CN102762204B - 造血细胞激酶(p59-hck)的抑制剂及其在流感感染治疗中的用途 - Google Patents

造血细胞激酶(p59-hck)的抑制剂及其在流感感染治疗中的用途 Download PDF

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CN102762204B
CN102762204B CN201080063651.5A CN201080063651A CN102762204B CN 102762204 B CN102762204 B CN 102762204B CN 201080063651 A CN201080063651 A CN 201080063651A CN 102762204 B CN102762204 B CN 102762204B
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mmol
alkyl
tert
compound
pyridine
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CN102762204A (zh
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C.E.查伦
R.芬顿
S.克罗
伊藤一洋
P.斯特朗
G.拉帕波特
K.雷
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Respivert Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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CN201080063651.5A 2009-12-11 2010-12-10 造血细胞激酶(p59-hck)的抑制剂及其在流感感染治疗中的用途 Active CN102762204B (zh)

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Application Number Priority Date Filing Date Title
GB0921730.8 2009-12-11
GBGB0921730.8A GB0921730D0 (en) 2009-12-11 2009-12-11 Method of treatment
PCT/GB2010/052067 WO2011070369A1 (en) 2009-12-11 2010-12-10 Inhibitors of hemopoietic cell kinase (p59-hck) and their use in the treatment of influenza infection

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CN102762204B true CN102762204B (zh) 2014-11-19

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US (3) US20120244120A1 (cg-RX-API-DMAC10.html)
EP (1) EP2509595B1 (cg-RX-API-DMAC10.html)
JP (2) JP2013513596A (cg-RX-API-DMAC10.html)
CN (1) CN102762204B (cg-RX-API-DMAC10.html)
AU (1) AU2010329645B2 (cg-RX-API-DMAC10.html)
GB (1) GB0921730D0 (cg-RX-API-DMAC10.html)
WO (1) WO2011070369A1 (cg-RX-API-DMAC10.html)

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EP2509595A1 (en) 2012-10-17
US20160045512A1 (en) 2016-02-18
JP2016128489A (ja) 2016-07-14
AU2010329645B2 (en) 2015-05-28
US20180000830A1 (en) 2018-01-04
GB0921730D0 (en) 2010-01-27
WO2011070369A1 (en) 2011-06-16
EP2509595B1 (en) 2018-04-11
JP2013513596A (ja) 2013-04-22
JP6247709B2 (ja) 2017-12-13
CN102762204A (zh) 2012-10-31
US20120244120A1 (en) 2012-09-27
AU2010329645A1 (en) 2012-06-07

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