CA2783306C - Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions - Google Patents

Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions Download PDF

Info

Publication number
CA2783306C
CA2783306C CA2783306A CA2783306A CA2783306C CA 2783306 C CA2783306 C CA 2783306C CA 2783306 A CA2783306 A CA 2783306A CA 2783306 A CA2783306 A CA 2783306A CA 2783306 C CA2783306 C CA 2783306C
Authority
CA
Canada
Prior art keywords
crown
group
groups
crown ether
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2783306A
Other languages
English (en)
French (fr)
Other versions
CA2783306A1 (en
Inventor
Paolo Botti
Sylvie Tchertchian
Doriane Theurillat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capsugel Belgium NV
Original Assignee
Capsugel Belgium NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Capsugel Belgium NV filed Critical Capsugel Belgium NV
Publication of CA2783306A1 publication Critical patent/CA2783306A1/en
Application granted granted Critical
Publication of CA2783306C publication Critical patent/CA2783306C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2783306A 2009-11-25 2010-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions Active CA2783306C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09014693.7 2009-11-25
EP09014693A EP2332929A1 (en) 2009-11-25 2009-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions
PCT/EP2010/068224 WO2011064300A1 (en) 2009-11-25 2010-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions

Publications (2)

Publication Number Publication Date
CA2783306A1 CA2783306A1 (en) 2011-06-03
CA2783306C true CA2783306C (en) 2021-01-19

Family

ID=42101959

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2783306A Active CA2783306C (en) 2009-11-25 2010-11-25 Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions

Country Status (10)

Country Link
US (1) US8624044B2 (enExample)
EP (2) EP2332929A1 (enExample)
JP (1) JP5848708B2 (enExample)
CN (1) CN102770421B (enExample)
AU (1) AU2010323101B2 (enExample)
BR (1) BR112012012539B8 (enExample)
CA (1) CA2783306C (enExample)
ES (1) ES2557916T3 (enExample)
IL (1) IL219966A (enExample)
WO (1) WO2011064300A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
EP2526971A1 (en) * 2011-05-25 2012-11-28 ArisGen SA Mucosal delivery of drugs
EP3000811B1 (en) 2014-09-24 2017-11-08 Friedrich-Alexander-Universität Erlangen-Nürnberg Crown Ether Complexes and Methods for Poducing the Same
JP7480132B2 (ja) * 2018-10-12 2024-05-09 アドヴァンスド アクセラレーター アプリケーションズ インターナショナル エセ．アー． 放射性標識されたｇｐｒｐアンタゴニスト及び界面活性剤を含む医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113739A (en) * 1974-01-28 1978-09-12 The Dow Chemical Company Process for preparation of (poly)cyclic polyethers
US4474963A (en) * 1980-11-03 1984-10-02 W. R. Grace & Co. Crown ether compositions with sidearms affording enhanced cation binding
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
ATE455171T1 (de) 1995-09-21 2010-01-15 Genentech Inc Varianten des menschlichen wachstumshormons
EP1905454A1 (en) * 2006-09-27 2008-04-02 Paolo Botti Formulations comprising cyclic compounds

Also Published As

Publication number Publication date
BR112012012539B1 (pt) 2021-05-11
BR112012012539B8 (pt) 2021-05-25
BR112012012539A2 (pt) 2016-05-03
IL219966A0 (en) 2012-07-31
EP2332929A1 (en) 2011-06-15
JP2013512221A (ja) 2013-04-11
AU2010323101B2 (en) 2014-10-02
EP2504327A1 (en) 2012-10-03
ES2557916T3 (es) 2016-01-29
IL219966A (en) 2014-12-31
CN102770421A (zh) 2012-11-07
US20120301401A1 (en) 2012-11-29
WO2011064300A1 (en) 2011-06-03
US8624044B2 (en) 2014-01-07
CA2783306A1 (en) 2011-06-03
JP5848708B2 (ja) 2016-01-27
CN102770421B (zh) 2014-11-26
AU2010323101A1 (en) 2012-06-07
EP2504327B1 (en) 2015-07-29

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