CN102770407A - 交联的两性离子水凝胶 - Google Patents

交联的两性离子水凝胶 Download PDF

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CN102770407A
CN102770407A CN201080055967XA CN201080055967A CN102770407A CN 102770407 A CN102770407 A CN 102770407A CN 201080055967X A CN201080055967X A CN 201080055967XA CN 201080055967 A CN201080055967 A CN 201080055967A CN 102770407 A CN102770407 A CN 102770407A
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hydrogel
hydrogels
integer
cbmax
zwitterionic
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Chinese (zh)
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S·江
L·R·卡尔
H·薛
W·杨
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University of Washington Center for Commercialization
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
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    • C08J2433/14—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
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CN201080055967XA 2009-11-06 2010-11-08 交联的两性离子水凝胶 Pending CN102770407A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25907409P 2009-11-06 2009-11-06
US61/259,074 2009-11-06
PCT/US2010/055875 WO2011057219A2 (en) 2009-11-06 2010-11-08 Crosslinked zwitterionic hydrogels

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CN102770407A true CN102770407A (zh) 2012-11-07

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US (3) US8835671B2 (enExample)
EP (1) EP2496550B1 (enExample)
JP (2) JP6067376B2 (enExample)
CN (1) CN102770407A (enExample)
WO (1) WO2011057219A2 (enExample)

Cited By (8)

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CN107835826A (zh) * 2015-06-02 2018-03-23 华盛顿大学 自支撑型不污聚合物、其组合物和有关单体
CN109928889A (zh) * 2019-02-01 2019-06-25 中国医学科学院生物医学工程研究所 羧酸甜菜碱型含氟化合物及其合成方法和应用
CN110381956A (zh) * 2017-01-27 2019-10-25 康奈尔大学 两性离子修饰的聚合物和水凝胶
CN110520462A (zh) * 2017-04-18 2019-11-29 基础科学研究院 高分子凝胶及其制造方法、以及包含该高分子凝胶的物品
CN111164115A (zh) * 2017-10-18 2020-05-15 富士胶片株式会社 固化性组合物、膜、固化物及医疗用部件
CN111807979A (zh) * 2020-08-14 2020-10-23 中国医学科学院生物医学工程研究所 两性离子氟化交联剂、纳米凝胶及其应用
US20220079877A1 (en) * 2017-09-22 2022-03-17 University Of Florida Research Foundation, Inc. Devices and methods for reducing cystine crystals in vivo
CN114621743A (zh) * 2022-03-31 2022-06-14 中国石油大学(华东) 缓交联耐温耐盐聚合物冻胶压裂液及其制备方法和应用

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JP6067376B2 (ja) * 2009-11-06 2017-01-25 ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション 架橋した双性イオンヒドロゲル
US9599613B2 (en) 2011-07-20 2017-03-21 University Of Washington Through Its Center For Commercialization Photonic blood typing
US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
US9139684B2 (en) 2012-07-20 2015-09-22 The United States Of America, As Represented By The Secretary Of The Navy Carboxybetaine-functionalized diols and zwitterionic polyurethane hydrogels derived therefrom
US9644076B2 (en) 2012-09-25 2017-05-09 Max-Planck-Gesellschaft zur Foerderung der Wissenschafen e. V. Cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof
US9788765B2 (en) * 2012-09-28 2017-10-17 Dexcom, Inc. Zwitterion surface modifications for continuous sensors
US9737250B2 (en) 2013-03-15 2017-08-22 Dexcom, Inc. Membrane for continuous analyte sensors
US10494538B2 (en) * 2013-05-30 2019-12-03 The University Of Akron Switchable antimicrobial and antifouling carboxybetaine-based hydrogels and elastomers with enhanced mechanical properties
WO2015054484A1 (en) * 2013-10-09 2015-04-16 The University Of Akron Integrated zwitterionic conjugated polymers for bioelectronics, biosensing, regenerative medicine, and energy applications
CN106999270B (zh) 2014-09-09 2021-01-01 华盛顿大学 官能化的两性离子和混合电荷聚合物、相关的水凝胶及它们的使用方法
WO2016138528A1 (en) * 2015-02-27 2016-09-01 Wayne State University Methods and compositions relating to biocompatible implants
US10723842B2 (en) * 2015-03-11 2020-07-28 University Of Florida Research Foundation, Inc. Mesh size control of lubrication in gemini hydrogels
US10351524B2 (en) * 2015-07-01 2019-07-16 National Chung Cheng University Hydrocarbyl carboxybetaine and method for preventing hofmann elimination in alkaline environment
JP2018168202A (ja) * 2015-08-31 2018-11-01 富士フイルム株式会社 光硬化性組成物、硬化物、部材、及び、装置
WO2017117468A1 (en) * 2015-12-30 2017-07-06 Dexcom, Inc. Enzyme immobilized adhesive layer for analyte sensors
BR112018075841A2 (pt) 2016-06-13 2019-03-19 Massachusetts Institute Of Technology polímero biocompatível, hidrogel, dispositivo, biomaterial e método de preparação do hidrogel
CA3028732A1 (en) 2016-06-24 2017-12-28 University Of Iowa Research Foundation Durable photopolymerizable cross-linked anti-fouling coatings
JP7042252B2 (ja) * 2016-07-27 2022-03-25 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 架橋密度の勾配を有するポリマー足場を作出するための方法
US10676575B2 (en) 2016-10-06 2020-06-09 Johnson & Johnson Vision Care, Inc. Tri-block prepolymers and their use in silicone hydrogels
JP2020522534A (ja) 2017-06-06 2020-07-30 ウェイン ステート ユニバーシティＷａｙｎｅ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ カルニチン由来材料に関する方法および組成物
WO2018231862A1 (en) * 2017-06-12 2018-12-20 Mayo Foundation For Medical Education And Research Hydrogel based encapsulation device
WO2018236735A1 (en) 2017-06-20 2018-12-27 Dow Global Technologies Llc Polyvinyl chloride compositions containing impact modifiers and calcium carbonate
JP6986090B2 (ja) * 2017-10-18 2021-12-22 富士フイルム株式会社 硬化性組成物、膜、硬化物、医療用部材
US10996491B2 (en) 2018-03-23 2021-05-04 Johnson & Johnson Vision Care, Inc. Ink composition for cosmetic contact lenses
CA3093581A1 (en) 2018-05-15 2019-11-21 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
US20230098968A1 (en) 2018-05-25 2023-03-30 The University Of North Carolina At Chapel Hill Formation of arrays of planar intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone
EP3836969A4 (en) * 2018-08-14 2022-06-01 University of Washington ZTWTERIONIC DOUBLE MESH HYDROGELE
JP2022511375A (ja) 2018-11-16 2022-01-31 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル インビトロ細胞培養粘液系
US11912894B2 (en) 2018-11-26 2024-02-27 Cornell University Antimicrobial and antifouling conformal hydrogel coatings
US11891526B2 (en) 2019-09-12 2024-02-06 Johnson & Johnson Vision Care, Inc. Ink composition for cosmetic contact lenses
US20230002650A1 (en) * 2019-10-25 2023-01-05 Kyushu University, National University Corporation Biocompatible adhesive
CN114106232B (zh) * 2021-11-25 2022-08-30 华南农业大学 一种两面粘附性不同的水凝胶及其制备方法和应用
CN119573542B (zh) * 2023-09-05 2025-12-09 中国科学院上海硅酸盐研究所 一种基于离子聚合物凝胶的高灵敏弯曲传感器
CN119119353A (zh) * 2024-08-30 2024-12-13 山东大学 一种水下粘附性凝胶及其制备方法与应用

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WO2007024393A2 (en) * 2005-08-25 2007-03-01 University Of Washington Super-low fouling sulfobetaine and carboxybetaine materials and related methods

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