偶联受体的化合物和方法
CN102772745A (zh) * 2012-08-21 2012-11-14 卢速江 一种治疗癌症的中药制剂及其制备方法
CN105209446A (zh) * 2013-03-14 2015-12-30 詹森药业有限公司 用于治疗ii型糖尿病的gpr120激动剂

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101646660A (zh) * 2007-02-22 2010-02-10 Irm责任有限公司 调节g蛋白偶联受体的化合物和方法
CN102772745A (zh) * 2012-08-21 2012-11-14 卢速江 一种治疗癌症的中药制剂及其制备方法
CN105209446A (zh) * 2013-03-14 2015-12-30 詹森药业有限公司 用于治疗ii型糖尿病的gpr120激动剂

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105749187A (zh) * 2016-05-05 2016-07-13 王爱华 一种治疗乳腺癌的中药制剂

Similar Documents

Publication Publication Date Title
CN101987123B (zh) 一种用于缓解颈肩、腰腿、关节、肌肉疼痛的药物及其制备方法
CN101987122B (zh) 一种用于缓解人体疼痛的药物及其制备方法
CN101234168B (zh) 一种复方当归制剂及制备方法和用途
CN103251912B (zh) 一种治疗糖尿病的药剂
CN104225536A (zh) 一种治疗胃、十二指肠溃疡的中药
CN102488743A (zh) 中药组合物、制备方法及中药制剂
CN102114195B (zh) 一种纯中药的戒毒胶囊
CN104435686A (zh) 一种中药制剂在制备治疗皮肤瘙痒、粟疮药物中的用途
CN105477451A (zh) 一种治疗癌症及癌症疼痛、发热的中药组合物
CN101574471A (zh) 治疗糖尿病的药物及其制备方法
CN101152352A (zh) 治疗肠痈的中药
CN103099788A (zh) 中药煮散颗粒组合物及其制备、煎煮方法和剂量关系
CN103272136B (zh) 一种治疗妇女更年期综合症中药
CN104147526A (zh) 一种治疗黄疸型肝炎的中药颗粒及其制备方法
CN104587267A (zh) 一种治疗银屑病的中药组合物
CN104644857A (zh) 一种治疗痤疮的中药配方
CN103251915B (zh) 一种治疗糖尿病的中药组合物
CN105267897A (zh) 一种治疗癌症骨转移的中药组合物
CN113713009A (zh) 一种改善特禀体质的中药组合物及其制备方法和应用
CN101721577A (zh) 一种治疗慢性肾功能衰竭的薄膜衣片剂的制备方法
CN103006877B (zh) 治疗系统性红斑狼疮的药物组方
CN105456946A (zh) 一种治疗癌症的中药药剂
CN104491318A (zh) 一种治疗哮喘的中药制剂及其制备方法
CN104826075A (zh) 一种治疗顽固性头痛的中药
CN1259961C (zh) 治疗肾病的药物及其制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160413

RJ01 Rejection of invention patent application after publication