CN102665422B - 通过口服施用重组乳酸乳球菌微型胶囊的免疫保护方法 - Google Patents

通过口服施用重组乳酸乳球菌微型胶囊的免疫保护方法 Download PDF

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Publication number
CN102665422B
CN102665422B CN201080058158.4A CN201080058158A CN102665422B CN 102665422 B CN102665422 B CN 102665422B CN 201080058158 A CN201080058158 A CN 201080058158A CN 102665422 B CN102665422 B CN 102665422B
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China
Prior art keywords
lactococcus lactis
antigen
immune response
composition
virus
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Expired - Fee Related
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CN201080058158.4A
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English (en)
Chinese (zh)
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CN102665422A (zh
Inventor
林文傑
徐宇虹
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VaxGene Corp
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VaxGene Corp
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Priority claimed from PCT/US2010/041792 external-priority patent/WO2011008735A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080058158.4A 2009-12-23 2010-12-23 通过口服施用重组乳酸乳球菌微型胶囊的免疫保护方法 Expired - Fee Related CN102665422B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28966309P 2009-12-23 2009-12-23
US61/289,663 2009-12-23
PCT/US2010/041792 WO2011008735A1 (en) 2009-07-13 2010-07-13 Oral vaccines produced and administered using edible micro-organism
USPCT/US2010/041792 2010-07-13
PCT/US2010/062034 WO2011079282A1 (en) 2009-12-23 2010-12-23 Immunoprotection by oral administration of recombinant lactococcus lactis mini-capsules

Publications (2)

Publication Number Publication Date
CN102665422A CN102665422A (zh) 2012-09-12
CN102665422B true CN102665422B (zh) 2015-01-28

Family

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Family Applications (1)

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CN201080058158.4A Expired - Fee Related CN102665422B (zh) 2009-12-23 2010-12-23 通过口服施用重组乳酸乳球菌微型胶囊的免疫保护方法

Country Status (4)

Country Link
EP (1) EP2515661A4 (OSRAM)
JP (1) JP2013515490A (OSRAM)
CN (1) CN102665422B (OSRAM)
WO (1) WO2011079282A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014047625A1 (en) 2012-09-24 2014-03-27 Montana State University Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
CN102965388A (zh) * 2012-12-07 2013-03-13 山东信得科技股份有限公司 一种表达猪传染性胃肠炎病毒基因工程菌制备方法
JP6617935B2 (ja) 2014-04-10 2019-12-11 国立研究開発法人理化学研究所 Ｔｈ１７細胞の誘導のための組成物及び方法
CN104587458B (zh) * 2014-12-04 2017-01-04 吉林医药学院 预防贾第虫病的二价dna疫苗及其肠溶制剂
CN110511399B (zh) * 2019-07-26 2022-03-04 广西大学 一种控释型纳米纤维素抗菌微凝胶的制备方法
CN116083240B (zh) * 2023-04-07 2023-08-29 深圳市第二人民医院(深圳市转化医学研究院) 工程化细菌及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017117A1 (en) * 1992-02-27 1993-09-02 Lynxvale Limited Heterologous gene expression in lactococcus, and the expression products therefrom
US20080020036A1 (en) * 2004-06-17 2008-01-24 Amano Enzyme Usa., Ltd. Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
CN101578111A (zh) * 2006-04-21 2009-11-11 美国陶氏益农公司 禽流感疫苗和使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08508247A (ja) * 1993-03-11 1996-09-03 セクレテック，インク． 粘膜表面への免疫原の輸送における重合的粘膜付着体
US6328967B1 (en) * 1998-03-12 2001-12-11 Allergenics, Inc. Delivery system to modulate immune response
EP2275133A1 (en) * 1999-02-26 2011-01-19 Novartis Vaccines and Diagnostics, Inc. Use of bioadhesives and adjuvants for the mucosal delivery of antigens
US8168228B2 (en) * 2003-10-17 2012-05-01 Sandoz Ag Antibiotic clarithromycin micropellet compositions
US20090324638A1 (en) * 2006-06-12 2009-12-31 Biopeptides Corp. Live bacterial vaccine
CA2704949A1 (en) * 2007-11-13 2009-05-22 Meritage Pharma, Inc. Gastrointestinal delivery systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017117A1 (en) * 1992-02-27 1993-09-02 Lynxvale Limited Heterologous gene expression in lactococcus, and the expression products therefrom
US20080020036A1 (en) * 2004-06-17 2008-01-24 Amano Enzyme Usa., Ltd. Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
CN101578111A (zh) * 2006-04-21 2009-11-11 美国陶氏益农公司 禽流感疫苗和使用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A gene-based avian influenza vaccine in poultry;RAO et al.;《Poultry Science》;20090430;第88卷;第860-866页 *

Also Published As

Publication number Publication date
JP2013515490A (ja) 2013-05-09
EP2515661A4 (en) 2013-11-13
WO2011079282A1 (en) 2011-06-30
EP2515661A1 (en) 2012-10-31
CN102665422A (zh) 2012-09-12

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