Summary of the invention
Technical problem to be solved by this invention is that the medicine that is used to treat beriberi in the prior art contains antibiotic, skin is had stimulation; To the problem of vesicle type beriberi and erosive type treating beri-beri weak effect, provide a kind of and do not contain antibiotic, non-stimulated and erosive type and vesicle type vitamin B1 deficiency had the Chinese medicine composition and a method for preparing of good efficacy skin.
The invention provides a kind of Chinese medicine composition, the weight portion of said composition crude drug is: Oleum Camelliae 20-40 part, Rhizoma Coptidis 3-6 part, Flos Sophorae 5-15 part; Herba Hylothelephii Verticillati 5-15 part, Herba Menthae powder 3-8 part, alum powder 5-15 part, charcoal powder 3-8 part; Sulfa powder 3-8 part, Flos Firmianae (Flow Flos firmianae) 5-15 part, vaseline 6-12 part.
The weight portion of preferred crude drug of the present invention is: Oleum Camelliae 25-35 part, Rhizoma Coptidis 3-6 part, Flos Sophorae 8-12 part, Herba Hylothelephii Verticillati 8-12 part, Herba Menthae powder 4-6 part, alum powder 8-12 part, charcoal powder 4-6 part, sulfa powder 4-6 part, Flos Firmianae (Flow Flos firmianae) 8-12 part, vaseline 7-9 part.
The weight portion of best crude drug of the present invention is: 30 parts of Oleum Camelliae, 8 parts of Rhizoma Coptidis, 10 parts in Flos Sophorae, 10 parts of Herba Hylothelephii Verticillatis, 5 parts of Herba Menthae powders, 10 parts of alum powders, 10 parts of charcoal powders, 5 parts of sulfa powders, 10 parts of Flos Firmianae (Flow Flos firmianae), 8 parts in vaseline.
Said Chinese medicine composition is made into any external-use drug form.
Said Chinese medicine composition is made into unguentum, patch or liquor.
The method for preparing of described Chinese medicine composition comprises the steps:
A) get Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Hylothelephii Verticillati respectively cleaning, drying be crushed to fine powder;
B) Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried ripe and stir;
C) above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder respectively, the grass meal of reviving after death, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir;
D) with the vaseline heating for dissolving, add above-mentioned medicinal liquid, stirring gets final product.
Fine powder is 120 orders in the said step a).
The invention still further relates to the purposes of said Chinese medicine composition in preparation treatment beriberi.
Theory of Chinese medical science thinks that beriberi is because of the affection of exogenous damp pathogenic wind toxic, or the diet savoury hinders, long-pending humidogene heat, and multiple abscess legs and feet and causing a disease so the principle of Chinese traditional treatment beriberi mainly is a heat clearing and damp drying, detoxify, and parasite killing is antipruritic.
Oleum Camelliae is cool in nature, and sweet in the mouth is returned large intestine channel, the effect of tool heat-clearing and toxic substances removing, parasite killing, and Rhizoma Coptidis is cold in nature; Bitter in the mouth, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, the tool heat clearing and damp drying, the effect of eliminating fire and detoxication, alum powder is cold in nature; Sour in the mouth, puckery, tool detoxifcation parasite killing, dampness removing to stop itchin, the effect of hemostasis heat clearing away, three's phase 5; Play heat clearing and damp drying, detoxifcation, parasite killing, itching-relieving efficacies is monarch drug altogether.
The significant antiinflammatory of sulfa powder tool, antibacterial effect, Flos Sophorae is cool in nature, and bitter in the mouth is returned liver, large intestine channel, the effect of tool clearing away heat-fire, cooling blood for hemostasis, both phases 5 strengthen heat clearing away, parasite killing, antipruritic effect is ministerial drug altogether.
Herba Menthae powder is cool in nature, and acrid in the mouth is returned lung, Liver Channel, the effect of tool detumescence antiinflammatory, analgesic hemostatic; Herba Hylothelephii Verticillati property is flat, bitter in the mouth, the effect of tool detoxifcation, detumescence, hemostasis, the effect of charcoal powder Bearberry Extract hemostasis; Flos Firmianae (Flow Flos firmianae) property is flat, sweet in the mouth, the effect of tool reducing swelling and alleviating pain, this phase 5; Playing the effect of astringing to arrest bleeding, putrefaction-removing granulation-promoting, detumescence, in order to the blister that causes of treatment vitamin B1 deficiency, fester, is adjuvant drug altogether.
Vaseline also has skin protection, skin moistening, antiinflammatory and deodorant effect simultaneously as excipient.
More than ten flavor medicine fit applications, the effect of playing heat clearing and damp drying, detoxifying and relieving itching, hemostasia and detumescence, analgesic antiphlogistic, putrefaction-removing granulation-promoting altogether all has good efficacy to vitamin B1 deficiency and complication thereof.
The present invention has following advantage:
The present invention selects Oleum Camelliae for use, Rhizoma Coptidis, Flos Sophorae, Herba Hylothelephii Verticillati; Herba Menthae powder, alum powder, charcoal powder, sulfa powder; Flos Firmianae (Flow Flos firmianae), vaseline are raw material, and the effect of playing heat clearing and damp drying, detoxifying and relieving itching, hemostasia and detumescence, analgesic antiphlogistic, putrefaction-removing granulation-promoting altogether all has good efficacy to vitamin B1 deficiency and complication thereof.Because crude drug does not contain antibiotic; Avoided the generation of " super bacterium "; Except that sulfa powder, the present invention does not contain other chemicals composition, the damage of having avoided a large amount of chemicalses that skin is caused; Owing to Herba Menthae powder, Herba Hylothelephii Verticillati, charcoal powder, Flos Firmianae (Flow Flos firmianae) in the crude drug of the present invention have the effect of astringing to arrest bleeding, putrefaction-removing granulation-promoting, detumescence, therefore effective in addition to vesicle type beriberi and erosive type treating beri-beri.
The specific embodiment
Embodiment 1
Take by weighing Oleum Camelliae 20g, Rhizoma Coptidis 3g, Flos Sophorae 5g, Herba Selaginellae 5g, Herba Menthae powder 3g, alum powder 5g, charcoal powder 3g, sulfa powder 3g, Flos Firmianae (Flow Flos firmianae) 5g, vaseline 6g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 80 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried ripe and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stirring gets final product.
Embodiment 2
Take by weighing Oleum Camelliae 30g, Rhizoma Coptidis 4.5g, Flos Sophorae 10g, Herba Selaginellae 10g, Herba Menthae powder 5g, alum powder 10g, charcoal powder 5g, sulfa powder 5g, Flos Firmianae (Flow Flos firmianae) 10g, vaseline 9g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 160 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stirring gets final product.
Embodiment 3
Take by weighing Oleum Camelliae 40g, Rhizoma Coptidis 6g, Flos Sophorae 15g, Herba Selaginellae 15g, Herba Menthae powder 8g, alum powder 15g, charcoal powder 8g, sulfa powder 8g, Flos Firmianae (Flow Flos firmianae) 15g, vaseline 12g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 120 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stir into the pitchy ointment.
Embodiment 4
Take by weighing Oleum Camelliae 25g, Rhizoma Coptidis 3g, Flos Sophorae 8g, Herba Selaginellae 8g, Herba Menthae powder 4g, alum powder 8g, charcoal powder 4g, sulfa powder 4g, Flos Firmianae (Flow Flos firmianae) 8g, vaseline 7g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 120 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stir into the pitchy ointment.
Embodiment 5
Take by weighing Oleum Camelliae 30g, Rhizoma Coptidis 4.5g, Flos Sophorae 10g, Herba Selaginellae 10g, Herba Menthae powder 5g, alum powder 10g, charcoal powder 5g, sulfa powder 5g, Flos Firmianae (Flow Flos firmianae) 10g, vaseline 8g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 100 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stirring gets final product.
Embodiment 6
Take by weighing Oleum Camelliae 35g, Rhizoma Coptidis 6g, Flos Sophorae 12g, Herba Selaginellae 12g, Herba Menthae powder 6g, alum powder 12g, charcoal powder 6g, sulfa powder 6g, Flos Firmianae (Flow Flos firmianae) 12g, vaseline 9g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 120 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stir into the pitchy ointment.
Embodiment 7
Take by weighing Oleum Camelliae 30g, Rhizoma Coptidis 8g, Flos Sophorae 10g, Herba Selaginellae 10g, Herba Menthae powder 5g, alum powder 10g, charcoal powder 10g, sulfa powder 5g, Flos Firmianae (Flow Flos firmianae) 10g, vaseline 8g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 120 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stir into the pitchy ointment.
Embodiment 8
Take by weighing Oleum Camelliae 30g, Rhizoma Coptidis 8g, Flos Sophorae 10g, Herba Selaginellae 10g, Herba Menthae powder 5g, alum powder 10g, charcoal powder 10g, sulfa powder 5g, Flos Firmianae (Flow Flos firmianae) 10g, vaseline 8g;
With Flos Sophorae, Flos Firmianae (Flow Flos firmianae), Herba Selaginellae respectively cleaning, drying be crushed to 120 order fine powders; Oleum Camelliae is heated to 80-100 ℃, adds Flos Sophorae powder, Firmiana platanifolia (Linn. f.) Marsili pollen respectively, fried to pitchy and stir; Above-mentioned Oleum Camelliae liquid is cooled to 20-30 ℃, adds sulfa powder, Herba Selaginellae powder, alum powder, charcoal powder, Rhizoma Coptidis powder, after this add Herba Menthae powder, stir into the pitchy medicinal liquid; With the vaseline heating for dissolving, add above-mentioned medicinal liquid, stir into the pitchy ointment, evenly on coating and the cotton, prepare patch.
Experimental example
In order to show the therapeutic effect of this Chinese medicine composition to beriberi, the present invention is through the clinical observation of 100 routine systems, vesicle type beriberi patient 30 examples wherein, erosive type beriberi patient 30 example and keratinization type beriberi patient 40 examples.In the process of above-mentioned clinical observation, and the work of above-mentioned patient being write down its medical history, the state of an illness, age and curative effect.
The criterion of clinical therapeutic efficacy is:
Clinical cure: foot odor, foot pruritus, desquamation, blister, abscess, red moistening complete obiteration, sweaty foot recover normal.
Produce effects: foot odor, foot pruritus, sweaty foot, desquamation, blister, abscess, red moisteningly obviously alleviate.
Effectively: foot odor, foot pruritus, sweaty foot alleviate.
Invalid: foot odor, foot pruritus, sweaty foot disappear not obvious or increase the weight of.
Medication is: smear the unguentum of embodiment 7 preparations for patient's affected part.
The course of treatment: 15 days is a course of treatment, uses every day twice.
Clinical experiment is the result show, only uses this Chinese medicine composition of a course of treatment, and original symptom obviously alleviates.According to statistics, the light patient of 5% symptom can once cure, use a course of treatment after, reach 95% cure rate, 5% produce effects or improvement, no invalid situation (seeing table 1).
Contrast experiment's example
Take by weighing Cortex Phellodendri 5g, Borneolum Syntheticum 4g, Mentholum 5g, Alumen 2.5g, Pulvis Talci 55g, sulfamethoxazole 2.5g, metronidazole 10g, griseofulvin 4.5g, chloromycetin 2.5g, aspirin 2.5g, chlorphenamine 1.5g, vitamin B
11.5g nanometer silver powder 0.5g processes medicated powder according to aforementioned Chinese patent document CN101810720A disclosed method.Use this product that 100 routine patients of identical body constitution, state of an illness state are carried out clinic trial, medication is a 33g, 2 times on the one, and the diet irritable food.According to the 1 disclosed method administration of aforementioned Chinese patent document CN101810720A application examples.
Behind the successive administration 15 days, the result is as shown in table 2, and its average cure rate reaches 65%, and has part patient affected part to produce " super bacterium ", and the red swelling of the skin phenomenon is wherein especially poor to vesicle type beriberi and erosive type treating beri-beri effect.
Though the present invention has carried out detailed elaboration through above-mentioned specific embodiment to it; But; Any form that does not exceed the claim protection domain that those skilled in the art should be understood that on this basis to be made and the variation of details all belong to invention which is intended to be protected.