CN103536748A - 治疗肝郁化火证型瘿病的中药 - Google Patents
治疗肝郁化火证型瘿病的中药 Download PDFInfo
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Abstract
本发明公开了一种治疗肝郁化火证型瘿病的中药，其特征是由下列重量配比的原料制成的：柴胡10份、白术10份、茯苓20份、当归10份、牡丹皮10份、栀子10份、牡蛎30份、夏枯草30份、香附15份、玄参12份、浙贝母10份、橘核15份、荔枝核15份、穿山甲2份、王不留行10份、甘草6份、连翅20份、猫爪草15份。本发明能有效治疗肝郁化火证型瘿病，其治疗效果好，治愈率高。
Description
技术领域
本发明涉及到一种中药，特别是一种用于治疗肝郁化火证型瘿病的中药。
背景技术
瘿病是指体内甲状腺激素分泌过多所致的神经、心血管等系统兴奋性增高和代谢亢进为主要表现的一组内分泌疾病的总称，包括甲状腺瘤、单纯性甲肿、甲状腺机能亢进（简称甲亢）等病，统属“瘿病”范畴。此病以20-40岁发生率最高，女性较多，男女比例一般为1：4-6。随着人们生活和工作节奏的不断加快，瘿病的发生率也在不断增加，使人们生活质量受到严重威胁。依据中医基础理论，甲状腺与肝经关系密切，瘿病的症候多属肝象病变范畴，而瘿病的论治也多从肝而治。凡因情志不遂，忧思恼怒等情志变化，都可引起肝木疏泄失常，木不疏土则脾不健运，痰湿内聚，气机不畅，血滞为瘀，肝气挟痰、挟瘀循厥阴之脉上逆，聚结于颈，留而不去，则成瘿病。在瘿病的临床证型构成中，从肝论治的证型包括肝火上亢、肝郁化火、心肝火旺、肝肾阴虚等数个证型，其所占比例达到63%，其中肝郁化火证在全部证型中所占的比例最大，达到32%。目前，治疗肝郁化火证型瘿病的方法一般有纯西药治疗、纯中药治疗、中西药结合治疗。纯西药治疗效果不是很好，而且长期服药对肝的负作用较大。中药治疗是比较好的治疗方法，但目前所公开的各种可用于治疗肝郁化火证型瘿病的中药，存在着治愈率等缺陷。
发明内容
本发明的目的是想提供一种用于治疗肝郁化火证型瘿病的中药，该中药能有效治疗肝郁化火证型瘿病，其治疗效果好，治愈率高。
为实现本发明的上述目的所采用的技术方案是：一种治疗肝郁化火证型瘿病的中药，其特征是由下列重量配比的原料制成的：柴胡10份、白术10份、茯苓20份、当归10份、牡丹皮10份、栀子10份、牡蛎30份、夏枯草30份、香附15份、玄参12份、浙贝母10份、橘核15份、荔枝核15份、穿山甲2份、王不留行10份、甘草6份、连翅20份、猫爪草15份。
柴胡【来源】 本品为伞形科植物柴胡Bupleurum chinense DC.或狭叶柴胡Bupleurum scorzonerifolium Willd.的干燥根。【性味】 苦，微寒。【归经】 归肝、胆经。【功能主治】 和解表里，疏肝，升阳。用于感冒发热，寒热往来，胸胁胀痛，月经不调，子官脱垂，脱肛。
白术【来源】 本品为菊科植物白术Atractylodes macrocephala Koidz.的干燥根茎。【性味】 苦、甘，温。【归经】 归脾、胃经。【功能主治】 健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
茯苓【来源】 本品为多孔菌科真菌茯苓 Poria cocos （Schw.） Wolf 的干燥菌核。【性味】 甘、淡，平。【归经】 归心、肺、脾、肾经。【功能主治】 利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
当归【来源】 本品为伞形科植物当归Angelica sinensis （Oliv.） Diels 的干燥根。【性味】 甘、辛，温。【归经】 归肝、心、脾经。【功能主治】 补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。
牡丹皮【来源】 本品为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮。【性味】 苦、辛，微寒。【归经】 归心、肝、肾经。【功能主治】 清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。
栀子【来源】 本品为茜草科植物栀子Gardenia jasminoides Ellis的干燥成熟果实，其根也可入药。【性味】 苦，寒。【归经】 归心、肺、三焦经。【功能主治】 果实：泻火除烦，清热利尿，凉血解毒。用于热病心烦，黄疸尿赤，血淋涩痛，血热吐衄，目赤肿痛，火毒疮疡；外治扭挫伤痛。
牡蛎【来源】 本品为牡蛎科动物长牡蛎Ostrea gigas Thunberg、大连湾牡蛎Ostrea talienwhanensis Crosse 或近江牡蛎Ostrea rivularis Gould的贝壳。【性味】 咸，微寒。【归经】 归肝、胆、肾经。【功能主治】 重镇安神，潜阳补阴，软坚散结。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，症瘕痞块。
夏枯草【来源】 本品为唇形科植物夏枯草Prunella vulgaris L. 的干燥果穗。【性味】 辛、苦，寒。【归经】 归肝、胆经。【功能主治】 清火，明目，散结，消肿。用于目赤肿痛，目珠夜痛，头痛眩晕，瘰疬，瘿瘤，乳痈肿痛；甲状腺肿大，淋巴结结核，乳腺增生，高血压。
香附【来源】 本品为莎草科植物莎草Cyperus rotundus L. 的干燥根茎。【性味】 辛、微苦、微甘，平。【归经】 归肝、脾、三焦经。【功能主治】 行气解郁，调经止痛。用于肝郁气滞，胸、胁、脘腹胀痛，消化不良，胸脘痞闷，寒疝腹痛，乳房胀痛，月经不调，经闭痛经。
玄参【来源】本品为玄参科植物玄参Scrophularia ningpoensis Hemsl. 的干燥根。【性味】味甘、苦咸、性寒。【归经】归肺、胃、肾经。【功能主治】有清热解毒，养阴生津的功能。主治热病烦渴、发斑、咽喉肿痛、痈肿、便秘和瘰疬等症。
浙贝母【来源】 本品为百合科植物浙贝母Fritillaria thunbergii Miq.的干燥鳞茎。【性味】 苦，寒。【归经】 归肺、心经。【功能主治】 清热散结，化痰止咳，用于风热犯肺，痰火咳嗽，肺痈，乳痈，瘰疬，疮毒。
橘核【来源】 本品为芸香科植物橘Citrus reticulata Blanco 及其栽培变种的干燥成熟种子。【性味】 苦，平。【归经】 归肝、肾经。【功能主治】 理气，散结，止痛。用于小肠疝气，睾丸肿痛，乳痈肿痛。
荔枝核【来源】 本品为无患子科植物荔枝Litchi chinensis Sonn. 的干燥成熟种子。【性味】 甘、微苦，温。【归经】 归肝、肾经。
【功能主治】 行气散结，祛寒止痛。用于寒疝腹痛，睾丸肿痛。
穿山甲【来源】 本品为鲮鲤科动物穿山甲Manis pentadactyla Linnaeus的鳞甲。【性味】 咸，微寒。【归经】 归肝、胃经。【功能主治】 通经下乳，消肿排脓，搜风通络。用于经闭癓瘕，乳汁不通，痈肿疮毒，关节痹痛，麻木拘挛。
王不留行【来源】该品为双子叶植物石竹科 Caryophyllaceae 麦蓝菜Vaccaria segetalis （Neck.） Garcke 的干燥成熟种子。【性味】苦，平。【归经】归肝，胃经。【功能主治】活血通乳、催生下乳、产后胸腺疏通。用于血瘀经闭，痛经，难产；产后乳汁不下，乳痈肿痛；热淋，血淋，石淋。
甘草【来源】 本品为豆科植物甘草 Glycyrrhiza uralensis Fisch.、胀果甘草 Glycyrrhiza inflata Bat. 或光果甘草 Glycyrrhiza glabra L. 的干燥根。【性味】 甘，平。【归经】 归心、肺、脾、胃经。【功能主治】 补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
连翅【来源】本品为木犀科植物连翘Forsythia suspensa （Thunb.）Vahl的干燥果实。【性味】苦，微寒。【归经】归肺、心、小肠经。【功能主治】清热解毒，消肿散结。用于痈疽，瘰疠，乳痈，丹毒，风热感冒，温病初起，温热入营，高热烦渴，神昏发斑，热淋尿闭。
猫爪草【来源】 本品为毛茛科植物小毛茛Ranunculus ternatus Thunb. 的干燥块根。【性味】 甘、辛，温。【归经】 归肝、肺经。
【功能主治】 散结，消肿。用于瘰疬未溃、淋巴结结核。
由于长期恚怒忧思，久郁不解，或突受精神刺激，情志不遂，导致肝气不舒，疏泄失常，气机不畅，水湿停聚，肝气挟痰循厥阴肝经上行，聚于颈部，留而不去。若肝气横逆，木克脾土，脾失健运，痰湿内停，顺势下行则大便泄泻。若肝郁日久化热，邪火内炽，则急躁易怒，口干口苦。肝火挟痰挟瘀循经上聚于目，则目胀突，逆于头则眩晕。木火相生，心火亦盛，汗乃心之液，热迫心液外溢则多汗。肝火烁心，耗损心阴，则心悸、失眠。若肝火灼胃，或心火移于胃腑，则胃火炽盛，热能杀谷，则多食善饥。因脾运失常，虽多食而不荣肌肤，故消瘦。若肝火灼伤阴血，肝血不足，难以荣筋，故筋弱无力。肝血不足无以充养冲任，则女性月经量少或闭经。肝肾同源，肝血不足，肾精亦虚，故男性阳痿不举。阴虚生内热，故多见舌红少苔，脉细数等。阴虚阳亢，肝风内动则肢体、舌震颤。总之，肝失疏泄，郁而化热，肝阳亢盛是本病的主要病机。本发明采用合适的药材及其配比，各药物之间相互配合，协同作用，所制得的中药具有清肝泄火，泻肝健脾，消瘿散结的功效，5年来，通过对40名患者的使用表明，有效率达80%，随访治疗效果好，愈全不复发。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2007年11月-2012年11月间共收集了60例肝郁化火证型瘿病门诊患者，年龄28-41岁，其中，男，12人，女52人，病情3个月-18个月。随机分为：治疗组40例，对照组20例。两组年龄等资料无显著性差异，具有可比性。
2、试验方法
2.1对照组口服消瘿丸，按照说明书服用。疗程90天。
2.2治疗组口服本发明按照具体实施例1制得的胶囊，早、中、晚各一次。疗程90天。
3、疗效标准及治疗结果
3.1疗效标准：
痊愈：临床症状全部消失，试验室检查正常。好转：临床症状减轻，病情得到控制，实验检查改善或正常。无效：临床症状无明显好转或加重。
3.2治疗统计结果见表1。
表1 两组疗效比较
| 组别 | n | 痊愈 | 好转 | 无效 | 总有效率（%） |
| 治疗组 | 40 | 6 | 26 | 8 | 80% |
| 对照组 | 20 | 2 | 9 | 9 | 55% |
由此可见，本发明制得的药物能够安全有效治疗肝郁化火证型瘿病。
具体实施方式
为了更好地理解与实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取柴胡10克、白术10克、茯苓20克、当归10克、牡丹皮10克、栀子10克、牡蛎30克、夏枯草30克、香附15克、玄参12克、浙贝母10克、橘核15克、荔枝核15克、穿山甲2克、王不留行10克、甘草6克、连翅20克、猫爪草15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，装入胶囊壳，即得符合正常成人1天用量的胶囊剂。
用于治疗肝郁化火证型瘿病。口服，每日分早、中、晚三次服用。
具体实施例2
称取柴胡10克、白术10克、茯苓20克、当归10克、牡丹皮10克、栀子10克、牡蛎30克、夏枯草30克、香附15克、玄参12克、浙贝母10克、橘核15克、荔枝核15克、穿山甲2克、王不留行10克、甘草6克、连翅20克、猫爪草15克，加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人1天用量的散剂。
用于治疗肝郁化火证型瘿病。口服，每日分早、中、晚三次服用。
具体实施例3
称取柴胡10克、白术10克、茯苓20克、当归10克、牡丹皮10克、栀子10克、牡蛎30克、夏枯草30克、香附15克、玄参12克、浙贝母10克、橘核15克、荔枝核15克、穿山甲2克、王不留行10克、甘草6克、连翅20克、猫爪草15克，加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩，干燥，再加入适量糊精和矫味剂，按照本领域常规工艺制粒，包装，即得符合正常成人1天用量的颗粒剂。
用于治疗肝郁化火证型瘿病。口服，每日分早、中、晚三次服用。
Claims (1)
1.一种治疗肝郁化火证型瘿病的中药，其特征是由下列重量配比的原料制成的：柴胡10份、白术10份、茯苓20份、当归10份、牡丹皮10份、栀子10份、牡蛎30份、夏枯草30份、香附15份、玄参12份、浙贝母10份、橘核15份、荔枝核15份、穿山甲2份、王不留行10份、甘草6份、连翅20份、猫爪草15份。
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| CN116407594A (zh) * | 2022-03-10 | 2023-07-11 | 广西中医药大学第一附属医院 | 一种治疗甲状腺囊肿的中药组合物及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104491364A (zh) * | 2014-12-16 | 2015-04-08 | 牛永菡 | 一种治疗慢性淋巴细胞性甲状腺炎的药丸及制备方法 |
| CN104491364B (zh) * | 2014-12-16 | 2018-11-09 | 武威天健药业有限公司 | 一种治疗慢性淋巴细胞性甲状腺炎的药丸及制备方法 |
| CN104547736A (zh) * | 2014-12-25 | 2015-04-29 | 张祯 | 一种治疗甲状腺肿的药物 |
| CN104666829A (zh) * | 2015-02-14 | 2015-06-03 | 苏桂华 | 一种治疗甲亢的中药 |
| CN105477124A (zh) * | 2015-12-01 | 2016-04-13 | 孙世林 | 一种治疗肝郁化火证型头痛病的中药 |
| CN109481566A (zh) * | 2019-01-03 | 2019-03-19 | 徐东梅 | 一种防治桥本甲状腺炎的中药及其应用 |
| CN116407594A (zh) * | 2022-03-10 | 2023-07-11 | 广西中医药大学第一附属医院 | 一种治疗甲状腺囊肿的中药组合物及其制备方法 |
| CN116407594B (zh) * | 2022-03-10 | 2023-11-03 | 广西中医药大学第一附属医院 | 一种治疗甲状腺囊肿的中药组合物及其制备方法 |
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