CN102657245B - Disinfectant prepared from plant extracts as well as preparation method for disinfectant - Google Patents
Disinfectant prepared from plant extracts as well as preparation method for disinfectant Download PDFInfo
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Abstract
The invention relates to a disinfectant prepared from plant extracts. The disinfectant prepared from the plant extracts comprises the following raw materials in percentage by weight: 0.05 to 0.5 percent of chlorogenic acid, 0.1 to 1 percent of gallic acid, 0 to 1 percent of sophocarpidine, 0 to 0.8 percent of clove oil, 0 to 1 percent of peppermint oil, 0 to 1 percent of moxa volatile oil or spearmint oil, 0.1 to 2 percent of tween 80, 5 to 50 percent of ethanol, 0.1 to 1 percent of sodium citrate, 0 to 0.8 percent of lauryl sodium sulfate, 0 to 0.5 percent of fragrance regulator and the balance of pure water. The invention also provides a preparation method for the disinfectant. The disinfectant prepared from the plant extracts and the preparation method for the disinfectant have the beneficial effects that: the disinfectant belongs to a pure Chinese medicine compound disinfectant preparation, is safe for human and livestock to use, does not have corrosivity and toxic or side effect, is insusceptible to medicine resistance after a long-time use, has good disinfection effect, avoids environmental pollution, has wide application, can be used for disinfecting air and can also be used for disinfecting the surfaces of skin, clothes, tableware, furniture and the like, and meets universal requirements of people.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of thimerosal that plant extracts makes and preparation method thereof that adopts.
Background technology
Air is the surrounding medium that the mankind depend on for existence, and the quality of air quality and people's is healthy closely bound up.Because the fast development of industry, the environment that the mankind depend on for existence is affected, and the increase of bacterium, virus and harmful chemical has increased the probability that people suffer from various diseases greatly in the air.Harmful bacterium is at ordinary times attached to body surface, human body skin surface or hide at inside of human body, breed in a large number germ, surpassing will be diseases induced under human immune system's the load condition: adopting thimerosal can cut off the route of transmission of malignant bacteria, also is infection prevention simple and easy to do and the most most economical pathogenetic method in our daily life.The existing market thimerosal is of a great variety, all is chemicals mostly, as the most frequently used Peracetic acid, formaldehyde, bromogeramine, hundred poisonings etc.The a certain chemicals of prolonged application cause drug-resistance of bacteria easily, owing to itself how much have excitant and corrosivity, the meeting toxic side effect be the more important thing is to lack real environmental protection safety.
Summary of the invention
Purpose of the present invention is intended to overcome weak point of the prior art, a kind of thimerosal that plant extracts makes and preparation method thereof that adopts is provided, this thimerosal is that raw material is made for adopting natural plants, it is a kind of pure Chinese medicine compound prescription disinfectant preparation, people and animals can use safely, non-corrosiveness, have no side effect, the long-term use is difficult for producing drug resistance, and Disinfection Effect is good, environmentally safe, this thimerosal is of many uses, not only can be used for air sterillization, can also carry out disinfection to body surfaces such as skin, clothing, tableware, households, satisfy people's universal demand.
An object of the present invention is to be achieved through the following technical solutions:
A kind of thimerosal that adopts plant extracts to make comprises following raw materials by weight percent: chlorogenic acid is 0.05-0.5%, and gallic acid is 0.1-1%, matrine is 0-1%, caryophyllus oil is 0-0.8%, and peppermint oil is 0-1%, and volatile argyi leaf oil or spearmint oil are 0-1%, Tween 80 is 0.1-2%, ethanol is 5-50%, and sodium citrate is 0.1-1%, and lauryl sodium sulfate is 0-0.8%, the fragrance conditioning agent is 0-0.5%, and surplus is a purified water.
Further, the preferred following percentage by weight of described raw material: chlorogenic acid is 0.2%, and gallic acid is 0.5%, and matrine is 0.3%, caryophyllus oil is 0.2%, peppermint oil is 0.2%, and spearmint oil is 0.4%, and Tween 80 is 0.5%, ethanol is 30%, sodium citrate is 0.2%, and lauryl sodium sulfate is 0.2%, and surplus is a purified water.
Described chlorogenic acid is a Honegsukle flower P.E; Described gallic acid is a times flower extract; Described matrine is a shrubby sophora extract.Described peppermint oil, caryophyllus oil, volatile argyi leaf oil, stay blue sesame oil to be the pharmaceutical grade commercially available prod to get final product, also can make by oneself.Sodium citrate, Tween 80, ethanol, lauryl sodium sulfate, fragrance adjuvant etc. are pharmaceutical grade or the food-grade commercially available prod gets final product.
The composition that mainly plays the antibiotic and sterilizing effect in the thimerosal of the present invention is chlorogenic acid, gallic acid, has the removing free radical, immunological regulation, anti-inflammatory, antibiotic, effect such as antiviral grade, matrine has the bactericidal activity than wide spectrum, except that anti-inflammatory bacteriostatic activity pharmaceutically, in agricultural production, aqueous matrine solution be China registration the botanical fungicide kind.The volatile oil of separate sources has stronger antimicrobial spectrum, and bacterium, fungi, virus, prokaryotes, insect etc. are all had certain inhibitory action.Thimerosal people and animals of the present invention can use safely, non-corrosiveness, have no side effect, and long-term the use is difficult for producing drug resistance, and Disinfection Effect is good, environmentally safe; And of many uses, not only can be used for air sterillization, can also carry out disinfection to body surfaces such as skin, clothing, tableware, households, satisfied people's general antibiotic and sterilizing requirement.
Another object of the present invention provides the preparation method of described thimerosal, may further comprise the steps:
(1) get material: get material according to following percentage by weight: chlorogenic acid is 0.05-0.5%, gallic acid is 0.1-1%, and matrine is 0-1%, and caryophyllus oil is 0-0.8%, peppermint oil is 0-1%, volatile argyi leaf oil or spearmint oil are 0-1%, and Tween 80 is 0.1-2%, and ethanol is 5-50%, sodium citrate is 0.1-1%, lauryl sodium sulfate is 0-0.8%, and the fragrance conditioning agent is 0-0.5%, and surplus is a purified water;
(2) described chlorogenic acid, gallic acid, matrine, caryophyllus oil, peppermint oil, volatile argyi leaf oil or the spearmint oil of step (1), Tween 80 and ethanol are mixed and stir, a part that adds described purified water again stirs, add described lauryl sodium sulfate, fragrance conditioning agent mixing then successively, regulate PH to 4～6 with sodium citrate again, the remainder that adds described purified water, filter behind the mixing, the thimerosal that obtains clarifying homogeneous gets final product.
Further, the preparation method of described chlorogenic acid is: the preparation method of the chlorogenic acid in the described step (1) is: select the honeysuckle raw material, Tumble Dry, pulverize, form the honeysuckle material powder, in powder, add 6～10 times of volume purified water and stirring extraction below 60 ℃, extract once the back and filter collection filtrate, filter residue so extracts with 6～10 times of volume purified water once more, extract altogether three times, extracted 1～2 hour at every turn, filter once more behind the merging extract, filtrate is adopted the macroreticular resin absorbing method purifies and separates, promptly gets the chlorogenic acid powder after the refined solution atomized drying.
The preparation method of described gallic acid is: get dry doubly flower fine powder, add 3 times of volume purified water, stir the sodium hydroxide solution that the back adds concentration 20%-40%, added hot reflux 2 hours, add concentrated hydrochloric acid, filtered while hot, filtrate crystallisation by cooling, crystallization is added 5 times of water-soluble separating, add activated carbon and added hot reflux 30 minutes, filtered while hot, filtrate crystallisation by cooling, separating, washing promptly gets the gallic acid of crystal state after the vacuum drying.
The preparation method of described matrine is: get the radix sophorae meal with 65% alcohol heating reflux of 10～15 times of volumes 2 times, the each backflow 3 hours, the gained ethanol extract is evaporated to 1/2 of stoste, the HCl that adds concentration 1% regulates pH to 3-4, filter, filtrate adds 5%NaOH to pH=9-10, uses chloroform extraction, reclaim chloroform solution, the evaporate to dryness chloroform gets matrine.
Thimerosal preparation method of the present invention is simple, and cost is low, and the efficient height is suitable for suitability for industrialized production.
Embodiment
Embodiment 1
The percentage by weight of needed raw material is in this example: chlorogenic acid is 0.2%, gallic acid is 0.5%, matrine is 0.3%, and caryophyllus oil is 0.2%, and peppermint oil is 0.2%, spearmint oil is 0.4%, Tween 80 is 0.5%, and ethanol is 30%, and sodium citrate is 0.2%, lauryl sodium sulfate is 0.2%, and purified water is 67.3%.
The preparation method:
1) preparation chlorogenic acid: select the honeysuckle raw material, Tumble Dry, pulverize, adopting 8 times of volume purified water to stir extraction below 60 ℃, extract three times, extracted 1 hour at every turn, filter behind the merging extract, filtrate is adopted the macroreticular resin absorbing method purifies and separates, promptly gets the chlorogenic acid powder after the refined solution atomized drying;
2) preparation gallic acid: get dry doubly flower fine powder, add 3 times of volume purified water, stir the sodium hydroxide solution that the back adds concentration 30%, added hot reflux 2 hours, add concentrated hydrochloric acid, filtered while hot, filtrate crystallisation by cooling, crystallization is added 5 times of water-soluble separating, add activated carbon and added hot reflux 30 minutes, filtered while hot, filtrate crystallisation by cooling, separating, washing promptly gets the gallic acid crystal after the vacuum drying;
3) preparation matrine: get the radix sophorae meal with the alcohol heating reflux of concentration 65% 2 times, the each backflow 3 hours, the gained ethanol extract is evaporated to 1/2 of stoste, the HCl that adds concentration 1% regulates pH to 3, filter, filtrate adds 5%NaOH to pH to 10, uses chloroform extraction, reclaim chloroform solution, the evaporate to dryness chloroform gets matrine.
4) get the 2g chlorogenic acid, 5g gallic acid, 3g matrine, 2g caryophyllus oil, 2g peppermint oil, 4g volatile argyi leaf oil, 5g Tween 80,300g ethanol, 2g sodium citrate, 2g lauryl sodium sulfate, 673g purified water; At first chlorogenic acid, gallic acid, matrine, ethanol, Tween 80, peppermint oil, caryophyllus oil, volatile argyi leaf oil are mixed and stir, partial purification water, dodecyl sulphate stir successively then, regulate PH to 6 with sodium citrate again, add the residue purified water, filter behind the mixing, obtain clarifying the solution of homogeneous.
Embodiment 2
The percentage by weight of needed raw material is: chlorogenic acid is 0.1%, gallic acid is 0.5%, and matrine is 1%, and caryophyllus oil is 0.4%, peppermint oil is 0.5%, volatile argyi leaf oil is 1%, and Tween 80 is 1%, and ethanol is 10%, sodium citrate is 1%, lauryl sodium sulfate is 0.8%, and the fragrance conditioning agent is 0.2%, and purified water is 83.5%.
The preparation method:
1) preparation chlorogenic acid: select the honeysuckle raw material, Tumble Dry, pulverize, adopting 7 times of volume purified water to stir extraction below 60 ℃, extract three times, extracted 1 hour at every turn, filter behind the merging extract, filtrate is adopted the macroreticular resin absorbing method purifies and separates, promptly gets the chlorogenic acid powder after the refined solution atomized drying;
2) preparation gallic acid: get dry doubly flower fine powder, add 3 times of volume purified water, stir the sodium hydroxide solution that the back adds concentration 20%, added hot reflux 2 hours, add concentrated hydrochloric acid, filtered while hot, filtrate crystallisation by cooling, crystallization is added 5 times of water-soluble separating, add activated carbon and added hot reflux 30 minutes, filtered while hot, filtrate crystallisation by cooling, separating, washing promptly gets the gallic acid crystal after the vacuum drying;
3) preparation matrine: get the radix sophorae meal with the alcohol heating reflux of concentration 65% 2 times, the each backflow 3 hours, the gained ethanol extract is evaporated to 1/2 of stoste, the HCl that adds concentration 1% regulates pH to 4, filter, filtrate adds 5%NaOH to pH to 10, uses chloroform extraction, reclaim chloroform solution, the evaporate to dryness chloroform gets matrine;
4) get the 1g chlorogenic acid, 5g gallic acid, 10g matrine, 4g caryophyllus oil, 5g peppermint oil, 10g volatile argyi leaf oil, 10g Tween 80,100g ethanol, 10g sodium citrate, 8g lauryl sodium sulfate, 2g fragrance conditioning agent, 835g purified water; At first chlorogenic acid, gallic acid, matrine, ethanol, Tween 80, peppermint oil, caryophyllus oil, volatile argyi leaf oil are mixed and stir, adding partial purification water again stirs, add lauryl sodium sulfate, fragrance conditioning agent mixing then successively, regulate PH to 4 with sodium citrate again, add the residue purified water, filter behind the mixing, obtain clarifying the solution of homogeneous.
Embodiment 3
The percentage by weight of needed raw material is: chlorogenic acid is 0.5%, gallic acid is 1%, and matrine is 0.5%, and caryophyllus oil is 0.8%, peppermint oil is 1%, spearmint oil is 0.2%, and Tween 80 is 2%, and ethanol is 50%, sodium citrate is 0.5%, lauryl sodium sulfate is 0.5%, and the fragrance conditioning agent is 0.5%, and purified water is 42.5%.
The preparation method:
1) preparation chlorogenic acid: select the honeysuckle raw material, Tumble Dry, pulverize, adopting 10 times of volume purified water to stir extraction below 60 ℃, extract three times, extracted 2 hours at every turn, filter behind the merging extract, filtrate is adopted the macroreticular resin absorbing method purifies and separates, promptly gets the chlorogenic acid powder after the refined solution atomized drying;
2) preparation gallic acid: get dry doubly flower fine powder, add 3 times of volume purified water, stir the sodium hydroxide solution that the back adds concentration 40%, added hot reflux 2 hours, add concentrated hydrochloric acid, filtered while hot, filtrate crystallisation by cooling, crystallization is added 5 times of water-soluble separating, add activated carbon and added hot reflux 30 minutes, filtered while hot, filtrate crystallisation by cooling, separating, washing promptly gets the gallic acid crystal after the vacuum drying;
3) preparation matrine: get the radix sophorae meal with the alcohol heating reflux of concentration 65% 2 times, the each backflow 3 hours, the gained ethanol extract is evaporated to 1/2 of stoste, the HCl that adds concentration 1% regulates pH to 3, filter, filtrate adds 5%NaOH to pH to 9, uses chloroform extraction, reclaim chloroform solution, the evaporate to dryness chloroform gets matrine;
4) get the 5g chlorogenic acid, 10g gallic acid, 5g matrine, 8g caryophyllus oil, 10g peppermint oil, 2g volatile argyi leaf oil, 20g Tween 80,500g ethanol, 5g sodium citrate, 5g lauryl sodium sulfate, 5g fragrance conditioning agent, 672g purified water; At first chlorogenic acid, gallic acid, matrine, ethanol, Tween 80, peppermint oil, caryophyllus oil, volatile argyi leaf oil are mixed and stir, adding partial purification water again stirs, add lauryl sodium sulfate, fragrance conditioning agent mixing then successively, regulate PH to 5 with sodium citrate again, add the residue purified water, filter behind the mixing, obtain clarifying the solution of homogeneous.
It is as follows that the present invention makes after the spray Disinfection Effect of room air:
Press 2-3ml/m
3Consumption in the spray booth, falls the sum (cfu/m of bacterium in the air
3): air sterillization is preceding 668 ± 239, after the air sterillization 178 ± 97, is significantly less than China's national standard (operating room 500cfu/m3), near WHO II level operating room standard (II level operating room＜170cfu/m
3), the Disinfection Effect excellence.In addition, the used fragrance adjuvant of the present invention is pure plant extracts, and sterilization back room air is clearly pleasant, and the effect that produces refreshing effect to the mind is arranged.
Assert that through sterile products inspection body Shandong Province's Experimental Animal Center that Shandong Province Department of Public Health is assert plant extract thimerosal of the present invention has following experimental result:
The bacteria colony count of plant extract thimerosal (cfu/ml), coliform, Pseudomonas aeruginosa, hemolytic streptococcus, staphylococcus aureus, fungus colony sum (cfu/ml) all meet 2002 version " disinfection technology standard " requirement.
Under 19-21 ℃ of condition, contain the phosphate buffer neutralizer of 0.1% sodium thiosulfate+0.1% lecithin+2% Tween 80 and the neutralized reaction product that forms with stoste of the present invention thereof, staphylococcus aureus growth and medium there is not influence, and quantitatively kill in the test inhibitory action of the stoste of the present invention that can effectively neutralize at suspension to bacterial propagule.
Under 19-21 ℃ of condition, spraying stoste of the present invention effect was on average killed logarithm value all＞5.00 to staphylococcus aureus, Escherichia coli after 5 minutes.
Acute toxicity experience finds, stoste of the present invention is to the LC50＞5000mg/kgbw of the acute oral toxicity test of female, male mouse, to the LC50＞10000mg/m of the acute toxicity on inhalation test of female, male mouse
3Bw.According to version " disinfection technology standard " acute toxicity grading criteria in 2002, all true border of acute oral toxicity test of the present invention, acute toxicity on inhalation test was nontoxic.
According to version " disinfection technology standard " skin irritatin in 2002 reaction scoring and stimulus intensity grade scale, stoste of the present invention is carried out repeatedly intact skin irritant test with experimental rabbit, skin is belonged to non-stimulated.
According to version " disinfection technology standard " eye in 2002 irritant reaction scoring and eye irritant reaction grade scale, stoste of the present invention is carried out acute eye with experimental rabbit and is stimulated irritant test, belongs to non-stimulated.
Claims (4)
1. thimerosal that adopts plant extracts to make, it is characterized in that comprising following raw materials by weight percent: chlorogenic acid is 0.05-0.5%, gallic acid is 0.1-1%, matrine is 0-1%, caryophyllus oil is 0-0.8%, and peppermint oil is 0-1%, and volatile argyi leaf oil or spearmint oil are 0-1%, Tween 80 is 0.1-2%, ethanol is 5-50%, and sodium citrate is 0.1-1%, and lauryl sodium sulfate is 0-0.8%, the fragrance conditioning agent is 0-0.5%, and surplus is a purified water; The preparation method of described chlorogenic acid is: select the honeysuckle raw material, Tumble Dry, pulverize, form the honeysuckle material powder, in powder, add 6～10 times of volume purified water and stirring extraction below 60 ℃, extract once the back and filter collection filtrate, filter residue so extracts with 6～10 times of volume purified water once more, extracts altogether three times, the each extraction 1～2 hour, filter once more after merging extract, filtrate is adopted the macroreticular resin absorbing method purifies and separates, promptly gets the chlorogenic acid powder after the refined solution atomized drying; The preparation method of described gallic acid is: get dry doubly flower fine powder, add 3 times of volume purified water, stir the sodium hydroxide solution that the back adds concentration 20%-40%, added hot reflux 2 hours, add concentrated hydrochloric acid, filtered while hot, filtrate crystallisation by cooling, crystallization is added 5 times of water-soluble separating, add activated carbon and added hot reflux 30 minutes, filtered while hot, filtrate crystallisation by cooling, separating, washing promptly gets the gallic acid of crystal state after the vacuum drying; The preparation method of described matrine is: get the radix sophorae meal with 65% alcohol heating reflux of 10～15 times of volumes 2 times, the each backflow 3 hours, the gained ethanol extract is evaporated to 1/2 of stoste, the HCl that adds concentration 1% regulates pH to 3-4, filter, filtrate adds 5%NaOH to pH=9-10, uses chloroform extraction, reclaim chloroform solution, the evaporate to dryness chloroform gets matrine.
2. the thimerosal that employing plant extracts according to claim 1 is made, it is characterized in that comprising following raw materials by weight percent: chlorogenic acid is 0.2%, and gallic acid is 0.5%, and matrine is 0.3%, caryophyllus oil is 0.2%, peppermint oil is 0.2%, and spearmint oil is 0.4%, and Tween 80 is 0.5%, ethanol is 30%, sodium citrate is 0.2%, and lauryl sodium sulfate is 0.2%, and surplus is a purified water.
3. the thimerosal that employing plant extracts according to claim 1 and 2 is made is characterized in that: described chlorogenic acid is a Honegsukle flower P.E; Described gallic acid is a times flower extract; Described matrine is a shrubby sophora extract.
4. the preparation method of the thimerosal of claim 1 is characterized in that may further comprise the steps:
(1) get material: get material according to following percentage by weight: chlorogenic acid is 0.05-0.5%, gallic acid is 0.1-1%, and matrine is 0-1%, and caryophyllus oil is 0-0.8%, peppermint oil is 0-1%, volatile argyi leaf oil or spearmint oil are 0-1%, and Tween 80 is 0.1-2%, and ethanol is 5-50%, sodium citrate is 0.1-1%, lauryl sodium sulfate is 0-0.8%, and the fragrance conditioning agent is 0-0.5%, and surplus is a purified water;
(2) described chlorogenic acid, gallic acid, matrine, caryophyllus oil, peppermint oil, volatile argyi leaf oil or the spearmint oil of step (1), Tween 80 and ethanol are mixed and stir, a part that adds described purified water again stirs, add described lauryl sodium sulfate, fragrance conditioning agent mixing then successively, regulate pH to 4～6 with sodium citrate again, the remainder that adds described purified water, filter behind the mixing, the thimerosal that obtains clarifying homogeneous gets final product.
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| CN104782672A (en) * | 2015-03-25 | 2015-07-22 | 申爱华 | Disinfectant for cleaning urine analyzer and preparation method of disinfectant |
| CN104996503B (en) * | 2015-07-22 | 2017-09-29 | 四川农业大学 | It is a kind of for Chinese medicine compound prescription air sterillization spray of plant and preparation method thereof |
| CN105561364A (en) * | 2016-01-21 | 2016-05-11 | 苏州派腾生物医药科技有限公司 | Air freshener with sterilizing function |
| CN105664214A (en) * | 2016-01-21 | 2016-06-15 | 苏州派腾生物医药科技有限公司 | Traditional Chinese medicine based air refresher |
| CN106962420A (en) * | 2017-05-16 | 2017-07-21 | 广州肽然生物科技有限公司 | A kind of disposable thimerosal based on plant extracts and preparation method thereof |
| CN107821483A (en) * | 2017-11-27 | 2018-03-23 | 广西协成日用化工有限公司 | A kind of table-ware disinfection liquid |
| CN107812177A (en) * | 2017-12-08 | 2018-03-20 | 裴润琼 | Chinese medicine preparation domestic disinfectant liquid and preparation method thereof |
| CN108675578A (en) * | 2018-06-12 | 2018-10-19 | 蒙城县京徽蒙农业科技发展有限公司 | A kind of deodorant and preparation method thereof for livestock and poultry feces processing |
| CN111494259A (en) * | 2020-04-23 | 2020-08-07 | 苦蒲丹(山东)中药科技有限公司 | Herbal antibacterial disinfectant |
| CN112316012A (en) * | 2020-11-19 | 2021-02-05 | 陕西康乐实业有限公司 | Moisturizing antibacterial gel and preparation method thereof |
| CN115039797A (en) * | 2022-03-24 | 2022-09-13 | 福建省农业科学院亚热带农业研究所（福建省农业科学院蔗麻研究中心） | Clove essential oil antibacterial mixed solution and application thereof |
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