CN102725291B - 作为沉默调节蛋白调节剂的双环吡啶和相关的类似物 - Google Patents

作为沉默调节蛋白调节剂的双环吡啶和相关的类似物 Download PDF

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Publication number
CN102725291B
CN102725291B CN201080060180.2A CN201080060180A CN102725291B CN 102725291 B CN102725291 B CN 102725291B CN 201080060180 A CN201080060180 A CN 201080060180A CN 102725291 B CN102725291 B CN 102725291B
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alkyl
compound
fluorine
sirtuin
substituted
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CN102725291A (zh
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吴佩仪
C.布卢姆
L.麦克弗森
R.B.珀尼
C.B.武
M.M.阿迈德
J.S.迪奇
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Sirtris Pharmaceuticals Inc
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P5/00—Drugs for disorders of the endocrine system
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Endocrinology (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080060180.2A 2009-10-29 2010-10-29 作为沉默调节蛋白调节剂的双环吡啶和相关的类似物 Expired - Fee Related CN102725291B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25626909P 2009-10-29 2009-10-29
US61/256,269 2009-10-29
PCT/US2010/054880 WO2011059839A1 (en) 2009-10-29 2010-10-29 Bicyclic pyridines and analogs as sirtuin modulators

Publications (2)

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CN102725291A CN102725291A (zh) 2012-10-10
CN102725291B true CN102725291B (zh) 2016-12-21

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US (1) US9556201B2 (enrdf_load_stackoverflow)
EP (1) EP2493888B1 (enrdf_load_stackoverflow)
JP (1) JP2013509442A (enrdf_load_stackoverflow)
KR (1) KR20120092141A (enrdf_load_stackoverflow)
CN (1) CN102725291B (enrdf_load_stackoverflow)
AU (1) AU2010319842A1 (enrdf_load_stackoverflow)
BR (1) BR112012010010A2 (enrdf_load_stackoverflow)
CA (1) CA2779303A1 (enrdf_load_stackoverflow)
ES (1) ES2574927T3 (enrdf_load_stackoverflow)
IL (1) IL219372A0 (enrdf_load_stackoverflow)
IN (1) IN2012DN03799A (enrdf_load_stackoverflow)
MX (1) MX2012004995A (enrdf_load_stackoverflow)
RU (1) RU2550821C2 (enrdf_load_stackoverflow)
WO (1) WO2011059839A1 (enrdf_load_stackoverflow)

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