CN102762560A - 二取代的杂芳基-稠合的吡啶 - Google Patents

二取代的杂芳基-稠合的吡啶 Download PDF

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Publication number
CN102762560A
CN102762560A CN2010800643114A CN201080064311A CN102762560A CN 102762560 A CN102762560 A CN 102762560A CN 2010800643114 A CN2010800643114 A CN 2010800643114A CN 201080064311 A CN201080064311 A CN 201080064311A CN 102762560 A CN102762560 A CN 102762560A
Authority
CN
China
Prior art keywords
pyrazolo
ring system
pyridin
acetamide
yloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800643114A
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English (en)
Chinese (zh)
Inventor
S·巴迪格
D·本克
C·贝特斯查尔特
V·乔杜里
M·舍布罗鲁
S·科斯特斯塔
S·安特曼
C·潘迪特
A·迈尔
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Novartis AG
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Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN102762560A publication Critical patent/CN102762560A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2010800643114A 2009-12-21 2010-12-20 二取代的杂芳基-稠合的吡啶 Pending CN102762560A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2664DE2009 2009-12-21
IN2664/DEL/2009 2009-12-21
PCT/EP2010/070260 WO2011076744A1 (en) 2009-12-21 2010-12-20 Disubstituted heteroaryl-fused pyridines

Publications (1)

Publication Number Publication Date
CN102762560A true CN102762560A (zh) 2012-10-31

Family

ID=43640661

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800643114A Pending CN102762560A (zh) 2009-12-21 2010-12-20 二取代的杂芳基-稠合的吡啶

Country Status (6)

Country Link
US (1) US8742106B2 (enExample)
EP (1) EP2516437B1 (enExample)
JP (1) JP2013515032A (enExample)
CN (1) CN102762560A (enExample)
ES (1) ES2460915T3 (enExample)
WO (1) WO2011076744A1 (enExample)

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* Cited by examiner, † Cited by third party
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CN105541719A (zh) * 2016-02-03 2016-05-04 安徽工业大学 一种以乳清酸为原料制备5-氨基-1,2二氢吡唑-3-酮的方法

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US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
RU2014136339A (ru) 2012-02-07 2016-03-27 Иолас Терапьютикс, Инк. Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов
BR102012024778A2 (pt) 2012-09-28 2014-08-19 Cristalia Prod Quimicos Farm Compostos heteroaromáticos; processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
JP6903580B2 (ja) 2014-12-29 2021-07-14 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ 乳酸脱水素酵素の小分子阻害剤及びその使用方法
KR102738491B1 (ko) 2016-02-12 2024-12-03 아스트라제네카 아베 오렉신 수용체 조정제로서의 할로-치환된 피페리딘
EP3515907A1 (en) 2016-09-22 2019-07-31 Bayer CropScience Aktiengesellschaft Novel triazole derivatives
WO2018054829A1 (en) 2016-09-22 2018-03-29 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives and their use as fungicides
AU2017333333A1 (en) 2016-09-29 2019-03-21 Bayer Aktiengesellschaft 5-substituted imidazolylmethyldioxolane derivatives as fungiciides
US20200031778A1 (en) 2016-09-29 2020-01-30 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazolylmethyl derivatives
US20200045967A1 (en) 2017-02-08 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
BR112019016241A2 (pt) 2017-02-08 2020-04-07 Bayer Cropscience Ag derivados de triazol e seu uso como fungicidas
CA3052519A1 (en) 2017-02-08 2018-08-16 Andreas Gortz Triazolethione derivatives
KR20190115449A (ko) 2017-02-10 2019-10-11 바이엘 악티엔게젤샤프트 1-(페녹시-피리디닐)-2-(1,2,4-트리아졸-1-일)-에탄올 유도체를 포함하는 유해 미생물을 방제하기 위한 조성물
WO2020020816A1 (en) 2018-07-26 2020-01-30 Bayer Aktiengesellschaft Novel triazole derivatives
CN112930336A (zh) * 2018-10-18 2021-06-08 勃林格殷格翰国际有限公司 光学活性的1-环丙基烷基-1-胺的可放大合成
WO2022094012A1 (en) * 2020-11-02 2022-05-05 Merck Sharp & Dohme Corp. Macrocyclic urea orexin receptor agonists

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WO2001098301A1 (en) * 2000-06-20 2001-12-27 Japan Tobacco Inc. Pyrazolopyridine compounds and use thereof as drugs
WO2007122591A2 (en) * 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
WO2009003993A1 (en) * 2007-07-03 2009-01-08 Glaxo Group Limited Piperidine derivatives useful as orexin receptor antagonists

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PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
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WO2001098301A1 (en) * 2000-06-20 2001-12-27 Japan Tobacco Inc. Pyrazolopyridine compounds and use thereof as drugs
WO2007122591A2 (en) * 2006-04-26 2007-11-01 Actelion Pharmaceuticals Ltd Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
WO2009003993A1 (en) * 2007-07-03 2009-01-08 Glaxo Group Limited Piperidine derivatives useful as orexin receptor antagonists

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JIAQIANG CAI ET AL: "Antagonists of the orexin receptors", 《EXPERT OPIN.THER.PATENTS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105541719A (zh) * 2016-02-03 2016-05-04 安徽工业大学 一种以乳清酸为原料制备5-氨基-1,2二氢吡唑-3-酮的方法

Also Published As

Publication number Publication date
WO2011076744A1 (en) 2011-06-30
JP2013515032A (ja) 2013-05-02
US20120258973A1 (en) 2012-10-11
EP2516437A1 (en) 2012-10-31
US8742106B2 (en) 2014-06-03
EP2516437B1 (en) 2014-01-29
ES2460915T3 (es) 2014-05-16

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SE01 Entry into force of request for substantive examination
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Address after: Basel

Applicant after: Novartis Ag

Address before: Basel

Applicant before: Novartis AG

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
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Application publication date: 20121031