CN102695792B - 对辛伐他汀合成表现出改善性质的LovD突变体 - Google Patents

对辛伐他汀合成表现出改善性质的LovD突变体 Download PDF

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CN102695792B
CN102695792B CN201080055195.XA CN201080055195A CN102695792B CN 102695792 B CN102695792 B CN 102695792B CN 201080055195 A CN201080055195 A CN 201080055195A CN 102695792 B CN102695792 B CN 102695792B
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lovd
variant
simvastatin
acyl
red
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CN102695792A (zh
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唐奕
高雪
谢新开
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
CN201080055195.XA 2009-10-08 2010-10-08 对辛伐他汀合成表现出改善性质的LovD突变体 Active CN102695792B (zh)

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Application Number Priority Date Filing Date Title
US24989409P 2009-10-08 2009-10-08
US61/249,894 2009-10-08
PCT/US2010/052038 WO2011044496A2 (en) 2009-10-08 2010-10-08 LovD MUTANTS EXHIBITING IMPROVED PROPERTIES TOWARDS SIMVASTATIN SYNTHESIS

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CN102695792A CN102695792A (zh) 2012-09-26
CN102695792B true CN102695792B (zh) 2015-02-18

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US (1) US8981056B2 (enExample)
EP (1) EP2486129B1 (enExample)
CN (1) CN102695792B (enExample)
IL (2) IL219112B (enExample)
IN (1) IN2012DN03403A (enExample)
SG (1) SG10201504099WA (enExample)
WO (1) WO2011044496A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9499803B2 (en) * 2009-10-08 2016-11-22 The Regents Of The University Of California Variant LovD polypeptide
CN104342416B (zh) * 2013-07-26 2020-01-17 石药集团中奇制药技术（石家庄）有限公司 含有一个或几个点突变的洛伐他汀酰基转移酶
CN104342417A (zh) * 2013-08-09 2015-02-11 南京朗恩生物科技有限公司 源于土曲霉的活性增强的酰基转移酶突变体
CN103725727B (zh) * 2014-01-06 2016-06-08 苏州汉酶生物技术有限公司 一种辛伐他汀铵盐的制备方法
CN105586325A (zh) * 2016-01-29 2016-05-18 重庆西南合成制药有限公司 一种洛伐他汀酰基转移酶突变体
WO2019055816A1 (en) 2017-09-14 2019-03-21 Lifemine Therapeutics, Inc. HUMAN THERAPEUTIC TARGETS AND MODULATORS THEREFOR

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IL266709A (en) 2019-07-31
WO2011044496A3 (en) 2011-06-03
SG10201504099WA (en) 2015-06-29
EP2486129B1 (en) 2016-04-13
WO2011044496A2 (en) 2011-04-14
IN2012DN03403A (enExample) 2015-10-23
IL219112B (en) 2019-06-30
CN102695792A (zh) 2012-09-26
IL219112A0 (en) 2012-06-28
US20120190038A1 (en) 2012-07-26
US8981056B2 (en) 2015-03-17
EP2486129A2 (en) 2012-08-15
IL266709B (en) 2020-10-29
EP2486129A4 (en) 2013-03-27

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