CN102757505A - 具有延长的体内半衰期的生理学活性多肽缀合物 - Google Patents
具有延长的体内半衰期的生理学活性多肽缀合物 Download PDFInfo
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- CN102757505A CN102757505A CN2012102179394A CN201210217939A CN102757505A CN 102757505 A CN102757505 A CN 102757505A CN 2012102179394 A CN2012102179394 A CN 2012102179394A CN 201210217939 A CN201210217939 A CN 201210217939A CN 102757505 A CN102757505 A CN 102757505A
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Abstract
Description
理论值(kDa) | 测定值(kDa) | |
INFα-PEG-AG IgG(实施例11) | 169.6 | 170.0 |
EPO-PEG-AG IgG(实施例12) | 182.4 | 180.0 |
Claims (23)
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KR10-2003-0015744 | 2003-03-13 | ||
KR20030015744 | 2003-03-13 | ||
KR20030036408 | 2003-06-05 | ||
KR10-2003-0036408 | 2003-06-05 | ||
CNA2004800068263A CN1761684A (zh) | 2003-03-13 | 2004-03-13 | 具有延长的体内半衰期的生理学活性多肽缀合物 |
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CN201210217939.4A Expired - Lifetime CN102757505B (zh) | 2003-03-13 | 2004-03-13 | 具有延长的体内半衰期的生理学活性多肽缀合物 |
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EP (1) | EP1601698B1 (zh) |
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CN (2) | CN1761684A (zh) |
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CA (1) | CA2519059C (zh) |
DE (1) | DE602004019887D1 (zh) |
ES (1) | ES2324298T3 (zh) |
HK (1) | HK1177465A1 (zh) |
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CN114364393A (zh) * | 2019-05-31 | 2022-04-15 | 光谱制药有限公司 | 使用g-csf蛋白质复合物治疗的方法 |
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US7083787B2 (en) * | 2000-11-15 | 2006-08-01 | Globeimmune, Inc. | Yeast-dendritic cell vaccines and uses thereof |
CN103212084B (zh) | 2003-11-13 | 2018-07-13 | 韩美科学株式会社 | 含有免疫球蛋白fc区作为载体的药物组合物 |
US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
WO2006005058A2 (en) * | 2004-06-30 | 2006-01-12 | Nektar Therapeutics Al, Corporation | Polymer-factor ix moiety conjugates |
WO2006053299A2 (en) | 2004-11-12 | 2006-05-18 | Bayer Healthcare Llc | Site-directed modification of fviii |
ES2434035T3 (es) | 2004-12-27 | 2013-12-13 | Baxter International Inc. | Conjugados de polímero-factor von Willebrand |
KR100754667B1 (ko) * | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
CA2609702C (en) | 2005-04-28 | 2013-05-28 | Ventana Medical Systems, Inc. | Antibody conjugates via heterobifunctional peg linkers |
EP1899368A2 (en) * | 2005-05-26 | 2008-03-19 | Schering Corporation | Interferon-igg fusion |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
KR20080072639A (ko) * | 2005-10-27 | 2008-08-06 | 주식회사 펩트론 | 생리활성 기질-혈액 단백질 복합체 및 이를 이용하는생리활성 기질의 안정화 방법 |
DK2963011T3 (en) | 2005-11-23 | 2018-08-06 | Ventana Med Syst Inc | MOLECULAR CONJUGATE |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
CA2647314A1 (en) | 2006-03-31 | 2007-11-08 | Baxter International Inc. | Pegylated factor viii |
US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
PL3896090T3 (pl) | 2006-06-14 | 2022-05-02 | Csl Behring Gmbh | Rozszczepialne proteolitycznie białko fuzyjne zawierające czynnik krzepnięcia krwi |
EP1867660A1 (en) | 2006-06-14 | 2007-12-19 | CSL Behring GmbH | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
US7939632B2 (en) | 2006-06-14 | 2011-05-10 | Csl Behring Gmbh | Proteolytically cleavable fusion proteins with high molar specific activity |
WO2008077616A1 (en) | 2006-12-22 | 2008-07-03 | Csl Behring Gmbh | Modified coagulation factors with prolonged in vivo half-life |
JP2010530222A (ja) * | 2007-06-06 | 2010-09-09 | べーリンガー インゲルハイム インターナショナル ゲーエムベーハー | ナトリウム利尿融合タンパク質 |
AU2008290217B2 (en) | 2007-08-20 | 2013-09-05 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
US20090181037A1 (en) * | 2007-11-02 | 2009-07-16 | George Heavner | Semi-Synthetic GLP-1 Peptide-FC Fusion Constructs, Methods and Uses |
JP5546107B2 (ja) * | 2008-04-17 | 2014-07-09 | 国立大学法人宇都宮大学 | RNAウイルスBmMLV陰性カイコ培養細胞株 |
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JPWO2010074082A1 (ja) * | 2008-12-24 | 2012-06-21 | 塩野義製薬株式会社 | バソヒビン修飾体 |
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PT1601698E (pt) | 2009-06-17 |
BRPI0408331A8 (pt) | 2016-06-07 |
ES2324298T3 (es) | 2009-08-04 |
BRPI0408331A (pt) | 2006-03-21 |
EP1601698B1 (en) | 2009-03-11 |
BRPI0408331B8 (pt) | 2021-05-25 |
IL170685A0 (en) | 2009-02-11 |
IL170685A (en) | 2012-05-31 |
CA2519059C (en) | 2012-12-18 |
EP1601698A4 (en) | 2006-05-03 |
JP4481980B2 (ja) | 2010-06-16 |
CN1761684A (zh) | 2006-04-19 |
KR100567902B1 (ko) | 2006-04-04 |
RU2005128504A (ru) | 2006-03-10 |
EP1601698A1 (en) | 2005-12-07 |
ATE425188T1 (de) | 2009-03-15 |
AU2004220163B2 (en) | 2008-01-31 |
KR20040081378A (ko) | 2004-09-21 |
US8163889B2 (en) | 2012-04-24 |
AU2004220163A1 (en) | 2004-09-23 |
US20050176108A1 (en) | 2005-08-11 |
CN102757505B (zh) | 2015-10-07 |
JP2007528346A (ja) | 2007-10-11 |
HK1177465A1 (zh) | 2013-08-23 |
WO2004081053A1 (en) | 2004-09-23 |
CA2519059A1 (en) | 2004-09-23 |
DE602004019887D1 (de) | 2009-04-23 |
BRPI0408331B1 (pt) | 2019-09-17 |
US20100105869A1 (en) | 2010-04-29 |
RU2312868C2 (ru) | 2007-12-20 |
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