CN102671032B - 一种治疗复发性口疮的中药 - Google Patents
一种治疗复发性口疮的中药 Download PDFInfo
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Abstract
本发明涉及一种治疗复发性口疮的中药组合物，由以下重量配比的药材制成：生地黄20-30份，人参20-30份，丹参20-30份，玄参20-30份，生三七20-30份，白茯苓20-30份，五味子10-20份，远志10-20份，炒桔梗10-20份，当归10-20份，天门冬10-20份，柏子仁10-20份，苦竹沥10-20份，朱砂1-2份。实验证明，本发明能够安全有效治疗复发性口疮。
Description
技术领域
本发明涉及一种中药，具体涉及一种治疗复发性口疮的中药。
背景技术
复发性口疮是口腔粘膜疾病中发病率最高的一种疾病，若口疮经常发生或此起彼伏称复发性口疮。其病损呈溃疡性损害，溃疡具有周期性、复发性及自限性等特点。目前治疗采用的药物有较大的毒副作用，成本高，易反复，治愈率低，在治疗效果方面不能令人满意。因此研究开发一种安全有效治疗复发性口疮的中药非常有实用价值。
本发明中药所涉及药材的研究现状如下：
生地黄：【来源】本品为玄参科植物地黄Rehmannia glutinosa Libosch. 的或干燥块根。【功能主治】清热凉血，养阴，生津。用于热病舌绛烦渴，阴虚内热，骨蒸劳热，内热消渴，吐血，衄血，发斑发疹。
人参:【来源】本品为五加科植物人参Panax ginseng C. A. Mey.的干燥根。【功能主治】大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心原性休克。
丹参:【来源】本品为唇形科植物丹参Salvia miltiorrhiza Bunge. 的干燥根及根茎。【功能主治】祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，症瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。
玄参:【来源】本品为玄参科植物玄参Scrophularia ningpoensis Hemsl.的干燥根。【功能主治】凉血滋阴，泻火解毒。用于热病伤阴，舌绛烦渴，温毒发斑，津伤便秘，骨蒸劳嗽，目赤，咽痛，瘰疠，白喉，痈肿疮毒。
生三七：【来源】本品为五加科植物三七Panax notoginseng （Burk.）F. H. Chen的干燥根。【功能主治】散瘀止血，消肿定痛。用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹剌痛，跌扑肿痛。
白茯苓: 【来源】本品为多孔菌科真菌茯苓 Poria cocos （Schw.） Wolf 的干燥菌核。【功能主治】利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
五味子：【来源】本品为木兰科植物五味子Schisandra chinensis （Turcz.）Baill.或华中五味子Schisandra sphenanthera Rehd. et Wils.的干燥成熟果实。【功能主治】收敛固涩，益气生津，补肾宁心。用于久嗽虚喘，梦遗滑精，遗尿尿频，久泻不止，自汗，盗汗，津伤口渴，短气脉虚，内热消渴，心悸失眠。
远志:【来源】本品为远志科植物远志Polygala tenuifolia Willd.或卵叶远志Polygala sibirica L. 的干燥根。【功能主治】安神益智，祛痰，消肿。用于心肾不交引起的失眠多梦，健忘惊悸，神志恍惚，咳痰不爽，疮疡肿毒，乳房肿痛。
炒桔梗：【来源】本品为梗:双子叶植物桔梗[1]科Campanulaceae 桔梗Platycodon grandiflorum( Jacq.) A. DC.的根。功能主治：宣肺，利咽，祛痰，排脓。用于咳嗽痰多，胸闷不畅，音哑，肺痈吐脓，疮疡脓成不溃。
当归：【来源】本品为伞形科植物当归Angelica sinensis （Oliv.） Diels 的干燥根。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。
天门冬：【来源】本品为百合科植物天门冬Asparagus cochinchinensis （Lour.）Merr. 的干燥块根。【功能主治】养阴润燥，清肺生津。用于肺燥干咳，顿咳痰黏，咽干口渴，肠燥便秘。
柏子仁：【来源】本品为柏科植物侧柏Platycladus orientalis （L.） Franco的干燥成熟种仁。【功能主治】养心安神，止汗，润肠。用于虚烦失眠，心悸怔忡，阴虚盗汗，肠燥便秘。
苦竹沥：【来源】为禾本科植物苦竹的茎秆，用火烤灼时流出的液汁。【功能主治】清火；解毒利窍。主目赤；牙痛；口疮。
朱砂：【来源】本品为硫化物类矿物辰砂族辰砂，主含硫化汞（HgS）。【功能主治】清心镇惊，安神解毒。用于心悸易惊，失眠多梦，癫痫发狂，小儿惊风，视物昏花，口疮，喉痹，疮疡肿毒。
发明内容
本发明旨在提供一种治疗复发性口疮的中药，通过选择合适的药材及其配比，达到安全有效治愈复发性口疮的目的。
为了达到上述目的，本发明采用以下技术方案：
一种治疗复发性口疮的中药组合物，其特征在于，由以下重量配比的药材制成：生地黄20-30份，人参20-30份，丹参20-30份，玄参20-30份， 生三七20-30份，白茯苓20-30份，五味子10-20份，远志10-20份，炒桔梗10-20份，当归10-20份，天门冬10-20份，柏子仁10-20份，苦竹沥10-20份，朱砂1-2份。
其中优选：生地黄25份，人参25份，丹参25份，玄参25份， 生三七25份，白茯苓25份，五味子15份，远志15份，炒桔梗15份，当归15份，天门冬15份，柏子仁15份，苦竹沥15份，朱砂1.5份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2008年6月-2012年2月间共收集75例复发性口疮的门诊患者，其中男37例，女38例，年龄16-55岁，病程1-5年。随机分为：治疗组50例，对照组25例。两组性别、年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组采用冰硼散 ，常规剂量每天3次。疗程2周。
2.2治疗组采用口服本发明中药优选配方按照具体实施例1制得的药品。疗程2周。
2.3观察项目：治疗前后溃疡面，颗粒的大小、数目，溃烂程度等。观察三个月有无反复。
3、疗效标准与治疗结果
3.1疗效标准
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，实验室检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率(%) |
| 治疗组 | 50 | 38(76%) | 10（20%) | 2(4%) | 96% |
| 对照组 | 25 | 16(64%) | 2(8%) | 7(28%) | 72% |
可见，本发明优选实施方式制得的药物能够安全有效治疗复发性口疮的中药。
根据上述临床实验数据，结合本领域公知常识，本领域技术人员容易推知，运用本发明中的药材，在最佳重量份附近取值，至少在“生地黄20-30份，人参20-30份，丹参20-30份，玄参20-30份， 生三七20-30份，白茯苓20-30份，五味子10-20份，远志10-20份，炒桔梗10-20份，当归10-20份，天门冬10-20份，柏子仁10-20份，苦竹沥10-20份，朱砂1-2份”的范围内，可以取得与本发明优选实施方式制得的药物类似的技术效果。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取生地黄20克，人参20克，丹参20克，玄参20克， 生三七20克，白茯苓20克，五味子10克，远志10克，炒桔梗10克，当归10克，天门冬10克，柏子仁10克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，加苦竹沥10克，朱砂1克浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗复发性口疮。口服，每日分早晚两次服用。
具体实施例2
称取生地黄25克，人参25克，丹参25克，玄参25克， 生三七25克，白茯苓25克，五味子15克，远志15克，炒桔梗15克，当归15克，天门冬15克，柏子仁15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，加苦竹沥15克，朱砂1.5克浓缩，干燥，装入胶囊壳，即得符合正常即得符合正常成年人一天用量的散剂。
用于治疗复发性口疮。口服，每日分早中晚3次服用。
具体实施例3
称取生地黄30克，人参30克，丹参30克，玄参30克， 生三七30克，白茯苓30克，五味子20克，远志20克，炒桔梗20克，当归20克，天门冬20克，柏子仁20克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，加苦竹沥20克，朱砂2克浓缩，干燥，浓缩，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即可制得符合正常成人一天用量的颗粒剂。
用于复发性口疮。口服，每日分早中晚3次服用。
Claims (2)
1.一种治疗复发性口疮的中药组合物，其特征在于，由以下重量配比的药材制成：生地黄20-30份，人参20-30份，丹参20-30份，玄参20-30份， 生三七20-30份，白茯苓20-30份，五味子10-20份，远志10-20份，炒桔梗10-20份，当归10-20份，天门冬10-20份，柏子仁10-20份，苦竹沥10-20份，朱砂1-2份。
2.按照权利要求1所述的一种治疗复发性口疮的中药组合物，其特征在于，由以下重量配比的药材制成：生地黄25份，人参25份，丹参25份，玄参25份， 生三七25份，白茯苓25份，五味子15份，远志15份，炒桔梗15份，当归15份，天门冬15份，柏子仁15份，苦竹沥15份，朱砂1.5份。
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