JP2013515490A - 組み換え型乳酸連鎖球菌のミニカプセルの経口投与による免疫保護 - Google Patents

組み換え型乳酸連鎖球菌のミニカプセルの経口投与による免疫保護 Download PDF

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JP2013515490A
JP2013515490A JP2012546239A JP2012546239A JP2013515490A JP 2013515490 A JP2013515490 A JP 2013515490A JP 2012546239 A JP2012546239 A JP 2012546239A JP 2012546239 A JP2012546239 A JP 2012546239A JP 2013515490 A JP2013515490 A JP 2013515490A
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antigen
composition
lactic acid
bacterium
immune response
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Japanese (ja)
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JP2013515490A5 (OSRAM
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ラム,ドミニク,マン−キット
スー,ユーホン
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ヴァックスジーン コーポレーション
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Priority claimed from PCT/US2010/041792 external-priority patent/WO2011008735A1/en
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Publication of JP2013515490A publication Critical patent/JP2013515490A/ja
Publication of JP2013515490A5 publication Critical patent/JP2013515490A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012546239A 2009-12-23 2010-12-23 組み換え型乳酸連鎖球菌のミニカプセルの経口投与による免疫保護 Pending JP2013515490A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28966309P 2009-12-23 2009-12-23
US61/289,663 2009-12-23
PCT/US2010/041792 WO2011008735A1 (en) 2009-07-13 2010-07-13 Oral vaccines produced and administered using edible micro-organism
USPCT/US2010/041792 2010-07-13
PCT/US2010/062034 WO2011079282A1 (en) 2009-12-23 2010-12-23 Immunoprotection by oral administration of recombinant lactococcus lactis mini-capsules

Publications (2)

Publication Number Publication Date
JP2013515490A true JP2013515490A (ja) 2013-05-09
JP2013515490A5 JP2013515490A5 (OSRAM) 2014-02-06

Family

ID=44196157

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012546239A Pending JP2013515490A (ja) 2009-12-23 2010-12-23 組み換え型乳酸連鎖球菌のミニカプセルの経口投与による免疫保護

Country Status (4)

Country Link
EP (1) EP2515661A4 (OSRAM)
JP (1) JP2013515490A (OSRAM)
CN (1) CN102665422B (OSRAM)
WO (1) WO2011079282A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014047625A1 (en) 2012-09-24 2014-03-27 Montana State University Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
CN102965388A (zh) * 2012-12-07 2013-03-13 山东信得科技股份有限公司 一种表达猪传染性胃肠炎病毒基因工程菌制备方法
EP3129035B1 (en) * 2014-04-10 2024-09-18 Riken Compositions and methods for induction of th17 cells
CN104587458B (zh) * 2014-12-04 2017-01-04 吉林医药学院 预防贾第虫病的二价dna疫苗及其肠溶制剂
CN110511399B (zh) * 2019-07-26 2022-03-04 广西大学 一种控释型纳米纤维素抗菌微凝胶的制备方法
CN116083240B (zh) * 2023-04-07 2023-08-29 深圳市第二人民医院(深圳市转化医学研究院) 工程化细菌及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508351A (ja) * 2003-10-17 2007-04-05 サンド・アクチエンゲゼルシヤフト 抗生物質組成物
WO2009064458A2 (en) * 2007-11-13 2009-05-22 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2278358B (en) * 1992-02-27 1995-07-26 Lynxvale Ltd Heterologous gene expression in Lactococcus,and the expression products therefrom
WO1994020070A1 (en) * 1993-03-11 1994-09-15 Secretech, Inc. Polymeric mucoadhesives in the delivery of immunogens at mucosal surfaces
US6328967B1 (en) * 1998-03-12 2001-12-11 Allergenics, Inc. Delivery system to modulate immune response
ATE481108T1 (de) * 1999-02-26 2010-10-15 Novartis Vaccines & Diagnostic Verwendung von bioadhaesiven und adjuvantien für die mukosale anwendung von antigenen
WO2006009764A1 (en) * 2004-06-17 2006-01-26 Amano Enzyme Usa., Ltd. Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
CA2650091A1 (en) * 2006-04-21 2008-05-22 Dow Agrosciences Llc Vaccine for avian influenza and methods of use
US20090324638A1 (en) * 2006-06-12 2009-12-31 Biopeptides Corp. Live bacterial vaccine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007508351A (ja) * 2003-10-17 2007-04-05 サンド・アクチエンゲゼルシヤフト 抗生物質組成物
WO2009064458A2 (en) * 2007-11-13 2009-05-22 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN6015007180; 'Applied Microbiology and Biotechnology' 2005, Vol.68, pp.220-227 *
JPN6015007183; 'Vaccine' 2008, Vol.26, pp.1145-1154 *
JPN6015007185; 'Blood' 2003, Vol.102, pp.223-228 *
JPN6015007188; 'Virus Genes' 2009.07.24, Vol.39, pp.238-245 *
JPN6015007189; 'FEMS Microbiology Letters' 2003, Vol.229, pp.37-42 *
JPN6015007190; 'European Journal of Pharmaceutics and Biopharmaceutics' 2008, Vol.69, pp.969-976 *
JPN6015007193; 'European Journal of Pharmaceutics and Biopharmaceutics' 2005, Vol.60, pp.349-359 *

Also Published As

Publication number Publication date
WO2011079282A1 (en) 2011-06-30
EP2515661A1 (en) 2012-10-31
CN102665422A (zh) 2012-09-12
EP2515661A4 (en) 2013-11-13
CN102665422B (zh) 2015-01-28

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