CN102770421B - 作为药物和诊断组合物的载体的冠醚的原酸酯衍生物 - Google Patents

作为药物和诊断组合物的载体的冠醚的原酸酯衍生物 Download PDF

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Publication number
CN102770421B
CN102770421B CN201080062354.9A CN201080062354A CN102770421B CN 102770421 B CN102770421 B CN 102770421B CN 201080062354 A CN201080062354 A CN 201080062354A CN 102770421 B CN102770421 B CN 102770421B
Authority
CN
China
Prior art keywords
groups
group
crown ether
crown
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080062354.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN102770421A (zh
Inventor
保罗·博蒂
西尔维·切尔特基安
多里安·特伊里拉特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cape Suzhe Belgian Ltd By Share Ltd
Paul Botty
Original Assignee
Arisgen SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arisgen SA filed Critical Arisgen SA
Publication of CN102770421A publication Critical patent/CN102770421A/zh
Application granted granted Critical
Publication of CN102770421B publication Critical patent/CN102770421B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201080062354.9A 2009-11-25 2010-11-25 作为药物和诊断组合物的载体的冠醚的原酸酯衍生物 Expired - Fee Related CN102770421B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09014693A EP2332929A1 (en) 2009-11-25 2009-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
EP09014693.7 2009-11-25
PCT/EP2010/068224 WO2011064300A1 (en) 2009-11-25 2010-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions

Publications (2)

Publication Number Publication Date
CN102770421A CN102770421A (zh) 2012-11-07
CN102770421B true CN102770421B (zh) 2014-11-26

Family

ID=42101959

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080062354.9A Expired - Fee Related CN102770421B (zh) 2009-11-25 2010-11-25 作为药物和诊断组合物的载体的冠醚的原酸酯衍生物

Country Status (10)

Country Link
US (1) US8624044B2 (enExample)
EP (2) EP2332929A1 (enExample)
JP (1) JP5848708B2 (enExample)
CN (1) CN102770421B (enExample)
AU (1) AU2010323101B2 (enExample)
BR (1) BR112012012539B8 (enExample)
CA (1) CA2783306C (enExample)
ES (1) ES2557916T3 (enExample)
IL (1) IL219966A (enExample)
WO (1) WO2011064300A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
EP2526971A1 (en) * 2011-05-25 2012-11-28 ArisGen SA Mucosal delivery of drugs
EP3000811B1 (en) 2014-09-24 2017-11-08 Friedrich-Alexander-Universität Erlangen-Nürnberg Crown Ether Complexes and Methods for Poducing the Same
WO2020074691A1 (en) * 2018-10-12 2020-04-16 Advanced Accelerator Applications International Sa Pharmaceutical composition comprising a radiolabeled gprp antagonist and a surfactant

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1905454A1 (en) * 2006-09-27 2008-04-02 Paolo Botti Formulations comprising cyclic compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113739A (en) * 1974-01-28 1978-09-12 The Dow Chemical Company Process for preparation of (poly)cyclic polyethers
US4474963A (en) * 1980-11-03 1984-10-02 W. R. Grace & Co. Crown ether compositions with sidearms affording enhanced cation binding
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
CA2658039A1 (en) 1995-09-21 1997-03-27 Genentech, Inc. Human growth hormone variants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1905454A1 (en) * 2006-09-27 2008-04-02 Paolo Botti Formulations comprising cyclic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PbOH+-selective membrane electrode based on crown ethers;Wolfgang Hasse et al.;《Sensors and Actuators B: Chemical》;19941231;第19卷;383-386 *

Also Published As

Publication number Publication date
BR112012012539A2 (pt) 2016-05-03
CA2783306C (en) 2021-01-19
AU2010323101A1 (en) 2012-06-07
IL219966A (en) 2014-12-31
BR112012012539B1 (pt) 2021-05-11
WO2011064300A1 (en) 2011-06-03
BR112012012539B8 (pt) 2021-05-25
US20120301401A1 (en) 2012-11-29
CN102770421A (zh) 2012-11-07
JP5848708B2 (ja) 2016-01-27
EP2504327B1 (en) 2015-07-29
CA2783306A1 (en) 2011-06-03
US8624044B2 (en) 2014-01-07
EP2504327A1 (en) 2012-10-03
EP2332929A1 (en) 2011-06-15
IL219966A0 (en) 2012-07-31
JP2013512221A (ja) 2013-04-11
AU2010323101B2 (en) 2014-10-02
ES2557916T3 (es) 2016-01-29

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180919

Address after: Belgian rum

Patentee after: Cape Suzhe Belgian Limited by Share Ltd.

Address before: Geneva, Switzerland

Patentee before: Paul Botty

Effective date of registration: 20180919

Address after: Geneva, Switzerland

Patentee after: Paul Botty

Address before: Prams Batas, Switzerland

Patentee before: ARISGEN S.A.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20141126