CN102657634A - 一种硝呋酚酰肼微囊粉及其生产方法 - Google Patents
一种硝呋酚酰肼微囊粉及其生产方法 Download PDFInfo
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- CN102657634A CN102657634A CN2012101414607A CN201210141460A CN102657634A CN 102657634 A CN102657634 A CN 102657634A CN 2012101414607 A CN2012101414607 A CN 2012101414607A CN 201210141460 A CN201210141460 A CN 201210141460A CN 102657634 A CN102657634 A CN 102657634A
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- nifuroxazide
- powder
- encircle
- polyethylene glycol
- fine
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- 239000000843 powder Substances 0.000 title claims abstract description 83
- YCWSUKQGVSGXJO-NTUHNPAUSA-N nifuroxazide Chemical compound C1=CC(O)=CC=C1C(=O)N\N=C\C1=CC=C([N+]([O-])=O)O1 YCWSUKQGVSGXJO-NTUHNPAUSA-N 0.000 title claims abstract description 71
- 229960003888 nifuroxazide Drugs 0.000 title claims abstract description 71
- 239000003094 microcapsule Substances 0.000 title claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 48
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- 238000003756 stirring Methods 0.000 claims abstract description 36
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 23
- 239000011162 core material Substances 0.000 claims abstract description 19
- 238000001723 curing Methods 0.000 claims abstract description 13
- 238000001816 cooling Methods 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 238000001035 drying Methods 0.000 claims abstract description 11
- 239000011229 interlayer Substances 0.000 claims abstract description 11
- 239000002245 particle Substances 0.000 claims abstract description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 8
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 25
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 claims description 21
- 239000002775 capsule Substances 0.000 claims description 19
- 230000001476 alcoholic effect Effects 0.000 claims description 16
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 13
- 230000004927 fusion Effects 0.000 claims description 11
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 239000005457 ice water Substances 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 239000000080 wetting agent Substances 0.000 claims description 2
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 abstract description 3
- 230000003031 feeding effect Effects 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 15
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 13
- 239000003814 drug Substances 0.000 description 12
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- 244000144977 poultry Species 0.000 description 5
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- 238000010521 absorption reaction Methods 0.000 description 3
- 239000003674 animal food additive Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
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- 235000013305 food Nutrition 0.000 description 3
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
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- 230000009885 systemic effect Effects 0.000 description 2
- 239000000273 veterinary drug Substances 0.000 description 2
- 208000003495 Coccidiosis Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010023076 Isosporiasis Diseases 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 206010034107 Pasteurella infections Diseases 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
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- 235000009508 confectionery Nutrition 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 201000005115 pasteurellosis Diseases 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
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- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
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CN2012101414607A CN102657634B (zh) | 2012-05-09 | 2012-05-09 | 一种硝呋酚酰肼微囊粉及其生产方法 |
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CN2012101414607A CN102657634B (zh) | 2012-05-09 | 2012-05-09 | 一种硝呋酚酰肼微囊粉及其生产方法 |
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CN102657634A true CN102657634A (zh) | 2012-09-12 |
CN102657634B CN102657634B (zh) | 2013-06-12 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102948609A (zh) * | 2012-10-16 | 2013-03-06 | 安徽省正大源饲料集团有限公司 | 一种改性氨基酸螯合铁饲料添加剂的制备方法 |
CN106561998A (zh) * | 2016-11-14 | 2017-04-19 | 赵清国 | 一种微囊包被丁酸钠及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101269310A (zh) * | 2008-05-06 | 2008-09-24 | 大连赛诺微囊技术有限公司 | 冷水分散型微囊粉的制备方法 |
CN101743960A (zh) * | 2010-02-01 | 2010-06-23 | 吴学民 | 噻虫啉微囊粉剂和悬浮剂及其制备方法和用途 |
CN101969933A (zh) * | 2008-01-25 | 2011-02-09 | 杜奥-戈公司 | 通过包覆物结合的口服药物的组合 |
CN102258499A (zh) * | 2011-08-11 | 2011-11-30 | 石河子大学医学院第一附属医院 | 叶黄素微囊的制备方法 |
-
2012
- 2012-05-09 CN CN2012101414607A patent/CN102657634B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101969933A (zh) * | 2008-01-25 | 2011-02-09 | 杜奥-戈公司 | 通过包覆物结合的口服药物的组合 |
CN101269310A (zh) * | 2008-05-06 | 2008-09-24 | 大连赛诺微囊技术有限公司 | 冷水分散型微囊粉的制备方法 |
CN101743960A (zh) * | 2010-02-01 | 2010-06-23 | 吴学民 | 噻虫啉微囊粉剂和悬浮剂及其制备方法和用途 |
CN102258499A (zh) * | 2011-08-11 | 2011-11-30 | 石河子大学医学院第一附属医院 | 叶黄素微囊的制备方法 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102948609A (zh) * | 2012-10-16 | 2013-03-06 | 安徽省正大源饲料集团有限公司 | 一种改性氨基酸螯合铁饲料添加剂的制备方法 |
CN102948609B (zh) * | 2012-10-16 | 2013-12-18 | 安徽省正大源饲料集团有限公司 | 一种改性氨基酸螯合铁饲料添加剂的制备方法 |
CN106561998A (zh) * | 2016-11-14 | 2017-04-19 | 赵清国 | 一种微囊包被丁酸钠及其制备方法 |
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Effective date of registration: 20201228 Address after: 8319 Huangshan Avenue, Bengbu City, Anhui Province (Room 301, building 6, Shangli University Science and Technology Park) Patentee after: Anhui huajingdao Technology Service Co.,Ltd. Address before: 221300 rooms 1-201, 8 / F, Tongsheng International Plaza North, Jianshe South Road, Pizhou City, Xuzhou City, Jiangsu Province Patentee before: Zhang Kuichang |
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Effective date of registration: 20210521 Address after: 201612 1st floor, No. 781, Xinmiao 3rd road, Xinqiao Town, Songjiang District, Shanghai Patentee after: SHANGHAI E.K.M BIOTECHNOLOGY Co.,Ltd. Address before: 8319 Huangshan Avenue, Bengbu City, Anhui Province (Room 301, building 6, Shangli University Science and Technology Park) Patentee before: Anhui huajingdao Technology Service Co.,Ltd. |
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